Cited by 85Metabolism, Diabetes, and CancerMesenchymal stem cell researchCancer, Hypoxia, and Metabolism

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Metabolic regulation of somatic stem cells in vivo

Meacham, Corbin E., DeVilbiss, Andrew W., Morrison, Sean J.·2022·Nature Reviews Molecular Cell Biology

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Abstract

Metabolism has been studied mainly in cultured cells or at the level of whole tissues or whole organisms in vivo. Consequently, our understanding of metabolic heterogeneity among cells within tissues is limited, particularly when it comes to rare cells with biologically distinct properties, such as stem cells. Stem cell function, tissue regeneration and cancer suppression are all metabolically regulated, although it is not yet clear whether there are metabolic mechanisms unique to stem cells that regulate their activity and function. Recent work has, however, provided evidence that stem cells do have a metabolic signature that is distinct from that of restricted progenitors and that metabolic changes influence tissue homeostasis and regeneration. Stem cell maintenance throughout life in many tissues depends upon minimizing anabolic pathway activation and cell division. Consequently, stem cell activation by tissue injury is associated with changes in mitochondrial function, lysosome activity and lipid metabolism, potentially at the cost of eroding self-renewal potential. Stem cell metabolism is also regulated by the environment: stem cells metabolically interact with other cells in their niches and are able to sense and adapt to dietary changes. The accelerating understanding of stem cell metabolism is revealing new aspects of tissue homeostasis with the potential to promote tissue regeneration and cancer suppression.

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Authors: Meacham, C. E., DeVilbiss, A. W., & Morrison, S. J.
Affiliations: The University of Texas Southwestern Medical Center (US)
Howard Hughes Medical Institute (US)
Corresponding author: Morrison, Sean J.
ORCID: DeVilbiss, Andrew W.
Morrison, Sean J.
Venue: Nature Reviews Molecular Cell Biology
Publisher: Springer Science and Business Media LLC
Published: 2022-02-28
Volume: 23
Issue: 6
Pages: 428-443
ISSN: 1471-0072 (ISSN-L)
1471-0080
DOI: 10.1038/s41580-022-00462-1
OpenAlex: W4214652191
Cited by: 85
References: 216
Citations by year: 2026: 17 · 2025: 21 · 2024: 18 · 2023: 23 · 2022: 6
FWCI: 1.77
Type: journal article
Language: en
Open access: closed
Licence: www.springer.com/tdm (tdm)
www.springer.com/tdm (vor)
Locations: Nature Reviews Molecular Cell Biology (publishedVersion)
PubMed (publishedVersion)
Funders: Howard Hughes Medical Institute
National Heart, Lung, and Blood Institute (F32HL135975)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Metabolism, Diabetes, and Cancer
Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Mesenchymal stem cell research
Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Cancer, Hypoxia, and Metabolism
Keywords: adult stem cells, stem cell metabolism, metabolic heterogeneity, tissue regeneration, tissue homeostasis, stem cell niche, mitochondrial function, lipid metabolism, self-renewal, stem cell activation, dietary regulation, tumor suppression
MeSH terms: Cell Differentiation, Cell Division, Homeostasis, Stem Cells, Adult Stem Cells, Metabolic Networks and Pathways

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Metabolic regulation of somatic stem cells in vivo

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