The DOI matches its Crossref record; 133 of the 134 references it cites were found in a registry or an index.
The m6A epitranscriptome: transcriptome plasticity in brain development and function
Abstract
The field of epitranscriptomics examines the recently deciphered form of gene expression regulation that is mediated by type- and site-specific RNA modifications. Similarly to the role played by epigenetic mechanisms - which operate via DNA and histone modifications - epitranscriptomic modifications are involved in the control of the delicate gene expression patterns that are needed for the development and activity of the nervous system and are essential for basic and higher brain functions. Here we describe the mechanisms that are involved in the writing, erasing and reading of N 6-methyladenosine, the most prevalent internal mRNA modification, and the emerging roles played by N 6-methyladenosine in the nervous system.
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“To date, among all RNA modifications, N6-methyladenosine (m6A) accounts for two-thirds of all RNA modifications that can be “written”, “read”, and “erased” via the actions of a complex network of proteins348,349”
From Epigenetic regulation in major depression and other stress-related disorders: molecular mechanisms, clinical relevance and therapeutic potential (2023) · cites this paper as [349]
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1 retracted
RETRACTED: The RasGAP-associated endoribonuclease G3BP assembles stress granules
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RetractedTopology of the human and mouse m6A RNA methylomes revealed by m6A-seq
Dominissini, D., Moshitch-Moshkovitz, S., Schwartz, S., Salmon-Divon, M., Ungar, L., Osenberg, S., Cesarkas, K., Jacob-Hirsch, J., Amariglio, N., Kupiec, M., et al. (2012) · Nature · doi:10.1038/nature11112 · Cited by 4,884
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N6-methyladenosine-dependent regulation of messenger RNA stability
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Comprehensive Analysis of mRNA Methylation Reveals Enrichment in 3′ UTRs and near Stop Codons
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N6-Methyladenosine in nuclear RNA is a major substrate of the obesity-associated FTO
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ALKBH5 Is a Mammalian RNA Demethylase that Impacts RNA Metabolism and Mouse Fertility
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N6-methyladenosine Modulates Messenger RNA Translation Efficiency
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Sorted by citations
The role of m6A modification in the biological functions and diseases
Jiang, X., Liu, B., Nie, Z., Duan, L., Xiong, Q., Jin, Z., Yang, C., & Chen, Y. (2021) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-020-00450-x · Cited by 2,335
Roles of METTL3 in cancer: mechanisms and therapeutic targeting
Zeng, C., Huang, W., Li, Y., & Weng, H. (2020) · Journal of Hematology & Oncology · doi:10.1186/s13045-020-00951-w · Cited by 645
Absolute quantification of single-base m6A methylation in the mammalian transcriptome using GLORI
Liu, C., Sun, H., Yi, Y., Shen, W., Li, K., Xiao, Y., Li, F., Li, Y., Hou, Y., Lu, B., et al. (2023) · Nature Biotechnology · doi:10.1038/s41587-022-01487-9 · Cited by 386
Shafik, A. M., Zhang, F., Guo, Z., Dai, Q., Pajdzik, K., Li, Y., Kang, Y., Yao, B., Wu, H., He, C., et al. (2021) · Genome biology · doi:10.1186/s13059-020-02249-z · Cited by 264
Yuan, M., Yang, B., Rothschild, G., Mann, J. J., Sanford, L. D., Tang, X., Huang, C., Wang, C., & Zhang, W. (2023) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-023-01519-z · Cited by 246
Metadata
- Authors
- Livneh, I., Moshitch-Moshkovitz, S., Amariglio, N., Rechavi, G., & Dominissini, D.
- Affiliations
- Technion – Israel Institute of Technology (IL)
- Tel Aviv University (IL)
- Bar-Ilan University (IL)
- Corresponding author
- Dominissini, Dan
- Venue
- Nature Reviews Neuroscience
- Published
- 2019-12-05
- Volume
- 21
- Issue
- 1
- Pages
- 36-51
- ISSN
- 1471-003X (ISSN-L)
- 1471-0048
- OpenAlex
- W2992866845
- Cited by
- 330
- References
- 134
- Citations by year
- 2026: 38 · 2025: 50 · 2024: 49 · 2023: 57 · 2022: 45 · 2021: 70 · 2020: 20
- FWCI
- 3.18
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Nature reviews. Neuroscience (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › RNA modifications and cancer
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › RNA regulation and disease
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Epigenetics and DNA Methylation
- Keywords
- N6-methyladenosine, m6A epitranscriptome, RNA methylation, RNA modification, epitranscriptomic regulation, brain development, nervous system function, gene expression regulation, RNA demethylation, RNA demethylase, RNA methyltransferase, RNA-binding proteins
- MeSH terms
- Axon Guidance, Adenosine, Animals, Brain, Gene Expression Regulation, Humans, Neuroglia, RNA, Messenger, Epigenesis, Genetic, Neurogenesis, Transcriptome
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