Oral-lung microbiome interactions in lung diseases.
Abstract
The proximity and continuity of the oral cavity and the lower respiratory tract allows the oropharyngeal microbiome to be a major determinant of the lung microbiome. In addition, host-pathogen interactions related to the oropharyngeal microbiome or its metabolites could propagate systemic inflammation or modulate host defense mechanisms that could affect other organs, including the lung. There is increasing appreciation of the pathophysiologic significance of the lung microbiome, not only in the classical infection-related diseases, pneumonia, bronchiectasis, and cystic fibrosis, but also in chronic noninfectious lung diseases, such as chronic obstructive pulmonary disease, asthma, and pulmonary fibrosis. In this review, we will explore the relationship of the oral microbiome with lung diseases, such as pneumonia, chronic obstructive pulmonary disease, asthma, and cystic fibrosis.
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An oral-lung aspiration axis is a key factor leading to many infectious diseases.
“It is well-known that an oral-lung aspiration axis is a key factor leading to many infectious diseases (Mammen et al., 2020).”
From Oral Microbiome and SARS-CoV-2: Beware of Lung Co-infection (2020) · cites this paper as Mammen et al., 2020
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- Authors
- Mammen, M. J., Scannapieco, F. A., & Sethi, S.
- Affiliations
- University at Buffalo, State University of New York (US)
- VA Western New York Healthcare System (US)
- Corresponding author
- Sethi, Sanjay
- Venue
- Periodontology 2000
- Publisher
- Wiley
- Published
- 2020-05-08
- Volume
- 83
- Issue
- 1
- Pages
- 234-241
- ISSN
- 0906-6713 (ISSN-L)
- 1600-0757
- OpenAlex
- W3023660982
- Semantic Scholar
- cfc10aa68719455c63066a1e4c1a097c72c6b9c9
- Cited by
- 179
- References
- 44
- Citations by year
- 2026: 21 · 2025: 23 · 2024: 43 · 2023: 33 · 2022: 33 · 2021: 22 · 2020: 4
- FWCI
- 3.76
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Periodontology 2000 (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Dentistry › Periodontics › Oral microbiology and periodontitis research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Chronic Obstructive Pulmonary Disease (COPD) Research
- Keywords
- oral microbiota, lung microbiome, host-pathogen interaction, systemic inflammation, pneumonia, chronic obstructive pulmonary disease, asthma, cystic fibrosis, bronchiectasis, pulmonary fibrosis
- MeSH terms
- Asthma, Cystic Fibrosis, Humans, Lung, Pulmonary Disease, Chronic Obstructive, Microbiota
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