Embracing diversity in the 5-HT neuronal system

Neurotransmitter Switching in the Developing and Adult Brain

Spitzer, N. C. (2017) · Annual Review of Neuroscience · doi:10.1146/annurev-neuro-072116-031204 · Cited by 109

A serotonin-containing pathway from the area postrema to the parabrachial nucleus in the rat

Lança, A. J., & van der Kooy, D. (1985) · Neuroscience · doi:10.1016/0306-4522(85)90281-7 · Cited by 108

Neurochemical identification of stereotypic burst‐firing neurons in the rat dorsal raphe nucleus using juxtacellular labelling methods

Hajós, M., Allers, K. A., Jennings, K. A., Sharp, T., Charette, G., Attila Gabor, S. I. K., & Kocsis, B. (2007) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2006.05276.x · Cited by 108

Suppression of Serotonin Neuron Firing Increases Aggression in Mice

Audero, E., Mlinar, B., Baccini, G., Skachokova, Z. K., Corradetti, R., & Gross, C. T. (2013) · Journal of Neuroscience · doi:10.1523/jneurosci.2067-12.2013 · Cited by 107

Development of raphe serotonin neurons from specification to guidance

Kiyasova, V., & Gaspar, P. (2011) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2011.07910.x · Cited by 105

Mapping cell fate and function using recombinase-based intersectional strategies

Dymecki, S. M., Ray, R. S., & Kim, J. C. (2010) · Methods in Enzymology · doi:10.1016/s0076-6879(10)77011-7 · Cited by 104

Distinct transcriptomes define rostral and caudal serotonin neurons

Wylie, C. J., Hendricks, T. J., Zhang, B., Wang, L., Lu, P., Leahy, P., Fox, S., Maeno, H., & Deneris, E. S. (2010) · The Journal of Neuroscience · doi:10.1523/jneurosci.4656-09.2010 · Cited by 104

Combined immunocytochemistry and autoradiography after in vivo injections of monoclonal antibody to Substance P and 3H-serotonin:

Chan‐Palay, V. (1979) · Anatomy and Embryology · doi:10.1007/bf00299625 · Cited by 103

Serotonin immunoreactive boutons make synapses with feline phrenic motoneurons

Pilowsky, P. M., de Castro, D., Llewellyn‐Smith, I. J., et al. (1990) · Journal of Neuroscience · doi:10.1523/jneurosci.10-04-01091.1990 · Cited by 102

Thyrotropin-releasing hormone in spinal cord: coexistence with serotonin and with substance P in fibers and terminals apposing identified preganglionic sympathetic neurons

Appel, N. M., Wessendorf, M. W., & Elde, R. P. (1987) · Brain Research · doi:10.1016/0006-8993(87)90276-9 · Cited by 102

Whole-Brain Mapping of Neuronal Activity in the Learned Helplessness Model of Depression

Kim, Y., Perova, Z., Mirrione, M. M., Pradhan, K., Henn, F. A., Shea, S. D., Osten, P., & Li, B. (2016) · Frontiers in Neural Circuits · doi:10.3389/fncir.2016.00003 · Cited by 102

Uncontrollable, But Not Controllable, Stress Desensitizes 5-HT1AReceptors in the Dorsal Raphe Nucleus

Rozeske, R. R., Evans, A. K., Frank, M. G., Watkins, L. R., Lowry, C. A., & Maier, S. F. (2011) · The Journal of Neuroscience · doi:10.1523/jneurosci.3095-11.2011 · Cited by 100

Multiscale single-cell analysis reveals unique phenotypes of raphe 5-HT neurons projecting to the forebrain

Fernandez, S. P., Cauli, B., Cabezas, C., Muzerelle, A., Poncer, J.-C., & Gaspar, P. (2016) · Brain Structure and Function · doi:10.1007/s00429-015-1142-4 · Cited by 100

Glutamatergic drive of the dorsal raphe nucleus

Soiza‐Reilly, M., & Commons, K. G. (2011) · Journal of Chemical Neuroanatomy · doi:10.1016/j.jchemneu.2011.04.004 · Cited by 98

Adverse experience during early life and adulthood interact to elevate tph2 mRNA expression in serotonergic neurons within the dorsal raphe nucleus

Gardner, K. L., Hale, M. W., Oldfield, S., Lightman, S. L., Plotsky, P. M., & Lowry, C. A. (2009) · Neuroscience · doi:10.1016/j.neuroscience.2009.07.055 · Cited by 97

Neurotransmitter Switching? No Surprise

Spitzer, N. C. (2015) · Neuron · doi:10.1016/j.neuron.2015.05.028 · Cited by 96

Response of serotonin-containing neurons in nucleus raphe magnus to morphine, noxious stimuli, and periaqueductal gray stimulation in freely moving cats

Auerbach, S. B., Fornal, C. A., & Jacobs, B. L. (1985) · Experimental Neurology · doi:10.1016/0014-4886(85)90075-5 · Cited by 96

Serotonin and substance P co-exist in dorsal raphe neurons of the human brain

Sergeyev, V., Hökfelt, T. G. M., & Hurd, Y. L. (1999) · Neuroreport · doi:10.1097/00001756-199912160-00044 · Cited by 96

Increased Intrinsic Excitability of Lateral Wing Serotonin Neurons of the Dorsal Raphe: A Mechanism for Selective Activation in Stress Circuits

Crawford, L. K., Craige, C. P., & Beck, S. G. (2010) · Journal of Neurophysiology · doi:10.1152/jn.01132.2009 · Cited by 96

Distribution of VGLUT3 in Highly Collateralized Axons from the Rat Dorsal Raphe Nucleus as Revealed by Single-Neuron Reconstructions

Gagnon, D., & Parent, M. (2014) · PLoS ONE · doi:10.1371/journal.pone.0087709 · Cited by 95

Developmental expression of monoamine oxidases A and B in the central and peripheral nervous systems of the mouse

Vitalis, T., Fouquet, C., Alvarez, C., Seif, I., Price, D. J., Gaspar, P., & Cases, O. (2002) · The Journal of Comparative Neurology · doi:10.1002/cne.10093 · Cited by 94

Chronic non-invasive corticosterone administration abolishes the diurnal pattern of tph2 expression

Donner, N. C., Montoya, C. D., Lukkes, J. L., & Lowry, C. A. (2011) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2011.08.008 · Cited by 94

Serotonin‐immunoreactive axon terminals innervate pyramidal cells and interneurons in the rat basolateral amygdala

Muller, J. F., Mascagni, F., & McDonald, A. J. (2007) · The Journal of Comparative Neurology · doi:10.1002/cne.21486 · Cited by 93

Manipulation of dorsal raphe serotonergic neurons modulates active coping to inescapable stress and anxiety-related behaviors in mice and rats

Nishitani, N., Nagayasu, K., Asaoka, N., Yamashiro, M., Andoh, C., Nagai, Y., Kinoshita, H., Kawai, H., Shibui, N., Liu, B., et al. (2019) · Neuropsychopharmacology · doi:10.1038/s41386-018-0254-y · Cited by 92

Coexpression of vesicular glutamate transporter‐3 and γ‐aminobutyric acidergic markers in rat rostral medullary raphe and intermediolateral cell column

Stornetta, R. L., Rosin, D. L., Simmons, J. R., McQuiston, T. J., Vujović, N., Weston, M. C., & Guyenet, P. G. (2005) · The Journal of Comparative Neurology · doi:10.1002/cne.20742 · Cited by 91

Cytoarchitecture of serotonin‐synthesizing neurons in the pontine tegmentum of the human brain

Baker, K. G., Halliday, G. M., Halasz, P., Hornung, J., Geffen, L. B., Cotton, R. G. H., & Törk, I. (1991) · Synapse · doi:10.1002/syn.890070407 · Cited by 90

Learning and Stress Shape the Reward Response Patterns of Serotonin Neurons

Zhong, W., Li, Y., Feng, Q., & Luo, M. (2017) · Journal of Neuroscience · doi:10.1523/jneurosci.1181-17.2017 · Cited by 90

The paratrigeminal nucleus. II. Identification and inter-relations of catecholamine axons, indoleamine axons, and Substance P immunoreactive cells in the neuropil

Chan‐Palay, V. (1978) · Journal of Neurocytology · doi:10.1007/bf01173989 · Cited by 89

Transmitters of the raphe-spinal complex: Immunocytochemical studies

Bowker, R. M., Westlund, K. N., Sullivan, M. C., Wilber, J. F., & Coulter, J. D. (1982) · Peptides · doi:10.1016/0196-9781(82)90089-4 · Cited by 89

The Disruption ofCelf6, a Gene Identified by Translational Profiling of Serotonergic Neurons, Results in Autism-Related Behaviors

Dougherty, J. D., Maloney, S. E., Wozniak, D. F., Rieger, M. A., Sonnenblick, L. I., Coppola, G., Mahieu, N. G., Zhang, J., Cai, J., Patti, G. J., et al. (2013) · Journal of Neuroscience · doi:10.1523/jneurosci.4762-12.2013 · Cited by 88

l-Trypophan as a selective histochemical marker for serotonergic neurons in single-cell recording studies

Aghajanian, G. K., & Haigler, H. J. (1974) · Brain Research · doi:10.1016/0006-8993(74)90954-8 · Cited by 86

Ricerche sul secreto delle cellule enterocromaffini

VIALLI, M., & Erspamer, V. (1937) · Cell and Tissue Research · doi:10.1007/bf00391792 · Cited by 85

Chemically Specific Circuit Composed of Vesicular Glutamate Transporter 3- and Preprotachykinin B-producing Interneurons in the Rat Neocortex

Hioki, H. (2004) · Cerebral Cortex · doi:10.1093/cercor/bhh088 · Cited by 83

Disruption of GABAergic tone in the dorsomedial hypothalamus attenuates responses in a subset of serotonergic neurons in the dorsal raphe nucleus following lactate-induced panic

Johnson, P. L., Lowry, C. A., Truitt, W. A., & Shekhar, A. (2008) · Journal of Psychopharmacology · doi:10.1177/0269881107082900 · Cited by 82

Regrowth of Serotonin Axons in the Adult Mouse Brain Following Injury

Jin, Y., Dougherty, S., Wood, K. M., Sun, L. T., Cudmore, R. H., Abdalla, A., Kannan, G., Pletnikov, M. V., Hashemi, P., & Linden, D. J. (2016) · Neuron · doi:10.1016/j.neuron.2016.07.024 · Cited by 82

Do dorsal raphe 5-HT neurons encode “beneficialness”?

Luo, M., Li, Y., & Zhong, W. (2016) · Neurobiology of Learning and Memory · doi:10.1016/j.nlm.2016.08.008 · Cited by 81

Chronic social isolation reduces 5-HT neuronal activity via upregulated SK3 calcium-activated potassium channels

Sargin, D., Oliver, D. K., & Lambe, E. K. (2016) · eLife · doi:10.7554/elife.21416 · Cited by 81

Inescapable shock activates serotonergic neurons in all raphe nuclei of rat

Takase, L. F., Nogueira, M. I., Baratta, M. V., Bland, S. T., Watkins, L. R., Maier, S. F., Fornal, C. A., & Jacobs, B. L. (2004) · Behavioural Brain Research · doi:10.1016/j.bbr.2003.12.020 · Cited by 79

Cellular expression of mRNAs encoding monoamine oxidases A and B in the rat central nervous system

Luque, J. M., Kwan, S., Abell, C. W., Prada, M. D., & Richards, J. G. (1995) · The Journal of Comparative Neurology · doi:10.1002/cne.903630410 · Cited by 79

Benzodiazepine and Serotonergic Modulation of Antipredator and Conspecific Defense

Blanchard, D. C. (1998) · Neuroscience & Biobehavioral Reviews · doi:10.1016/s0149-7634(97)00054-7 · Cited by 79

Postnatal loss of brainstem serotonin neurones compromises the ability of neonatal rats to survive episodic severe hypoxia

Cummings, K. J., Hewitt, J. C., Li, A., Daubenspeck, J. A., & Nattie, E. (2011) · The Journal of Physiology · doi:10.1113/jphysiol.2011.214445 · Cited by 78

Somatodendritic autoreceptor regulation of serotonergic neurons: dependence on l ‐tryptophan and tryptophan hydroxylase‐activating kinases

Liu, R., Lambe, E. K., & Aghajanian, G. K. (2005) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2005.03930.x · Cited by 75

Ascending serotonin neuron diversity under two umbrellas

Commons, K. G. (2016) · Brain Structure and Function · doi:10.1007/s00429-015-1176-7 · Cited by 75

Circadian change in tryptophan hydroxylase protein levels within the rat intergeniculate leaflets and raphe nuclei

Malek, Z. S., Pévet, P., & Raison, S. (2004) · Neuroscience · doi:10.1016/j.neuroscience.2004.01.031 · Cited by 71

Development of Serotonergic Fibers in the Post-Natal Mouse Brain

Maddaloni, G., Bertero, A., Pratelli, M., Barsotti, N., Boonstra, A., Giorgi, A. U. D., Migliarini, S., & Pasqualetti, M. (2017) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2017.00202 · Cited by 71

Requirement of the MASH-1 transcription factor for neuroendocrine differentiation of thyroid C cells

Lanigan, T. M., DeRaad, S. K., & Russo, A. F. (1998) · Journal of Neurobiology · doi:10.1002/(sici)1097-4695(19980205)34:2 · Cited by 70

Evidence for significant contribution of a newly identified monoamine transporter (PMAT) to serotonin uptake in the human brain

Zhou, M., Engel, K., & Wang, J. (2006) · Biochemical Pharmacology · doi:10.1016/j.bcp.2006.09.008 · Cited by 70

Engrailed genes control developmental fate of serotonergic and noradrenergic neurons in mid- and hindbrain in a gene dose-dependent manner

Simon, H. H., Scholz, C., & O’Leary, D. D. M. (2004) · Molecular and Cellular Neuroscience · doi:10.1016/j.mcn.2004.08.016 · Cited by 68

Disruption of Transient Serotonin Accumulation by Non-Serotonin-Producing Neurons Impairs Cortical Map Development

Chen, X., Ye, R., Gargus, J. J., Blakely, R., Dobrenis, K., & Sze, J. Y. (2015) · Cell Reports · doi:10.1016/j.celrep.2014.12.033 · Cited by 67

Cellular architecture and transmitter phenotypes of neurons of the mouse median raphe region

Sos, K. E., Mayer, M. I., Cserép, C., Takács, F., Szőnyi, A., Freund, T. F., & Nyíri, G. (2016) · Brain Structure and Function · doi:10.1007/s00429-016-1217-x · Cited by 67

Neurotransmitter Switching Regulated by miRNAs Controls Changes in Social Preference

Dulcis, D., Lippi, G., Stark, C. J., Do, L. H., Berg, D. K., & Spitzer, N. C. (2017) · Neuron · doi:10.1016/j.neuron.2017.08.023 · Cited by 67

A single gene codes for aromatic L-amino acid decarboxylase in both neuronal and non-neuronal tissues.

Albert, V. R., Allen, J. M., & Joh, T. H. (1987) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)48094-5 · Cited by 65

Lack of response of serotonergic neurons in the dorsal raphe nucleus of freely moving cats to stressful stimuli.

Wilkinson, L., & Jacobs, B. (1988) · Experimental Neurology · doi:10.1016/0014-4886(88)90055-6 · Cited by 65

Serotonin Neuron Diversity in the Dorsal Raphe

Andrade, R., & Haj‐Dahmane, S. (2013) · ACS Chemical Neuroscience · doi:10.1021/cn300224n · Cited by 65

Involvement of dorsal raphe nucleus and dorsal periaqueductal gray 5-HT receptors in the modulation of mouse defensive behaviors

Pobbe, R. L. H., Zangrossi, H., Blanchard, D. C., & Blanchard, R. J. (2010) · European Neuropsychopharmacology · doi:10.1016/j.euroneuro.2010.05.004 · Cited by 65

Estrogen receptor‐β regulates human tryptophan hydroxylase‐2 through an estrogen response element in the 5′ untranslated region

Hiroi, R., & Handa, R. J. (2013) · Journal of Neurochemistry · doi:10.1111/jnc.12401 · Cited by 65

Dorsal Raphe Serotonin Neurons in Mice: Immature Hyperexcitability Transitions to Adult State during First Three Postnatal Weeks Suggesting Sensitive Period for Environmental Perturbation

Rood, B. D., Calizo, L. H., Piel, D., Spangler, Z., Campbell, K., & Beck, S. G. (2014) · Journal of Neuroscience · doi:10.1523/jneurosci.1498-13.2014 · Cited by 64

Light and electron microscopic immunocytochemical analysis of the serotonin innervation of the rat visual cortex

Papadopoulos, G. C., Parnavelas, J. G., & Buijs, R. M. (1987) · Journal of Neurocytology · doi:10.1007/bf01611992 · Cited by 64

Mouse Fgf8 ‐Cre‐LacZ lineage analysis defines the territory of the postnatal mammalian isthmus

WATSON, C. R. R., Shimogori, T., & Puelles, L. (2017) · The Journal of Comparative Neurology · doi:10.1002/cne.24242 · Cited by 63

Activity of nucleus raphe pallidus neurons across the sleep-waking cycle in freely moving cats

Trulson, M. E., & Trulson, V. M. (1982) · Brain Research · doi:10.1016/0006-8993(82)90572-8 · Cited by 62

Activation of Raphe Efferents to the Medial Prefrontal Cortex by Corticotropin-Releasing Factor: Correlation with Anxiety-Like Behavior

Meloni, E. G., Reedy, C. L., Cohen, B. M., & Carlezon, W. A. (2007) · Biological Psychiatry · doi:10.1016/j.biopsych.2007.10.016 · Cited by 62

Pet-1 Switches Transcriptional Targets Postnatally to Regulate Maturation of Serotonin Neuron Excitability

Wyler, S. C., Spencer, W. C., Green, N. H., Rood, B. D., Crawford, L. K., Craige, C. P., Gresch, P. J., McMahon, D. G., Beck, S. G., & Deneris, E. S. (2016) · Journal of Neuroscience · doi:10.1523/jneurosci.3798-15.2016 · Cited by 61

Locally collateralizing glutamate neurons in the dorsal raphe nucleus responsive to substance P contain vesicular glutamate transporter 3 (VGLUT3)

Commons, K. G. (2009) · Journal of Chemical Neuroanatomy · doi:10.1016/j.jchemneu.2009.05.005 · Cited by 60

The median raphe nucleus in anxiety revisited

Andrade, T. G., Zangrossi, H., & Graeff, F. G. (2013) · Journal of Psychopharmacology · doi:10.1177/0269881113499208 · Cited by 60

Low doses of corticotropin-releasing hormone injected into the dorsal raphe nucleus block the behavioral consequences of uncontrollable stress

Hammack, S. E., Pepin, J. L., DesMarteau, J. S., Watkins, L. R., & Maier, S. F. (2003) · Behavioural Brain Research · doi:10.1016/s0166-4328(03)00133-5 · Cited by 60

Firing Properties of Genetically Identified Dorsal Raphe Serotonergic Neurons in Brain Slices

Mlinar, B., Montalbano, A., Piszczek, Ł., Gross, C. T., & Corradetti, R. (2016) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2016.00195 · Cited by 58

Serotonergic neuron regulation informed by in vivo single‐cell transcriptomics

Spaethling, J. M., Piel, D., Dueck, H., Buckley, P. T., Morris, J. F., Fisher, S. A., Lee, J., Sul, J., Kim, J., Bartfai, T., et al. (2014) · The FASEB Journal · doi:10.1096/fj.13-240267 · Cited by 57

Distinct Neurochemical and Functional Properties of GAD67-Containing 5-HT Neurons in the Rat Dorsal Raphe Nucleus

Shikanai, H., Yoshida, T., Konno, K., Yamasaki, M., Izumi, T., Ohmura, Y., Watanabe, M., & Yoshioka, M. (2012) · Journal of Neuroscience · doi:10.1523/jneurosci.5929-11.2012 · Cited by 56

Optogenetic Recruitment of Dorsal Raphe Serotonergic Neurons Acutely Decreases Mechanosensory Responsivity in Behaving Mice

Dugué, G. P., Lörincz, M. L., Lottem, E., Audero, E., Matias, S., Correia, P. A., Léna, C., & Mainen, Z. F. (2014) · PLoS ONE · doi:10.1371/journal.pone.0105941 · Cited by 54

Essentials of Recombinase-Based Genetic Fate Mapping in Mice

Jensen, P., & Dymecki, S. M. (2014) · Methods in Molecular Biology · doi:10.1007/978-1-60327-292-6_26 · Cited by 54

The distribution of substance P, enkephalin, and serotonin immunoreactivities in the area postrema of the rat and cat

Newton, B. W., Maley, B. E., & Traurig, H. H. (1985) · The Journal of Comparative Neurology · doi:10.1002/cne.902340107 · Cited by 52

Ultrastructure of the Serotonin Innervation in the Mammalian Central Nervous System

Descarries, L., Riad, M., & Parent, M. (2010) · Handbook of behavioral neuroscience · doi:10.1016/s1569-7339(10)70072-2 · Cited by 52

Medullary serotonin neurons are CO2 sensitive in situ

Iceman, K. E., Richerson, G. B., & Harris, M. B. (2013) · Journal of Neurophysiology · doi:10.1152/jn.00288.2013 · Cited by 52

ELEVATED tph2 mRNA EXPRESSION IN A RAT MODEL OF CHRONIC ANXIETY

Donner, N. C., Johnson, P. L., Fitz, S. D., Kellen, K. E., Shekhar, A., & Lowry, C. A. (2012) · Depression and Anxiety · doi:10.1002/da.21925 · Cited by 51

Activity of Tachykinin1 -Expressing Pet1 Raphe Neurons Modulates the Respiratory Chemoreflex

Hennessy, M. L., Corcoran, A. E., Brust, R. D., Chang, Y., Nattie, E., & Dymecki, S. M. (2017) · Journal of Neuroscience · doi:10.1523/jneurosci.2316-16.2016 · Cited by 51

Molecular neuroanatomy of monoamine oxidases in human brainstem

Richards, J. G., Saura, J., ULRICH, J., et al. (1992) · Psychopharmacology · doi:10.1007/bf02246228 · Cited by 50

Action potential-independent and pharmacologically unique vesicular serotonin release from dendrites

Colgan, L. A., Cavolo, S. L., Commons, K. G., & Levitan, E. S. (2012) · The Journal of Neuroscience · doi:10.1523/jneurosci.0020-12.2012 · Cited by 48

Generation of Pet1210-Cre Transgenic Mouse Line Reveals Non-Serotonergic Expression Domains of Pet1 Both in CNS and Periphery

Pelosi, B., Migliarini, S., Pacini, G., Pratelli, M., & Pasqualetti, M. (2014) · PLoS ONE · doi:10.1371/journal.pone.0104318 · Cited by 48

Two distinct subtypes of serotonergic fibers classified by co-expression with vesicular glutamate transporter 3 in rat forebrain

Shutoh, F., Ina, A., Yoshida, S., Konno, J., & Hisano, S. (2008) · Neuroscience Letters · doi:10.1016/j.neulet.2007.12.050 · Cited by 47

Two major network domains in the dorsal raphe nucleus

Commons, K. G. (2015) · Journal of Comparative Neurology · doi:10.1002/cne.23748 · Cited by 46

Glutamate-like immunoreactivity in medulla oblongata catecholamine/substance P neurons

Nicholas, A. P., Cuello, A. C., Goldstein, M., et al. (1990) · Neuroreport · doi:10.1097/00001756-199011000-00016 · Cited by 45

Inducible gene manipulations in serotonergic neurons

Weber, T. (2009) · Frontiers in Molecular Neuroscience · doi:10.3389/neuro.02.024.2009 · Cited by 45

Preimmunization with a heat-killed preparation of Mycobacterium vaccae enhances fear extinction in the fear-potentiated startle paradigm

Fox, J. H., Hassell, J. E., Siebler, P. H., Arnold, M. R., Lamb, A. K., Smith, D. G., Day, H. E. W., Smith, T. M., Simmerman, E. M., Outzen, A. A., et al. (2017) · Brain, Behavior, and Immunity · doi:10.1016/j.bbi.2017.08.014 · Cited by 44

Serotonin transporter deficient mice are vulnerable to escape deficits following inescapable shocks

Muller, J. M., Morelli, E., Ansorge, M. S., & Gingrich, J. A. (2010) · Genes Brain & Behavior · doi:10.1111/j.1601-183x.2010.00652.x · Cited by 43

Bradycardia in serotonin-deficientPet-1−/−mice: influence of respiratory dysfunction and hyperthermia over the first 2 postnatal weeks

Cummings, K. J., Li, A., Deneris, E. S., et al. (2010) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00110.2010 · Cited by 41

Serotonin depletion causes valproate-responsive manic-like condition and increased hippocampal neuroplasticity that are reversed by stress

Maddaloni, G., Migliarini, S., Napolitano, F., Giorgi, A. U. D., Nazzi, S., Biasci, D., Felice, A. D., Gritti, M., Cavaccini, A., Galbusera, A., et al. (2018) · Scientific Reports · doi:10.1038/s41598-018-30291-2 · Cited by 41

Non-Cell-Autonomous Mechanism of Activity-Dependent Neurotransmitter Switching

Guemez‐Gamboa, A., Xu, L., Meng, D., & Spitzer, N. C. (2014) · Neuron · doi:10.1016/j.neuron.2014.04.029 · Cited by 40

Serotonergic innervation of the mature and developing lateral septum of the rat: A light and electron microscopic immunocytochemical analysis

Dinopoulos, A., Dori, I., & Parnavelas, J. G. (1993) · Neuroscience · doi:10.1016/0306-4522(93)90467-t · Cited by 39

Neurophysiological and Neurochemical Studies of Brain Serotonergic Neurons in Behaving Animalsa

Jacobs, B. L., Fornal, C. A., & Wilkinson, L. O. (1990) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1990.tb16888.x · Cited by 39

Dorsal Raphe Serotonergic Neurons Control Intertemporal Choice under Trade-off

Xu, S., Das, G., Hueske, E., & Tonegawa, S. (2017) · Current Biology · doi:10.1016/j.cub.2017.09.008 · Cited by 39

Acute perturbation of Pet1-neuron activity in neonatal mice impairs cardiorespiratory homeostatic recovery

Dosumu-Johnson, R. T., Cocoran, A. E., Chang, Y., Nattie, E., & Dymecki, S. M. (2018) · eLife · doi:10.7554/elife.37857 · Cited by 36

Activity of serotonin-containing nucleus centralis superior (raphe medianus) neurons in freely moving cats

Trulson, M. E., Crisp, T., & Trulson, V. M. (1984) · Experimental Brain Research · doi:10.1007/bf00235816 · Cited by 34

Axonal Segregation and Role of the Vesicular Glutamate Transporter VGLUT3 in Serotonin Neurons

Voisin, A. N., Mnie‐Filali, O., Giguère, N., Fortin, G. M., Vigneault, É., Mestikawy, S. E., Descarries, L., & Trudeau, L. (2016) · Frontiers in Neuroanatomy · doi:10.3389/fnana.2016.00039 · Cited by 34

Gata2 and Gata3 regulate the differentiation of serotonergic and glutamatergic neuron subtypes of the dorsal raphe

Haugas, M., Tikker, L., Achim, K., Salminen, M., & Partanen, J. M. (2016) · Development · doi:10.1242/dev.136614 · Cited by 34

Coexistence of varying combinations of neuropeptides with 5-hydroxytryptamine in neurons of the raphe pallidus et obscurus projecting to the spinal cord

Chiba, T., & Masuko, S. (1989) · Neuroscience Research · doi:10.1016/0168-0102(89)90033-3 · Cited by 32

Serotonin axons in the neocortex of the adult female mouse regrow after traumatic brain injury

Kajstura, T. J., Dougherty, S., & Linden, D. J. (2017) · Journal of Neuroscience Research · doi:10.1002/jnr.24059 · Cited by 32

Nuclear derivatives and axonal projections originating from rhombomere 4 in the mouse hindbrain

Bonito, M. D., Studer, M., & Puelles, L. (2017) · Brain Structure and Function · doi:10.1007/s00429-017-1416-0 · Cited by 31

Electrophysiological and histochemical properties of postnatal rat serotonergic neurons in dissociated cell culture

Johnson, M. D. (1994) · Neuroscience · doi:10.1016/0306-4522(94)90522-3 · Cited by 30

Regulatory Mechanisms Controlling Maturation of Serotonin Neuron Identity and Function

Spencer, W. C., & Deneris, E. S. (2017) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2017.00215 · Cited by 30

Partial Raphe Dysfunction in Neurotransmission Is Sufficient to Increase Mortality after Anoxic Exposures in Mice at a Critical Period in Postnatal Development

Barrett, K. T., Dosumu-Johnson, R. T., Daubenspeck, J. A., Brust, R. D., Kreouzis, V., Kim, J. C., Li, A., Dymecki, S. M., & Nattie, E. (2016) · Journal of Neuroscience · doi:10.1523/jneurosci.1796-15.2016 · Cited by 29

Regional distribution and cellular localization of the ETS-domain transcription factor, FEV, mRNA in the human postmortem brain

Iyo, A. H., Porter, B., Deneris, E. S., & Austin, M. C. (2005) · Synapse · doi:10.1002/syn.20178 · Cited by 28

Development×environment interactions control tph2 mRNA expression

Lukkes, J. L., Kopelman, J. M., Donner, N. C., Hale, M. W., & Lowry, C. A. (2013) · Neuroscience · doi:10.1016/j.neuroscience.2013.01.070 · Cited by 28

Medullary Serotonin Neuron Abnormalities in an Australian Cohort of Sudden Infant Death Syndrome

Bright, F., Byard, R. W., Vink, R., & Paterson, D. S. (2017) · Journal of Neuropathology & Experimental Neurology · doi:10.1093/jnen/nlx071 · Cited by 28

Inactivation of the dorsal raphé nucleus reduces the anxiogenic response of rats running an alley for intravenous cocaine

Ettenberg, A., Ofer, O. A., Mueller, C. L., Waldroup, S. A., Cohen, A., & Ben‐Shahar, O. (2010) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2010.11.008 · Cited by 27

Ultrastructure of electrophysiologically-characterized synapses formed by serotonergic raphe neurons in culture

Johnson, M. D., & Yee, A. (1995) · Neuroscience · doi:10.1016/0306-4522(95)00010-g · Cited by 27

Nonexocytotic serotonin release tonically suppresses serotonergic neuron activity

Mlinar, B., Montalbano, A., Baccini, G., Tatini, F., Palmini, R. B., & Corradetti, R. (2015) · The Journal of General Physiology · doi:10.1085/jgp.201411330 · Cited by 26

ON and OFF retinal ganglion cells differentially regulate serotonergic and GABAergic activity in the dorsal raphe nucleus

Zhang, T., Huang, L., Zhang, L., Tan, M., Pu, M., Pickard, G. E., So, K., & Ren, C. (2016) · Scientific Reports · doi:10.1038/srep26060 · Cited by 26

Vasoactive intestinal polypeptide in sacral primary sensory pathways in the cat

Morgan, C. W., Ohara, P. T., & Scott, D. E. (1999) · The Journal of Comparative Neurology · doi:10.1002/(sici)1096-9861(19990510)407:3 · Cited by 25

Divergent in vivo activity of non‐serotonergic and serotonergic VGluT3–neurones in the median raphe region

Domonkos, A., Nikitidou Ledri, L., Laszlovszky, T., Cserép, C., Borhegyi, Z., Papp, E., Nyiri, G., Freund, T. F., & Varga, V. (2016) · The Journal of Physiology · doi:10.1113/jp272036 · Cited by 25

Neurochemical differences between target-specific populations of rat dorsal raphe projection neurons

Prouty, E. W., Chandler, D. J., & Waterhouse, B. D. (2017) · Brain Research · doi:10.1016/j.brainres.2017.08.031 · Cited by 25

Neurotransmitter segregation: Functional and plastic implications

Sámano, C., Cifuentes, F., & Morales, M. A. (2012) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2012.04.004 · Cited by 23

Intracellular recording in vivo from serotonergic neurons in the rat dorsal raphe nucleus: methodological considerations.

Aghajanian, G. K., & VanderMaelen, C. P. (1982) · Journal of Histochemistry & Cytochemistry · doi:10.1177/30.8.6749973 · Cited by 22

Pet-1 Controls Tetrahydrobiopterin Pathway andSlc22a3Transporter Genes in Serotonin Neurons

Wyler, S. C., Donovan, L. J., Yeager, M., & Deneris, E. S. (2015) · ACS Chemical Neuroscience · doi:10.1021/cn500331z · Cited by 21

Beyond Gene Inactivation: Evolution of Tools for Analysis of Serotonergic Circuitry

Hainer, C., Mosienko, V., Koutsikou, S., Crook, J. J., Gloss, B. R., Kasparov, S., Lumb, B. M., & Alenina, N. V. (2015) · ACS Chemical Neuroscience · doi:10.1021/acschemneuro.5b00045 · Cited by 20

Specific connectivity and unique molecular identity of MET receptor tyrosine kinase expressing serotonergic neurons in the caudal dorsal raphe nuclei

Kast, R. J., Wu, H.-H., Williams, P., Gaspar, P., & Levitt, P. (2017) · ACS Chemical Neuroscience · doi:10.1021/acschemneuro.7b00020 · Cited by 20

Serotonergic mechanisms in aggression

Olivier, B. (2005) · Novartis Foundation symposium · doi:10.1002/0470010703.ch12 · Cited by 19

Differential effects of hallucinogenic drugs on the activity of serotonin-containing neurons in the nucleus centralis superior and nucleus raphe pallidus in freely moving cats.

Trulson, M. E., Preussler, D. W., & Trulson, V. M. (1984) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(25)21616-0 · Cited by 17

5-HT Receptor Nomenclature: Naming Names, Does It Matter? A Tribute to Maurice Rapport

Hoyer, D. (2017) · ACS Chemical Neuroscience · doi:10.1021/acschemneuro.7b00011 · Cited by 17

Toward a multiscale modeling framework for understanding serotonergic function

Wong‐Lin, K., Wang, D., Moustafa, A. A., Cohen, J. Y., & Nakamura, K. (2017) · Journal of Psychopharmacology · doi:10.1177/0269881117699612 · Cited by 16

Identifying Candidate Genes that Underlie Cellular pH Sensitivity in Serotonin Neurons Using Transcriptomics: A Potential Role for Kir5.1 Channels

Puissant, M. M., Mouradian, G. C., Liu, P., & Hodges, M. R. (2017) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2017.00034 · Cited by 15

Central Serotonin Neurons and Thermoregulation

CORRODI, H., Fuxé, K., & Hökfelt, T. G. M. (1968) · Advances in pharmacology · doi:10.1016/s1054-3589(08)60294-x · Cited by 14

Single‐unit responses of serotonergic medullary raphe neurons to cardiovascular challenges in freely moving cats

Martín‐Cora, F., Fornal, C. A., & Jacobs, B. L. (2005) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2005.04519.x · Cited by 12

Intermittent severe hypoxia induces plasticity within serotonergic and catecholaminergic neurons in the neonatal rat ventrolateral medulla

Givan, S. A., & Cummings, K. J. (2016) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00048.2016 · Cited by 12

Normative distribution of substance P and its tachykinin neurokinin-1 receptor in the medullary serotonergic network of the human infant during postnatal development

Bright, F., Byard, R. W., Vink, R., & Paterson, D. S. (2018) · Brain Research Bulletin · doi:10.1016/j.brainresbull.2018.01.009 · Cited by 12

Activation of serotonergic neurons in the medullary caudal raphe shortens the laryngeal chemoreflex in anaesthetized neonatal rats

Donnelly, W. T., Xia, L., Bartlett, D., et al. (2017) · Experimental Physiology · doi:10.1113/ep086082 · Cited by 11

Evidence for the Coexistence of Serotonin and Substance P in Single Raphe Cells and Fiber Plexuses: Combined Immunocytochemistry and Autoradiography

Chan‐Palay, V. (1981) · Advances in experimental medicine and biology · doi:10.1007/978-1-4684-3860-4_5 · Cited by 9

Impaired Chemosensitivity of Mouse Dorsal Raphe Serotonergic Neurons Overexpressing Serotonin 1A (Htr1a) Receptors

Baccini, G., Mlinar, B., Audero, E., et al. (2012) · PLoS ONE · doi:10.1371/journal.pone.0045072 · Cited by 9

5-HT neurons of the area postrema become c-Fos-activated after increases in plasma sodium levels and transmit interoceptive information to the nucleus accumbens

Miller, R. L., & Loewy, A. D. (2014) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00563.2013 · Cited by 8

Lmx1b controls peptide phenotypes in serotonergic and dopaminergic neurons

Yan, R., Huang, T., Xie, Z., Xia, G.-N., Qian, H., Zhao, X., & Cheng, L. (2013) · Acta Biochimica et Biophysica Sinica · doi:10.1093/abbs/gmt023 · Cited by 8

Plasticity in breathing and arterial blood pressure following acute intermittent hypercapnic hypoxia in infant rat pups with a partial loss of 5-HT neurons

Magnusson, J. L., & Cummings, K. J. (2015) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00241.2015 · Cited by 5

Prefrontal cortical projections to longitudinal columns in the midbrain periaqueductal gray in Macaque monkeys

An, X., Bandler, R., �ng�r, D., & Price, J. L. (1998) · The Journal of Comparative Neurology · doi:10.1002/(sici)1096-9861(19981130)401:4

Single-cell transcriptomes and whole-brain projections of serotonin neurons in the mouse dorsal and median raphe nuclei

Ren, J., Isakova, A., Friedmann, D., Zeng, J., Grutzner, S. M., Pun, A., Zhao, G. Q., Kolluru, S. S., Wang, R., Lin, R., et al. (2019) · eLife · doi:10.7554/elife.49424 · Cited by 304

Serotonin regulation of behavior via large-scale neuromodulation of serotonin receptor networks

Salvan, P., Fonseca, M., Winkler, A. M., Beauchamp, A., Lerch, J. P., & Johansen-Berg, H. (2023) · Nature Neuroscience · doi:10.1038/s41593-022-01213-3 · Cited by 101

Neural circuits regulating prosocial behaviors

Walsh, J. J., Christoffel, D. J., & Malenka, R. C. (2023) · Neuropsychopharmacology · doi:10.1038/s41386-022-01348-8 · Cited by 72

The Formation and Function of the VTA Dopamine System

Hou, G., Hao, M., Duan, J., & Han, M.-H. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25073875 · Cited by 65

Selective filtering of excitatory inputs to nucleus accumbens by dopamine and serotonin

Christoffel, D. J., Walsh, J. J., Hoerbelt, P., Heifets, B. D., Llorach, P., Lopez, R. C., Ramakrishnan, C., Deisseroth, K., & Malenka, R. C. (2021) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2106648118 · Cited by 54

Presynaptic Mechanisms Underlying Neurotransmitter Synthesis, Storage, Release, and Inactivation

Steward, O. (2000) · Springer eBooks · doi:10.1007/978-1-4612-1198-3_6

[Endoplasmic reticulum and regulation of neuromediator release in presynaptic terminals].

Verkhrats'kyĭ, O. N., & Fedulova, S. A. (2004) · PubMed

Presynaptic origins of distinct modes of neurotransmitter release

Chanaday, N. L., & Kavalali, E. T. (2018) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2018.03.005 · Cited by 80

Astrocyte sodium signaling and the regulation of neurotransmission

Kirischuk, S., Héja, L., Kardos, J., & Billups, B. (2015) · Glia · doi:10.1002/glia.22943 · Cited by 82

Synaptic transmission: how is the release of neurotransmitter controlled?

Simmons, P. J. (1989) · Journal of Biological Education · doi:10.1080/00219266.1989.9655040