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Cited by 78Dementia and Cognitive Impairment ResearchFunctional Brain Connectivity StudiesAlzheimer's disease research and treatments

A computational model of neurodegeneration in Alzheimer’s disease

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Jones, D., Lowe, V., Graff-Radford, J., Botha, H., Barnard, L., Wiepert, D., Murphy, M. C., Murray, M. +7 more·2022·Nature Communications
DOI 10.1038/s41467-022-29047-4PMC PMC8960876
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Abstract

Disruption of mental functions in Alzheimer’s disease (AD) and related disorders is accompanied by selective degeneration of brain regions. These regions comprise large-scale ensembles of cells organized into systems for mental functioning, however the relationship between clinical symptoms of dementia, patterns of neurodegeneration, and functional systems is not clear. Here we present a model of the association between dementia symptoms and degenerative brain anatomy using F18-fluorodeoxyglucose PET and dimensionality reduction techniques in two cohorts of patients with AD. This reflected a simple information processing-based functional description of macroscale brain anatomy which we link to AD physiology, functional networks, and mental abilities. We further apply the model to normal aging and seven degenerative diseases of mental functions. We propose a global information processing model for mental functions that links neuroanatomy, cognitive neuroscience and clinical neurology.

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  • The participants in this study were relatively young (average age 65 years) compared to ADNI and BioFinder cohorts.

    “According to our inclusion criteria, the participants in this study were relatively young (average age: 65 years) comparing to ADNI and BioFinder cohorts11,40,41.”

    From Integrated algorithm combining plasma biomarkers and cognitive assessments accurately predicts brain β-amyloid pathology (2023) · cites this paper as [41]

    Table 1 in Results > Patients reports a median age of 74.5 years for the ADNI cohort, supporting the comparison with participants aged about 65. The paper does not report a BioFinder cohort age, and its age-65 figure refers to a separate group of cognitively unimpaired Mayo participants, not the citing study’s participants. The citing study’s average age is therefore not established by this source. (LLM, conf=0.85)

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Cited by

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Authors
Jones, D., Lowe, V., Graff-Radford, J., Botha, H., Barnard, L., Wiepert, D., Murphy, M. C., Murray, M., Senjem, M., Gunter, J., Wiste, H., Boeve, B., Knopman, D., Petersen, R., & Jack, C.
Affiliations
Mayo Clinic (US)
Corresponding author
Jones, D.
ORCID
Venue
Nature Communications
Publisher
Springer Science and Business Media LLC
Published
2022-03-28
Volume
13
Issue
1
Pages
1643-1643
ISSN
2041-1723 (ISSN-L)
DOI
10.1038/s41467-022-29047-4
PMC
PMC8960876
OpenAlex
W4220841730
Cited by
78
References
11
Citations by year
2026: 7 · 2025: 17 · 2024: 25 · 2023: 22 · 2022: 7
FWCI
11.57
Type
journal article
Language
en
Open access
Licence
Locations
  • Nature Communications (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • RePEc: Research Papers in Economics (submittedVersion)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Funders
  • U.S. Department of Health & Human Services | National Institutes of Health (P30 AG62677, P50 AG016574)
  • U.S. Department of Health & Human Services | NIH | National Institute on Aging (U01 AG06786, R01 AG011378, R01 AG041851)
Topics
  • Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Functional Brain Connectivity Studies
  • Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
Keywords
Alzheimer's disease, neurodegeneration, dementia symptoms, dimensionality reduction, functional brain networks, information processing model, cognitive function, normal aging, neurodegenerative diseases, computational model of cognition
MeSH terms
Alzheimer Disease, Brain, Cognition, Humans, Fluorodeoxyglucose F18, Positron-Emission Tomography

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