The DOI matches its Crossref record; 213 of the 216 references it cites were found in a registry or an index.
Deconstructing cortical folding: genetic, cellular and mechanical determinants
Abstract
Folding of the cerebral cortex is a fundamental milestone of mammalian brain evolution and is associated with dramatic increases in size and complexity. New animal models, genetic tools and bioengineering materials have moved the study of cortical folding from simple phenomenological observation to sophisticated experimental testing. Here, we provide an overview of how genetics, cell biology and biomechanics shape this complex and multifaceted process and affect each other. We discuss the evolution of cortical folding and the genomic changes in the primate lineage that seem to be responsible for the advent of larger brains and cortical folding. Emerging technologies now provide unprecedented tools to analyse and manipulate cortical folding, with the promise of elucidating the mechanisms underlying the stereotyped folding of the cerebral cortex in its full complexity.
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“Although the basic principles of cortical development may be similar in all mammals, the modifications of developmental events during millennia of primate evolution produce not only quantitative but also qualitative changes of its cellular structure and synaptic circuitry [13, 20].”
From Development of prefrontal cortex (2022) · cites this paper as [20]
Citations
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Development of prefrontal cortex
Kolk, S. M., & Rakic, P. (2022) · Neuropsychopharmacology · doi:10.1038/s41386-021-01137-9 · Cited by 378
“And if we were to focus more on the evolutionary aspects of prefrontal development in terms of structural organization and function, should we not include longitudinal neurodevelopmental studies on more species [18, 19]? Although the basic principles of cortical development may be similar in all mammals, the modificat…”
BackgroundProgrammed and self-organized flow of information during morphogenesis
Collinet, C., & Lecuit, T. (2021) · Nature Reviews Molecular Cell Biology · doi:10.1038/s41580-020-00318-6 · Cited by 322
MRI of the Neonatal Brain: A Review of Methodological Challenges and Neuroscientific Advances
Dubois, J., Alison, M., Counsell, S. J., Hertz‐Pannier, L., Hüppi, P. S., & Benders, M. J. N. L. (2021) · Journal of Magnetic Resonance Imaging · doi:10.1002/jmri.27192 · Cited by 226
Cortical Malformations: Lessons in Human Brain Development
Subramanian, L., Calcagnotto, M. E., & Paredes, M. F. (2020) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2019.00576 · Cited by 138
“, 2012) has led to the hypothesis that the presence of this expanded progenitor pool might be an important driver of cortical folding (Stahl et al., 2013; Wang et al., 2016; Borrell, 2018; Llinares-Benadero and Borrell, 2019).”
BackgroundA 2020 view of tension-based cortical morphogenesis
Essen, D. C. V. (2020) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2016830117 · Cited by 124
“In such models it is important to distinguish between “bona fide” folding (with a smooth underlying ventricular suface) and wrinkling that includes all layers of the cerebral wall (75, 109) (SI Appendix, Topic 9).”
Influential
Metadata
- Authors
- Llinares-Benadero, C., & Borrell, V.
- Affiliations
- Consejo Superior de Investigaciones Científicas (ES)
- Venue
- Nature Reviews Neuroscience
- Published
- 2019-01-04
- Volume
- 20
- Issue
- 3
- Pages
- 161-176
- ISSN
- 1471-003X (ISSN-L)
- 1471-0048
- OpenAlex
- W2907389933
- Semantic Scholar
- 5e11290de5ea2c272c18ac0c97260aae0579a518
- Cited by
- 243
- References
- 216
- Citations by year
- 2026: 24 · 2025: 16 · 2024: 52 · 2023: 44 · 2022: 27 · 2021: 33 · 2020: 36 · 2019: 11
- FWCI
- 3.37
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Nature reviews. Neuroscience (publishedVersion)
- PubMed (publishedVersion)
- DIGITAL.CSIC (Spanish National Research Council (CSIC)) (submittedVersion)
- Topics
- Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
- Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Fetal and Pediatric Neurological Disorders
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetics and Neurodevelopmental Disorders
- Keywords
- cortical folding, cerebral cortex, brain evolution
- MeSH terms
- Animals, Cell Movement, Cerebral Cortex, Biological Evolution, Humans, Neuroglia, Neurons, Neurogenesis
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