The DOI matches its Crossref record; 264 of the 264 references it cites were found in a registry or an index.
Glomerular hyperfiltration
Abstract
Circulating blood is filtered across the glomerular barrier to form an ultrafiltrate of plasma in the Bowman's space. The volume of glomerular filtration adjusted by time is defined as the glomerular filtration rate (GFR), and the total GFR is the sum of all single-nephron GFRs. Thus, when the single-nephron GFR is increased in the context of a normal number of functioning nephrons, single glomerular hyperfiltration results in 'absolute' hyperfiltration in the kidney. 'Absolute' hyperfiltration can occur in healthy people after high protein intake, during pregnancy and in patients with diabetes, obesity or autosomal-dominant polycystic kidney disease. When the number of functioning nephrons is reduced, single-nephron glomerular hyperfiltration can result in a GFR that is within or below the normal range. This 'relative' hyperfiltration can occur in patients with a congenitally reduced nephron number or with an acquired reduction in nephron mass consequent to surgery or kidney disease. Improved understanding of the mechanisms that underlie 'absolute' and 'relative' glomerular hyperfiltration in different clinical settings, and of whether and how the single-nephron haemodynamic and related biomechanical forces that underlie glomerular hyperfiltration promote glomerular injury, will pave the way toward the development of novel therapeutic interventions that attenuate glomerular hyperfiltration and potentially prevent or limit consequent progressive kidney injury and loss of function.
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“In contrast with this study, NOX4-derived hydrogen peroxide exhibited anti-atherosclerotic effects by smooth muscle cell regulation in diabetic mice (Di Marco et al. 2016; Cortinovis et al. 2022).”
From Reactive Oxygen Species, Toxicity, Oxidative Stress, and Antioxidants: Chronic Diseases and Aging (2023) · cites this paper as Cortinovis et al. 2022
Citations
Cites
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Reactive Oxygen Species, Toxicity, Oxidative Stress, and Antioxidants: Chronic Diseases and Aging
Jomova, K., Raptova, R., Alomar, S. Y., Alwasel, S. H., Nepovimova, E., Kuca, K., & Valko, M. (2023) · Archives of Toxicology · doi:10.1007/s00204-023-03562-9 · Cited by 2,638
Association of metabolic syndrome and chronic kidney disease
Scurt, F. G., Ganz, M. J., Herzog, C., Bose, K., Mertens, P. R., & Chatzikyrkou, C. (2024) · Obesity Reviews · doi:10.1111/obr.13649 · Cited by 155
Taibl, K. R., Liang, D., Dunlop, A. L., Barr, D. B., Smith, M. R., Steenland, K., Tan, Y., Ryan, P. B., Panuwet, P., Everson, T., et al. (2023) · Environmental Pollution · doi:10.1016/j.envpol.2023.121331 · Cited by 28
Metadata
- Authors
- Cortinovis, M., Perico, N., Ruggenenti, P., Remuzzi, A., & Remuzzi, G.
- Affiliations
- Mario Negri Institute for Pharmacological Research (IT)
- University of Bergamo (IT)
- Corresponding author
- Remuzzi, Giuseppe
- Venue
- Nature Reviews Nephrology
- Published
- 2022-04-01
- Volume
- 18
- Issue
- 7
- Pages
- 435-451
- ISSN
- 1745-8323 (ISSN-L)
- 1759-5061
- 1759-507X
- OpenAlex
- W4220773194
- Cited by
- 214
- References
- 264
- Citations by year
- 2026: 48 · 2025: 62 · 2024: 48 · 2023: 42 · 2022: 13
- FWCI
- 6.20
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Nature Reviews Nephrology (publishedVersion)
- PubMed (publishedVersion)
- Aisberg (University of Bergamo) (submittedVersion)
- Topics
- Health Sciences › Medicine › Nephrology › Chronic Kidney Disease and Diabetes
- Health Sciences › Medicine › Nephrology › Renal Diseases and Glomerulopathies
- Health Sciences › Medicine › Nephrology › Renal and Vascular Pathologies
- Keywords
- glomerular hyperfiltration, glomerular filtration rate, single nephron glomerular filtration rate, nephron number, glomerular injury, kidney injury, renal protection, protein intake, pregnancy, diabetes mellitus, obesity, polycystic kidney disease
- MeSH terms
- Female, Glomerular Filtration Rate, Humans, Kidney, Kidney Glomerulus, Nephrons, Pregnancy, Polycystic Kidney, Autosomal Dominant
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