Two major network domains in the dorsal raphe nucleus
Open accessAbstract
Serotonin neurons in the dorsal and median raphe nuclei (DR and MR) are clustered into heterogeneous groups that give rise to topographically organized forebrain projections. However, a compelling definition of the key subgroups of serotonin neurons within these areas has remained elusive. In order to be functionally distinct, neurons must participate in distinct networks. Therefore, we analyzed subregions of the DR and MR by their afferent input. Clustering methods and principal component analysis were applied in mouse to anterograde tract-tracing experiments available from the Allen Mouse Brain Connectivity Atlas. The results revealed a major break in the networks of the DR such that the caudal third of the DR was more similar in afferent innervation to the MR than it was to the rostral two-thirds of the DR. The rostral part of the DR is associated with networks controlling motor and motivated behavior, while the caudal DR is more closely aligned with regions that regulate rhythmic hippocampal activity. Thus, a major source of heterogeneity within the DR is inclusion of the caudal component, which may be more accurately viewed as a dorsal extension of the MR.
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The cDR has been suggested to be more similar to the MR than to the pDR in afferent innervation (Commons, 2015).
“The cDR has been suggested to be more similar to the MR than to the pDR in afferent innervation (Commons, 2015).”
From Single-cell transcriptomes and whole-brain projections of serotonin neurons in the mouse dorsal and median raphe nuclei (2019) · cites this paper as Commons, 2015
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- Authors
- Commons, K. G.
- Affiliations
- Boston Children's Hospital (US)
- Corresponding author
- Commons, Kathryn G.
- ORCID
- Commons, Kathryn G.
- Venue
- Journal of Comparative Neurology
- Publisher
- Wiley
- Published
- 2015-03-16
- Volume
- 523
- Issue
- 10
- Pages
- 1488-1504
- ISSN
- 0021-9967 (ISSN-L)
- 1096-9861
- PMC
- PMC4439335
- OpenAlex
- W1481621994
- Cited by
- 46
- References
- 37
- Citations by year
- 2026: 1 · 2025: 2 · 2024: 1 · 2023: 3 · 2022: 1 · 2021: 2 · 2020: 8 · 2019: 7 · 2018: 7 · 2017: 5 · 2016: 4 · 2015: 5
- FWCI
- 3.25
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- The Journal of Comparative Neurology (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institutes of Health (021801)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Keywords
- dorsal raphe nucleus, median raphe nucleus, serotonergic neurons, afferent input, forebrain projections, neural tracing
- MeSH terms
- Afferent Pathways, Animals, Biotin, Dextrans, Efferent Pathways, Humans, Mice, Inbred C57BL, Mice, Transgenic, Neurons, Raphe Nuclei, RNA, Messenger, Serotonin, Tryptophan Hydroxylase, Cluster Analysis, Synapsins, Green Fluorescent Proteins, Mice
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