Cited by 475Nuclear Structure and FunctionCellular Mechanics and InteractionsSkin and Cellular Biology Research

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Mechanics and functional consequences of nuclear deformations

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Kalukula, Yohalie, Stephens, Andrew D., Lammerding, Jan, Gabriele, Sylvain·2022·Nature Reviews Molecular Cell Biology

DOI 10.1038/s41580-022-00480-zPMC PMC9902167

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Abstract

As the home of cellular genetic information, the nucleus has a critical role in determining cell fate and function in response to various signals and stimuli. In addition to biochemical inputs, the nucleus is constantly exposed to intrinsic and extrinsic mechanical forces that trigger dynamic changes in nuclear structure and morphology. Emerging data suggest that the physical deformation of the nucleus modulates many cellular and nuclear functions. These functions have long been considered to be downstream of cytoplasmic signalling pathways and dictated by gene expression. In this Review, we discuss an emerging perspective on the mechanoregulation of the nucleus that considers the physical connections from chromatin to nuclear lamina and cytoskeletal filaments as a single mechanical unit. We describe key mechanisms of nuclear deformations in time and space and provide a critical review of the structural and functional adaptive responses of the nucleus to deformations. We then consider the contribution of nuclear deformations to the regulation of important cellular functions, including muscle contraction, cell migration and human disease pathogenesis. Collectively, these emerging insights shed new light on the dynamics of nuclear deformations and their roles in cellular mechanobiology.

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Additional file 1 of Laminin-associated integrins mediate Diffuse Intrinsic Pontine Glioma infiltration and therapy response within a neural assembloid model
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Additional file 2 of Laminin-associated integrins mediate Diffuse Intrinsic Pontine Glioma infiltration and therapy response within a neural assembloid model
Sinha, S., Huang, M. S., Mikos, G., Bedi, Y. S., Soto, L., Lensch, S., Ayushman, M., Bintu, L., Bhutani, N., Heilshorn, S. C., et al. (2024) · Figshare · doi:10.6084/m9.figshare.26716276
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“Nuclear and chromatin mechanics play a key role in cellular mechanotransduction [14, 15], influencing processes such as cell migration, during which the nucleus and chromatin could deform under mechanical stresses [16, 17], potentially leading to DNA damage [18, 19], genome reorganization [20, 21],…”

Authors: Kalukula, Y., Stephens, A. D., Lammerding, J., & Gabriele, S.
Affiliations: University of Mons (BE)
University of Massachusetts Amherst (US)
Cornell University (US)
Corresponding author: Lammerding, Jan
Gabriele, Sylvain
ORCID: Kalukula, Yohalie
Stephens, Andrew D.
Lammerding, Jan
Gabriele, Sylvain
Venue: Nature Reviews Molecular Cell Biology
Publisher: Springer Science and Business Media LLC
Published: 2022-05-05
Volume: 23
Issue: 9
Pages: 583-602
ISSN: 1471-0072 (ISSN-L)
1471-0080
DOI: 10.1038/s41580-022-00480-z
PMC: PMC9902167
OpenAlex: W4229069131
Cited by: 475
References: 291
Citations by year: 2026: 111 · 2025: 154 · 2024: 116 · 2023: 77 · 2022: 15
FWCI: 9.45
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: www.springer.com/tdm (tdm)
www.springer.com/tdm (vor)
Locations: Nature Reviews Molecular Cell Biology (publishedVersion)
PubMed (publishedVersion)
PubMed Central (acceptedVersion)
ORBi UMONS (submittedVersion, other-oa)
Funders: National Science Foundation (2022048, U54CA210184)
Volkswagen Foundation (96733)
Fonds De La Recherche Scientifique - FNRS (T.0092.21)
Vlaamse regering
National Institutes of Health
Fonds pour la Formation à la Recherche dans l’Industrie et dans l’Agriculture
European Regional Development Fund (1510614)
National Heart, Lung, and Blood Institute (R01HL082792)
National Human Genome Research Institute (UM1HG011536)
National Cancer Institute (U54CA210184)
National Institute of General Medical Sciences (R01GM137605, R00GM123195)
Interreg
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Nuclear Structure and Function
Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Cellular Mechanics and Interactions
Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Skin and Cellular Biology Research
Keywords: nuclear deformation, mechanobiology, nuclear mechanics, nuclear lamina, chromatin, cytoskeletal filaments, genome organization, cell migration, muscle contraction, signal transduction
MeSH terms: Cell Differentiation, Cell Nucleus, Chromatin, Cytoskeleton, Humans, Signal Transduction

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Mechanics and functional consequences of nuclear deformations

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