Cited by 462Functional Brain Connectivity StudiesAdvanced Neuroimaging Techniques and ApplicationsMental Health Research Topics

The DOI matches its Crossref record; 210 of the 210 references it cites were found in a registry or an index.

A cross-disorder connectome landscape of brain dysconnectivity

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van den Heuvel, Martijn P., Sporns, Olaf·2019·Nature Reviews Neuroscience

Abstract

Many human brain disorders are associated with characteristic alterations in the structural and functional connectivity of the brain. In this article, we explore how commonalities and differences in connectome alterations can reveal relationships across disorders. We survey recent literature on connectivity changes in neurological and psychiatric disorders in the context of key organizational principles of the human connectome and observe that several disturbances to network properties of the human brain have a common role in a wide range of brain disorders and point towards potentially shared network mechanisms underpinning disorders. We hypothesize that the distinct dimensions along which connectome networks are organized (for example, 'modularity' and 'integration') provide a general coordinate system that allows description and categorization of relationships between seemingly disparate disorders. We outline a cross-disorder 'connectome landscape of dysconnectivity' along these principal dimensions of network organization that may place shared connectome alterations between brain disorders in a common framework.

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  1. Wolf, D. A. & Mash, E. J. (eds) Behavioral and Emotional Disorders in Adolescents: Nature, Assessment, and Treatment (Guilford Press, 2008).

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Metadata

Authors
van den Heuvel, M. P., & Sporns, O.
Affiliations
Indiana University Bloomington (US)
Venue
Nature Reviews Neuroscience
Published
2019-05-24
Volume
20
Issue
7
Pages
435-446
ISSN
  • 1471-003X (ISSN-L)
  • 1471-0048
OpenAlex
W2945032471
Cited by
462
References
207
Citations by year
2026: 58 · 2025: 73 · 2024: 60 · 2023: 55 · 2022: 75 · 2021: 76 · 2020: 56 · 2019: 9
FWCI
6.84
Type
journal article
Language
en
Open access
Locations
  • Nature reviews. Neuroscience (publishedVersion)
  • PubMed (publishedVersion)
  • Pure Amsterdam UMC (publishedVersion, other-oa)
  • Amsterdam UMC (VU Amsterdam) - Institutional Repository (publishedVersion)
  • VU Research Portal (publishedVersion, other-oa)
  • PubMed Central (acceptedVersion)
  • Data Archiving and Networked Services (DANS) (submittedVersion, other-oa)
  • Data Archiving and Networked Services (DANS) (submittedVersion)
Funders
  • Nederlandse Organisatie voor Wetenschappelijk Onderzoek (452-16-015, VIDI-452-16-015, ALWOP.179)
  • National Institutes of Health
  • National Center for Complementary and Integrative Health (R01AT009036)
Topics
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Functional Brain Connectivity Studies
  • Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Advanced Neuroimaging Techniques and Applications
  • Social Sciences › Psychology › Experimental and Cognitive Psychology › Mental Health Research Topics
Keywords
brain dysconnectivity, connectome, cross-disorder analysis, structural connectivity, functional connectivity, network modularity, network integration, neurological disorders, mental illness
MeSH terms
Animals, Brain, Brain Diseases, Humans, Nerve Net, Connectome

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