The m6A epitranscriptome: transcriptome plasticity in brain development and function

Topology of the human and mouse m6A RNA methylomes revealed by m6A-seq

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N6-methyladenosine-dependent regulation of messenger RNA stability

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Comprehensive Analysis of mRNA Methylation Reveals Enrichment in 3′ UTRs and near Stop Codons

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N6-Methyladenosine in nuclear RNA is a major substrate of the obesity-associated FTO

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ALKBH5 Is a Mammalian RNA Demethylase that Impacts RNA Metabolism and Mouse Fertility

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Dynamic RNA Modifications in Gene Expression Regulation

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N6-methyladenosine Modulates Messenger RNA Translation Efficiency

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A METTL3–METTL14 complex mediates mammalian nuclear RNA N6-adenosine methylation

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The role of m6A modification in the biological functions and diseases

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Roles of METTL3 in cancer: mechanisms and therapeutic targeting

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Absolute quantification of single-base m6A methylation in the mammalian transcriptome using GLORI

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N6-methyladenosine dynamics in neurodevelopment and aging, and its potential role in Alzheimer’s disease

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Epigenetic regulation in major depression and other stress-related disorders: molecular mechanisms, clinical relevance and therapeutic potential

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Altered Expression of the m6A Methyltransferase METTL3 in Alzheimer’s Disease

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Hakai is required for stabilization of core components of the m6A mRNA methylation machinery

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N6-methyladenosine and Neurological Diseases

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Genetic drivers of m6A methylation in human brain, lung, heart and muscle

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Methylation across the central dogma in health and diseases: new therapeutic strategies

Liu, R., Zhao, E., Yu, H., Yuan, C., Abbas, M. N., & Cui, H. (2023) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-023-01528-y · Cited by 155

Function and evolution of RNA N6-methyladenosine modification

Zhu, Z., Huo, F., & Pei, D. (2020) · International Journal of Biological Sciences · doi:10.7150/ijbs.45231 · Cited by 136

Prediction of m6A and m5C at single-molecule resolution reveals a transcriptome-wide co-occurrence of RNA modifications

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Fat mass and obesity-associated protein regulates RNA methylation associated with depression-like behavior in mice

Liu, S., Xiu, J., Zhu, C., Meng, K., Li, C., Han, R., Du, T., Li, L., Xu, L., Liu, R., et al. (2021) · Nature Communications · doi:10.1038/s41467-021-27044-7 · Cited by 118

The role of N6-methyladenosine mRNA in the tumor microenvironment

Li, M., Zha, X., & Wang, S. (2021) · Biochimica et Biophysica Acta (BBA) - Reviews on Cancer · doi:10.1016/j.bbcan.2021.188522 · Cited by 114

The m6A epitranscriptome on neural development and degeneration

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The rise of epitranscriptomics: recent developments and future directions

Cerneckis, J., Ming, G., Song, H., He, C., & Shi, Y. (2023) · Trends in Pharmacological Sciences · doi:10.1016/j.tips.2023.11.002 · Cited by 100

Ythdf is a N6‐methyladenosine reader that modulates Fmr1 target mRNA selection and restricts axonal growth in Drosophila

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A neural m6A/Ythdf pathway is required for learning and memory in Drosophila

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m6A modification regulates lung fibroblast-to-myofibroblast transition through modulating KCNH6 mRNA translation

Zhang, J., Huang, P.-J., Wang, D.-P., Yang, W.-Y., Lu, J. L., Zhu, Y., Meng, X., Wu, X., Lin, Q., Lv, H., et al. (2021) · Molecular Therapy · doi:10.1016/j.ymthe.2021.06.008 · Cited by 87

Globally reduced N6-methyladenosine (m6A) in C9ORF72-ALS/FTD dysregulates RNA metabolism and contributes to neurodegeneration

Li, Y., Dou, X., Liu, J., Xiao, Y., Zhang, Z., Hayes, L. R., Wu, R., Fu, X., Ye, Y., Yang, B., et al. (2023) · Nature Neuroscience · doi:10.1038/s41593-023-01374-9 · Cited by 85

PDGF signaling inhibits mitophagy in glioblastoma stem cells through N-methyladenosine

Lv, D., Gimple, R. C., Zhong, C., Wu, Q., Yang, K., Prager, B. C., Godugu, B., Qiu, Z., Zhao, L., Zhang, G., et al. (2022) · Developmental Cell · doi:10.1016/j.devcel.2022.05.007 · Cited by 83

FTO-targeted siRNA delivery by MSC-derived exosomes synergistically alleviates dopaminergic neuronal death in Parkinson's disease via m6A-dependent regulation of ATM mRNA

Geng, Y., Long, X., Zhang, Y., Wang, Y., You, G., Guo, W., Zhang, Y., Zhang, Y., Cheng, X., Yuan, Z., et al. (2023) · Journal of Translational Medicine · doi:10.1186/s12967-023-04461-4 · Cited by 83

Astrocytic ALKBH5 in stress response contributes to depressive-like behaviors in mice

Guo, F., Fan, J., Liu, J., Kong, P., Ren, J., Mo, J., Lu, C., Zhong, Q., Chen, L.-Y., Jiang, H.-T., et al. (2024) · Nature Communications · doi:10.1038/s41467-024-48730-2 · Cited by 79

RNA Modifications and RNA Metabolism in Neurological Disease Pathogenesis

Chatterjee, B., Shen, C.-K. J., & Majumder, P. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms222111870 · Cited by 68

Regulatory Mechanisms of the RNA Modification m6A and Significance in Brain Function in Health and Disease

Mathoux, J., Henshall, D. C., & Brennan, G. P. (2021) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2021.671932 · Cited by 69

SPI1-induced downregulation of FTO promotes GBM progression by regulating pri-miR-10a processing in an m6A-dependent manner

Zhang, S., Zhao, S., Qi, Y., Li, B., Wang, H., Pan, Z., Xue, H., Jin, C., Qiu, W., Chen, Z., et al. (2022) · Molecular Therapy — Nucleic Acids · doi:10.1016/j.omtn.2021.12.035 · Cited by 64

WTAP participates in neuronal damage by protein translation of NLRP3 in an m6A-YTHDF1-dependent manner after traumatic brain injury

Chen, Y., Long, T., Chen, J., Wei, H., Meng, J., Kang, M., Wang, J., Zhang, X., Xu, Q., Zhang, C., et al. (2024) · International Journal of Surgery · doi:10.1097/js9.0000000000001794 · Cited by 64

Emerging Roles of N6-Methyladenosine Modification in Neurodevelopment and Neurodegeneration

Shu, L., Huang, X., Cheng, X., & Li, X. (2021) · Cells · doi:10.3390/cells10102694 · Cited by 59

METTL3 protects METTL14 from STUB1‐mediated degradation to maintain m6A homeostasis

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RNA dysregulation in neurodegenerative diseases

Li, Y., & Sun, S. (2025) · The EMBO Journal · doi:10.1038/s44318-024-00352-6 · Cited by 65

The potential role of m6A RNA methylation in diabetic retinopathy.

Kumari, N., Karmakar, A., Khan, M. M. A., & Ganesan, S. K. (2021) · Experimental Eye Research · doi:10.1016/j.exer.2021.108616 · Cited by 50

Quantification of m6A RNA methylation modulators pattern was a potential biomarker for prognosis and associated with tumor immune microenvironment of pancreatic adenocarcinoma

Wang, L., Zhang, S., Li, H., Xu, Y. Y., Wu, Q., Shen, J., Li, T., & Xu, Y. (2021) · BMC Cancer · doi:10.1186/s12885-021-08550-9 · Cited by 57

Me, Myself and My Insula: An Oasis in the Forefront of Self-Consciousness

Tisserand, A., Philippi, N., Botzung, A., & Blanc, F. (2023) · Biology · doi:10.3390/biology12040599 · Cited by 67

Regulation of RNA N6-methyladenosine modification and its emerging roles in skeletal muscle development

Li, J., Pei, Y., Zhou, R., Tang, Z., & Yang, Y. (2021) · International Journal of Biological Sciences · doi:10.7150/ijbs.56251 · Cited by 55

Protective role of mRNA demethylase FTO on axon guidance molecules of nigro-striatal projection system in manganese-induced parkinsonism

Qi, Z., Wang, S., Li, J., Wen, Y., Cui, R., Zhang, K., Liu, Y., Yang, X., Zhang, L., Xu, B., et al. (2021) · Journal of Hazardous Materials · doi:10.1016/j.jhazmat.2021.128099 · Cited by 52

Small-Molecule Inhibitors of the RNA M6A Demethylases FTO Potently Support the Survival of Dopamine Neurons

Selberg, S., Yu, L.-Y., Bondarenko, O. M., Kankuri, E. M., Seli, N., Kovaleva, V. D., Herodes, K., Saarma, M., & Karelson, M. M. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22094537 · Cited by 53

N 6 ‐methyladenosine (m 6 A) RNA modification in human cancer

Huo, F., Zhu, Z., & Pei, D. (2020) · Cell Proliferation · doi:10.1111/cpr.12921 · Cited by 50

SEDT2/METTL14-mediated m6A methylation awakening contributes to hypoxia-induced pulmonary arterial hypertension in mice

Zhou, X., Huang, F.-J., Li, Y., Huang, H., & Wu, Q. (2021) · Aging · doi:10.18632/aging.202616 · Cited by 51

YTHDF2 mediates LPS-induced osteoclastogenesis and inflammatory response via the NF-κB and MAPK signaling pathways

Fang, C., He, M., Li, D., & Xu, Q. (2021) · Cellular Signalling · doi:10.1016/j.cellsig.2021.110060 · Cited by 50

From A to m6A: The Emerging Viral Epitranscriptome

Baquero-Pérez, B., Geers, D., & Díez, J. (2021) · Viruses · doi:10.3390/v13061049 · Cited by 50

Identification of the function and mechanism of m6A reader IGF2BP2 in Alzheimer’s disease

Deng, Y., Zhu, H., Xiao, L., Liu, C., Liu, Y., & Gao, W. (2021) · Aging · doi:10.18632/aging.203652 · Cited by 48

The N6-methyladenosine-mediated lncRNA WEE2-AS1 promotes glioblastoma progression by stabilizing RPN2

Li, B., Zhao, R., Qiu, W., Pan, Z., Zhao, S., Qi, Y., Qiu, J., Zhang, S., Guo, Q., Yang, F., et al. (2022) · Theranostics · doi:10.7150/thno.74600 · Cited by 47

HNRNPA2B1, as a m6A Reader, Promotes Tumorigenesis and Metastasis of Oral Squamous Cell Carcinoma

Zhu, F., Yang, T., Yao, M., Shen, T., & Fang, C. (2021) · Frontiers in Oncology · doi:10.3389/fonc.2021.716921 · Cited by 47

Altered m6A RNA methylation contributes to hippocampal memory deficits in Huntington’s disease mice

Pupak, A., Singh, A., Sancho‐Balsells, A., Alcalá‐Vida, R., Espina, M., Giralt, A., Martí, E., Ørom, U. A., Ginés, S., & Brito, V. (2022) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-022-04444-6 · Cited by 46

Mild and ultrafast GLORI enables absolute quantification of m6A methylome from low-input samples

Sun, H., Lu, B., Zhang, Z., Xiao, Y., Zhou, Z. C., Lin, X., Li, Z., Jiang, Z., Zhang, J., Wang, M., et al. (2025) · Nature Methods · doi:10.1038/s41592-025-02680-9 · Cited by 46

The epitranscriptome in stem cell biology and neural development

Vissers, C. B., Sinha, A., Ming, G., & Song, H. (2020) · Neurobiology of Disease · doi:10.1016/j.nbd.2020.105139 · Cited by 44

Epitranscriptomic regulation of cortical neurogenesis via Mettl8-dependent mitochondrial tRNA m3C modification

Zhang, F., Yoon, K., Zhang, D. Y., Kim, N., Ming, G., & Song, H. (2023) · Cell stem cell · doi:10.1016/j.stem.2023.01.007 · Cited by 43

Low RNA stability signifies increased post-transcriptional regulation of cell identity genes

Li, Y., Yang, Y., Lv, J., Gao, X., Yu, Y., Babu, S. S., Bruno, I., Zhao, D., Xia, B., Peng, W., et al. (2023) · Nucleic Acids Research · doi:10.1093/nar/gkad300 · Cited by 43

Melatonin: Regulation of Biomolecular Condensates in Neurodegenerative Disorders

Loh, D., & Reiter, R. J. (2021) · Antioxidants · doi:10.3390/antiox10091483 · Cited by 45

Exploring the methyl-verse: Dynamic interplay of epigenome and m6A epitranscriptome

Pilala, K., Panoutsopoulou, K., Papadimitriou, M., Soureas, K., Scorilas, A., & Avgeris, M. (2024) · Molecular Therapy · doi:10.1016/j.ymthe.2024.12.003 · Cited by 43

m6A RNA methylation regulates mitochondrial function

Kahl, M., Xu, Z., Arumugam, S., Edens, B. M., Fischietti, M., Zhu, A. C., Platanias, L. C., He, C., Zhuang, X., & Ma, Y. C. (2024) · Human Molecular Genetics · doi:10.1093/hmg/ddae029 · Cited by 41

N6-methyladenosine (m6A) modification and its clinical relevance in cognitive dysfunctions

Du, B., Zhang, Y., Liang, M., Du, Z., Li, H., Fan, C., Zhang, H., Jiang, Y., & Bi, X. (2021) · Aging · doi:10.18632/aging.203457 · Cited by 38

The m6A reader YTHDF2 is a negative regulator for dendrite development and maintenance of retinal ganglion cells

Niu, F., Han, P., Zhang, J., She, Y., Yang, L., Yu, J., Zhuang, M., Tang, K., Shi, Y., Yang, B., et al. (2022) · eLife · doi:10.7554/elife.75827 · Cited by 39

Progression of m6A in the tumor microenvironment: hypoxia, immune and metabolic reprogramming

Han, X., Zhu, Y., Ke, J., Zhai, Y., Huang, M., Zhang, X., He, H., Zhang, X., Zhao, X., Guo, K., et al. (2024) · Cell Death Discovery · doi:10.1038/s41420-024-02092-2 · Cited by 40

Histone Variants and Histone Modifications in Neurogenesis

Zhang, M., Zhao, J., Lv, Y., Wang, W., Feng, C., Zou, W., Su, L., & Jiao, J. (2020) · Trends in Cell Biology · doi:10.1016/j.tcb.2020.09.003 · Cited by 37

Conditional deficiency of m6A methyltransferase Mettl14 in substantia nigra alters dopaminergic neuron function

Teng, Y., Liu, Z., Chen, X., Liu, Y., Geng, F., Le, W., Jiang, H., & Yang, L. (2021) · Journal of Cellular and Molecular Medicine · doi:10.1111/jcmm.16740 · Cited by 36

Specific Regulation of m6A by SRSF7 Promotes the Progression of Glioblastoma

Cun, Y., An, S., Zheng, H., Lan, J., Chen, W., Luo, W., Yao, C., Li, X., Huang, X., Sun, X., et al. (2021) · Genomics Proteomics & Bioinformatics · doi:10.1016/j.gpb.2021.11.001 · Cited by 36

Chinese Ecliptae herba (Eclipta prostrata (L.) L.) extract and its component wedelolactone enhances osteoblastogenesis of bone marrow mesenchymal stem cells via targeting METTL3-mediated m6A RNA methylation

Tian, S., Li, Y., Wang, J., Dong, R.-C., Wei, J., Ma, Y., & Liu, Y. (2023) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2023.116433 · Cited by 37

Nuclear retention coupled with sequential polyadenylation dictates post-transcriptional m6A modification in the nucleus

Tang, P., Yang, J., Chen, Z., Du, C., Yang, Y., Zhao, H., Huang, L., Li, G., Liu, F., Dong, B., et al. (2024) · Molecular Cell · doi:10.1016/j.molcel.2024.07.017 · Cited by 39

Aging through an epitranscriptomic lens

McMahon, M. E., Forester, C. M., & Buffenstein, R. (2021) · Nature Aging · doi:10.1038/s43587-021-00058-y · Cited by 34

Potential Roles of m6A and FTO in Synaptic Connectivity and Major Depressive Disorder

Mitsuhashi, H., & Nagy, C. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24076220 · Cited by 42

New Insights on the Role of N6-Methyladenosine RNA Methylation in the Physiology and Pathology of the Nervous System

Dermentzaki, G., & Lotti, F. (2020) · Frontiers in Molecular Biosciences · doi:10.3389/fmolb.2020.555372 · Cited by 36

Chemical biology and medicinal chemistry of RNA methyltransferases

Fischer, T. R., Meidner, J. L., Schwickert, M., Weber, M., Zimmermann, R. A., Kersten, C., Schirmeister, T., & Helm, M. (2022) · Nucleic Acids Research · doi:10.1093/nar/gkac224 · Cited by 37

N 2-methylguanosine modifications on human tRNAs and snRNA U6 are important for cell proliferation, protein translation and pre-mRNA splicing

Wang, C., Ulryck, N., Herzel, L., Pythoud, N., Kleiber, N., Guérineau, V., Jactel, V., Moritz, C., Bohnsack, M. T., Carapito, C., et al. (2023) · Nucleic Acids Research · doi:10.1093/nar/gkad487 · Cited by 34

Distinct roles of Fto and Mettl3 in controlling development of the cerebral cortex through transcriptional and translational regulations

Du, K., Zhang, Z., Zeng, Z., Tang, J., Lee, T., & Sun, T. (2021) · Cell Death and Disease · doi:10.1038/s41419-021-03992-2 · Cited by 34

Streptozotocin-induced astrocyte mitochondrial dysfunction is ameliorated by FTO inhibitor MO-I-500

Cockova, Z., Honc, O., Telensky, P., Olsen, M. J., & Novotny, J. (2021) · ACS Chemical Neuroscience · doi:10.1021/acschemneuro.1c00063 · Cited by 34

m6A Modification in Non-Coding RNA: The Role in Cancer Drug Resistance

Chen, C., Guo, Y., Guo, Y., Wu, X., Si, C., Xu, Y., Kang, Q., & Sun, Z. (2021) · Frontiers in Oncology · doi:10.3389/fonc.2021.746789 · Cited by 35

The m6A-epitranscriptome in brain plasticity, learning and memory

Widagdo, J., Wong, J. J. L., & Anggono, V. (2021) · Seminars in Cell and Developmental Biology · doi:10.1016/j.semcdb.2021.05.023 · Cited by 33

CMTr cap-adjacent 2′-O-ribose mRNA methyltransferases are required for reward learning and mRNA localization to synapses

Haussmann, I. U., Wu, Y., Nallasivan, M. P., Archer, N., Bódi, Z., Hebenstreit, D., Waddell, S., Fray, R. G., & Soller, M. (2022) · Nature Communications · doi:10.1038/s41467-022-28549-5 · Cited by 32

Emerging Role of Epitranscriptomics in Diabetes Mellitus and Its Complications

Geng, X., Li, Z., & Yang, Y. (2022) · Frontiers in Endocrinology · doi:10.3389/fendo.2022.907060 · Cited by 35

RBM45 is an m6A-binding protein that affects neuronal differentiation and the splicing of a subset of mRNAs

Choi, S. H., Flamand, M. N., Liu, B., Zhu, H., Hu, M., Wang, M., Sewell, J., Holley, C. L., Al‐Hashimi, H. M., & Meyer, K. D. (2022) · Cell Reports · doi:10.1016/j.celrep.2022.111293 · Cited by 33

Emerging Role of m6 A Methylome in Brain Development: Implications for Neurological Disorders and Potential Treatment

Sokpor, G., Xie, Y., Nguyen, H. P., & Tuoc, T. (2021) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2021.656849 · Cited by 32

Techniques for investigating lncRNA transcript functions in neurodevelopment

Srinivas, T., Soares, E. S., & Guil, S. (2023) · Molecular Psychiatry · doi:10.1038/s41380-023-02377-5 · Cited by 37

The Role of N6-Methyladenosine Modified Circular RNA in Pathophysiological Processes

Tang, M., & Lv, Y. (2021) · International Journal of Biological Sciences · doi:10.7150/ijbs.60131 · Cited by 32

N-acetyltransferase 10 mediates cognitive dysfunction through the acetylation of GABA B R1 mRNA in sepsis-associated encephalopathy

Gao, S., Shen, R., Li, J., Jiang, Y., Sun, H., Wu, X., Li, X., Miao, C., He, M., Wang, J., et al. (2024) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2410564121 · Cited by 31

RNA Editing and Modifications in Mood Disorders

Barbon, A., & Magri, C. (2020) · Genes · doi:10.3390/genes11080872 · Cited by 30

Epitranscriptomic Modifications Modulate Normal and Pathological Functions in CNS

Chokkalla, A. K., Mehta, S. L., & Vemuganti, R. (2021) · Translational Stroke Research · doi:10.1007/s12975-021-00927-z · Cited by 30

The epitranscriptome of long noncoding RNAs in metabolic diseases

Yin, L., Zhu, X., Novák, P., Zhou, L., Gao, L., Yang, M., Zhao, G., & Yin, K. (2021) · Clinica Chimica Acta · doi:10.1016/j.cca.2021.01.001 · Cited by 28

m6A demethylase ALKBH5 suppression contributes to esophageal squamous cell carcinoma progression

Xiao, D., Fang, T., Ye, L., Xiao, S., Xia, J., Lin, T., Li, Y., Zhai, J., Li, X., Huang, S., et al. (2021) · Aging · doi:10.18632/aging.203490 · Cited by 28

Alteration of N6-Methyladenosine RNA Profiles in Cisplatin-Induced Acute Kidney Injury in Mice

Li, C., Li, M., Zhao, W., Ye, Z., & Peng, H. (2021) · Frontiers in Molecular Biosciences · doi:10.3389/fmolb.2021.654465 · Cited by 27

YTHDF2 in dentate gyrus is the m6A reader mediating m6A modification in hippocampus-dependent learning and memory

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M6A RNA Methylation-Based Epitranscriptomic Modifications in Plasticity-Related Genes via miR-124-C/EBPα-FTO-Transcriptional Axis in the Hippocampus of Learned Helplessness Rats

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