The DOI matches its Crossref record; 295 of the 295 references it cites were found in a registry or an index.
ERK signalling: a master regulator of cell behaviour, life and fate
Abstract
The proteins extracellular signal-regulated kinase 1 (ERK1) and ERK2 are the downstream components of a phosphorelay pathway that conveys growth and mitogenic signals largely channelled by the small RAS GTPases. By phosphorylating widely diverse substrates, ERK proteins govern a variety of evolutionarily conserved cellular processes in metazoans, the dysregulation of which contributes to the cause of distinct human diseases. The mechanisms underlying the regulation of ERK1 and ERK2, their mode of action and their impact on the development and homeostasis of various organisms have been the focus of much attention for nearly three decades. In this Review, we discuss the current understanding of this important class of kinases. We begin with a brief overview of the structure, regulation, substrate recognition and subcellular localization of ERK1 and ERK2. We then systematically discuss how ERK signalling regulates six fundamental cellular processes in response to extracellular cues. These processes are cell proliferation, cell survival, cell growth, cell metabolism, cell migration and cell differentiation.
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“which are associated with a poor prognosis and resistance to certain treatments”
From The Role of KRAS Mutations in Colorectal Cancer: Biological Insights, Clinical Implications, and Future Therapeutic Perspectives (2025) · cites this paper as [12]
In the citing paper
“these mutations promote persistent activation of oncogenic pathways such as MAPK/ERK and PI3K/AKT”
From The Role of KRAS Mutations in Colorectal Cancer: Biological Insights, Clinical Implications, and Future Therapeutic Perspectives (2025) · cites this paper as [12]
In the citing paper
“KRAS mutations in colorectal cancer lead to the sustained activation of critical downstream signaling pathways, including the MAPK/ERK and PI3K/AKT pathways. These pathways promote uncontrolled cell proliferation, inhibit apoptosis, and support tumor growth and metastasis [12].”
From The Role of KRAS Mutations in Colorectal Cancer: Biological Insights, Clinical Implications, and Future Therapeutic Perspectives (2025) · cites this paper as [12]
In the citing paper
“ERK plays important roles in the processes involving cell growth, cell proliferation, and cell survival (Lavoie et al. 2020).”
From Reactive Oxygen Species, Toxicity, Oxidative Stress, and Antioxidants: Chronic Diseases and Aging (2023) · cites this paper as Lavoie et al. 2020
Citations
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Takeda, M., Yoshida, S., Inoue, T., Sekido, Y., Hata, T., Hamabe, A., Ogino, T., Miyoshi, N., Uemura, M., Yamamoto, H., et al. (2025) · Cancers · doi:10.3390/cancers17030428 · Cited by 82
“…regulatory mechanisms. uncontrolled cell proliferation, inhibit apoptosis, and support tumor growth and metastasis [ Notably, point mutations at codons 12 and 13 are common and typically a ff ect the glycine residues within the GTP-binding pocket, which play a critical role in GTPase activity.”
Recent Updates on the Significance of KRAS Mutations in Colorectal Cancer Biology
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“…under CR conditions, including AKT, ERK, TGF-β/SMAD, Notch, and β-catenin signaling, are closely linked to transcriptional regulation, lineage specification, cell-state maintenance, and epigenetic control (Ligaba et al. 2015; Bray 2016; Hill 2016; Nusse and Clevers 2017; Lavoie et al. 2020).”
Metadata
- Authors
- Lavoie, H., Gagnon, J., & Therrien, M.
- Affiliations
- Institute for Research in Immunology and Cancer (CA)
- Corresponding author
- Therrien, Marc
- Venue
- Nature Reviews Molecular Cell Biology
- Published
- 2020-06-23
- Volume
- 21
- Issue
- 10
- Pages
- 607-632
- ISSN
- 1471-0072 (ISSN-L)
- 1471-0080
- OpenAlex
- W3036759197
- Cited by
- 1,185
- References
- 295
- Citations by year
- 2026: 195 · 2025: 253 · 2024: 248 · 2023: 208 · 2022: 163 · 2021: 110 · 2020: 7
- FWCI
- 11.77
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Nature Reviews Molecular Cell Biology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Canadian Institutes of Health Research (FDN 388023)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Protein Kinase Regulation and GTPase Signaling
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Melanoma and MAPK Pathways
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Protein Tyrosine Phosphatases
- Keywords
- ERK1, ERK2, MAPK signaling, Ras GTPase, kinase regulation, substrate recognition, subcellular localization, cell proliferation, cell survival, cell growth, cellular metabolism, cell migration, cell differentiation, disease
- MeSH terms
- Animals, Cell Differentiation, Cell Movement, Humans, Signal Transduction, Extracellular Signal-Regulated MAP Kinases, Cell Proliferation
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