Biogeography of the Oral Microbiome: The Site-Specialist Hypothesis
Open accessAbstract
Microbial communities are complex and dynamic, composed of hundreds of taxa interacting across multiple spatial scales. Advances in sequencing and imaging technology have led to great strides in understanding both the composition and the spatial organization of these complex communities. In the human mouth, sequencing results indicate that distinct sites host microbial communities that not only are distinguishable but to a meaningful degree are composed of entirely different microbes. Imaging suggests that the spatial organization of these communities is also distinct. Together, the literature supports the idea that most oral microbes are site specialists. A clear understanding of microbiota structure at different sites in the mouth enables mechanistic studies, informs the generation of hypotheses, and strengthens the position of oral microbiology as a model system for microbial ecology in general.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
The oral cavity as a microbial environment is complicated by spatial gradients created by salivary flow, nutrient availability, oxygen concentration, saliva, and gingival crevicular fluids, in addition to regular environmental disturbances caused by eating and mastication, facial movement related to speaking and expression, and oral hygiene practices.
“The oral cavity as a microbial environment is further complicated by spatial gradients created by salivary flow, nutrient availability, oxygen concentration, saliva, and gingival crevicular fluids,61, 227, 231, 232 in addition to regular environmental disturbances caused by eating and mastication, facial movement related to speaking and expression, and oral hygiene practices.227”
From The oral microbiome: Role of key organisms and complex networks in oral health and disease (2021) · cites this paper as [227]
Site specialization is dictated by the ability of a microbe to adhere, colonize, grow, and divide at that site.
“Site specialization is dictated by the ability of a microbe to adhere, colonize, grow, and divide at that site.227, 234”
From The oral microbiome: Role of key organisms and complex networks in oral health and disease (2021) · cites this paper as [227]
The nonshedding enamel surfaces, the gingival crevice, the mucosal epithelium of the cheeks, the tongue dorsum, and tonsillar crypts together present the oral cavity as a complex microbial environment with wide-ranging topography.
“The nonshedding enamel surfaces, the gingival crevice, the mucosal epithelium of the cheeks, the tongue dorsum, and tonsillar crypts, together present the oral cavity as a complex microbial environment with wide‐ranging topography.227, 228”
From The oral microbiome: Role of key organisms and complex networks in oral health and disease (2021) · cites this paper as [227]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
DADA2: High–resolution sample inference from Illumina amplicon data
Callahan, B. J., McMurdie, P. J., Rosen, M. J., Han, A. W., Johnson, A. J. A., & Holmes, S. P. (2016) · Nature Methods · doi:10.1038/nmeth.3869 · Cited by 35,698 · see citing works
Structure, function and diversity of the healthy human microbiome
The Human Microbiome Project Consortium (2012) · Nature · doi:10.1038/nature11234 · Cited by 11,726 · see citing works
Darwin, C. R., Darwin, C. R., & Edmonds & Remnants (1859) · J. Murray eBooks · doi:10.5962/bhl.title.59991 · Cited by 7,019 · see citing works
Dewhirst, F. E., Chen, T., Izard, J., Paster, B. J., Tanner, A. C. R., Yu, W.-H., Lakshmanan, A., & Wade, W. G. (2010) · Journal of Bacteriology · doi:10.1128/jb.00542-10 · Cited by 3,352 · see citing works
Self-citationBacterial Community Variation in Human Body Habitats Across Space and Time
Costello, E. K., Lauber, C. L., Hamady, M., Fierer, N., Gordon, J. I., & Knight, R. (2009) · Science · doi:10.1126/science.1177486 · Cited by 3,231 · see citing works
Defining the normal bacterial flora of the oral cavity
Aas, J. A., Paster, B. J., Stokes, L. N., Olsen, I., & Dewhirst, F. E. (2005) · Journal of Clinical Microbiology · doi:10.1128/jcm.43.11.5721-5732.2005 · Cited by 3,092 · see citing works
Self-citationPhysiological heterogeneity in biofilms
Stewart, P. S., & Franklin, M. J. (2008) · Nature Reviews Microbiology · doi:10.1038/nrmicro1838 · Cited by 2,480 · see citing works
Occlusal Caries: Biological Approach for Its Diagnosis and Management
Carvalho, J. C., Dige, I., Mačhiulskienė, V., Qvist, V., Bakhshandeh, A., Parolo, C. C. F., & Maltz, M. (2016) · Caries Research · doi:10.1159/000448662 · Cited by 2,159 · see citing works
Socransky, S. S., & Haffajee, A. D. (2005) · Periodontology 2000 · doi:10.1111/j.1600-0757.2005.00107.x · Cited by 1,691 · see citing works
Defining the healthy “core microbiome” of oral microbial communities
Zaura, E., Keijser, B. J., Huse, S. M., & Crielaard, W. (2009) · BMC Microbiology · doi:10.1186/1471-2180-9-259 · Cited by 1,323 · see citing works
Oral multispecies biofilm development and the key role of cell–cell distance
Kolenbrander, P. E., Palmer, R. J., Periasamy, S., & Jakubovics, N. S. (2010) · Nature Reviews Microbiology · doi:10.1038/nrmicro2381 · Cited by 1,309 · see citing works
Strains, functions and dynamics in the expanded Human Microbiome Project
Lloyd-Price, J., Mahurkar, A., Rahnavard, G., Crabtree, J., Orvis, J., Hall, A. B., Brady, A., Creasy, H. H., McCracken, C., Giglio, M. G., et al. (2017) · Nature · doi:10.1038/nature23889 · Cited by 1,267 · see citing works
Stewart, P. S. (2003) · Journal of Bacteriology · doi:10.1128/jb.185.5.1485-1491.2003 · Cited by 1,188 · see citing works
Segata, N., Haake, S. K., Mannon, P., Lemon, K. P., Waldron, L., Gevers, D., Huttenhower, C., & Izard, J. (2012) · Genome Biology · doi:10.1186/gb-2012-13-6-r42 · Cited by 1,076 · see citing works
Biogeography of a human oral microbiome at the micron scale
Mark Welch, J. L., Rossetti, B. J., Rieken, C. W., Dewhirst, F. E., & Borisy, G. G. (2016) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1522149113 · Cited by 968 · see citing works
Self-citationHost lifestyle affects human microbiota on daily timescales
David, L. A., Materna, A. C., Friedman, J., Campos-Baptista, M. I., Blackburn, M. C., Perrotta, A., Erdman, S. E., & Alm, E. J. (2014) · Genome biology · doi:10.1186/gb-2014-15-7-r89 · Cited by 950 · cited 1× · see citing works
“Even highly abundant organisms vary widely in relative abundance from day to day in samples from the mouth (14, 94).”
BackgroundDarwin, C. R. (1888) · Springer eBooks · doi:10.1007/978-3-319-19650-3_303511 · Cited by 869 · see citing works
BACTERIAL ADHERENCE IN ORAL MICROBIAL ECOLOGY
Gibbons, R. J., & van Houte, J. (1975) · Annual Review of Microbiology · doi:10.1146/annurev.mi.29.100175.000315 · Cited by 864 · see citing works
The microbiome of uncontacted Amerindians
Clemente, J. C., Pehrsson, E. C., Blaser, M. J., Sandhu, K., Gao, Z., Wang, B., Magris, M., Hidalgo, G., Contreras, M., Noya-Alarcón, Ó., et al. (2015) · Science Advances · doi:10.1126/sciadv.1500183 · Cited by 851 · see citing works
Review: Diversity of Microorganisms in Global Fermented Foods and Beverages
Tamang, J. P., Watanabe, K., & Holzapfel, W. H. (2016) · Frontiers in Microbiology · doi:10.3389/fmicb.2016.00377 · Cited by 824 · see citing works
Bacterial interactions and successions during plaque development
Kolenbrander, P. E., Palmer, R. J., Rickard, A. H., Jakubovics, N. S., Chalmers, N. I., & Diaz, P. I. (2006) · Periodontology 2000 · doi:10.1111/j.1600-0757.2006.00187.x · Cited by 791 · see citing works
New concepts of destructive periodontal disease
Socransky, S. S., Haffajee, A. D., Goodson, J. M., & Lindhe, J. (1984) · Journal Of Clinical Periodontology · doi:10.1111/j.1600-051x.1984.tb01305.x · Cited by 735 · see citing works
"Checkerboard" DNA-DNA hybridization.
Socransky, S. S., Smith, C., Martin, L., Paster, B. J., Dewhirst, F. E., & Levin, A. E. (1994) · PubMed · Cited by 725 · see citing works
Self-citationOral Biofilm Architecture on Natural Teeth
Zijnge, V., van Leeuwen, M. B. M., Degener, J. E., Abbas, F., Thurnheer, T., Gmür, R., & Harmsen, H. J. M. (2010) · PLoS ONE · doi:10.1371/journal.pone.0009321 · Cited by 689 · see citing works
Biogeography of the ecosystems of the healthy human body
Zhou, Y., Gao, H., Mihindukulasuriya, K. A., Rosa, P. S. L., Wylie, K. M., Vishnivetskaya, T. A., Podar, M., Warner, B., Tarr, P. I., Nelson, D. E., et al. (2013) · Genome biology · doi:10.1186/gb-2013-14-1-r1 · Cited by 684 · see citing works
Pyrosequencing analysis of the oral microflora of healthy adults
Keijser, B. J. F., Zaura, E., Huse, S. M., van der Vossen, J. M. B. M., Schuren, F. H. J., Montijn, R. C., ten Cate, J. M., & Crielaard, W. (2008) · Journal of Dental Research · doi:10.1177/154405910808701104 · Cited by 669 · cited 2× · see citing works
“In a quest for yet greater sequencing depth at lower cost, work shifted to short-read, highthroughput sequencing, using technologies that could generate hundreds of thousands to millions of sequencing reads at a time, where each individual read was only a few hundred nucleotides in length (12, 19, 44, 48, 58, 81, 105).”
Background<i>Streptococcus</i> Adherence and Colonization
Nobbs, A. H., Lamont, R. J., & Jenkinson, H. F. (2009) · Microbiology and Molecular Biology Reviews · doi:10.1128/mmbr.00014-09 · Cited by 657 · see citing works
Bacterial diversity in the oral cavity of 10 healthy individuals
Bik, E. M., Long, C. D., Armitage, G. C., Loomer, P., Emerson, J., Mongodin, E. F., Nelson, K. E., Gill, S. R., Fraser-Liggett, C. M., & Relman, D. A. (2010) · The ISME Journal · doi:10.1038/ismej.2010.30 · Cited by 651 · see citing works
Oligotyping: differentiating between closely related microbial taxa using 16S rRNA gene data
Eren, A. M., Maignien, L., Sul, W. J., Murphy, L. G., Grim, S. L., Morrison, H. G., & Sogin, M. L. (2013) · Methods in Ecology and Evolution · doi:10.1111/2041-210x.12114 · Cited by 620 · see citing works
Escapa, I. F., Chen, T., Huang, Y., Gajare, P., Dewhirst, F. E., & Lemon, K. P. (2018) · mSystems · doi:10.1128/msystems.00187-18 · Cited by 593 · see citing works
Self-citationComparison of the microbiota of supra‐ and subgingival plaque in health and periodontitis
Ximenez‐Fyvie, L., Haffajee, A. D., & Socransky, S. S. (2000) · Journal Of Clinical Periodontology · doi:10.1034/j.1600-051x.2000.027009648.x · Cited by 577 · see citing works
Circadian rhythms in human salivary flow rate and composition
Dawes, C. (1972) · The Journal of Physiology · doi:10.1113/jphysiol.1972.sp009721 · Cited by 557 · see citing works
Distribution of selected bacterial species on intraoral surfaces
Mager, D. L., Ximenez‐Fyvie, L., Haffajee, A. D., & Socransky, S. S. (2003) · Journal Of Clinical Periodontology · doi:10.1034/j.1600-051x.2003.00376.x · Cited by 481 · see citing works
Global diversity in the human salivary microbiomePreprint
Nasidze, I., Li, J., Quinque, D., Tang, K., & Stoneking, M. (2009) · Genome Research · doi:10.1101/gr.084616.108 · Cited by 464 · see citing works
Dental plaque biofilms: communities, conflict and control
Marsh, P. D., Moter, A., & DeVine, D. (2010) · Periodontology 2000 · doi:10.1111/j.1600-0757.2009.00339.x · Cited by 432 · see citing works
Molecular Characterization of Subject-Specific Oral Microflora during Initial Colonization of Enamel
Diaz, P. I., Chalmers, N. I., Rickard, A. H., Kong, C., Milburn, C. L., Palmer, R. J., Jr., & Kolenbrander, P. E. (2006) · Applied and Environmental Microbiology · doi:10.1128/aem.72.4.2837-2848.2006 · Cited by 426 · see citing works
Gingival crevicular fluid as a source of biomarkers for periodontitis
Barros, S. P., Williams, R. C., Offenbacher, S., & Morelli, T. (2015) · Periodontology 2000 · doi:10.1111/prd.12107 · Cited by 422 · see citing works
The Oral Microbiota of Man From Birth to Senility
Socransky, S. S., & Manganiello, S. D. (1971) · Journal of Periodontology · doi:10.1902/jop.1971.42.8.485 · Cited by 395 · see citing works
Oligotyping analysis of the human oral microbiome
Eren, A. M., Borisy, G. G., Huse, S. M., & Mark Welch, J. L. (2014) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1409644111 · Cited by 347 · see citing works
Self-citationValm, A. M., Welch, J. L. M., Rieken, C. W., Hasegawa, Y., Sogin, M. L., Oldenbourg, R., Dewhirst, F. E., & Borisy, G. G. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1101134108 · Cited by 340 · see citing works
Self-citationOral cavity contains distinct niches with dynamic microbial communities
Xu, X., He, J., Xue, J., Wang, Y., Li, K., Zhang, K., Guo, Q., Liu, X., Zhou, Y., Cheng, L., et al. (2015) · Environmental Microbiology · doi:10.1111/1462-2920.12502 · Cited by 335 · see citing works
It's all relative: analyzing microbiome data as compositions
Gloor, G. B., Wu, J. R., Pawlowsky-Glahn, V., & Egozcue, J. J. (2016) · Annals of Epidemiology · doi:10.1016/j.annepidem.2016.03.003 · Cited by 323 · see citing works
The microbiota of the gingival crevice area of man—I
Socransky, S. S., Gibbons, R. J., Dale, A. C., Bortnick, L., Rosenthal, E. J. K., & Macdonald, J. B. (1963) · Archives of Oral Biology · doi:10.1016/0003-9969(63)90019-0 · Cited by 302 · see citing works
Palmer, R. J., Jr., Gordon, S. M., Cisar, J. O., & Kolenbrander, P. E. (2003) · Journal of Bacteriology · doi:10.1128/jb.185.11.3400-3409.2003 · Cited by 291 · see citing works
Microbial Geography of the Oral Cavity
Simón‐Soro, Á., Tomás, I., Cabrera‐Rubio, R., Catalan, M. D., Nyvad, B., & Mira, Á. (2013) · Journal of Dental Research · doi:10.1177/0022034513488119 · Cited by 278 · see citing works
Human glandular salivas: their separate collection and analysis
Veerman, E. C. I., van den Keybus, P. A. M., Vissink, A., & Amerongen, A. V. N. (1996) · European Journal Of Oral Sciences · doi:10.1111/j.1600-0722.1996.tb00090.x · Cited by 254 · see citing works
Architecture of Intact Natural Human Plaque Biofilms Studied by Confocal Laser Scanning Microscopy
Wood, S. R., Kirkham, J., Marsh, P. D., Shore, R. F., Nattress, B. R., & Robinson, C. (2000) · Journal of Dental Research · doi:10.1177/00220345000790010201 · Cited by 253 · see citing works
Hall, M. W., Singh, N., Ng, K. F., Lam, D. K., Goldberg, M. B., Tenenbaum, H. C., Neufeld, J. D., G. Beiko, R., & Senadheera, D. B. (2017) · npj Biofilms and Microbiomes · doi:10.1038/s41522-016-0011-0 · Cited by 226 · see citing works
Multiplex FISH analysis of a six-species bacterial biofilm
Thurnheer, T., Gmür, R., & Guggenheim, B. (2003) · Journal of Microbiological Methods · doi:10.1016/j.mimet.2003.09.003 · Cited by 222 · see citing works
Development of Dental Plaque on Epoxy Resin Crowns in Man: A Light and Electron Microscopic Study
Listgarten, M. A., Mayo, H. E., & Tremblay, R. (1975) · Journal of Periodontology · doi:10.1902/jop.1975.46.1.10 · Cited by 206 · see citing works
Deep Sequencing Identifies Ethnicity-Specific Bacterial Signatures in the Oral Microbiome
Mason, M. R., Nagaraja, H. N., Camerlengo, T., Joshi, V., & Kumar, P. (2013) · PLoS ONE · doi:10.1371/journal.pone.0077287 · Cited by 205 · see citing works
The Landscape Ecology and Microbiota of the Human Nose, Mouth, and Throat
Proctor, D. M., & Relman, D. A. (2017) · Cell Host & Microbe · doi:10.1016/j.chom.2017.03.011 · Cited by 200 · see citing works
Kleinberg, I., & Jenkins, G. N. (1964) · Archives of Oral Biology · doi:10.1016/0003-9969(64)90015-9 · Cited by 185 · see citing works
Li, J., Quinque, D., Horz, H., Li, M., Rzhetskaya, M., Raff, J., Hayes, M. G., & Stoneking, M. (2014) · BMC Microbiology · doi:10.1186/s12866-014-0316-1 · Cited by 182 · see citing works
Oxygen Tension (pO2) in Untreated Human Periodontal Pockets
Mettraux, G., Gusberti, F. A., & Graf, H. A. (1984) · Journal of Periodontology · doi:10.1902/jop.1984.55.9.516 · Cited by 170 · see citing works
Al‐Ahmad, A., Wunder, A., Auschill, T. M., Follo, M., Braun, G., Hellwig, E., & Arweiler, N. B. (2007) · Journal of Medical Microbiology · doi:10.1099/jmm.0.47094-0 · Cited by 169 · see citing works
The microbiota of the gingival crevice area of man—II
Gibbons, R. J., Socransky, S. S., Sawyer, S. J., Kapsimalis, B., & Macdonald, J. B. (1963) · Archives of Oral Biology · doi:10.1016/0003-9969(63)90020-7 · Cited by 169 · see citing works
Studies of the predominant cultivable microbiota of dental plaque
Gibbons, R. J., Socransky, S. S., de Araújo, W. C., & van Houte, J. (1964) · Archives of Oral Biology · doi:10.1016/0003-9969(64)90069-x · Cited by 145 · see citing works
Actinomyces naeslundii in initial dental biofilm formation
Dige, I., Raarup, M. K., Nyengaard, J. R., Kilian, M., & Nyvad, B. (2009) · Microbiology · doi:10.1099/mic.0.027706-0 · Cited by 145 · see citing works
Oxygen Limitation within a Bacterial Aggregate
Wessel, A. K., Arshad, T. A., Fitzpatrick, M. D., Connell, J. L., Bonnecaze, R. T., Shear, J. B., & Whiteley, M. (2014) · mBio · doi:10.1128/mbio.00992-14 · Cited by 144 · see citing works
Nyvad, B., & Fejerskov, O. (1987) · European Journal Of Oral Sciences · doi:10.1111/j.1600-0722.1987.tb01845.x · Cited by 143 · see citing works
Characterizing oral microbial communities across dentition states and colonization niches
Mason, M. R., Chambers, S., Dabdoub, S. M., Thikkurissy, S., & Kumar, P. S. (2018) · Microbiome · doi:10.1186/s40168-018-0443-2 · Cited by 142 · see citing works
Subspecies in the global human gut microbiome
Costea, P. I., Coelho, L. P., Sunagawa, S., Munch, R., Huerta‐Cepas, J., Forslund, S. K., Hildebrand, F., Kushugulova, A. R., Zeller, G., & Bork, P. (2017) · Molecular Systems Biology · doi:10.15252/msb.20177589 · Cited by 141 · see citing works
The source of salivary bacteria
Gibbons, R. J., Kapsimalis, B., & Socransky, S. S. (1964) · Archives of Oral Biology · doi:10.1016/0003-9969(64)90052-4 · Cited by 134 · see citing works
The Prevalence of Species and Strains in the Human Microbiome: A Resource for Experimental Efforts
Kraal, L., Abubucker, S., Kota, K., Fischbach, M. A., & Mitreva, M. (2014) · PLoS ONE · doi:10.1371/journal.pone.0097279 · Cited by 121 · see citing works
Using high throughput sequencing to explore the biodiversity in oral bacterial communities
Diaz, P. I., Dupuy, A. K., Abusleme, L., Reese, B., Obergfell, C. J., Choquette, L. E., Dongari‐Bagtzoglou, A. I., Peterson, D. E., Terzi, E., & Strausbaugh, L. D. (2012) · Molecular Oral Microbiology · doi:10.1111/j.2041-1014.2012.00642.x · Cited by 118 · see citing works
A spatial gradient of bacterial diversity in the human oral cavity shaped by salivary flow
Proctor, D. M., Fukuyama, J. A., Loomer, P. M., Armitage, G. C., Lee, S. A., Davis, N. M., Ryder, M. I., Holmes, S. P., & Relman, D. A. (2018) · Nature Communications · doi:10.1038/s41467-018-02900-1 · Cited by 115 · see citing works
The mucosal pellicle – An underestimated factor in oral physiology
Hannig, C., Hannig, M., Kensche, A., & Carpenter, G. H. (2017) · Archives of Oral Biology · doi:10.1016/j.archoralbio.2017.04.001 · Cited by 110 · see citing works
Functional expression of dental plaque microbiota
Peterson, S. N., Meißner, T., Su, A. I., Snesrud, E. C., Ong, A., Schork, N. J., & Bretz, W. A. (2014) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2014.00108 · Cited by 106 · see citing works
Dige, I., Nilsson, H., Kilian, M., & Nyvad, B. (2007) · European Journal Of Oral Sciences · doi:10.1111/j.1600-0722.2007.00494.x · Cited by 106 · see citing works
An update on minor salivary gland secretions
Eliasson, L., & Carlén, A. (2010) · European Journal Of Oral Sciences · doi:10.1111/j.1600-0722.2010.00766.x · Cited by 105 · see citing works
CLASI-FISH: Principles of combinatorial labeling and spectral imaging
Valm, A. M., Welch, J. L. M., & Borisy, G. G. (2012) · Systematic and Applied Microbiology · doi:10.1016/j.syapm.2012.03.004 · Cited by 105 · see citing works
Self-citationEspinoza, J. L., Harkins, D. M., Torralba, M., Gomez, A. M., Highlander, S. K., Jones, M. B., Leong, P., Saffery, R., Bockmann, M. R., Kuelbs, C., et al. (2018) · mBio · doi:10.1128/mbio.01631-18 · Cited by 105 · see citing works
Chaves‐López, C., Angelis, M. D., Martuscelli, M., Serio, A., Paparella, A., & Suzzi, G. (2006) · Journal of Applied Microbiology · doi:10.1111/j.1365-2672.2006.02941.x · Cited by 103 · see citing works
The Localization of Periodontal-disease-associated Bacteria in Human Periodontal Pockets
Noiri, Y., Li, L., & Ebisu, S. (2001) · Journal of Dental Research · doi:10.1177/00220345010800101301 · Cited by 101 · see citing works
Proteome of Human Minor Salivary Gland Secretion
Siqueira, W. L., Salih, E., Wan, D. L., Helmerhorst, E. J., & Oppenheim, F. G. (2008) · Journal of Dental Research · doi:10.1177/154405910808700508 · Cited by 99 · see citing works
A novel technique for monitoring the development of bacterial biofilms in human periodontal pockets
Wecke, J., Kersten, T., Madela, K., Moter, A., Göbel, U. B., Friedmann, A., & Bernimoulin, J. (2000) · FEMS Microbiology Letters · doi:10.1111/j.1574-6968.2000.tb09324.x · Cited by 97 · see citing works
Studies of the predominant cultivable micro-organisms from the human tongue
Gordon, D. F., & Gibbons, R. J. (1966) · Archives of Oral Biology · doi:10.1016/0003-9969(66)90229-9 · Cited by 97 · see citing works
Bacterial colonization of enamel in situ investigated using fluorescence in situ hybridization
Al‐Ahmad, A., Follo, M., Selzer, A.-C., Hellwig, E., Hannig, M., & Hannig, C. (2009) · Journal of Medical Microbiology · doi:10.1099/jmm.0.011213-0 · Cited by 95 · see citing works
Individuality, Stability, and Variability of the Plaque Microbiome
Utter, D. R., Welch, J. L. M., & Borisy, G. G. (2016) · Frontiers in Microbiology · doi:10.3389/fmicb.2016.00564 · Cited by 94 · see citing works
Self-citationRapid Succession within the Veillonella Population of a Developing Human Oral Biofilm In Situ
Palmer, R. J., Jr., Diaz, P. I., & Kolenbrander, P. E. (2006) · Journal of Bacteriology · doi:10.1128/jb.01958-05 · Cited by 93 · see citing works
Multiplexed Spectral Imaging of 120 Different Fluorescent Labels
Valm, A. M., Oldenbourg, R., & Borisy, G. G. (2016) · PLoS ONE · doi:10.1371/journal.pone.0158495 · Cited by 88 · see citing works
Self-citationDistinct composition of the oral indigenous microbiota in South Korean and Japanese adults
Takeshita, T., Matsuo, K., Furuta, M., Shibata, Y., Fukami, K., Shimazaki, Y., Akifusa, S., Han, D.-H., Kim, H., Yokoyama, T., et al. (2014) · Scientific Reports · doi:10.1038/srep06990 · Cited by 82 · see citing works
Temperature as a periodontal diagnostic
Kung, R. T. V., Ochs, B., & Goodson, J. M. (1990) · Journal Of Clinical Periodontology · doi:10.1111/j.1600-051x.1990.tb01105.x · Cited by 75 · see citing works
Clock Genes Show Circadian Rhythms in Salivary Glands
Zheng, L., Seon, Y. J., McHugh, J. B., Papagerakis, S. M., & Papagerakis, P. (2012) · Journal of Dental Research · doi:10.1177/0022034512451450 · Cited by 67 · see citing works
Noiri, Y., Ozaki, K., Nakae, H., Matsuo, T., & Ebisu, S. (1997) · Journal of Periodontal Research · doi:10.1111/j.1600-0765.1997.tb00937.x · Cited by 66 · see citing works
Interbacterial Adhesion Networks within Early Oral Biofilms of Single Human Hosts
Palmer, R. J., Jr., Shah, N., Valm, A. M., Paster, B. J., Dewhirst, F. E., Inui, T., & Cisar, J. O. (2017) · Applied and Environmental Microbiology · doi:10.1128/aem.00407-17 · Cited by 66 · see citing works
Self-citationListgarten, M. A., Mayo, H. E., & Amsterdam, M. (1973) · Archives of Oral Biology · doi:10.1016/0003-9969(73)90105-2 · Cited by 65 · see citing works
Sato, Y., Yamagishi, J., Yamashita, R., Shinozaki, N. O., Ye, B., Yamada, T., Yamamoto, M. P., Nagasaki, M., & Tsuboi, A. (2015) · PLoS ONE · doi:10.1371/journal.pone.0131607 · Cited by 64 · see citing works
Lecomte, P. B., & Dawes, C. (1987) · Journal of Dental Research · doi:10.1177/00220345870660110101 · Cited by 64 · see citing works
Shi, W., Tian, J., Xu, H., Zhou, Q., & Qin, M. (2018) · PLoS ONE · doi:10.1371/journal.pone.0200337 · Cited by 64 · see citing works
Penetration of Oxygen into Bacterial Colonies
WIMPENNY, J. W. T., & Coombs, J. P. (1983) · Microbiology · doi:10.1099/00221287-129-4-1239 · Cited by 62 · see citing works
Shigella Strains Are Not Clones of Escherichia Coli but Sister Species in the Genus Escherichia
Zuo, G., Xu, Z. L., & Hao, B. (2012) · Genomics Proteomics & Bioinformatics · doi:10.1016/j.gpb.2012.11.002 · Cited by 61 · see citing works
Molecular Studies of the Structural Ecology of Natural Occlusal Caries
Dige, I., Grønkjær, L., & Nyvad, B. (2014) · Caries Research · doi:10.1159/000357920 · Cited by 59 · see citing works
Edlund, A., Yang, Y., Yooseph, S., He, X., Shi, W., & McLean, J. S. (2018) · Microbiome · doi:10.1186/s40168-018-0591-4 · Cited by 57 · see citing works
Factors affecting human supragingival biofilm composition. II. Tooth position
Haffajee, A. D., Teles, R. P., Patel, M., Song, X., Yaskell, T., & Socransky, S. S. (2008) · Journal of Periodontal Research · doi:10.1111/j.1600-0765.2008.01155.x · Cited by 56 · see citing works
Filiform Papillae of Human, Rat and Swine Tongue
KULLAA‐MIKKONEN, A., Hynynen, M., & Hyvönen, P. (1987) · Cells Tissues Organs · doi:10.1159/000146457 · Cited by 53 · see citing works
Localization of Porphyromonas gingivalis -carrying Fimbriae in situ in Human Periodontal Pockets
Noiri, Y., Li, L., Yoshimura, F., & Ebisu, S. (2004) · Journal of Dental Research · doi:10.1177/154405910408301210 · Cited by 52 · see citing works
Dawes, C. (1989) · Journal of Dental Research · doi:10.1177/00220345890680110301 · Cited by 52 · see citing works
Microbial profiling of dental plaque from mechanically ventilated patients
Sands, K. M., Twigg, J. A., Lewis, M. A. O., Wise, M. P., Marchesi, J. R., Smith, A., Wilson, M. J., & Williams, D. W. (2015) · Journal of Medical Microbiology · doi:10.1099/jmm.0.000212 · Cited by 50 · see citing works
Molecular epidemiology and spatial distribution of Selenomonas spp. in subgingival biofilms
Drescher, J., Schlafer, S., Schaudinn, C., Riep, B., Neumann, K., Friedmann, A., Petrich, A., Göbel, U. B., & Moter, A. (2010) · European Journal Of Oral Sciences · doi:10.1111/j.1600-0722.2010.00765.x · Cited by 47 · see citing works
Indigenous Flora from Human Saliva
Gordon, D. F., & Jong, B. B. (1968) · Applied Microbiology · doi:10.1128/am.16.2.428-429.1968 · Cited by 46 · see citing works
Dynamics of tongue microbial communities with single-nucleotide resolution using oligotyping
Welch, J. L. M., Utter, D. R., Rossetti, B. J., Welch, D. B. M., Eren, A. M., & Borisy, G. G. (2014) · Frontiers in Microbiology · doi:10.3389/fmicb.2014.00568 · Cited by 46 · see citing works
Self-citationMouthguards: does the indigenous microbiome play a role in maintaining oral health?
Kumar, P., & Mason, M. R. (2015) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2015.00035 · Cited by 36 · see citing works
The complexity of oral physiology and its impact on salivary diagnostics
Helmerhorst, E. J., Dawes, C., & Oppenheim, F. G. (2017) · Oral Diseases · doi:10.1111/odi.12780 · Cited by 33 · see citing works
Microstructure of Oral Epithelial Cells as an Underlying Basis for Salivary Mucosal Pellicle
Kullaa, A. M., Asikainen, P., Herrala, M., Ukkonen, H., & Mikkonen, J. J. W. (2014) · Ultrastructural Pathology · doi:10.3109/01913123.2014.944732 · Cited by 29 · see citing works
Al-Hebshi, N. N., Abdulhaq, A. A., Albarrag, A., Basode, V. K., & Chen, T. (2016) · Journal of Oral Microbiology · doi:10.3402/jom.v8.31444 · Cited by 26 · see citing works
Li, F., Tao, D., Feng, X., Wong, M. C. M., & Lu, H. (2018) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2018.00422 · Cited by 26 · see citing works
Experimental study of the migration of charcoal particles in the human mouth
Jenkins, G. N., & Krebsbach, P. H. (1985) · Archives of Oral Biology · doi:10.1016/0003-9969(85)90158-x · Cited by 24 · see citing works
The Impact of Various Time Intervals on the Supragingival Plaque Dynamic Core Microbiome
Jiang, W., Hu, Y., Gao, L., He, Z., Zhu, C.-L., Ma, R., & Huang, Z. (2015) · PLoS ONE · doi:10.1371/journal.pone.0124631 · Cited by 21 · see citing works
Microplicae – Specialized Surface Structure of Epithelial Cells of Wet-Surfaced Oral Mucosa
Asikainen, P., Sirviö, E., Mikkonen, J. J. W., Singh, S. P., Schulten, E. A. J. M., Bruggenkate, C. M. T., Koistinen, A. P., & Kullaa, A. M. (2015) · Ultrastructural Pathology · doi:10.3109/01913123.2015.1054015 · Cited by 20 · see citing works
Flagged first, then by citations
Research works printed but not linked: 1
- [72]Nyvad B, Fejerskov O. 1987 Scanning electron microscopy of early microbial colonization of human enamel and root surfaces in vivo. Scandinavian Journal of Dental Research 95: 287– 296. 3476984
Cited by
Sorted by citations
The oral microbiome: Role of key organisms and complex networks in oral health and disease
Sedghi, L., DiMassa, V., Harrington, A., Lynch, S. V., & Kapila, Y. L. (2021) · Periodontology 2000 · doi:10.1111/prd.12393 · Cited by 755 · see citing works
The oral microbiome: diversity, biogeography and human health
Baker, J. L., Mark Welch, J. L., Kauffman, K. M., McLean, J. S., & He, X. (2024) · Nature Reviews Microbiology · doi:10.1038/s41579-023-00963-6 · Cited by 661 · see citing works
The oralome and its dysbiosis: New insights into oral microbiome-host interactions
Radaic, A., & Kapila, Y. L. (2021) · Computational and Structural Biotechnology Journal · doi:10.1016/j.csbj.2021.02.010 · Cited by 492 · see citing works
The Nexus Between Periodontal Inflammation and Dysbiosis
Dyke, T. E. V., Bartold, P. M., & Reynolds, E. C. (2020) · Frontiers in Immunology · doi:10.3389/fimmu.2020.00511 · Cited by 465 · see citing works
Gradients and consequences of heterogeneity in biofilms
Jo, J., Price‐Whelan, A., & Dietrich, L. E. P. (2022) · Nature Reviews Microbiology · doi:10.1038/s41579-022-00692-2 · Cited by 327 · see citing works
Oral Microbiome Geography: Micron-Scale Habitat and Niche
Welch, J. L. M., Ramírez-Puebla, S. T., & Borisy, G. G. (2020) · Cell Host & Microbe · doi:10.1016/j.chom.2020.07.009 · Cited by 267 · see citing works
Self-citationShaiber, A., Willis, A. D., Delmont, T. O., Roux, S., Chen, L.-X., Schmid, A. C., Yousef, M., Watson, A. R., Lolans, K., Esen, Ö. C., et al. (2020) · Genome biology · doi:10.1186/s13059-020-02195-w · Cited by 227 · see citing works
Self-citationOral polymicrobial communities: Assembly, function, and impact on diseases
Hajishengallis, G., Lamont, R. J., & Koo, H. (2023) · Cell Host & Microbe · doi:10.1016/j.chom.2023.02.009 · Cited by 221 · see citing works
Kim, D., Barraza, J. P., Arthur, R. A., Hara, A. T., Lewis, K. J., Liu, Y., Scisci, E., Hajishengallis, E., Whiteley, M., & Koo, H. (2020) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1919099117 · Cited by 221 · see citing works
Bioadhesion in the oral cavity and approaches for biofilm management by surface modifications
Sterzenbach, T., Helbig, R., Hannig, C., & Hannig, M. (2020) · Clinical Oral Investigations · doi:10.1007/s00784-020-03646-1 · Cited by 212 · see citing works
Spatial Ecology of the Human Tongue Dorsum Microbiome
Wilbert, S. A., Welch, J. L. M., & Borisy, G. G. (2019) · Cell Reports · doi:10.1016/j.celrep.2020.02.097 · Cited by 194 · see citing works
Self-citationThe role of oral bacteria in inflammatory bowel disease
Read, E., Curtis, M. A., & Neves, J. F. (2021) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/s41575-021-00488-4 · Cited by 198 · see citing works
The evolution and changing ecology of the African hominid oral microbiome
Yates, J. A. F., Velsko, I. M., Aron, F., Posth, C., Hofman, C. A., Austin, R. M., Parker, C., Mann, A. E., Nägele, K., Arthur, K. W., et al. (2021) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2021655118 · Cited by 176 · see citing works
Self-citationTargeting implant-associated infections: titanium surface loaded with antimicrobial
Souza, J. G. S., Bertolini, M., Costa, R. C., NAGAY, B. E., Dongari‐Bagtzoglou, A. I., & Barão, V. A. R. (2020) · iScience · doi:10.1016/j.isci.2020.102008 · Cited by 171 · see citing works
Veillonellae: Beyond Bridging Species in Oral Biofilm Ecology
Zhou, P., Manoil, D., Belibasakis, G. N., & Kotsakis, G. A. (2021) · Frontiers in Oral Health · doi:10.3389/froh.2021.774115 · Cited by 159 · see citing works
Byrd, K. M., & Gulati, A. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.620124 · Cited by 118 · see citing works
Escapa, I. F., Huang, Y., Chen, T., Lin, M., Kokaras, A. S., Dewhirst, F. E., & Lemon, K. P. (2020) · Microbiome · doi:10.1186/s40168-020-00841-w · Cited by 111 · see citing works
Self-citationBacterial diversity and prevalence of antibiotic resistance genes in the oral microbiome
Almeida, V. D. S. M., Azevedo, J., Leal, H. F., Queiroz, A. T. L., Filho, H. P. D. S., & Pedreira, J. N. R. (2020) · PLoS ONE · doi:10.1371/journal.pone.0239664 · Cited by 99 · see citing works
Utter, D. R., Borisy, G. G., Eren, A. M., Cavanaugh, C. M., & Welch, J. L. M. (2020) · Genome biology · doi:10.1186/s13059-020-02200-2 · Cited by 81 · see citing works
Self-citationBarutta, F., Bellini, S., Durazzo, M., & Gruden, G. (2022) · Biomedicines · doi:10.3390/biomedicines10010178 · Cited by 83 · see citing works
The oral and gut microbiome in rheumatoid arthritis patients: a systematic review
Chu, X., Cao, N., Zhou, H., Meng, X. L., Guo, B., Zhang, H.-Y., & Li, B. (2020) · Lara D. Veeken · doi:10.1093/rheumatology/keaa835 · Cited by 74 · see citing works
Acquisition of oral microbiota is driven by environment, not host genetics
Mukherjee, C., Moyer, C. O., Steinkamp, H. M., Hashmi, S. B., Beall, C. J., Guo, X., Ni, A., Leys, E. J., & Griffen, A. L. (2021) · Microbiome · doi:10.1186/s40168-020-00986-8 · Cited by 72 · see citing works
Polymicrobial Aggregates in Human Saliva Build the Oral Biofilm
Simón‐Soro, Á., Ren, Z. F., Krom, B. P., Hoogenkamp, M. A., Cabello‐Yeves, P. J., Daniel, S. G., Bittinger, K. L., Tomás, I., Koo, H., & Mira, Á. (2022) · mBio · doi:10.1128/mbio.00131-22 · Cited by 74 · see citing works
Szafrański, S. P., Slots, J., & Stiesch, M. (2021) · Periodontology 2000 · doi:10.1111/prd.12363 · Cited by 67 · see citing works
Jiang, Y., Song, B., Brandt, B. W., Cheng, L., Zhou, X., Exterkate, R. A. M., Wim Crielaard, A., & Deng, D. (2021) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2021.727732 · Cited by 67 · see citing works
The biogeography of infection revisited
Azimi, S., Lewin, G. R., & Whiteley, M. (2022) · Nature Reviews Microbiology · doi:10.1038/s41579-022-00683-3 · Cited by 60 · see citing works
Metatranscriptomic analyses of the oral microbiome.
Duran-Pinedo, A. (2020) · Periodontology 2000 · doi:10.1111/prd.12350 · Cited by 44 · see citing works
The Type IX Secretion System and Its Role in Bacterial Function and Pathogenesis
Veith, P. D., Glew, M. D., Gorasia, D. G., Cascalès, E., & Reynolds, E. C. (2021) · Journal of Dental Research · doi:10.1177/00220345211051599 · Cited by 57 · see citing works
Oral microbiome variations related to ageing: possible implications beyond oral health
Kazarina, A., Kuzmicka, J., Bortkevica, S., Zayakin, P., Ķimsis, J., Igumnova, V., Sadovska, D., Freimane, L., Kivrāne, A., Namiņa, A., et al. (2023) · Archives of Microbiology · doi:10.1007/s00203-023-03464-5 · Cited by 56 · see citing works
Streptococcus mutans and Caries: A Systematic Review and Meta-Analysis
Mazurel, D., Brandt, B. W., Boomsma, M., Wim Crielaard, A., Lagerweij, M. D., Exterkate, R. A. M., & Deng, D. (2025) · Journal of Dental Research · doi:10.1177/00220345241303880 · Cited by 56 · see citing works
Oral microbiome in human health and diseases
Tian, S., Ding, T., & Li, H. (2024) · mLife · doi:10.1002/mlf2.12136 · Cited by 61 · see citing works
Caries Management—The Role of Surface Interactions in De- and Remineralization-Processes
Flemming, J., Hannig, C., & Hannig, M. (2022) · Journal of Clinical Medicine · doi:10.3390/jcm11237044 · Cited by 53 · see citing works
Corncob structures in dental plaque reveal microhabitat taxon specificity
Morillo-López, V., Sjaarda, A., Islam, I., Borisy, G. G., & Welch, J. L. M. (2022) · Microbiome · doi:10.1186/s40168-022-01323-x · Cited by 51 · see citing works
Self-citationThe interactions between oral-gut axis microbiota and Helicobacter pylori
Chen, X., Wang, N., Wang, J., Liao, B., Cheng, L., & Ren, B. (2022) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2022.914418 · Cited by 51 · see citing works
High-Throughput and Continuous Chaotic Bioprinting of Spatially Controlled Bacterial Microcosms
Ceballos‐González, C. F., Bolívar‐Monsalve, E. J., Quevedo‐Moreno, D. A., Lam‐Aguilar, L. L., Borrayo-Montaño, K. I., León, J. F. Y.-D., Zhang, Y. S., Álvarez, M. M., & Santiago, G. T. (2021) · ACS Biomaterials Science & Engineering · doi:10.1021/acsbiomaterials.0c01646 · Cited by 49 · see citing works
Role of the microbiome in oral cancer occurrence, progression and therapy
Li, Z., Liu, Y., & Zhang, L. (2022) · Microbial Pathogenesis · doi:10.1016/j.micpath.2022.105638 · Cited by 48 · see citing works
Bartsch, S., Kohnert, E., Kreutz, C., Woelber, J. P., Anderson, A. C., Burkhardt, A.-S., Hellwig, E., Buchalla, W., Hiller, K., Ratka‐Krueger, P., et al. (2024) · Frontiers in Microbiology · doi:10.3389/fmicb.2024.1429692 · Cited by 52 · see citing works
Omics for deciphering oral microecology
Lin, Y., Liang, X., Li, Z., Gong, T., Ren, B., Li, Y., & Peng, X. (2024) · International Journal of Oral Science · doi:10.1038/s41368-023-00264-x · Cited by 46 · see citing works
Spatial Design of Polymicrobial Oral Biofilm in Its Native Disease State
Kim, D.-M., & Koo, H. (2020) · Journal of Dental Research · doi:10.1177/0022034520909313 · Cited by 46 · see citing works
Polymicrobial Interactions of Oral Microbiota: a Historical Review and Current Perspective
Zhang, M., Whiteley, M., & Lewin, G. R. (2022) · mBio · doi:10.1128/mbio.00235-22 · Cited by 46 · see citing works
Tagg, J. R., Harold, L. K., Jain, R., & Hale, J. D. F. (2023) · Frontiers in Microbiology · doi:10.3389/fmicb.2023.1161155 · Cited by 45 · see citing works
Site Specialization of Human Oral Veillonella Species
Giacomini, J. J., Torres‐Morales, J., Dewhirst, F. E., Borisy, G. G., & Welch, J. L. M. (2023) · Microbiology Spectrum · doi:10.1128/spectrum.04042-22 · Cited by 44 · see citing works
Self-citationIntegrated Single-Cell Atlases Reveal an Oral SARS-CoV-2 Infection and Transmission AxisPreprint
Huang, N., Pérez, P., Kato, T., Mikami, Y., Okuda, K., Gilmore, R. C., Conde, C. D., Gasmi, B., Stein, S. R., Beach, M. E., et al. (2020) · medRxiv · doi:10.1101/2020.10.26.20219089 · Cited by 44 · see citing works
Wang, J., Feng, J., Zhu, Y., Li, D., Wang, J., & Chi, W. (2022) · Frontiers in Microbiology · doi:10.3389/fmicb.2022.931065 · Cited by 44 · see citing works
Site‐tropism of streptococci in the oral microbiome
McLean, A. R., Torres‐Morales, J., Dewhirst, F. E., Borisy, G. G., & Welch, J. L. M. (2022) · Molecular Oral Microbiology · doi:10.1111/omi.12387 · Cited by 43 · see citing works
Self-citationSalivary microbiome changes distinguish response to chemoradiotherapy in patients with oral cancer
de Medeiros, M. C., The, S., Bellile, E. L., Russo, N., Schmitd, L. B., Danella, E. B., Singh, P. A., Banerjee, R., Bassis, C. M., Murphy, G. R., et al. (2023) · Microbiome · doi:10.1186/s40168-023-01677-w · Cited by 43 · see citing works
Correlation between caries activity and salivary microbiota in preschool children
Lin, X., Wang, Y., Ma, Z., Xie, M., Liu, Z., Cheng, J., Tian, Y., & Shi, H. (2023) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2023.1141474 · Cited by 41 · see citing works
Fine, D. H., Schreiner, H. C., & Velusamy, S. K. (2020) · Pathogens · doi:10.3390/pathogens9030179 · Cited by 38 · see citing works
Blostein, F., Bhaumik, D., Davis, E., Salzman, E., Shedden, K., Duhaime, M. B., Bakulski, K. M., McNeil, D. W., Marazita, M. L., & Foxman, B. (2022) · Microbiome · doi:10.1186/s40168-022-01442-5 · Cited by 37 · see citing works
Three‐Dimensional Humanized Model of the Periodontal Gingival Pocket to Study Oral Microbiome
Adelfio, M., Martín‐Moldes, Z., Erndt-Marino, J. D., Tozzi, L., Duncan, M. J., Hastürk, H., Kaplan, D. L., & Ghezzi, C. E. (2023) · Advanced Science · doi:10.1002/advs.202205473 · Cited by 37 · see citing works
Li, Y., He, C., & Lü, N. (2024) · Chinese Medical Journal · doi:10.1097/cm9.0000000000003348 · Cited by 35 · see citing works
Debelius, J. W., Huang, T., Cai, Y., Ploner, A., Barrett, D., Zhou, X., Xiao, X., Li, Y., Liao, J., Zheng, Y., et al. (2020) · mSystems · doi:10.1128/msystems.00065-20 · Cited by 36 · see citing works
Mechanisms underlying interactions between two abundant oral commensal bacteria
Perera, D., McLean, A. R., Morillo-López, V., Cloutier-Leblanc, K., Almeida, E., Cabana, K., Welch, J. L. M., & Ramsey, M. M. (2021) · The ISME Journal · doi:10.1038/s41396-021-01141-3 · Cited by 33 · see citing works
Tardelli, J. D. C., Bagnato, V. S., & dos Reis, A. C. (2023) · Antibiotics · doi:10.3390/antibiotics12060994 · Cited by 32 · see citing works
Annavajhala, M. K., May, M. S., Compres, G., Freedberg, D. E., Graham, R., Stump, S., Que, J., Korem, T., Uhlemann, A., & Abrams, J. A. (2020) · Clinical and Translational Gastroenterology · doi:10.14309/ctg.0000000000000235 · Cited by 32 · see citing works
Tardelli, J. D. C., Schiavon, M. A., & dos Reis, A. C. (2024) · Carbohydrate Polymers · doi:10.1016/j.carbpol.2024.122496 · Cited by 32 · see citing works
Site-specialization of human oral Gemella species
Torres‐Morales, J., Welch, J. L. M., Dewhirst, F. E., & Borisy, G. G. (2023) · Journal of Oral Microbiology · doi:10.1080/20002297.2023.2225261 · Cited by 31 · see citing works
Self-citationThe human oral cavity microbiota composition during acute tonsillitis: a cross-sectional survey
Yeoh, Y. K., Chan, M. H., Chen, Z., Lam, E. W. H., Wong, P. Y., Ngai, C. M., Chan, P. K. S., & Hui, M. (2019) · BMC Oral Health · doi:10.1186/s12903-019-0956-5 · Cited by 30 · see citing works
Esberg, A., Barone, A., Eriksson, L., Holgerson, P. L., Teneberg, S., & Johansson, I. (2020) · Microorganisms · doi:10.3390/microorganisms8111780 · Cited by 30 · see citing works
Spatial structure: shaping the ecology and evolution of microbial communities
Bäcker, M., Doekes, H. M., Garza, D. R., Meijer, J., van Vliet, S., Allen, R. J., Hogeweg, P., Dutilh, B. E., & van Dijk, B. (2026) · FEMS Microbiology Reviews · doi:10.1093/femsre/fuaf067 · Cited by 30 · see citing works
Single-Cell Genomics and the Oral Microbiome
Balachandran, M., Cross, K. L., & Podar, M. (2020) · Journal of Dental Research · doi:10.1177/0022034520907380 · Cited by 29 · see citing works
Spirito, F. D., Amato, A., Romano, A., Dipalma, G., Xhajanka, E., Baroni, A., Serpico, R., Inchingolo, F., & Contaldo, M. (2022) · Applied Sciences · doi:10.3390/app12189135 · Cited by 29 · see citing works
Davis, E. M., & Weese, J. S. (2021) · Veterinary Clinics of North America Small Animal Practice · doi:10.1016/j.cvsm.2021.08.004 · Cited by 29 · see citing works
Alternative Antibiotics in Dentistry: Antimicrobial Peptides
Griffith, A., Mateen, A. I., Markowitz, K., Singer, S. R., Cugini, C., Shimizu, E., Wiedman, G. R., & Kumar, V. (2022) · Pharmaceutics · doi:10.3390/pharmaceutics14081679 · Cited by 32 · see citing works
Modified SHI medium supports growth of a disease‐state subgingival polymicrobial community in vitro
Lamont, E. I., Gadkari, A., Kerns, K. A., To, T. T., Daubert, D. M., Kotsakis, G. A., Bor, B., He, X., & McLean, J. S. (2020) · Molecular Oral Microbiology · doi:10.1111/omi.12323 · Cited by 26 · see citing works
Abdolahinia, E. D., & Han, X. (2023) · Cancers · doi:10.3390/cancers15174266 · Cited by 28 · see citing works
Oral bacteriome and oral potentially malignant disorders: A systematic review of the associations
Pignatelli, P., Curia, M. C., Tenore, G., Bondi, D., Piattelli, A., & Romeo, U. (2024) · Archives of Oral Biology · doi:10.1016/j.archoralbio.2024.105891 · Cited by 27 · see citing works
Impaired oral health: a required companion of bacterial aspiration pneumonia
Ashford, J. R. (2024) · Frontiers in Rehabilitation Sciences · doi:10.3389/fresc.2024.1337920 · Cited by 24 · see citing works
Saliva-derived microcosm biofilms grown on different oral surfaces in vitro
Li, X., Shang, L., Brandt, B. W., Buijs, M. J., Roffel, S., van Loveren, C., Wim Crielaard, A., Gibbs, S., & Deng, D. (2021) · npj Biofilms and Microbiomes · doi:10.1038/s41522-021-00246-z · Cited by 24 · see citing works
Diurnal and eating-associated microbial patterns revealed via high-frequency saliva samplingPreprint
Hu, Y., Amir, A., Huang, X., Li, Y., Huang, S. W., Wolfe, E., Weiss, S. J., Knight, R. D., & Xu, Z. Z. (2022) · Genome Research · doi:10.1101/gr.276482.121 · Cited by 24 · see citing works
Transcriptomic Responses to Coaggregation between Streptococcus gordonii and Streptococcus oralis
Choo, S. W., Mohammed, W. K., Mutha, N. V. R., Rostami, N., Ahmed, H., Krasnogor, N., Tan, G. Y. A., & Jakubovics, N. S. (2021) · Applied and Environmental Microbiology · doi:10.1128/aem.01558-21 · Cited by 24 · see citing works
Charalambous, E. G., Mériaux, S. B., Guébels, P., Muller, C. P., Leenen, F. A. D., Elwenspoek, M. M. C., Thiele, I., Hertel, J., & Turner, J. D. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms222312682 · Cited by 23 · see citing works
Development of standard protocols for biofilm-biomaterial interface testing
Cieplik, F., Aparicio, C., Kreth, J., & Schmalz, G. (2022) · JADA Foundational Science · doi:10.1016/j.jfscie.2022.100008 · Cited by 23 · see citing works
Galvin, S., Anishchuk, S., Healy, C. M., & Moran, G. P. (2023) · Journal of Oral Microbiology · doi:10.1080/20002297.2023.2263971 · Cited by 23 · see citing works
Spatial ecology of Haemophilus and Aggregatibacter in the human oral cavity
Giacomini, J. J., Torres‐Morales, J., Tang, J., Dewhirst, F. E., Borisy, G. G., & Welch, J. L. M. (2024) · Microbiology Spectrum · doi:10.1128/spectrum.04017-23 · Cited by 22 · see citing works
Self-citationOral microbiota–host interaction: the chief culprit of alveolar bone resorption
Xu, J., Yu, L., Ye, S., Ye, Z., Yang, L., & Xu, X. (2024) · Frontiers in Immunology · doi:10.3389/fimmu.2024.1254516 · Cited by 22 · see citing works
Voidarou, C. C., Αντωνιάδου, Μ., Rozos, G., Alexopoulos, A., Giorgi, E., Tzora, A., Skoufos, I. A., Varzakas, T. H., & Bezirtzoglou, E. (2021) · Applied Sciences · doi:10.3390/app11146318 · Cited by 22 · see citing works
Hammad, M. I., Conrads, G., & Abdelbary, M. M. H. (2023) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2023.1278582 · Cited by 21 · see citing works
Dysbiosis of Oral Microbiome: A Key Player in Oral Carcinogenesis? A Critical Review
Devaraja, K., & Aggarwal, S. (2025) · Biomedicines · doi:10.3390/biomedicines13020448 · Cited by 24 · see citing works
Disentangling the feedback loops driving spatial patterning in microbial communities
Henderson, A. D., Ridolfi, A. D. P., Schubert, O. T., Mitri, S., & van Vliet, S. (2025) · npj Biofilms and Microbiomes · doi:10.1038/s41522-025-00666-1 · Cited by 21 · see citing works
Metabolic Current Production by an Oral Biofilm Pathogen Corynebacterium matruchotii
Naradasu, D., Miran, W., & Okamoto, A. (2020) · Molecules · doi:10.3390/molecules25143141 · Cited by 21 · see citing works
Park, D.-Y., Hwang, J., Kim, Y., Lee, D., Kim, Y.-Y., Kim, H., & Hwang, I. (2023) · Scientific Reports · doi:10.1038/s41598-023-35168-7 · Cited by 21 · see citing works
Lewis, J. P., & Gui, Q. (2023) · Microbiology Spectrum · doi:10.1128/spectrum.04733-22 · Cited by 19 · see citing works
Oral microbial interactions from an ecological perspective: a narrative review
Fine, D. H., & Schreiner, H. C. (2023) · Frontiers in Oral Health · doi:10.3389/froh.2023.1229118 · Cited by 20 · see citing works
Sekundo, C., Langowski, E., Wolff, D., Boutin, S., & Frese, C. (2022) · Journal of Oral Microbiology · doi:10.1080/20002297.2022.2059891 · Cited by 20 · see citing works
Insights into the enigma of oral streptococci in carcinogenesis
Kumar, S. S., Johnson, M. D. L., & Wilson, J. E. (2024) · Microbiology and Molecular Biology Reviews · doi:10.1128/mmbr.00095-23 · Cited by 22 · see citing works
Associations of sex, oral hygiene and smoking with oral species in distinct habitats at age 32 years
Benn, A. M. L., Heng, N. C. K., Thomson, W. M., Sissons, C. H., Gellen, L. S., Gray, A. R., & Broadbent, J. M. (2021) · European Journal Of Oral Sciences · doi:10.1111/eos.12829 · Cited by 19 · see citing works
Succession of the oral microbiome with the increasing severity of periodontitis
Mi, J., Zhi, M., Kang, W., Liang, Q., Tang, D., Wang, T., Song, W., Sun, T., Li, M., Shao, J., et al. (2024) · Open Research (University of Surrey) · doi:10.1002/viw.20230118 · Cited by 18 · see citing works
Culp, D. J., Hull, W., Bremgartner, M. J., Atherly, T. A., Christian, K. N., Killeen, M., Dupuis, M. R., Schultz, A. C., Chakraborty, B., Lee, K., et al. (2020) · Applied and Environmental Microbiology · doi:10.1128/aem.02490-20 · Cited by 18 · see citing works
Niu, Q., Chen, S., Bai, R., Lu, Y., Peng, L., Han, B., & Yu, T. (2024) · iScience · doi:10.1016/j.isci.2024.111458 · Cited by 17 · see citing works
Oral microbial profile variation during canine ligature-induced peri-implantitis development
Qiao, S., Wu, D., Wang, M., Qian, S., Zhu, Y. M., Shi, J., Wei, Y., & Lai, H. (2020) · BMC Microbiology · doi:10.1186/s12866-020-01982-6 · Cited by 17 · see citing works
Individuals with substance use disorders have a distinct oral microbiome pattern
Kościółek, T., Victor, T. A., Kuplicki, R., Rossi, M., Estaki, M., Ackermann, G. L., Knight, R. D., & Paulus, M. P. (2021) · Brain Behavior & Immunity - Health · doi:10.1016/j.bbih.2021.100271 · Cited by 17 · see citing works
Dan, W., Peng, L., Yan, B., Li, Z., & Pan, F. (2022) · Frontiers in Microbiology · doi:10.3389/fmicb.2021.791274 · Cited by 16 · see citing works
Diwan, P., Nirwan, M., Bahuguna, M., Kumari, S. P., Wahlang, J., & Gupta, R. K. (2023) · Pathogens · doi:10.3390/pathogens12080996 · Cited by 18 · see citing works
Zhang, M., Zhao, Y., Umar, A., Zhang, H., Yang, L., Huang, J., Long, Y., & Yu, Z. (2024) · BMC Oral Health · doi:10.1186/s12903-024-04181-1 · Cited by 16 · see citing works
Site- and Time-Dependent Compositional Shifts in Oral Microbiota Communities
Esberg, A., Eriksson, L., & Johansson, I. (2022) · Frontiers in Oral Health · doi:10.3389/froh.2022.826996 · Cited by 16 · see citing works
Shaiber, A., Willis, A. D., Delmont, T. O., Roux, S., Chen, L.-X., Schmid, A. C., Yousef, M., Watson, A. R., Lolans, K., Esen, Ö. C., et al. (2020) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2020.04.29.069278 · Cited by 18 · see citing works
Self-citationKreth, J., & Merritt, J. L. (2022) · FEMS Microbiology Reviews · doi:10.1093/femsre/fuac052 · Cited by 15 · see citing works
Jalali, F., Ellett, F. E., Balani, P., Duncan, M. J., Dewhirst, F. E., Borisy, G. G., & Irimia, D. (2021) · MicrobiologyOpen · doi:10.1002/mbo3.1137 · Cited by 14 · see citing works
Self-citationVelsko, I. M., Gallois, S., Stahl, R., Henry, A. G., & Warinner, C. (2023) · Molecular Ecology · doi:10.1111/mec.16988 · Cited by 14 · see citing works
- Authors
- Mark Welch, J. L., Dewhirst, F. E., & Borisy, G. G.
- Affiliations
- Marine Biological Laboratory, Woods Hole, Massachusetts 02543, USA;
- Harvard University (US)
- The Forsyth Institute (US)
- Venue
- Annual Review of Microbiology
- Publisher
- Annual Reviews
- Published
- 2019-09-08
- Volume
- 73
- Issue
- 1
- Pages
- 335-358
- ISSN
- 0066-4227 (ISSN-L)
- 1545-3251
- PMC
- PMC7153577
- OpenAlex
- W2949610528
- Cited by
- 284
- References
- 111
- Citations by year
- 2026: 35 · 2025: 41 · 2024: 50 · 2023: 38 · 2022: 42 · 2021: 39 · 2020: 36 · 2019: 3
- FWCI
- 4.25
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Annual Review of Microbiology (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institute of Dental and Craniofacial Research (R37DE016937, R01DE022586, R01DE016937)
- Topics
- Health Sciences › Dentistry › Periodontics › Oral microbiology and periodontitis research
- Physical Sciences › Environmental Science › Ecology › Microbial Community Ecology and Physiology
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Keywords
- oral microbiota, biogeography, microbial ecology, oral microbiology
- MeSH terms
- Humans, Mouth, Spatial Analysis, Microbiota
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
