The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
The highly diverse antiphage defence systems of bacteria
Open accessAbstract
Bacteria and their viruses have coevolved for billions of years. This ancient and still ongoing arms race has led bacteria to develop a vast antiphage arsenal. The development of high-throughput screening methods expanded our knowledge of defence systems from a handful to more than a hundred systems, unveiling many different molecular mechanisms. These findings reveal that bacterial immunity is much more complex than previously thought. In this Review, we explore recently discovered bacterial antiphage defence systems, with a particular focus on their molecular diversity, and discuss the ecological and evolutionary drivers and implications of the existing diversity of antiphage defence mechanisms. In this Review, Georjon and Bernheim provide an overview of the molecular diversity of the most recently discovered bacterial antiphage defence systems and discuss their evolution and the ecological impact of their diversity.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Dynamic modulation of the gut microbiota and metabolome by bacteriophages in a mouse model
Hsu, B. B., Gibson, T. E., Yeliseyev, V., Liu, Q., Lyon, L., Bry, L., Silver, P. A., & Gerber, G. K. (2019) · Cell Host & Microbe · doi:10.1016/j.chom.2019.05.001 · Cited by 573
Deep, A., Gu, Y., Gao, Y.-Q., Ego, K. M., Herzik, M. A., Zhou, H., & Corbett, K. D. (2022) · Molecular Cell · doi:10.1016/j.molcel.2022.09.008 · Cited by 106
Cited by
Gaborieau, B., Vaysset, H., Tesson, F., Charachon, I., Dib, N., Bernier, J., Dequidt, T., Georjon, H., Clermont, O., Hersen, P., et al. (2024) · Nature Microbiology · doi:10.1038/s41564-024-01832-5 · Cited by 141
A break in mitochondrial endosymbiosis as a basis for inflammatory diseases
Murphy, M. P., & O’Neill, L. A. J. (2024) · Nature · doi:10.1038/s41586-023-06866-z · Cited by 138
Tesson, F., Planel, R., Egorov, A. A., Georjon, H., Vaysset, H., Brancotte, B., Néron, B., Mordret, E., Atkinson, G. C., Bernheim, A., et al. (2024) · Peer Community Journal · doi:10.24072/pcjournal.470 · Cited by 120
Self-citationDe novo gene synthesis by an antiviral reverse transcriptase
Tang, S., Conte, V., Zhang, D. J., Žedaveinytė, R., Lampe, G. D., Wiegand, T., Tang, L. C., Wang, M., Walker, M. W. G., George, J. T., et al. (2024) · Science · doi:10.1126/science.adq0876 · Cited by 58
DNA methylation activates retron Ec86 filaments for antiphage defense
Wang, Y., Wang, C., Guan, Z., Cao, J., Xu, J., Wang, S., Cui, Y., Wang, Q., Chen, Y., Yin, Y., et al. (2024) · Cell Reports · doi:10.1016/j.celrep.2024.114857 · Cited by 41
Humolli, D., Piel, D., Maffei, E., Heyer, Y., Agustoni, E., Shaidullina, A., Willi, L., Imwinkelried, P., Estermann, F., Cuénod, A., et al. (2025) · PLOS Biology · doi:10.1371/journal.pbio.3003063 · Cited by 36
Phages carry orphan antitoxin-like enzymes to neutralize the DarTG1 toxin-antitoxin defense system
Johannesman, A., Awasthi, L. C., Carlson, N., & LeRoux, M. (2025) · Nature Communications · doi:10.1038/s41467-025-56887-7 · Cited by 16
Systematic, high-throughput characterization of bacteriophage gene essentiality on diverse hosts
Chen, J., Nilsen, E. D., Chitboonthavisuk, C., Corban, J. E., Yang, M., Mo, C. Y., & Raman, S. (2025) · Cell Host & Microbe · doi:10.1016/j.chom.2025.06.018 · Cited by 16
Structure and activation mechanism of a Lamassu phage and plasmid defense system
Li, Y., Adams, D. W., Liu, H. W., Shaw, S. J., Uchikawa, E., Jaskólska, M., Stutzmann, S., Righi, L., Szczelkun, M. D., Blokesch, M., et al. (2025) · Nature Structural & Molecular Biology · doi:10.1038/s41594-025-01677-4 · Cited by 14
A phage protein screen identifies triggers of the bacterial innate immune system
Nagy, T. A., Gersabeck, G. W., Conte, A. N., & Whiteley, A. T. (2026) · Nature Microbiology · doi:10.1038/s41564-025-02239-6 · Cited by 8
Naha, A., Cameron, T. A., & Margolin, W. (2025) · Antibiotics · doi:10.3390/antibiotics14010052 · Cited by 3
Arnoux, J. (2026) · Thèse de doctorat, Université Paris-Saclay / PPanGGOLiN · doi:10.70675/eee354d9zf63dz48ebz9444zd1809f8fb74d
Metadata
- Authors
- Georjon, H., & Bernheim, A.
- Venue
- Nature Reviews Microbiology
- Published
- 2023-07-17
- Volume
- 21
- Issue
- 10
- Pages
- 686-700
- ISSN
- 1740-1526 (ISSN-L)
- 1740-1534
- OpenAlex
- W4384561875
- Cited by
- 508
- References
- 2
- FWCI
- 20.29
- Type
- journal article
- Language
- en
- Open access
- green
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
