The DOI matches its Crossref record; 280 of the 280 references it cites were found in a registry or an index.
Recovery from disorders of consciousness: mechanisms, prognosis and emerging therapies
Open accessAbstract
Substantial progress has been made over the past two decades in detecting, predicting and promoting recovery of consciousness in patients with disorders of consciousness (DoC) caused by severe brain injuries. Advanced neuroimaging and electrophysiological techniques have revealed new insights into the biological mechanisms underlying recovery of consciousness and have enabled the identification of preserved brain networks in patients who seem unresponsive, thus raising hope for more accurate diagnosis and prognosis. Emerging evidence suggests that covert consciousness, or cognitive motor dissociation (CMD), is present in up to 15–20% of patients with DoC and that detection of CMD in the intensive care unit can predict functional recovery at 1 year post injury. Although fundamental questions remain about which patients with DoC have the potential for recovery, novel pharmacological and electrophysiological therapies have shown the potential to reactivate injured neural networks and promote re-emergence of consciousness. In this Review, we focus on mechanisms of recovery from DoC in the acute and subacute-to-chronic stages, and we discuss recent progress in detecting and predicting recovery of consciousness. We also describe the developments in pharmacological and electrophysiological therapies that are creating new opportunities to improve the lives of patients with DoC. In this Review, the authors discuss recent progress in the detection and prediction of recovery of consciousness in patients with disorders of consciousness caused by severe brain injuries. They describe the ongoing development of pharmacological and electrophysiological therapies designed to enhance recovery.
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Cites
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Cited by
Beniczky, S., Trinka, E., Wirrell, E., Abdulla, F., Al Baradie, R., Alonso Vanegas, M., Auvin, S., Singh, M. B., Blumenfeld, H., Bogacz Fressola, A., et al. (2025) · Epilepsia · doi:10.1111/epi.18338 · Cited by 426
The Edge of Sentience: Risk and Precaution in Humans, Other Animals, and AI
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Metadata
- Authors
- Edlow, B. L., Claassen, J., Schiff, N. D., & Greer, D. M.
- Venue
- Nature Reviews Neurology
- Published
- 2020-12-14
- Volume
- 17
- Issue
- 3
- Pages
- 135-156
- ISSN
- 1759-4758 (ISSN-L)
- 1759-4766
- OpenAlex
- W3113180287
- Cited by
- 731
- References
- 280
- FWCI
- 13.78
- Type
- journal article
- Language
- en
- Open access
- hybrid
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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