The DOI matches its Crossref record; 215 of the 216 references it cites were found in a registry or an index.
Metabolic regulation of somatic stem cells in vivo
Abstract
Metabolism has been studied mainly in cultured cells or at the level of whole tissues or whole organisms in vivo. Consequently, our understanding of metabolic heterogeneity among cells within tissues is limited, particularly when it comes to rare cells with biologically distinct properties, such as stem cells. Stem cell function, tissue regeneration and cancer suppression are all metabolically regulated, although it is not yet clear whether there are metabolic mechanisms unique to stem cells that regulate their activity and function. Recent work has, however, provided evidence that stem cells do have a metabolic signature that is distinct from that of restricted progenitors and that metabolic changes influence tissue homeostasis and regeneration. Stem cell maintenance throughout life in many tissues depends upon minimizing anabolic pathway activation and cell division. Consequently, stem cell activation by tissue injury is associated with changes in mitochondrial function, lysosome activity and lipid metabolism, potentially at the cost of eroding self-renewal potential. Stem cell metabolism is also regulated by the environment: stem cells metabolically interact with other cells in their niches and are able to sense and adapt to dietary changes. The accelerating understanding of stem cell metabolism is revealing new aspects of tissue homeostasis with the potential to promote tissue regeneration and cancer suppression.
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“Various metabolites (for example, nicotinamide adenine dinucleotide (NAD), adenosine triphosphate, glucose, amino acids and lipids), and the enzymes that use or regulate them, are pivotal for the integration of external factors and the regulation of stem cell function114,115.”
From Ageing and rejuvenation of tissue stem cells and their niches (2023) · cites this paper as [115]
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Items 201–215 of 215
Essential role for autophagy protein ATG7 in the maintenance of intestinal stem cell integrity
Trentesaux, C., Fraudeau, M., Pitasi, C. L., Lemarchand, J., Jacques, S., Duche, A., Letourneur, F., Näser, E., Bailly, K., Schmitt, A., et al. (2020) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1917174117 · Cited by 68
Caloric Restriction Promotes Structural and Metabolic Changes in the Skin
Forni, M. F., Peloggia, J., Braga, T. T., Chinchilla, J. E. O., Shinohara, J. S., Navas, C. A., Câmara, N. O. S., & Kowaltowski, A. J. (2017) · Cell Reports · doi:10.1016/j.celrep.2017.08.052 · Cited by 64
The requirement for pyruvate dehydrogenase in leukemogenesis depends on cell lineage
Jun, S., Mahesula, S., Mathews, T. P., Martin-Sandoval, M. S., Zhao, Z., Piskounova, E., & Agathocleous, M. (2021) · Cell Metabolism · doi:10.1016/j.cmet.2021.07.016 · Cited by 58
Tasdogan, A., Kumar, S., Allies, G., Bausinger, J., Beckel, F., Hofemeister, H., Mulaw, M. A., Madan, V., Scharffetter‐Kochanek, K., Feuring‐Buske, M., et al. (2016) · Cell stem cell · doi:10.1016/j.stem.2016.08.007 · Cited by 56
Oguro, H., McDonald, J. G., Zhao, Z., Umetani, M., Shaul, P. W., & Morrison, S. J. (2017) · Journal of Clinical Investigation · doi:10.1172/jci94027 · Cited by 56
Self-citationSensitivity of hematopoietic stem cells to mitochondrial dysfunction by SdhD gene deletion
Bejarano-García, J. A., Millán‐Uclés, Á., Rosado, I. V., Sánchez‐Abarca, L. I., Caballero‐Velázquez, T., Durán-Galván, M. J., Pérez‐Simón, J. A., & Piruat, J. I. (2016) · Cell Death and Disease · doi:10.1038/cddis.2016.411 · Cited by 54
Wilkinson, A. C., Morita, M., Nakauchi, H., & Yamazaki, S. (2018) · Experimental Hematology · doi:10.1016/j.exphem.2018.04.004 · Cited by 48
Autophagy is required for stem cell mobilization by G-CSF
Leveque, L., Vu, T., Lineburg, K. E., Kuns, R. D., Bagger, F. O., Teal, B. E., Lor, M., Boyle, G. M., Bruedigam, C., Mintern, J. D., et al. (2015) · Blood · doi:10.1182/blood-2014-03-562660 · Cited by 45
Roles of vitamins in stem cells
Godoy-Parejo, C., Deng, C., Zhang, Y., Liu, W., & Chen, G. (2019) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-019-03352-6 · Cited by 45
Zhang, K., Zhou, Y., Zhao, T., Wu, L., Huang, X. H., Wu, K., Xu, L., Li, D., Liu, S., Zhao, Y., et al. (2015) · PLoS ONE · doi:10.1371/journal.pone.0140035 · Cited by 44
Mitochondria regulate intestinal stem cell proliferation and epithelial homeostasis through FOXO
Zhang, F., Pirooznia, M., & Xu, H. (2020) · Molecular Biology of the Cell · doi:10.1091/mbc.e19-10-0560 · Cited by 43
[FoxO3a is essential for the maintenance of hematopoietic stem cell pool].
Miyamoto, K. (2008) · PubMed · Cited by 41
Nutrients in the fate of pluripotent stem cells
Lu, V., Roy, I. J., & Teitell, M. A. (2021) · Cell Metabolism · doi:10.1016/j.cmet.2021.09.013 · Cited by 40
Yi, W., Zhang, Y., Liu, B., Zhou, Y., Liao, D., Qiao, X., Gao, D., Xie, T., Yao, Q., Zhang, Y., et al. (2021) · Cell Reports · doi:10.1016/j.celrep.2021.108922 · Cited by 23
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Mitochondria at the crossroads of health and disease
Suomalainen, A., & Nunnari, J. M. (2024) · Cell · doi:10.1016/j.cell.2024.04.037 · Cited by 528
Ageing and rejuvenation of tissue stem cells and their niches
Brunet, A., Goodell, M. A., & Rando, T. A. (2023) · Nature Reviews Molecular Cell Biology · doi:10.1038/s41580-022-00510-w · Cited by 407
Metabolites as signalling molecules
Baker, S. A., & Rutter, J. P. (2023) · Nature Reviews Molecular Cell Biology · doi:10.1038/s41580-022-00572-w · Cited by 398
Local and systemic mechanisms that control the hair follicle stem cell niche
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Metadata
- Authors
- Meacham, C. E., DeVilbiss, A. W., & Morrison, S. J.
- Affiliations
- The University of Texas Southwestern Medical Center (US)
- Howard Hughes Medical Institute (US)
- Corresponding author
- Morrison, Sean J.
- Venue
- Nature Reviews Molecular Cell Biology
- Published
- 2022-02-28
- Volume
- 23
- Issue
- 6
- Pages
- 428-443
- ISSN
- 1471-0072 (ISSN-L)
- 1471-0080
- OpenAlex
- W4214652191
- Cited by
- 85
- References
- 216
- Citations by year
- 2026: 17 · 2025: 21 · 2024: 18 · 2023: 23 · 2022: 6
- FWCI
- 1.77
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Nature Reviews Molecular Cell Biology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Howard Hughes Medical Institute
- National Heart, Lung, and Blood Institute (F32HL135975)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Metabolism, Diabetes, and Cancer
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Mesenchymal stem cell research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Cancer, Hypoxia, and Metabolism
- Keywords
- adult stem cells, stem cell metabolism, metabolic heterogeneity, tissue regeneration, tissue homeostasis, stem cell niche, mitochondrial function, lipid metabolism, self-renewal, stem cell activation, dietary regulation, tumor suppression
- MeSH terms
- Cell Differentiation, Cell Division, Homeostasis, Stem Cells, Adult Stem Cells, Metabolic Networks and Pathways
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