The DOI matches its Crossref record; 192 of the 195 references it cites were found in a registry or an index.
The gut microbiota–brain axis in behaviour and brain disorders
Abstract
In a striking display of trans-kingdom symbiosis, gut bacteria cooperate with their animal hosts to regulate the development and function of the immune, metabolic and nervous systems through dynamic bidirectional communication along the 'gut-brain axis'. These processes may affect human health, as certain animal behaviours appear to correlate with the composition of gut bacteria, and disruptions in microbial communities have been implicated in several neurological disorders. Most insights about host-microbiota interactions come from animal models, which represent crucial tools for studying the various pathways linking the gut and the brain. However, there are complexities and manifest limitations inherent in translating complex human disease to reductionist animal models. In this Review, we discuss emerging and exciting evidence of intricate and crucial connections between the gut microbiota and the brain involving multiple biological systems, and possible contributions by the gut microbiota to neurological disorders. Continued advances from this frontier of biomedicine may lead to tangible impacts on human health.
Overview
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“This two-way communication, involving the vagus nerve, immune modulation, and microbial metabolism, plays a crucial role in regulating emotions, cognitive function, and behavior.”
From The Impact of Weizmannia coagulans BC99 on Anxiety and Depression: An 8-Week Clinical Pilot Study Through the Gut Microbiota–Brain Axis (2025) · cites this paper as [10]
In the citing paper
“Evidence has unveiled the bidirectional communication between the gut microbiome and the central nervous system, referred to as the “microbiota–gut–brain axis”.”
From Microbiota–gut–brain axis and its therapeutic applications in neurodegenerative diseases (2024) · cites this paper as [31]
In the citing paper
“Although the gut and brain are anatomically separated, several pathways by which the gut microbiota communicates with the CNS have been proposed. These include modulation of the immune system, vagus nerve, enteric nervous system (ENS), neuroendocrine system, and circulatory system via the production of neuroactive substances, metabolites, and hormones (Fig. 1).31,32”
From Microbiota–gut–brain axis and its therapeutic applications in neurodegenerative diseases (2024) · cites this paper as [31]
In the citing paper
“The gut microbiota contributes to host physiology and brain health by generating a variety of metabolites through bacterial de novo metabolism and by modifying host-derived molecules.31,270”
From Microbiota–gut–brain axis and its therapeutic applications in neurodegenerative diseases (2024) · cites this paper as [31]
In the citing paper
“The gut microbiota influences the development and function of microglia, the brain’s resident immune cells [93].”
From Unraveling the Connections: Eating Issues, Microbiome, and Gastrointestinal Symptoms in Autism Spectrum Disorder (2025) · cites this paper as [93]
Citations
Cites
Diagnostic and Statistical Manual of Mental Disorders
American Psychiatric Association (2013) · doi:10.1176/appi.books.9780890425596 · Cited by 116,369
Kessler, R. C., Chiu, W. T., Demler, O., & Walters, E. E. (2005) · Archives of General Psychiatry · doi:10.1001/archpsyc.62.6.617 · Cited by 12,052
Staging of brain pathology related to sporadic Parkinson’s disease
Braak, H., Tredici, K. D., Rüb, U., de Vos, R. A. I., Jansen Steur, E. N. H., & Braak, E. (2003) · Neurobiology of Aging · doi:10.1016/s0197-4580(02)00065-9 · Cited by 10,777
Diet rapidly and reproducibly alters the human gut microbiome
David, L. A., Maurice, C. F., Carmody, R. N., Gootenberg, D. B., Button, J. E., Wolfe, B. E., Ling, A. V., Devlin, A. S., Varma, Y., Fischbach, M. A., et al. (2014) · Nature · doi:10.1038/nature12820 · Cited by 10,100
The gut microbiota as an environmental factor that regulates fat storage
Bäckhed, F., Ding, H., Wang, T., Hooper, L. V., Koh, G. Y., Nagy, A., Semenkovich, C. F., & Gordon, J. I. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0407076101 · Cited by 6,245
Baio, J., Wiggins, L., Christensen, D. L., Maenner, M. J., Daniels, J., Warren, Z., Kurzius-Spencer, M., Zahorodny, W., Robinson, C., Rosenberg, et al. (2018) · MMWR. Surveillance Summaries · doi:10.15585/mmwr.ss6706a1 · Cited by 6,078
Cryan, J. F., O'Riordan, K. J., Cowan, C. S. M., Sandhu, K. V., Bastiaanssen, T. F. S., Boehme, M., Codagnone, M. G., Cussotto, S., Fulling, C., Golubeva, A. V., et al. (2019) · Physiological Reviews · doi:10.1152/physrev.00018.2018 · Cited by 5,286
2016 Alzheimer's disease facts and figures
Alzheimer's Association (2016) · Alzheimer's & Dementia · doi:10.1016/j.jalz.2016.03.001 · Cited by 5,069
A Meta-Analysis of Cytokines in Major Depression
Dowlati, Y., Herrmann, N., Swardfager, W., Liu, H., Sham, L., Reim, E. K., & Lanctôt, K. L. (2010) · Biological Psychiatry · doi:10.1016/j.biopsych.2009.09.033 · Cited by 4,729
Interaction between microbiota and immunity in health and disease
Zheng, D., Liwinski, T., & Elinav, E. (2020) · Cell Research · doi:10.1038/s41422-020-0332-7 · Cited by 3,947
Cited by
Sorted by citations
Items 601–700 of 1,002
Ke, S., Wang, X., Ratanatharathorn, A. D., Huang, T., Roberts, A. L., Grodstein, F., Kubzansky, L. D., Koenen, K. C., & Liu, Y. (2023) · Nature Mental Health · doi:10.1038/s44220-023-00145-6 · Cited by 22
Muchhala, K. H., Kallurkar, P. S., Kang, M., Köşeli, E., Poklis, J. L., Xu, Q., Dewey, W. L., Fettweis, J. M., Jimenez, N. R., & Akbarali, H. I. (2024) · The FASEB Journal · doi:10.1096/fj.202301590rr · Cited by 20
Su, K., Shreffler, W. G., & Yuan, Q. (2021) · Annals of Allergy Asthma & Immunology · doi:10.1016/j.anai.2021.02.024 · Cited by 23
Extracellular Vesicles: A Crucial Player in the Intestinal Microenvironment and Beyond
Wang, S., Luo, J., Wang, H., Chen, T., Sun, J., Xi, Q., & Zhang, Y. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25063478 · Cited by 23
Interoception in Autism: A Narrative Review of Behavioral and Neurobiological Data
Loureiro, F., Ringold, S. M., & Aziz‐Zadeh, L. (2024) · Psychology Research and Behavior Management · doi:10.2147/prbm.s410605 · Cited by 31
Bacterial peptidoglycan serves as a critical modulator of the gut-immune-brain axis in Drosophila
Fioriti, F., Rifflet, A., Boneca, I. G., Zugasti, O., & Royet, J. (2024) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2024.05.009 · Cited by 20
Indole induces anxiety-like behaviour in mice mediated by brainstem locus coeruleus activation
Mir, H.-D., Yang, Q., Maximin, E., Montardy, Q., Ji, S., Cheng, Q., Shan, X., Wang, L., Naudon, L., Rabot, S., et al. (2024) · Neurobiology of Disease · doi:10.1016/j.nbd.2024.106606 · Cited by 21
Gut microbiota of children with autism spectrum disorder and healthy siblings: A comparative study
Abuljadayel, D. A., Alotibi, A., Alqothmi, K., Basingab, F. S., Alhazmi, S., Almuhammadi, A., Alharthi, A., Alyoubi, R. A., & Bahieldin, A. (2024) · Experimental and Therapeutic Medicine · doi:10.3892/etm.2024.12719 · Cited by 26
Kumar, D., Bishnoi, M., Kondepudi, K. K., & Sharma, S. S. (2025) · Probiotics and Antimicrobial Proteins · doi:10.1007/s12602-024-10433-x · Cited by 22
The microbiome as a modulator of neurological health across the maternal-offspring interface
Orchanian, S. B., & Hsiao, E. Y. (2025) · Journal of Clinical Investigation · doi:10.1172/jci184314 · Cited by 23
Diacova, T., Cifelli, C. J., Davis, C. D., Holscher, H. D., Kable, M. E., Lampe, J. W., Latulippe, M. E., Swanson, K. S., & Karl, J. P. (2025) · Advances in Nutrition · doi:10.1016/j.advnut.2025.100419 · Cited by 27
In utero human intestine contains maternally derived bacterial metabolites
Wang, W., Gu, W., Schweitzer, R., Koren, O., Khatib, S., Tseng, G. C., & Konnikova, L. (2025) · Microbiome · doi:10.1186/s40168-025-02110-0 · Cited by 25
Molecular Mechanisms of Chronic Pain and Therapeutic Interventions
Li, Z., Li, X., Liu, J., Sun, R., Ye, Y., Xiang, H., Luo, F., Li, S., & Luo, A. (2025) · MedComm · doi:10.1002/mco2.70325 · Cited by 31
Infant gut microbiome reprogramming following introduction of solid foods (weaning)
Ding, M., Ross, R. P., Dempsey, E. M., Li, B., & Stanton, C. (2025) · Gut Microbes · doi:10.1080/19490976.2025.2571428 · Cited by 22
Microbiota-gut-brain axis: A novel potential target of ketogenic diet for epilepsy
Tang, Y. C., Wang, Q., & Liu, J. (2021) · Current Opinion in Pharmacology · doi:10.1016/j.coph.2021.08.018 · Cited by 21
The Interaction among Microbiota, Epigenetic Regulation, and Air Pollutants in Disease Prevention
Pulliero, A., Traversi, D., Franchitti, E., Barchitta, M., Izzotti, A., & Agodi, A. (2021) · Journal of Personalized Medicine · doi:10.3390/jpm12010014 · Cited by 22
Monocyte regulation by gut microbial signals
Kolypetri, P., & Weiner, H. L. (2023) · Trends in Microbiology · doi:10.1016/j.tim.2023.05.006 · Cited by 21
Chronic Stress as a Risk Factor for Type 2 Diabetes: Endocrine, Metabolic, and Immune Implications
Lisco, G., Giagulli, V. A., Pergola, G. D., Guastamacchia, E., Jirillo, E., Vitale, E., & Triggiani, V. (2023) · Endocrine Metabolic & Immune Disorders - Drug Targets · doi:10.2174/1871530323666230803095118 · Cited by 25
Zhang, F., Guo, L., Shi, J., Jiang, H., Zhou, F., Zhou, Y., Lv, B., & Xu, M. (2023) · Neurobiology of Disease · doi:10.1016/j.nbd.2023.106390 · Cited by 22
Zhang, K., Guo, H., Zhang, X., Yang, H., Yuan, G., Zhu, Z., Lu, X., Zhang, J., Du, J. C., Shi, H., et al. (2024) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2024.01.012 · Cited by 26
Wen, J., Skampardoni, I., Tian, Y., Yang, Z., Cui, Y., Erus, G., Hwang, G., Varol, E., Boquet-Pujadas, A., Chand, G. B., et al. (2025) · Nature Biomedical Engineering · doi:10.1038/s41551-025-01412-w · Cited by 21
The Role of the Gut Microbiota in Anorexia Nervosa in Children and Adults—Systematic Review
Anton-Păduraru, D.-T., Trofin, F., Năstase, E. V., Miftode, R.-Ş., Miftode, I.-L., Trandafirescu, M. F., Cojocaru, E., Țarcă, E., Mîndru, D. E., & Dorneanu, O. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms25010041 · Cited by 21
Brain-Gut and Microbiota-Gut-Brain Communication in Type-2 Diabetes Linked Alzheimer’s Disease
Momen, Y. S., Mishra, J., & Kumar, N. (2024) · Nutrients · doi:10.3390/nu16152558 · Cited by 26
Emerging role of microglia in the developing dopaminergic system: Perturbation by early life stress
She, K., Yuan, N., Huang, M., Zhu, W., Tang, M., Ma, Q., & Chen, J. (2024) · Neural Regeneration Research · doi:10.4103/nrr.nrr-d-24-00742 · Cited by 20
Kim, J. H., Choi, Y., Lee, S.-M., & Oh, M. S. (2024) · Biomolecules & Therapeutics · doi:10.4062/biomolther.2024.215 · Cited by 22
Gut Feelings: How Microbes, Diet, and Host Immunity Shape Disease
Theis, B. F., Park, J. S., Kim, J. S., Zeydabadinejad, S., Vijay–Kumar, M., Yeoh, B. S., & Saha, P. (2025) · Biomedicines · doi:10.3390/biomedicines13061357 · Cited by 24
Recent advances in the application of microbiota transplantation in chickens
Zhao, H., Comer, L., Akram, M. Z., Corion, M., Li, Y., & Everaert, N. (2025) · Journal of Animal Science and Biotechnology/Journal of animal science and biotechnology · doi:10.1186/s40104-025-01233-6 · Cited by 20
Role of gut microbiota in neuroinflammation: a focus on perioperative neurocognitive disorders
Zhou, Q., Chen, T., Wang, X., Xu, Z., Song, Y., Liu, S., Ge, Y., & Gao, J. (2025) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2025.1582909 · Cited by 24
Naga, N. G., Taha, R. M., Hamed, E. A., Nawar, E. A., Jaheen, H. O., Mobarak, A. A., Radwan, Y. M., Faramawy, A. G., & Arayes, M. A. (2025) · Tropical Diseases Travel Medicine and Vaccines · doi:10.1186/s40794-025-00275-y · Cited by 20
Wang, N., Meng, F., Ma, S., & Fu, L. (2022) · Gene · doi:10.1016/j.gene.2022.146205 · Cited by 20
The Potential Crosstalk Between the Brain and Visceral Adipose Tissue in Alzheimer’s Development
Nguyen, T. T., Hulme, J., Vo, T. K., & Vo, G. V. (2022) · Neurochemical Research · doi:10.1007/s11064-022-03569-1 · Cited by 21
Gut Microbiota and Immunotherapy for Alzheimer’s Disease
Dai, C., Liu, F., Iqbal, K., & Gong, C. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms232315230 · Cited by 22
Komorniak, N., Kley, A. M., Nalian, A. G., Wroński, M., Kaseja, K., Kowalewski, B., Kaźmierczak-Siedlecka, K., Łoniewski, I., Kaczmarczyk, M., Podsiadło, K., et al. (2022) · Nutrients · doi:10.3390/nu14245372 · Cited by 21
Effects of a probiotic suspension Symprove™ on a rat early-stage Parkinson’s disease model
Sancandi, M., Caro, C. D., Cypaite, N., Marascio, N., Avagliano, C., Marco, C. D., Russo, E., Constanti, A., & Mercer, A. (2023) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2022.986127 · Cited by 22
The role of the gut microbiota and fecal microbiota transplantation in neuroimmune diseases
Wu, N., Li, X., Ma, H., Zhang, X., Liu, B., Yuan, W., Zheng, Q., & Fan, X. (2023) · Frontiers in Neurology · doi:10.3389/fneur.2023.1108738 · Cited by 22
Liu, J., Chen, H., Yu, T., Fu, X., Qian, C., & Feng, X. (2023) · Aging · doi:10.18632/aging.204642 · Cited by 20
Rhythms in barriers and fluids: Circadian clock regulation in the aging neurovascular unit
Skapetze, L., Owino, S., Lo, E. H., Arai, K., Merrow, M. W., & Harrington, M. E. (2023) · Neurobiology of Disease · doi:10.1016/j.nbd.2023.106120 · Cited by 20
Keubler, L. M., Talbot, S. R., Bleich, A., & Boyle, E. C. (2023) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2023.105316 · Cited by 20
Health-related quality of life is linked to the gut microbiome in kidney transplant recipients
Swarte, J. C., Knobbe, T. J., Björk, J. R., Gaćeša, R., Nieuwenhuis, L. M., Zhang, S., Vila, A. V., Kremer, D., Douwes, R. M., Post, A., et al. (2023) · Nature Communications · doi:10.1038/s41467-023-43431-8 · Cited by 20
Wan, Y., Zhang, L., Xu, Z., Su, Q., Leung, T.-F., Chan, D., Wong, O. W. H., Chan, S. S. M., Chan, F. K. L., Tun, H. M., et al. (2024) · Cell Reports Medicine · doi:10.1016/j.xcrm.2024.101409 · Cited by 23
Sancho‐Balsells, A., Borràs‐Pernas, S., Flotta, F., Chen, W., del Toro, D., Rodríguez, M. J., Alberch, J., Blivet, G., Touchon, J., Xifró, X., et al. (2024) · Journal of Affective Disorders · doi:10.1016/j.jad.2024.03.075 · Cited by 20
Jiang, Y., Zeng, X., Dai, H., Luo, S., & Zhang, X. (2024) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2024.134494 · Cited by 23
Gut microbiota metabolites: potential therapeutic targets for Alzheimer’s disease?
Zhang, S., Lu, J., Jin, Z., Xu, H., Zhang, D., Chen, J., & Wang, J. (2024) · Frontiers in Pharmacology · doi:10.3389/fphar.2024.1459655 · Cited by 25
Human microbiota peptides: important roles in human health
Shah, A. B., & Shim, S. H. (2024) · Natural Product Reports · doi:10.1039/d4np00042k · Cited by 22
Exploring the Connections: Autophagy, Gut Microbiota, and Inflammatory Bowel Disease Pathogenesis
Subramanian, A., Jahabardeen, A., Thamaraikani, T., Kumarasamy, V., Begum, M. Y., Sekar, M., Subramaniyan, V., Wong, L. S., & Fatease, A. M. A. (2024) · Journal of Inflammation Research · doi:10.2147/jir.s483958 · Cited by 19
Medication use is associated with distinct microbial features in anxiety and depression
Dilmore, A. H., Kuplicki, R., McDonald, D. L., Kumar, M., Estaki, M., Youngblut, N. D., Tyakht, A., Ackermann, G. L., Blach, C., MahmoudianDehkordi, S., et al. (2025) · Molecular Psychiatry · doi:10.1038/s41380-024-02857-2 · Cited by 21
The Microbiota–Human Health Axis
John, H. T., Thomas, T. C., Chukwuebuka, E. C., Ali, A. B., Anass, R., Tefera, Y. Y., Babu, B., Negruţ, N., Ferician, A. C., & Marian, P. (2025) · Microorganisms · doi:10.3390/microorganisms13040948 · Cited by 27
Mela, V., Heras, V., Iešmantaitė, M., García‐Martín, M. L., Bernal, M., Posligua-García, J. D., Subiri-Verdugo, A., Martínez‐Montoro, J. I., Gómez‐Pérez, A. M., Bandera, B., et al. (2025) · Gut · doi:10.1136/gutjnl-2025-335353 · Cited by 23
Mucus and mucin: changes in the mucus barrier in disease states
Fan, F., Guo, R., Pan, K., Xu, H., & Chu, X. (2025) · Tissue Barriers · doi:10.1080/21688370.2025.2499752 · Cited by 20
Peng, Z., Hou, T., Yang, K., Zhang, J., Mao, Y.-H., & Hou, X. (2025) · Nutrients · doi:10.3390/nu17111769 · Cited by 21
Arbutin ameliorated depression by inhibiting neuroinflammation and modulating intestinal flora
Cao, Y., Zhao, K., Zhao, Y., Ni, Y., Zhang, Z., Yuan, X., Ning, J., Song, Q., Zhao, F., He, L., et al. (2025) · Phytomedicine · doi:10.1016/j.phymed.2025.156944 · Cited by 21
Luo, S., Pan, M., Fu, G., Meng, X., Zhao, Z., Yu, H., Yue, G.-X., & Lei, T. (2025) · Pharmacological Research · doi:10.1016/j.phrs.2025.107974 · Cited by 19
Blecharz‐Klin, K., Świerczyńska, M., Piechal, A., Wawer, A., Joniec‐Maciejak, I., Pyrzanowska, J., Wojnar, E., Zawistowska‐Deniziak, A., Sulima-Celińska, A., Młocicki, D., et al. (2022) · PLoS Pathogens · doi:10.1371/journal.ppat.1010330 · Cited by 22
Gastrointestinal Changes and Alzheimer's Disease
Sohrabi, M., Sahu, B., Kaur, H., Hasler, W. A., Prakash, A. K., & Combs, C. K. (2022) · Current Alzheimer Research · doi:10.2174/1567205019666220617121255 · Cited by 18
Perturbed gut microbiota is gender-segregated in unipolar and bipolar depression
Li, Y., Zhang, H., Zheng, P., Yang, J., Wu, J., Huang, Y., Hu, X., Tan, X., Duan, J., Chai, T., et al. (2022) · Journal of Affective Disorders · doi:10.1016/j.jad.2022.08.027 · Cited by 20
Weber, T. M., Tatzl, E., Kashofer, K., Holter, M., Trajanoski, S., Berghold, A., Heinemann, Á., Holzer, P. D., & Herbert, M. K. (2022) · PLoS ONE · doi:10.1371/journal.pone.0274026 · Cited by 22
Neto, J., Jantsch, J., Rodrigues, F. D. S., Squizani, S., Eller, S. C. W. D. S., de Oliveira, T. F., Silveira, A. K., Moreira, J. C. F., Giovenardi, M., Porawski, M., et al. (2022) · Physiology & Behavior · doi:10.1016/j.physbeh.2022.114068 · Cited by 21
The influence of the microbiome on aggressive behavior: an insight into age-related aggression
Gulledge, L. M., Oyebode, D., & Donaldson, J. R. (2023) · FEMS Microbiology Letters · doi:10.1093/femsle/fnac114 · Cited by 20
Zeng, H., Zhou, K., Zhuang, Y., Li, A., Luo, B., & Zhang, Y. (2023) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2023.1273104 · Cited by 19
Santi, D., Debbi, V., Costantino, F., Spaggiari, G., Simoni, M., Greco, C., & Casarini, L. (2023) · Clocks & Sleep · doi:10.3390/clockssleep5040050 · Cited by 20
Gastrointestinal conditions in the multiple sclerosis prodrome
Yusuf, F. L. A., Zhu, F., Evans, C. D., Fisk, J. D., Zhao, Y., Marrie, R. A., & Tremlett, H. L. (2023) · Annals of Clinical and Translational Neurology · doi:10.1002/acn3.51945 · Cited by 19
The Probiotic Lactobacillus reuteri Preferentially Synthesizes Kynurenic Acid from Kynurenine
Schwarcz, R. M., Foo, A., Sathyasaikumar, K. V., & Notarangelo, F. M. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25073679 · Cited by 19
Pax, K., Buduneli, N., Alan, M., Meriç, P., Gürlek, Ö., Dabdoub, S. M., & Kumar, P. (2024) · Microbiome · doi:10.1186/s40168-024-01761-9 · Cited by 20
Pleasurable and problematic receptive anal intercourse and diseases of the colon, rectum and anus
Dickstein, D. R., Edwards, C. R., Rowan, C. R., Avanessian, B. K., Chubak, B. M., Wheldon, C. W., Simoes, P. K., Buckstein, M. H., Keefer, L., Safer, J. D., et al. (2024) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/s41575-024-00932-1 · Cited by 19
Coffee and Parkinson's disease
Asuku, A. O., Ayinla, M. T., Olajide, T. S., Oyerinde, T. O., Yusuf, J. A., Bayo-Olugbami, A. A., & Fajemidagba, G. A. (2024) · Progress in brain research · doi:10.1016/bs.pbr.2024.06.001 · Cited by 19
Singh, D. P., Kumar, A., Prajapati, J., Bijalwan, V., Kumar, J., Amin, P., Kandoriya, D., Vidhani, H., Patil, G. P., Bishnoi, M., et al. (2024) · Journal of Hazardous Materials · doi:10.1016/j.jhazmat.2024.135178 · Cited by 20
Maftoon, H., Siadat, S. D., Tarashi, S., Soroush, E., Asefi, M. B., Foroushani, A. R., & Dallal, M. M. S. (2024) · Brain Research · doi:10.1016/j.brainres.2024.149280 · Cited by 20
Cortes, G. M., Marcialis, M. A., Bardanzellu, F., Corrias, A., Fanos, V., & Mussap, M. (2022) · Frontiers in Microbiology · doi:10.3389/fmicb.2022.856165 · Cited by 21
Primary Cilia Structure Is Prolonged in Enteric Neurons of 5xFAD Alzheimer’s Disease Model Mice
Nguyen, V. T. T., Brücker, L., Volz, A.-K., Baumgärtner, J. C., dos Santos Guilherme, M., Valeri, F., May-Simera, H., & Endres, K. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms222413564 · Cited by 16
Role of sulfidogenic members of the gut microbiota in human disease
Pimenta, A. I., Bernardino, R. M., & Pereira, I. A. C. (2024) · Advances in microbial physiology/Advances in Microbial Physiology · doi:10.1016/bs.ampbs.2024.04.003 · Cited by 18
HIV-associated neurocognitive disorder: key implications of the microbiota-gut-brain axis
Hu, A., Zaongo, S. D., Harypursat, V., Wang, X., Ouyang, J., & Chen, Y. (2024) · Frontiers in Microbiology · doi:10.3389/fmicb.2024.1428239 · Cited by 18
Zhao, Y., Ma, S., Liang, L., Cao, S., Fan, Z., He, D., Shi, X., Zhang, Y., Liu, B., Zhai, M., et al. (2024) · Research · doi:10.34133/research.0482 · Cited by 21
Siripaopradit, Y., Chatsirisakul, O., Ariyapaisalkul, T., & Sereemaspun, A. (2024) · BMC Neurology · doi:10.1186/s12883-024-03978-5 · Cited by 27
Gamal, N. K., El‐Naga, R. N., Ayoub, I. M., & George, M. Y. (2025) · International Immunopharmacology · doi:10.1016/j.intimp.2025.114216 · Cited by 18
Wang, Z., Ma, X., Shi, W., Zhu, W., Feng, X., Xin, H., Zhang, Y., Cong, B., & Li, Y. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms26041698 · Cited by 18
Puetz, L., Delmont, T. O., Aizpurua, O., Guo, C., Zhang, G., Katajamaa, R., Jensen, P., & Gilbert, M. T. P. (2021) · Advanced Genetics · doi:10.1002/ggn2.202100018 · Cited by 18
Haditomo, A. H. C., Yonezawa, M., Yu, J., Mino, S., Sakai, Y., & Sawabe, T. (2021) · Frontiers in Marine Science · doi:10.3389/fmars.2021.802754 · Cited by 18
Trofimova, I. N., & Gaykalova, A. A. (2021) · Frontiers in Psychology · doi:10.3389/fpsyg.2021.781631 · Cited by 19
Animal models for assessing impact of C-section delivery on biological systems
Cabré, S., Ratsika, A., Rea, K., Stanton, C., & Cryan, J. F. (2022) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2022.104555 · Cited by 17
Xu, Y., Wang, Y., Xu, J., Song, Y., Liu, B., & Xiong, Z. (2022) · Microbiology Spectrum · doi:10.1128/spectrum.00331-22 · Cited by 18
Luo, B., Yu, J., He, F., He, F., Meng, F., Xu, C., Xu, C., Wen, X., 洪丽蓉, Gao, J., et al. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.781148 · Cited by 18
Liu, C., Wong, P. Y., Chow, S. K., Cheung, W., & Wong, R. M. Y. (2022) · Journal of Orthopaedic Translation · doi:10.1016/j.jot.2022.10.001 · Cited by 18
Wang, Y., Wang, M., Xie, B., Wen, D., Li, W., Zhou, M., Wang, X., Lu, Y., Cong, B., Ni, Z., et al. (2022) · Brain Research Bulletin · doi:10.1016/j.brainresbull.2022.12.003 · Cited by 18
de Llano, D. G., Roldán, M., Parro, L., Bartolomé, B., & Moreno-Arribas, M. V. (2023) · Metabolites · doi:10.3390/metabo13010108 · Cited by 19
The role of IL-23/IL-17 axis in ischemic stroke from the perspective of gut-brain axis
Jiang, Y., Dai, Y., Liu, Z., Liao, Y., Sun, S., Kong, X., Hu, J., & Tang, Y. (2023) · Neuropharmacology · doi:10.1016/j.neuropharm.2023.109505 · Cited by 18
Huang, T., Shang, Y., Dai, C., Zhang, Q., Hu, S., & Xie, J. M. (2023) · Annals of General Psychiatry · doi:10.1186/s12991-023-00453-2 · Cited by 18
The Role of the Microbiome in First Episode of Psychosis
Nuncio-Mora, L., Lanzagorta, N., Nicolini, H., Sarmiento, E., Ortiz, G., Sosa, F., & Mendoza, A. D. G. (2023) · Biomedicines · doi:10.3390/biomedicines11061770 · Cited by 18
Microbial metabolites regulate social novelty via CaMKII neurons in the BNST
Liou, C.-W., Cheng, S., Yao, T.-H., Lai, T.-T., Tsai, Y.-H., Chien, C.-W., Kuo, Y., Chou, S.-H., Hsu, C., & Wu, W. (2023) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2023.06.029 · Cited by 20
Novel therapeutic strategies in glioma targeting glutamatergic neurotransmission
Kumaria, A., & Ashkan, K. (2023) · Brain Research · doi:10.1016/j.brainres.2023.148515 · Cited by 20
Xu, K., Li, Z., Qiao, J.-C., Wang, S., Xie, P., Zong, Z., & Hu, C. (2023) · Environmental Pollution · doi:10.1016/j.envpol.2023.122439 · Cited by 18
Microbiota regulates life-cycle transition and nematocyte dynamics in jellyfish
Peng, S., Ye, L., Li, Y., Wang, F., Sun, T., Wang, L., Hao, W., Zhao, J.-M., & Dong, Z. (2023) · iScience · doi:10.1016/j.isci.2023.108444 · Cited by 18
Kiran, N. S., Yashaswini, C., & Chatterjee, A. (2023) · Life Sciences · doi:10.1016/j.lfs.2023.122311 · Cited by 19
Education as Risk Factor of Mild Cognitive Impairment: The Link to the Gut Microbiome
Klee, M., Aho, V. T. E., May, P., Heintz‐Buschart, A., Landoulsi, Z., Jónsdóttir, S. R., Pauly, C., Pavelka, L., Delacour, L., Kaysen, A., et al. (2024) · The Journal of Prevention of Alzheimer s Disease · doi:10.14283/jpad.2024.19 · Cited by 20
Bauer, N., Liu, D., Nguyen, T., & Wang, B. (2024) · ACS Chemical Neuroscience · doi:10.1021/acschemneuro.3c00742 · Cited by 19
Britton, R. A., Verdu, E. F., Rienzi, S. C. D., Reyes, A., Tarr, P. I., Preidis, G. A., Tomeo, N. J., Ranallo, R. T., Pimentel, M., & Chang, E. (2024) · Gastroenterology · doi:10.1053/j.gastro.2024.05.023 · Cited by 18
Barone, M., Martucci, M., Sciara, G., Conte, M., Medina, J., Iattoni, L., Miele, F., Fonti, C., Franceschi, C., Brigidi, P., et al. (2024) · The EPMA Journal · doi:10.1007/s13167-024-00369-1 · Cited by 22
Feng, J., Wu, Y., Meng, M., Zeng, R., Ma, Y., Luo, D., Zhang, L., Zhang, Y., Li, Y., Huang, W., et al. (2024) · International Journal of Surgery · doi:10.1097/js9.0000000000001831 · Cited by 19
Precision probiotics supplement strategy in aging population based on gut microbiome composition
Chuang, Y., Fan, K.-C., Su, Y.-Y., Wu, M.-F., Chiu, Y., Liu, Y., & Lin, C.-C. (2024) · Briefings in Bioinformatics · doi:10.1093/bib/bbae351 · Cited by 23
Wang, X., Xie, Z., Yuan, J., Jin, E., Lian, W., Chang, S., Sun, G., Feng, Z., Xu, H., Du, C., et al. (2024) · Cell Discovery · doi:10.1038/s41421-024-00725-5 · Cited by 19
Rizzi, F., Juan, B., Espadaler, J., Capellas, M., & Huedo, P. (2024) · Foods · doi:10.3390/foods13233851 · Cited by 21
Metadata
- Authors
- Morais, L. H., Schreiber, H. L., & Mazmanian, S. K.
- Affiliations
- California Institute of Technology (US)
- Corresponding author
- Mazmanian, Sarkis K.
- Venue
- Nature Reviews Microbiology
- Published
- 2020-10-22
- Volume
- 19
- Issue
- 4
- Pages
- 241-255
- ISSN
- 1740-1526 (ISSN-L)
- 1740-1534
- OpenAlex
- W3094330590
- Cited by
- 2,149
- References
- 195
- Citations by year
- 2026: 372 · 2025: 443 · 2024: 493 · 2023: 392 · 2022: 315 · 2021: 131 · 2020: 1
- FWCI
- 20.53
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Nature Reviews Microbiology (publishedVersion)
- PubMed (publishedVersion)
- CaltechAUTHORS (California Institute of Technology) (submittedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Health Sciences › Medicine › Gastroenterology › Gastrointestinal motility and disorders
- Life Sciences › Neuroscience › Biological Psychiatry › Tryptophan and brain disorders
- Keywords
- gut microbiota, gut-brain axis, host-microbiota interactions, animal behavior, neurological disorders, animal models of disease, two-way communication, immune regulation, metabolic regulation, brain development
- MeSH terms
- Gastrointestinal Microbiome, Host Microbial Interactions, Animals, Bacteria, Brain, Brain Diseases, Humans, Symbiosis, Models, Animal
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review