Cited by 1,185Protein Kinase Regulation and GTPase SignalingMelanoma and MAPK PathwaysProtein Tyrosine Phosphatases

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ERK signalling: a master regulator of cell behaviour, life and fate

Lavoie, Hugo, Gagnon, Jessica, Therrien, Marc·2020·Nature Reviews Molecular Cell Biology

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Abstract

The proteins extracellular signal-regulated kinase 1 (ERK1) and ERK2 are the downstream components of a phosphorelay pathway that conveys growth and mitogenic signals largely channelled by the small RAS GTPases. By phosphorylating widely diverse substrates, ERK proteins govern a variety of evolutionarily conserved cellular processes in metazoans, the dysregulation of which contributes to the cause of distinct human diseases. The mechanisms underlying the regulation of ERK1 and ERK2, their mode of action and their impact on the development and homeostasis of various organisms have been the focus of much attention for nearly three decades. In this Review, we discuss the current understanding of this important class of kinases. We begin with a brief overview of the structure, regulation, substrate recognition and subcellular localization of ERK1 and ERK2. We then systematically discuss how ERK signalling regulates six fundamental cellular processes in response to extracellular cues. These processes are cell proliferation, cell survival, cell growth, cell metabolism, cell migration and cell differentiation.

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Authors: Lavoie, H., Gagnon, J., & Therrien, M.
Affiliations: Institute for Research in Immunology and Cancer (CA)
Corresponding author: Therrien, Marc
ORCID: Lavoie, Hugo
Gagnon, Jessica
Therrien, Marc
Venue: Nature Reviews Molecular Cell Biology
Publisher: Springer Science and Business Media LLC
Published: 2020-06-23
Volume: 21
Issue: 10
Pages: 607-632
ISSN: 1471-0072 (ISSN-L)
1471-0080
DOI: 10.1038/s41580-020-0255-7
OpenAlex: W3036759197
Cited by: 1,185
References: 295
Citations by year: 2026: 195 · 2025: 253 · 2024: 248 · 2023: 208 · 2022: 163 · 2021: 110 · 2020: 7
FWCI: 11.77
Type: journal article
Language: en
Open access: closed
Licence: www.springer.com/tdm (tdm)
www.springer.com/tdm (vor)
Locations: Nature Reviews Molecular Cell Biology (publishedVersion)
PubMed (publishedVersion)
Funders: Canadian Institutes of Health Research (FDN 388023)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Protein Kinase Regulation and GTPase Signaling
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Melanoma and MAPK Pathways
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Protein Tyrosine Phosphatases
Keywords: ERK1, ERK2, MAPK signaling, Ras GTPase, kinase regulation, substrate recognition, subcellular localization, cell proliferation, cell survival, cell growth, cellular metabolism, cell migration, cell differentiation, disease
MeSH terms: Animals, Cell Differentiation, Cell Movement, Humans, Signal Transduction, Extracellular Signal-Regulated MAP Kinases, Cell Proliferation

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ERK signalling: a master regulator of cell behaviour, life and fate

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