Ageing as a risk factor for neurodegenerative disease

The Hallmarks of Aging

López-Otín, C., Blasco, M. A., Partridge, L., Serrano, M., & Kroemer, G. (2013) · Cell · doi:10.1016/j.cell.2013.05.039 · Cited by 14,982

NIA‐AA Research Framework: Toward a biological definition of Alzheimer's disease

Jack, C. R., Bennett, D. A., Blennow, K., Carrillo, M. C., Dunn, B., Haeberlein, S. B., Holtzman, D. M., Jagust, W., Jessen, F., Karlawish, J., et al. (2018) · Alzheimer's & Dementia · doi:10.1016/j.jalz.2018.02.018 · Cited by 10,537

Parkinson's disease

Kalia, L. V., & Lang, A. E. (2015) · The Lancet · doi:10.1016/s0140-6736(14)61393-3 · Cited by 6,184

The amyloid hypothesis of Alzheimer's disease at 25 years

Selkoe, D. J., & Hardy, J. (2016) · EMBO Molecular Medicine · doi:10.15252/emmm.201606210 · Cited by 6,164

The limited in vitro lifetime of human diploid cell strains

Hayflick, L. (1965) · Experimental Cell Research · doi:10.1016/0014-4827(65)90211-9 · Cited by 5,876

Parkinson disease

Poewe, W., Seppi, K., Tanner, C. M., Halliday, G. M., Brundin, P., Volkmann, J., Schrag, A.-E., & Lang, A. E. (2017) · Nature Reviews Disease Primers · doi:10.1038/nrdp.2017.13 · Cited by 5,415

The senescence-associated secretory phenotype: the dark side of tumor suppression

Coppé, J.-P., Desprez, P.-Y., Krtolica, A., & Campisi, J. (2010) · Annual Review of Pathology: Mechanisms of Disease · doi:10.1146/annurev-pathol-121808-102144 · Cited by 5,206

Apolipoprotein E and Alzheimer disease: risk, mechanisms and therapy

Liu, C.-C., Kanekiyo, T., Xu, H., & Bu, G. (2013) · Nature Reviews Neurology · doi:10.1038/nrneurol.2012.263 · Cited by 3,459

Severe COVID-19 induces molecular signatures of aging in the human brainPreprint

Mavrikaki, M., Lee, J. D., Solomon, I. H., & Slack, F. J. (2021) · medRxiv · doi:10.1101/2021.11.24.21266779 · Cited by 23

Transcription Blockage by DNA Damage in Nucleotide Excision Repair-Related Neurological Dysfunctions

Kajitani, G. S., Nascimento, L. L. D. S., Neves, M. R. D. C., Leandro, G. D. S., Garcia, C. C. M., & Menck, C. F. M. (2021) · Seminars in Cell & Developmental Biology · doi:10.1016/j.semcdb.2020.10.009 · Cited by 22

Priorities Towards Fair Allocation of Ventilators During COVID-19 Pandemic: A Delphi Study

Ghamari, S., Abbasi‐Kangevari, M., Zamani, N., Hassanian‐Moghaddam, H., & Kolahi, A. (2022) · Frontiers in Medicine · doi:10.3389/fmed.2021.769508 · Cited by 22

Highly Deformable Double‐Sided Neural Probe with All‐in‐One Electrode System for Real‐Time In Vivo Detection of Dopamine for Parkinson's Disease

Jung, H. H., Ha, J., Park, J., Kang, S., Kim, J., Jung, H. N., Kim, S., Yea, J., Lee, H., Oh, S., et al. (2023) · Advanced Functional Materials · doi:10.1002/adfm.202311436 · Cited by 22

The mitochondrial UPR induced by ATF5 attenuates intervertebral disc degeneration via cooperating with mitophagy

Xu, W., Zheng, H., Yang, R., Sun, Y.-F., Peng, B., Liu, C., Song, J., Jiang, S., & Zhu, L. (2024) · Cell Biology and Toxicology · doi:10.1007/s10565-024-09854-9 · Cited by 24

A deep‐learning retinal aging biomarker for cognitive decline and incident dementia

Sim, M. A., Tham, Y. C., Nusinovici, S., Quek, T. C., Yu, M., Xue, C. C., Chee, M. L., Peng, Q., Tan, E. S. J., Chan, S. P., et al. (2025) · Alzheimer s & Dementia · doi:10.1002/alz.14601 · Cited by 24

Design of engineered nanoparticles for biomedical applications by computational modeling

Chaparro, D., & Goudeli, E. (2025) · Nanoscale · doi:10.1039/d4nr05199h · Cited by 22

Interplay Between Aging and Tau Pathology in Alzheimer’s Disease: Mechanisms and Translational Perspectives

Alrouji, M., Alshammari, M. S., Syed, T., & Shamsi, A. (2025) · Antioxidants · doi:10.3390/antiox14070774 · Cited by 21

From exposure to neurotoxicity induced by micro-nanoplastics with brain accumulation and cognitive decline

Gao, H., Zhou, H.-Q., Ji, H., Shen, J. Z., Yin, D., & Wu, D. (2025) · Ecotoxicology and Environmental Safety · doi:10.1016/j.ecoenv.2025.119114 · Cited by 27

The rise of astrocytes: are they guardians or troublemakers of the brain disorder?

Kim, H. Y., Kim, S., Akaydin, A. N., Kim, S. S., Hyeon, S. J., Lee, J.-H., & Ryu, H. (2026) · Experimental & Molecular Medicine · doi:10.1038/s12276-025-01627-6 · Cited by 28

Preventive Electroacupuncture Ameliorates D‐Galactose‐Induced Alzheimer’s Disease‐Like Pathology and Memory Deficits Probably via Inhibition of GSK3β/mTOR Signaling Pathway

Yu, C.-C., Wang, J., Ye, S.-S., Gao, S., Li, J., Wang, L., Jiang, T., Wang, X., Li, B., Shu, Q., et al. (2020) · Evidence-based Complementary and Alternative Medicine · doi:10.1155/2020/1428752 · Cited by 23

Identifying Blood Transcriptome Biomarkers of Alzheimer’s Disease Using Transgenic Mice

Ochi, S., Iga, J., Funahashi, Y., Yoshino, Y., Yamazaki, K., Kumon, H., Mori, H., Ozaki, Y., Mori, T., & Ueno, S. (2020) · Molecular Neurobiology · doi:10.1007/s12035-020-02058-2 · Cited by 23

COllaborative Neuropathology NEtwork Characterizing ouTcomes of TBI (CONNECT-TBI)

Smith, D. H., Dollé, J.-P., Ameen‐Ali, K. E., Bretzin, A. C., Cortes, E. P., Crary, J. F., Dams-O’Connor, K., Diaz-Arrastia, R. R., Edlow, B. L., Folkerth, R. D., et al. (2021) · Acta Neuropathologica Communications · doi:10.1186/s40478-021-01122-9 · Cited by 23

Synergistic Neuroprotective Effects of a Natural Product Mixture against AD Hallmarks and Cognitive Decline in Caenorhabditis elegans and an SAMP8 Mice Model

Griñán‐Ferré, C., Bellver‐Sanchís, A., Olivares-Martín, M., Bañuelos, Ó., & Pallàs, M. (2021) · Nutrients · doi:10.3390/nu13072411 · Cited by 22

Fatal attraction – The role of hypoxia when alpha-synuclein gets intimate with mitochondria

Burtscher, J., Syed, M. M. K., Keller, M. A., Lashuel, H. A., & Millet, G. P. (2021) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2021.07.017 · Cited by 25

Spreading of Alzheimer tau seeds is enhanced by aging and template matching with limited impact of amyloid-β

Nies, S. H., Takahashi, H., Herber, C. S., Huttner, A. J., Chase, A., & Strittmatter, S. M. (2021) · Journal of Biological Chemistry · doi:10.1016/j.jbc.2021.101159 · Cited by 25

Astrocytic MicroRNA in Ageing, Inflammation, and Neurodegenerative Disease

Chu, A. J., & Williams, J. M. (2022) · Frontiers in Physiology · doi:10.3389/fphys.2021.826697 · Cited by 22

Fluid Biomarkers in Alzheimer’s Disease and Other Neurodegenerative Disorders: Toward Integrative Diagnostic Frameworks and Tailored Treatments

Giampietri, L., Belli, E., Beatino, M. F., Giannoni, S., Palermo, G., Campese, N., Tognoni, G., Siciliano, G., Ceravolo, R., Luca, C. D., et al. (2022) · Diagnostics · doi:10.3390/diagnostics12040796 · Cited by 22

Practices and Patterns of Hourly Neurochecks: Analysis of 8,936 Patients With Neurological Injury

LaBuzetta, J. N., Hirshman, B. R., Malhotra, A., Owens, R. L., & Kamdar, B. B. (2021) · Journal of Intensive Care Medicine · doi:10.1177/08850666211029220 · Cited by 23

Polymerases and DNA Repair in Neurons: Implications in Neuronal Survival and Neurodegenerative Diseases

Li, X., Cao, G., Liu, X., Tang, T.-S., Guo, C., & Liu, H. (2022) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2022.852002 · Cited by 22

Neurotrophic factor-secreting cells restored endogenous hippocampal neurogenesis through the Wnt/β-catenin signaling pathway in AD model mice

Bahlakeh, G., Rahbarghazi‬, R., Abedelahi, A., Sadigh‐Eteghad, S., & Karimipour, M. (2022) · Stem Cell Research & Therapy · doi:10.1186/s13287-022-03024-6 · Cited by 22

Adjustment for the Age- and Gender-Related Metabolic Changes Improves the Differential Diagnosis of Parkinsonism

Lu, J., Wang, M., Wu, P., Yakushev, I. Y., Zhang, H., Ziegler, S. I., Jiang, J., Förster, S., Wang, J., Schwaiger, M., et al. (2022) · Phenomics · doi:10.1007/s43657-022-00079-6 · Cited by 22

Therapeutic potential of melatonin and its derivatives in aging and neurodegenerative diseases

Verma, A. K., Singh, S., & Rizvi, S. I. (2022) · Biogerontology · doi:10.1007/s10522-022-10006-x · Cited by 23

Machine learning for predicting neurodegenerative diseases in the general older population: a cohort study

Aguayo, G., Zhang, L., Vaillant, M., Ngari, M. M., Perquin, M., Moran, V., Huiart, L., Krüger, R., Azuaje, F. J., Ferdynus, C., et al. (2023) · BMC Medical Research Methodology · doi:10.1186/s12874-023-01837-4 · Cited by 23

Functional screening of lysosomal storage disorder genes identifies modifiers of alpha-synuclein neurotoxicity

Yu, M., Ye, H., De-Paula, R. B., Mangleburg, C. G., Wu, T., Lee, T. V., Li, Y., Duong, D. M., Phillips, B., Cruchaga, C., et al. (2023) · PLoS Genetics · doi:10.1371/journal.pgen.1010760 · Cited by 22

Advanced biological ageing predicts future risk for neurological diagnoses and clinical examination findings

McMurran, C. E., Wang, Y., Mak, J. K. L., Karlsson, I., Tang, B., Ploner, A., Pedersen, N. L., & Hägg, S. (2023) · Brain · doi:10.1093/brain/awad252 · Cited by 21

Cyclophilin D in Mitochondrial Dysfunction: A Key Player in Neurodegeneration?

Coluccino, G., Muraca, V. P., Corazza, A., & Lippe, G. (2023) · Biomolecules · doi:10.3390/biom13081265 · Cited by 23

The gut microbiome: an important role in neurodegenerative diseases and their therapeutic advances

Li, S., Zhao, L., Xiao, J., Guo, Y., Fu, R., Zhang, Y., & Xu, S. (2023) · Molecular and Cellular Biochemistry · doi:10.1007/s11010-023-04853-6 · Cited by 23

Chitosan – An alternative drug delivery approach for neurodegenerative diseases

Iyer, M., Elangovan, A., Ramya, S., Babu, H. W. S., Saranya, T., Krishnan, J., Yadav, M., Gopalakrishnan, A. V., Narayanasamy, A., & Vellingiri, B. (2024) · Carbohydrate Polymer Technologies and Applications · doi:10.1016/j.carpta.2024.100460 · Cited by 23

Region-specific transcriptional signatures of brain aging in the absence of neuropathology at the single-cell level

Mesecar, M. E., Duffy, M. F., Acri, D. J., Ding, J., Langston, R. G., Shah, S. I., Nalls, M. A., Reed, X., Scholz, S. W., Whitaker, D. T., et al. (2026) · npj Aging · doi:10.1038/s41514-026-00391-9 · Cited by 28

FoxO3 transcription factor promotes autophagy after oxidative stress injury in HT22 cells

Deng, A., Ma, L., Zhou, X., Wang, X., Wang, S., & Chen, X. (2020) · Canadian Journal of Physiology and Pharmacology · doi:10.1139/cjpp-2020-0448 · Cited by 22

Emotion Regulation in Couples Across Adulthood

Haase, C. M. (2023) · Annual Review of Developmental Psychology · doi:10.1146/annurev-devpsych-120621-043836 · Cited by 29

Neuroprotective properties of exosomes and chitosan nanoparticles of Tomafran, a bioengineered tomato enriched in crocins

Etxebeste-Mitxeltorena, M., Niza, E., Fajardo, C. M., Gil, C., Gómez‐Gómez, L., Martı́nez, A., & Ahrazem, O. (2024) · Natural Products and Bioprospecting · doi:10.1007/s13659-023-00425-9 · Cited by 21

Alzheimer’s disease mortality among taxi and ambulance drivers: population based cross sectional study

Patel, V. R., Liu, M., Worsham, C. M., & Jena, A. B. (2024) · BMJ · doi:10.1136/bmj-2024-082194 · Cited by 21

Clinical biomarkers of perioperative neurocognitive disorder: initiation and recommendation

Liu, J., Li, C., Yao, J., Zhang, L., Zhao, X., Lv, X., Liu, Z., Miao, C., Wang, Y., Jiang, H., et al. (2025) · Science China Life Sciences · doi:10.1007/s11427-024-2797-x · Cited by 21

Morphological diversity of microglia: Implications for learning, environmental adaptation, ageing, sex differences and neuropathology

Augusto‐Oliveira, M., Arrifano, G. D. P., Leal-Nazaré, C. G., Chaves-Filho, A. J. M., Santos-Sacramento, L., Lopes-Araújo, A., Tremblay, M., & Lopez, M. E. C. (2025) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2025.106091 · Cited by 28

The Complementary Role of Morphology in Understanding Microglial Functional Heterogeneity

Godeanu, S., & Cătălin, B. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms26083811 · Cited by 22

Shared Mechanisms of Blood-Brain Barrier Dysfunction and Neuroinflammation in Coronavirus Disease 2019 and Alzheimer Disease

Mayer, M. G., & Fischer, T. (2025) · American Journal Of Pathology · doi:10.1016/j.ajpath.2025.03.011 · Cited by 22

Advances in research on mitochondrial dysfunction in neurodegenerative diseases

Zhang, Y., Li, X., Zhang, Y., & Li, X. (2025) · Journal of Neurology · doi:10.1007/s00415-025-13101-4 · Cited by 25

Extracellular vesicles in age-related diseases: disease pathogenesis, intervention, and biomarker

Putri, P. H. L., Alamudi, S. H., Dong, X., & Fu, Y. L. (2025) · Stem Cell Research & Therapy · doi:10.1186/s13287-025-04374-7 · Cited by 25

The current status, trends, and challenges of Alzheimer’s disease and other dementias in Asia (1990–2036)

He, Z., Zhang, H., Hu, G., Qiao, Y., Yin, C., Li, J., Lin, H., Wu, A., Qin, D., Law, B. Y. K., et al. (2025) · Frontiers in Public Health · doi:10.3389/fpubh.2025.1583339 · Cited by 29

Understanding the influence of TLR-mediated immune system on necroptosis-induced neurodegeneration in Parkinson’s disease

Jadhav, V. S., & Khatri, D. K. (2025) · Ageing Research Reviews · doi:10.1016/j.arr.2025.102872 · Cited by 22

Spatial and single-cell transcriptomics reveal the reorganization of cerebellar microglia with aging

Tsai, A. P., Henze, D. E., Lopez, E. R., Haberberger, J., Dong, C., Lu, N., Atkins, M., Costa, E. K., Farinas, A., Oh, H. S., et al. (2025) · Cell Reports · doi:10.1016/j.celrep.2025.116624 · Cited by 23

A review of nardosinone for pharmacological activities

Wen, J., Liu, L., Li, J., & He, Y. (2021) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2021.174343 · Cited by 22

Biomonitoring of Mycotoxins in Plasma of Patients with Alzheimer’s and Parkinson’s Disease

Arce-López, B., Alvarez‐Erviti, L., Santis, B. D., Izco, M., López-Calvo, S., Marzo-Sola, M. E., Debegnach, F., Lizarraga, E., de Ceráin, A. L., González‐Peñas, E., et al. (2021) · Toxins · doi:10.3390/toxins13070477 · Cited by 21

Identification of monoamine oxidases inhibitory peptides from soybean protein hydrolysate through ultrafiltration purification and in silico studies

Ying, F., Lin, S., Li, J., Zhang, X., & Chen, G. (2021) · Food Bioscience · doi:10.1016/j.fbio.2021.101355 · Cited by 21

Metformin and the risk of neurodegenerative diseases in patients with diabetes: A meta‐analysis of population‐based cohort studies

Zhang, Y., Zhang, Y., Shi, X., Han, J., Lin, B., Peng, W., Mei, Z., & Yang, L. (2022) · Diabetic Medicine · doi:10.1111/dme.14821 · Cited by 22

The major anthocyanin of Lycium ruthenicum Murr. relieves cognitive deficits, oxidative stress, neuroinflammation, and hippocampal metabolome alterations in aging rats

Chen, S., Hu, N., Wang, H., & Li, G. (2022) · Journal of Functional Foods · doi:10.1016/j.jff.2022.105104 · Cited by 21

The Neuroprotective Effects of Spray-Dried Porcine Plasma Supplementation Involve the Microbiota−Gut−Brain Axis

Rosell‐Cardona, C., Amat, C., Griñán‐Ferré, C., Polo, J., Pallàs, M., Pérez‐Bosque, A., Moretó, M., & Miró, L. (2022) · Nutrients · doi:10.3390/nu14112211 · Cited by 22

Two distinct evolutionary conserved neural degeneration pathways characterized in a colonial chordate

Anselmi, C., Kowarsky, M., Gasparini, F., Caicci, F., Ishizuka, K. J., Palmeri, K. J., Raveh, T., Sinha, R., Neff, N. F., Quake, S. R., et al. (2022) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2203032119 · Cited by 22

Socioeconomic inequality in health care use among cancer patients in China: Evidence from the China health and retirement longitudinal study

Zhang, H., Fu, Y., Chen, M., & Si, L. (2022) · Frontiers in Public Health · doi:10.3389/fpubh.2022.942911 · Cited by 21

Overview of the role of big data in mental health: A scoping review

Ahmed, A., Agus, M., Alzubaidi, M. S., Aziz, S., Abd-Alrazaq, A. A., Giannicchi, A., & Househ, M. S. (2022) · Computer Methods and Programs in Biomedicine Update · doi:10.1016/j.cmpbup.2022.100076 · Cited by 21

Age-related Decline of Intrinsic Cerebrospinal Fluid Outflow in Healthy Humans Detected with Non-contrast Spin-labeling MR Imaging

Malis, V., Bae, W. C., Yamamoto, A., McEvoy, L. K., McDonald, M. A., & Miyazaki, M. (2022) · Magnetic Resonance in Medical Sciences · doi:10.2463/mrms.mp.2022-0117 · Cited by 21

Vascular endothelial cells: a fundamental approach for brain waste clearance

Wei, H., Jiang, H., Zhou, Y., Xiao, X., Zhou, C., & Ji, X. (2022) · Brain · doi:10.1093/brain/awac495 · Cited by 20

Butyl benzyl phthalate as a key component of phthalate ester in relation to cognitive impairment in NHANES elderly individuals and experimental mice

Yu, Y., Wang, Y., Dong, Y. C., Shu, S., Zhang, D., Xu, J., Zhang, Y., Shi, W., & Wang, S. (2023) · Environmental Science and Pollution Research · doi:10.1007/s11356-023-25729-8 · Cited by 22

A ratiometric fluorescent probe for single and two-photon bioimaging of hydrogen peroxide in vitro and in vivo

Feng, Z., Wu, J., Liu, W., Ren, H., Zheng, X., Zhang, W., Lee, C., & Wang, P. (2023) · Sensors and Actuators B Chemical · doi:10.1016/j.snb.2023.133668 · Cited by 22

Is metformin neuroprotective against diabetes mellitus-induced neurodegeneration? An updated graphical review of molecular basis

Karami, F., Jamaati, H., Coleman‐Fuller, N., Zeini, M. S., Hayes, A. W., Gholami, M., Salehirad, M., Darabi, M., & Motaghinejad, M. (2023) · Pharmacological Reports · doi:10.1007/s43440-023-00469-1 · Cited by 21

Spatial orientation, postural control and the vestibular system in healthy elderly and Alzheimer’s dementia

Chepisheva, M. (2023) · PeerJ · doi:10.7717/peerj.15040 · Cited by 25

Diagnosis of neurodegenerative diseases with a refined Lempel–Ziv complexity

Zhao, H., Xie, J., Chen, Y., Cao, J., Liao, W., & Cao, H. (2023) · Cognitive Neurodynamics · doi:10.1007/s11571-023-09973-9 · Cited by 21

Microglia in brain aging: An overview of recent basic science and clinical research developments

Fan, H., Zhang, M., Wen, J., Wang, S., Yuan, M., Sun, H., Shu, L., Xu, Y., Pu, Y., & Cai, Z. (2023) · Journal of Biomedical Research · doi:10.7555/jbr.37.20220220 · Cited by 23

Perceived cognitive impairment is related to internalizing psychopathology but unrelated to objective cognitive performance among nongeriatric adults presenting for outpatient neuropsychological evaluation

Finley, J. A., Cladek, A., Gonzalez, C., & Brook, M. A. (2023) · The Clinical Neuropsychologist · doi:10.1080/13854046.2023.2241190 · Cited by 23

Healthy brain aging and delayed dementia in Texas rural elderly

Basu, T., Sehar, U., Malhotra, K., Culberson, J. W., Khan, H. M. R., Morton, H., Orlov, E., Brownell, M., & Reddy, P. H. (2023) · Ageing Research Reviews · doi:10.1016/j.arr.2023.102047 · Cited by 24

Novel 18-norspirostane steroidal saponins: Extending lifespan and mitigating neurodegeneration through promotion of mitophagy and mitochondrial biogenesis in Caenorhabditis elegans

Wu, A., Yong, Y.-Y., He, C., Li, Y.-P., Zhou, X., Yu, L., Chen, Q., Lan, C., Liu, J., Yu, C., et al. (2024) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2024.111901 · Cited by 21

Neuroprotective Roles of the Biliverdin Reductase-A/Bilirubin Axis in the Brain

Paul, B. D., & Pieper, A. A. (2024) · Biomolecules · doi:10.3390/biom14020155 · Cited by 21

miR-34a/TAN1/CREB Axis Engages in Alleviating Oligodendrocyte Trophic Factor-Induced Myelin Repair Function and Astrocyte-Dependent Neuroinflammation in the Early Stages of Alzheimer's Disease: The Anti-Neurodegenerative Effect of Treadmill Exercise

Liu, Y., Meng, X.-K., Shao, W.-Z., Liu, Y.-Q., Tang, C., Deng, S.-S., Tang, C., Zheng, L., & Guo, W. (2024) · Neurochemical Research · doi:10.1007/s11064-024-04108-w · Cited by 22

Hypoxia Sensing and Responses in Parkinson’s Disease

Burtscher, J., Duderstadt, Y., Gatterer, H., Burtscher, M., Vozdek, R., Millet, G. P., Hicks, A. A., Ehrenreich, H., & Kopp, M. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25031759 · Cited by 24

Lutein and the Underlying Neuroprotective Promise against Neurodegenerative Diseases

Iyer, S., Bhat, I., & Sheshappa, M. B. (2024) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.202300409 · Cited by 22

CNSMolGen: A Bidirectional Recurrent Neural Network-Based Generative Model for De Novo Central Nervous System Drug Design

Gou, R., Yang, J., Guo, M., Chen, Y., & Xue, W. (2024) · Journal of Chemical Information and Modeling · doi:10.1021/acs.jcim.4c00504 · Cited by 21

Suppressing UBE2N ameliorates Alzheimer's disease pathology through the clearance of amyloid beta

Zhang, C., Jia, Q., Zhu, L., Hou, J., Wang, X., Li, D., Zhang, J., Zhang, Y., Su, Y., Tu, Z., et al. (2024) · Alzheimer s & Dementia · doi:10.1002/alz.14122 · Cited by 19

Immunosenescence: A new direction in anti-aging research

Li, H., Lin, S., Wang, Y., Shi, Y., Fang, X., Wang, J., Cui, H., Bian, Y., & Qi, X. (2024) · International Immunopharmacology · doi:10.1016/j.intimp.2024.112900 · Cited by 21

Integrating IoMT and AI for Proactive Healthcare: Predictive Models and Emotion Detection in Neurodegenerative Diseases

Săndulescu, V., Ianculescu, M., Valeanu, L., & Alexandru, A. (2024) · Algorithms · doi:10.3390/a17090376 · Cited by 21

Neurodegeneration trajectory in pediatric and adult/late DM1: A follow‐up MRI study across a decade

Labayru, G., Jiménez-Marín, A., Fernández, E., Villanúa, J., Zulaica, M., Cortés, J. M., Diez, I. P., Sepulcre, J., de Munaín, A. L., & Sistiaga, A. (2020) · Annals of Clinical and Translational Neurology · doi:10.1002/acn3.51163 · Cited by 24

Pentoxifylline enhances antioxidative capability and promotes mitochondrial biogenesis for improving age-related behavioral deficits

Wang, Y., Kang, Y., Qi, C., Zhang, T., Zhao, H., Ji, X., Yan, W., Huang, Y., Cui, R., Zhang, G., et al. (2020) · Aging · doi:10.18632/aging.104155 · Cited by 23

Generation of RRMS and PPMS specific iPSCs as a platform for modeling Multiple Sclerosis

Mutukula, N., Man, Z., Takahashi, Y., Martinez, F. I., Morales, M., Guarnizo, E. C., Clares, R. H., García‐Bernal, D., Martinez, L. M., Lajara, J., et al. (2021) · Stem Cell Research · doi:10.1016/j.scr.2021.102319 · Cited by 19

Age-Related Adaptive Immune Changes in Parkinson’s Disease

Kouli, A., & Williams-Gray, C. H. (2022) · Journal of Parkinson's Disease · doi:10.3233/jpd-223228 · Cited by 20

COP-22 Alleviates d-Galactose–Induced Brain Aging by Attenuating Oxidative Stress, Inflammation, and Apoptosis in Mice

Ma, Y., Wang, X., Li, X., Chen, X., Teng, Z., Yang, J., Yang, J., & Liu, G. (2024) · Molecular Neurobiology · doi:10.1007/s12035-024-03976-1 · Cited by 20

Deformability of Heterogeneous Red Blood Cells in Aging and Related Pathologies

Prudinnik, D. S., Kussanova, A., Vorobjev, I. A., Tikhonov, A., Ataullakhanov, F. I., & Barteneva, N. S. (2024) · Aging and Disease · doi:10.14336/ad.2024.0526 · Cited by 21

Multifunctional PLGA nanosystems: enabling integrated diagnostic and therapeutic strategies

Li, Y., Tao, T., Xiong, Y., Guo, W., & Liang, Y. (2025) · Frontiers in Pharmacology · doi:10.3389/fphar.2025.1670397 · Cited by 24

The interplay between mitochondrial functionality and genome integrity in the prevention of human neurologic diseases

D’Errico, M., Parlanti, E., Pascucci, B., Filomeni, G., Mastroberardino, P. G., & Dogliotti, E. (2021) · Archives of Biochemistry and Biophysics · doi:10.1016/j.abb.2021.108977 · Cited by 20

Protein hydrolysates from Pleurotus geesteranus obtained by simulated gastrointestinal digestion exhibit neuroprotective effects in H 2 O 2 ‐injured PC12 cells

Wu, S., Chen, M., Liao, X., Huang, R., Wang, J., Xie, Y., Hu, H., Zhang, J., Wu, Q., & Ding, Y. (2021) · Journal of Food Biochemistry · doi:10.1111/jfbc.13879 · Cited by 20

Intestinal Dopamine Receptor D2 is Required for Neuroprotection Against 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced Dopaminergic Neurodegeneration

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A Model of Discovery: The Role of Imaging Established and Emerging Non-mammalian Models in Neuroscience

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Patients’ Stem Cells Differentiation in a 3D Environment as a Promising Experimental Tool for the Study of Amyotrophic Lateral Sclerosis

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The Role of Sesamin in Targeting Neurodegenerative Disorders: A Systematic Review

Ghaderi, M. A., Emami, S. A., Olia, M. D. B., & Javadi, B. (2022) · Mini-Reviews in Medicinal Chemistry · doi:10.2174/1389557522666220523112027 · Cited by 21

Neuroimaging Methods to Map In Vivo Changes of OXPHOS and Oxidative Stress in Neurodegenerative Disorders

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Mitophagy: An Emergence of New Player in Alzheimer’s Disease

Sharma, B., Pal, D., Sharma, U., & Kumar, A. (2022) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2022.921908 · Cited by 21

New Insights into the Molecular Interplay between Human Herpesviruses and Alzheimer’s Disease—A Narrative Review

Athanasiou, E., Gargalionis, A. N., Anastassopoulou, C. G., Tsakris, A., & Boufidou, F. (2022) · Brain Sciences · doi:10.3390/brainsci12081010 · Cited by 20

Characteristic Hallmarks of Aging and the Impact on Carcinogenesis

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Preclinical Alzheimer’s dementia: a useful concept or another dead end?

Mark, R. E., & Brehmer, Y. (2022) · European Journal of Ageing · doi:10.1007/s10433-022-00735-w · Cited by 20

Targeting amyloid proteins for clinical diagnosis of neurodegenerative diseases

Zhang, S., Dong, H., Bian, J., Li, D., & Liu, C. (2022) · Fundamental Research · doi:10.1016/j.fmre.2022.10.009 · Cited by 23

From kitchen to clinic: Pharmacotherapeutic potential of common spices in Indian cooking in age-related neurological disorders

Norouzkhani, N., Karimi, A. G., Badami, N., Jalalifar, E., Mahmoudvand, B., Ansari, A., Sariyarighan, N. P., Alijanzadeh, D., Aghakhani, S., Shayestehmehr, R., et al. (2022) · Frontiers in Pharmacology · doi:10.3389/fphar.2022.960037 · Cited by 24

PGRN deficiency exacerbates, whereas a brain penetrant PGRN derivative protects, GBA1 mutation-associated pathologies and diseases

Zhao, X., Lin, Y., Liou, B., Fu, W., Jian, J., Fannin, V., Zhang, W., Setchell, K. D. R., Grabowski, G. A., Sun, Y., et al. (2022) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2210442120 · Cited by 22

GABA signaling triggered by TMC-1/Tmc delays neuronal aging by inhibiting the PKC pathway in C. elegans

Wu, J., Wang, L., Ervin, J. F., Wang, S. J., Soderblom, E. J., Ko, D. C., & Yan, D. (2022) · Science Advances · doi:10.1126/sciadv.adc9236 · Cited by 17

Small molecules to perform big roles: The search for Parkinson's and Huntington's disease therapeutics

Pérez-Arancibia, R., Cisternas-Olmedo, M., Sepúlveda, D., Troncoso-Escudero, P., & Vidal, R. L. (2023) · Frontiers in Neuroscience · doi:10.3389/fnins.2022.1084493 · Cited by 21

Rhythms in barriers and fluids: Circadian clock regulation in the aging neurovascular unit

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The human neurosecretome: extracellular vesicles and particles (EVPs) of the brain for intercellular communication, therapy, and liquid-biopsy applications

Soleymani, T., Chen, T.-Y., Gonzalez‐Kozlova, E., & Dogra, N. (2023) · Frontiers in Molecular Biosciences · doi:10.3389/fmolb.2023.1156821 · Cited by 22

Escalating Bi-Directional Feedback Loops between Proinflammatory Microglia and Mitochondria in Ageing and Post-Diagnosis of Parkinson’s Disease

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AFG, an important maillard reaction product in red ginseng, alleviates D-galactose-induced brain aging in mice via correcting mitochondrial dysfunction induced by ROS accumulation

Zhang, J., Chen, K., Yin, J.-Y., Zheng, Y., Chen, R., Liu, W., Tang, S., Zhang, J., Zhang, M., Wang, Z., et al. (2023) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2023.175824 · Cited by 23

Arterial Spin Labeling (ASL) in Neuroradiological Diagnostics – Methodological Overview and Use Cases

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An enquiry to the role of CB1 receptors in neurodegeneration

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The Ageing Brain: Molecular and Cellular Basis of Neurodegeneration

Azam, S., Haque, M. E., Balakrishnan, R., Kim, I., & Choi, D. (2021) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2021.683459 · Cited by 273

Systematic review on nine hallmarks of neurodegenerative disease

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Aging, neurodegenerative diseases and geriatrics

Zhu, S., Gharti, S., Chhetri, J. K., & Chan, P. (2026) · Maturitas · doi:10.1016/j.maturitas.2026.108962

Aging and Neurodegenerative Diseases

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Ageing and Oxidative Stress

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