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Prediction of acute myeloid leukaemia risk in healthy individuals
Open accessAbstract
The incidence of acute myeloid leukaemia (AML) increases with age and mortality exceeds 90% when diagnosed after age 65. Most cases arise without any detectable early symptoms and patients usually present with the acute complications of bone marrow failure 1. The onset of such de novo AML cases is typically preceded by the accumulation of somatic mutations in preleukaemic haematopoietic stem and progenitor cells (HSPCs) that undergo clonal expansion 2,3. However, recurrent AML mutations also accumulate in HSPCs during ageing of healthy individuals who do not develop AML, a phenomenon referred to as age-related clonal haematopoiesis (ARCH)4-8. Here we use deep sequencing to analyse genes that are recurrently mutated in AML to distinguish between individuals who have a high risk of developing AML and those with benign ARCH. We analysed peripheral blood cells from 95 individuals that were obtained on average 6.3 years before AML diagnosis (pre-AML group), together with 414 unselected age- and gender-matched individuals (control group). Pre-AML cases were distinct from controls and had more mutations per sample, higher variant allele frequencies, indicating greater clonal expansion, and showed enrichment of mutations in specific genes. Genetic parameters were used to derive a model that accurately predicted AML-free survival; this model was validated in an independent cohort of 29 pre-AML cases and 262 controls. Because AML is rare, we also developed an AML predictive model using a large electronic health record database that identified individuals at greater risk. Collectively our findings provide proof-of-concept that it is possible to discriminate ARCH from pre-AML many years before malignant transformation. This could in future enable earlier detection and monitoring, and may help to inform intervention.
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“Furthermore, progression to hematological malignancies depends on the type and complexity of mutations in CHIP.2,5,6”
From Aging drives Tet2 +/− clonal hematopoiesis via IL-1 signaling (2023) · cites this paper as [5]
Experimental — accuracy not yet measuredThe source backs part of the claim, not all of it — or backs it for a different population, condition or comparison.
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“CH-associated variants of the epigenetic writers and erasers Dnmt3a and Tet2, respectively, that affect the HSPC methylome have been shown to alter functions of monocyte-derived tissue M F and promote cardiovascular pathologies 31-34 .”
From Clonal hematopoiesis-associated motoric deficits caused by monocyte-derived microglia accumulating in aging mice (2025) · cites this paper as [34]
Experimental — accuracy not yet measuredThe source backs part of the claim, not all of it — or backs it for a different population, condition or comparison.
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“CH prominently involves variants of epigenetic regulatory genes, such as DNMT3A and TET2, which constitute an increased risk for hematologic malignancies, cardiovascular events and stroke 34,45,70,71 .”
From Clonal hematopoiesis-associated motoric deficits caused by monocyte-derived microglia accumulating in aging mice (2025) · cites this paper as [34]
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“Clone size, which is approximated by the variant allele fraction (VAF), has previously been shown to be an important predictor of risk for blood cancer1,17 and cardiovascular outcomes8,9.”
From Clonal hematopoiesis is associated with protection from Alzheimer’s disease (2023) · cites this paper as [17]
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“CH prominently involves variants of epigenetic regulatory genes, such as DNMT3A and TET2, which constitute an increased risk for hematologic malignancies, cardiovascular events and stroke 34,45,70,71 .”
From Clonal hematopoiesis-associated motoric deficits caused by monocyte-derived microglia accumulating in aging mice (2025) · cites this paper as [34]
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“Both groups found that individuals with antecedent clonal hematopoiesis were at ~3 to 5-fold increased risk for developing AML in the subsequent years (Fig. 3A).”
From Clonal hematopoiesis in human aging and disease (2019) · cites this paper as [71]
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“The effect of specific gene variants on various outcomes may be quite different, as has been found in AML 71.”
From Clonal hematopoiesis in human aging and disease (2019) · cites this paper as [71]
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Citations
Cites
Fast and accurate short read alignment with Burrows-Wheeler transform
Li, H., & Durbin, R. (2009) · Bioinformatics · doi:10.1093/bioinformatics/btp324 · Cited by 58,607
The Genome Analysis Toolkit: A MapReduce framework for analyzing next-generation DNA sequencing data
McKenna, A., Hanna, M., Banks, E., Sivachenko, A., Cibulskis, K., Kernytsky, A., Garimella, K., Altshuler, D., Gabriel, S., Daly, M., et al. (2010) · Genome Research · doi:10.1101/gr.107524.110 · Cited by 27,895
BEDTools: a flexible suite of utilities for comparing genomic features
Quinlan, A. R., & Hall, I. M. (2010) · Bioinformatics · doi:10.1093/bioinformatics/btq033 · Cited by 27,437
Fast and accurate long-read alignment with Burrows-Wheeler transform.
Li, H., & Durbin, R. (2010) · Bioinformatics · doi:10.1093/bioinformatics/btp698 · Cited by 12,063
Arber, D. A., Orazi, A., Hasserjian, R., Thiele, J., Borowitz, M. J., Le Beau, M. M., Bloomfield, C. D., Cazzola, M., & Vardiman, J. W. (2016) · Blood · doi:10.1182/blood-2016-03-643544 · Cited by 10,119
Modeling Survival Data: Extending the Cox Model
Therneau, T. M., & Grambsch, P. M. (2000) · Statistics for Biology and Health · doi:10.1007/978-1-4757-3294-8 · Cited by 8,674
VarScan 2: Somatic mutation and copy number alteration discovery in cancer by exome sequencingPreprint
Koboldt, D. C., Zhang, Q., Larson, D. E., Shen, D., McLellan, M. D., Lin, L., Miller, C. A., Mardis, E. R., Ding, L., & Wilson, R. K. (2012) · Genome Research · doi:10.1101/gr.129684.111 · Cited by 4,954
Age-related clonal hematopoiesis associated with adverse outcomes
Jaiswal, S., Fontanillas, P., Flannick, J., Manning, A., Grauman, P. V., Mar, B. G., Lindsley, R. C., Mermel, C. H., Burtt, N., Chavez, A., et al. (2014) · New England Journal of Medicine · doi:10.1056/nejmoa1408617 · Cited by 4,841
Genomic classification and prognosis in acute myeloid leukemia
Papaemmanuil, E., Gerstung, M., Bullinger, L., Gaidzik, V. I., Paschka, P., Roberts, N. D., Potter, N. E., Heuser, M., Thol, F., Bolli, N., et al. (2016) · New England Journal of Medicine · doi:10.1056/nejmoa1516192 · Cited by 4,350
Self-citationClonal hematopoiesis and blood-cancer risk inferred from blood DNA sequence
Genovese, G., Kähler, A. K., Handsaker, R. E., Lindberg, J., Rose, S. A., Bakhoum, S. F., Chambert, K., Mick, E., Neale, B. M., Fromer, M., et al. (2014) · New England Journal of Medicine · doi:10.1056/nejmoa1409405 · Cited by 3,531
Cited by
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Items 501–600 of 847
Pryce, A., van Eerden, E., Cody, M. R., Oakes, J., DeSalvo, A. M., Bannon, S., Burlton, C., Pawson, R., Fingrut, W. B., Barriga, F., et al. (2023) · Transplantation and Cellular Therapy · doi:10.1016/j.jtct.2023.11.019 · Cited by 7
The concept of leukaemic stem cells in acute myeloid leukaemia 25 years on: hitting a moving target
Hokland, P., Woll, P. S., Hansen, M. H., & Bill, M. (2019) · British Journal of Haematology · doi:10.1111/bjh.16104 · Cited by 7
Nevejan, L., Nollet, F., Devos, H., Vynck, M., Vlierberghe, P. V., Tajdar, M., Lodewyck, T., & Selleslag, D. (2020) · Blood Advances · doi:10.1182/bloodadvances.2020003168 · Cited by 7
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Lam, K. K., Thean, L. F., & Cheah, P. Y. (2021) · The International Journal of Biochemistry & Cell Biology · doi:10.1016/j.biocel.2021.106032 · Cited by 7
Sidorova, O. A., Sayed, S., Paszkowski‐Rogacz, M., Seifert, M., Camgöz, A., Roeder, I., Bornhäuser, M., Thiede, C., & Buchholz, F. (2022) · Cells · doi:10.3390/cells11050854 · Cited by 7
A predictive model for bone marrow disease in cytopenia based on noninvasive procedures
Træden, D., Tulstrup, M., Cowland, J. B., Sjø, L. D., Bøgsted, M., Grønbæk, K., Andersen, M. K., & Hansen, J. W. (2022) · Blood Advances · doi:10.1182/bloodadvances.2021006649 · Cited by 7
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Zerdan, M. B., Nasr, L. F., Saba, L., Meouchy, P., Safi, N., Allam, S., Bhandari, J., & Chaulagain, C. P. (2022) · Cancers · doi:10.3390/cancers14153663 · Cited by 7
Donor-derived acute myeloid leukemia in solid organ transplantation
Marchionni, L., Lobo, F. P., Kostadinov, R. L., Serra, A., Besso, F. G., Deaglio, S., Stratta, P., Berrino, M., Zanettini, C., Imada, E. L., et al. (2022) · American Journal of Transplantation · doi:10.1111/ajt.17174 · Cited by 7
FLT3-ITD does not predict inferior prognosis in acute myeloid leukemia patients aged ≥60 years
Shimony, S. O., Fell, G. G., Chen, E. C., Tsai, H. K., Wadleigh, M., Winer, E. S., Garcia, J. S., Luskin, M. R., Stahl, M. F., Neuberg, D. S., et al. (2023) · Blood Advances · doi:10.1182/bloodadvances.2023009748 · Cited by 7
Feng, J., Hsu, P.-F., Esteva, E., Labella, R., Wang, Y., Khodadadi‐Jamayran, A., Pucella, J. N., Liu, C. Z., Arbini, A., Tsirigos, A., et al. (2023) · Blood · doi:10.1182/blood.2022018512 · Cited by 7
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Liu, J., Osman, A. E. G., Bolton, K. L., & Godley, L. A. (2023) · Leukemia Research · doi:10.1016/j.leukres.2023.107344 · Cited by 7
Chicken or Egg: Is Clonal Hematopoiesis Primarily Caused by Genetic or Epigenetic Aberrations?
Cypris, O., Božić, T., & Wagner, W. (2019) · Frontiers in Genetics · doi:10.3389/fgene.2019.00785 · Cited by 8
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Mason, C. C., Fiol, C. R., Baker, M. J., Nadal‐Melsio, E., Yebra‐Fernandez, E., Bicalho, L., Chowdhury, A., Albert, M., Reid, A. G., Claudiani, S., et al. (2020) · British Journal of Haematology · doi:10.1111/bjh.17129 · Cited by 7
Preleukemic stem cells: leave it or not?
Su, M., Cheng, H., & Cheng, T. (2020) · Blood Science · doi:10.1097/bs9.0000000000000042 · Cited by 6
Parry, A., Krueger, C., Lohoff, T., Wingett, S., Schoenfelder, S., & Reik, W. (2023) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2023.01.11.523441 · Cited by 7
Exploring the Potential of siRNA Delivery in Acute Myeloid Leukemia for Therapeutic Silencing
Ubeda, A., Bahadur, K. C. R., Brandwein, J. M., & Uludağ, H. (2023) · Nanomaterials · doi:10.3390/nano13243167 · Cited by 7
Seo, J., Lee, C., Koh, Y., Sun, C.-H., Lee, J.-M., An, H., & Kim, M. (2024) · iScience · doi:10.1016/j.isci.2024.111082 · Cited by 6
Tan, Z., Zhang, X., Feng, J., Zhao, Y., Hu, H., Wu, D., Yu, Q., Zhang, Y., Wu, L., Hu, T., et al. (2025) · Annals of Hematology · doi:10.1007/s00277-024-06152-6 · Cited by 6
Ali, M. A., Limerick, E. M., Hsieh, M. M., Upadhyaya, K., Xu, X., Phang, O. A., Mukendi, J. P. K., Calvo, K. R., Lopez-Ocasio, M. D., Dagur, P. K., et al. (2025) · American Journal of Hematology · doi:10.1002/ajh.27627 · Cited by 6
Cheng, W., Yi, X., Wang, Z., Li, J., Zhang, J., Zhang, R.-H., Zhang, Q.-Q., Weng, X., Huang, T., Zhu, Y., et al. (2025) · Blood · doi:10.1182/blood.2024027692 · Cited by 6
Clonal Hematopoiesis after 177Lu-PSMA-617 Radioligand Therapy in Prostate Cancer
Munzur, A. D., Herberts, C., Kwan, E. M., Emmett, L., Sandhu, S., Buteau, J. P., Iravani, A., Joshua, A. M., Francis, R. J., Lee, S.-T., et al. (2026) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-25-4001 · Cited by 10
The research progress of targeted therapy in acute myeloid leukemia based on bibliometric analysis
Huang, W., Sun, G., Wang, Q., & Long, Z. (2022) · Frontiers in Oncology · doi:10.3389/fonc.2022.957370 · Cited by 7
Su, M., Fleischer, T., Grosheva, I., Horev, M. B., Olszewska, M., Mattioli, C. C., Barr, H. M., Plotnikov, A. N., Carvalho, S., Moskovich, Y., et al. (2024) · iScience · doi:10.1016/j.isci.2024.109443 · Cited by 6
Xiao, H., Hu, X., Li, P., & Deng, J. (2024) · Frontiers in Oncology · doi:10.3389/fonc.2024.1404135 · Cited by 7
Association between genetic risk scores and risk of narcolepsy: a case-control study
Ouyang, H., Han, F., Zhou, Z., Zheng, Q., Wang, Y., & Zhang, J. (2020) · Annals of Translational Medicine · doi:10.21037/atm.2019.12.95 · Cited by 5
Clonal hematopoiesis: Molecular basis and clinical relevance
Kunimoto, H., & Nakajima, H. (2020) · Leukemia Research · doi:10.1016/j.leukres.2020.106457 · Cited by 7
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Quirós, P. M., Gu, M., Bárcena, C., Iyer, V., & Vassiliou, G. S. (2021) · Blood Advances · doi:10.1182/bloodadvances.2021005927 · Cited by 6
Yegorov, Y. E., Poznyak, A. V., Bezsonov, E. E., Zhuravlev, A. D., Nikiforov, N. G., Vishnyakova, K. S., & Orekhov, A. N. (2022) · Biomedicines · doi:10.3390/biomedicines10040782 · Cited by 6
Petrone, G. E. M., Gaulin, C., Derkach, A., Kishtagari, A., Robson, M. E., Parameswaran, R., & Stein, E. M. (2022) · Haematologica · doi:10.3324/haematol.2021.280437 · Cited by 6
Xia, M., Wang, S., Wang, L., Mei, Y., Tu, Y., & Gao, L. (2023) · Frontiers in Endocrinology · doi:10.3389/fendo.2023.1062317 · Cited by 6
Zerella, J. R., Homan, C. C., Arts, P., Brown, A. L., Scott, H. S., & Hahn, C. N. (2023) · Frontiers in Oncology · doi:10.3389/fonc.2023.1183318 · Cited by 5
Recipient clonal hematopoiesis in allogeneic bone marrow transplantation for lymphoid malignancies
Imus, P. H., Paşca, S., Tsai, H., Aljawai, Y. M., Cooke, K. R., Walston, J. D., Gocke, C. D., Varadhan, R., Jones, R. J., & Gondek, L. P. (2024) · Blood Advances · doi:10.1182/bloodadvances.2023011761 · Cited by 6
He, H., Wen, Y., Yu, H., Liu, J., Huo, Q., Jin, W., Wang, Z., Du, G., Du, J., Wang, H., et al. (2024) · Genes & Diseases · doi:10.1016/j.gendis.2024.101397 · Cited by 5
Zuckerman, T., & Rowe, J. M. (2019) · Current Opinion in Hematology · doi:10.1097/moh.0000000000000480 · Cited by 6
Sjövall, D., & Staffas, A. (2020) · Seminars in Hematology · doi:10.1053/j.seminhematol.2020.05.003 · Cited by 6
Epidemiology and Etiology of AML
Juliusson, G., Lehmann, S., & Lazarević, V. (2021) · Hematologic malignancies · doi:10.1007/978-3-030-72676-8_1 · Cited by 6
Myeloid Toxicity of Radionuclide Cancer Therapy
Kesavan, M., & Turner, J. H. (2021) · Cancer Biotherapy and Radiopharmaceuticals · doi:10.1089/cbr.2021.0286 · Cited by 6
Chen, T., Yao, C., Chen, Y., Yuan, C., Lin, C., Hsu, Y.-C., Chuang, P., Kao, C., Li, Y.-H., Hou, H., et al. (2022) · Oncogene · doi:10.1038/s41388-022-02193-1 · Cited by 7
Menendez-Gonzalez, J. B., & Rodrigues, N. P. (2022) · Methods in molecular biology · doi:10.1007/978-1-0716-1924-7_5 · Cited by 6
Diviney, A., Chobrutskiy, B. I., Zaman, S., & Blanck, G. (2019) · Cancer Cell International · doi:10.1186/s12935-019-0790-5 · Cited by 6
Mouse Models of Myeloid MalignanciesPreprint
Basheer, F., & Vassiliou, G. S. (2020) · Cold Spring Harbor Perspectives in Medicine · doi:10.1101/cshperspect.a035535 · Cited by 6
Clonal hematopoiesis in sickle cell diseasePreprint
Liggett, L. A., Cato, L. D., Weinstock, J. S., Zhang, Y., Nouraie, M. S., Gladwin, M. T., Garrett, M. E., Ashley‐Koch, A. E., Telen, M. J., Custer, B., et al. (2021) · medRxiv · doi:10.1101/2021.06.12.21258772 · Cited by 6
Dunn, W. G., Withnell, I., Gu, M., Quirós, P. M., Kovilakam, S. C., Marando, L., Wen, S., Fabre, M. A., Mohorianu, I. I., Vuckovic, D., et al. (2025) · HemaSphere · doi:10.1002/hem3.70169 · Cited by 5
Clonal haematopoiesis associates with distinct cytometric changes of red blood cells and platelets
Salzbrunn, J. B., van Zeventer, I. A., de Graaf, A. O., Klatte, S., van Pelt, L. J., Kamphuis, P., van Bergen, M. G. J. M., Dinmohamed, A. G., van der Reijden, B. A., Linssen, J., et al. (2025) · British Journal of Haematology · doi:10.1111/bjh.70031 · Cited by 5
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Marzban, S., Stiehl, T., Xie, Z., Andersen, M., Snyder, J. A., Gudmand‐Hoeyer, J., Ottesen, J. T., Père, N. V. M., Werner, B., Huang, W., et al. (2026) · Nature Genetics · doi:10.1038/s41588-026-02504-2 · Cited by 7
Symeonidou, V., Metzner, M., Usukhbayar, B., Jackson, A. E., Fox, S., Craddock, C., & Vyas, P. (2022) · eJHaem · doi:10.1002/jha2.527 · Cited by 5
TP53-MUTATED MYELODYSPLASIA AND ACUTE MYELOID LEUKEMIA
Testa, U., Castelli, G., & Pelosi, E. (2023) · Mediterranean Journal of Hematology and Infectious Diseases · doi:10.4084/mjhid.2023.038 · Cited by 6
The utility of liquid biopsy in clinical genetic diagnosis of cancer and monogenic mosaic disorders
Hallermayr, A., Keßler, T., Steinke‐Lange, V., Heitzer, E., Holinski‐Feder, E., & Speicher, M. R. (2023) · Medizinische Genetik · doi:10.1515/medgen-2023-2066 · Cited by 5
Age-related micro-environmental changes as drivers of clonal hematopoiesis
Bacharach, T., Kaushansky, N., & Shlush, L. I. (2023) · Current Opinion in Hematology · doi:10.1097/moh.0000000000000798 · Cited by 6
Identification of red blood cell distribution width as a prognostic factor in acute myeloid leukemia
Liu, Q., Zhai, Y., Hui, Y., Chen, J., Mi, Y., Wang, J., & Wei, H. (2024) · Experimental Hematology · doi:10.1016/j.exphem.2024.104206 · Cited by 5
Neuendorff, N. R., Frenzel, L. P., Leuschner, F., & Fremd, C. (2020) · Journal of Geriatric Oncology · doi:10.1016/j.jgo.2020.09.006 · Cited by 5
Deep resequencing identifies candidate functional genes in leprosy GWAS loci
Fava, V. M., Dallmann-Sauer, M., Orlova, M., Correa-Macedo, W., Thuc, N. V., Thai, V. H., Alcaïs, A., Abel, L., Cobat, A., & Schurr, E. (2021) · PLoS neglected tropical diseases · doi:10.1371/journal.pntd.0010029 · Cited by 5
Toward a systems-level probing of tumor clonality
Grody, E. I., Abraham, A., Shukla, V., & Goyal, Y. (2023) · iScience · doi:10.1016/j.isci.2023.106574 · Cited by 5
Clonal hematopoiesis in frequent whole blood donors
Karpova, D. (2023) · Hematology · doi:10.1182/hematology.2023000483 · Cited by 5
Yogo, T., Okazuka, K., Nashimoto, J., Uto, Y., Sato, K., Miyazaki, K., Ogura, M., Yoshiki, Y., Abe, Y., Tsukada, N., et al. (2019) · International Journal of Hematology · doi:10.1007/s12185-019-02692-0 · Cited by 5
Hoermann, G. (2022) · Journal of Laboratory Medicine · doi:10.1515/labmed-2022-0050 · Cited by 5
Li, H., Bi, K., Feng, S., Wang, Y., & Zhu, C. (2022) · Mediterranean Journal of Hematology and Infectious Diseases · doi:10.4084/mjhid.2022.062 · Cited by 5
Machine Learning and Bioinformatics Analysis for Laboratory Data in Pan‐Cancers Detection
Jia, Y. H., Liu, Z., Guo, J. F., He, C., Zhou, X., Xue, M., Nie, T., Sun, T., Kang, J., Lu, Q., et al. (2023) · Advanced Intelligent Systems · doi:10.1002/aisy.202300283 · Cited by 5
Clinical features and management of germline CEBPA-mutated carriers
Pan, L., Li, Y., Gao, H., Lai, X., Cai, Y., Chen, Z., Li, X., & Wang, S. (2024) · Leukemia Research · doi:10.1016/j.leukres.2024.107453 · Cited by 6
Transcriptional regulators CITED2 and PU.1 cooperate in maintaining hematopoietic stem cells
Mattes, K., Geugien, M., Korthuis, P. M., Brouwers-Vos, A. Z., Fehrmann, R. S. N., Todorova, T. I., Steidl, U. G., Vellenga, E., & Schepers, H. (2019) · Experimental Hematology · doi:10.1016/j.exphem.2019.03.003 · Cited by 5
Huang, X., Wu, J., Deng, X., Xu, X. L., Zhang, X., Ma, W., Hu, T., Yang, J., Guan, M., & Tang, G. (2020) · Journal of Bio-X Research · doi:10.1097/jbr.0000000000000061 · Cited by 5
Quantifying mutations in healthy blood
Curtis, C. N. (2020) · Science · doi:10.1126/science.aba9891 · Cited by 6
The beginning of a new therapeutic era in acute myeloid leukemia
Récher, C. (2021) · eJHaem · doi:10.1002/jha2.252 · Cited by 8
Diagnosis of Acute Myeloid Leukaemia Using Machine LearningPreprint
Angelakis, A., & Soulioti, I. (2021) · arXiv (Cornell University) · doi:10.48550/arxiv.2108.07396 · Cited by 5
Incidental discovery of acute myeloid leukemia during liquid biopsy of a lung cancer patientPreprint
Nkosi, D., Miller, C., Jajosky, A. N., & Oltvai, Z. N. (2022) · Molecular Case Studies · doi:10.1101/mcs.a006201 · Cited by 5
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Testa, U., Castelli, G., & Pelosi, E. (2025) · Hemato · doi:10.3390/hemato6020010 · Cited by 5
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Munzur, A. D., Bacon, J. V. W., Fishbein, F., Herberts, C., Donnellan, G., Bernales, C. Q., Parekh, K., Vandekerkhove, G. R., Müller, D. C., Liao, Y. J., et al. (2025) · npj Precision Oncology · doi:10.1038/s41698-025-00965-y · Cited by 5
Clonal Hematopoiesis of Indeterminate Potential After Radiation Therapy
Crants, S., Olson, S., Li, Y., Bejan, C. A., Vlasschaert, C., Mack, T., Pershad, Y., Kishtagari, A., Reed, S. C., Croessmann, S., et al. (2025) · International Journal of Radiation Oncology*Biology*Physics · doi:10.1016/j.ijrobp.2025.10.006 · Cited by 6
Moyen, T. B., Tomaz, V., Cortês, L. G. F., Rosa, S., Santos, F. P. D. S., Hamerschlak, N., Puga, R., Reis, R. D. S., Petroni, R. C., Silveira, C. N., et al. (2025) · Scientific Reports · doi:10.1038/s41598-025-24475-w · Cited by 4
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Ngo, S. D., Papazoglou, D., Encabo, H. H., & Bonnet, D. A. (2024) · Frontiers in Hematology · doi:10.3389/frhem.2024.1334807 · Cited by 4
Grenier, J. M. P., Testut, C., Bal, M., Bardin, F., Grandis, M. D., Gelsi‐Boyer, V., Vernerey, J., Delahaye, M. C., Granjeaud, S., Zemmour, C., et al. (2024) · Blood Advances · doi:10.1182/bloodadvances.2023011747 · Cited by 4
Soma, L. A., Crisan, L. L., Reid, J., Lee, W., Song, J. Y., Afkhami, M., Shouse, G., Fei, F., Danilova, O. V., Pillai, R. K., et al. (2024) · American Journal of Clinical Pathology · doi:10.1093/ajcp/aqae124 · Cited by 4
Marshall, C. H., Antonarakis, E. S., & Patnaik, M. M. (2025) · Blood Reviews · doi:10.1016/j.blre.2025.101269 · Cited by 4
Jamin, R. N., Al‐Kassou, B., Kleuker, T., Shamekhi, J., Bartsch, B., Ackerschott, A., Zaidi, M. A., Billig, H., Graef, C. M., Kelm, M., et al. (2025) · Clinical Research in Cardiology · doi:10.1007/s00392-025-02658-9 · Cited by 4
Munroe, M., Chamba, C. C., Yonazi, M., Mahfudh, S., Mawalla, W. F., Mbelekwa, K., Kaaya, G., Mwakichako, R. W., Mshiu, J. J., Lyimo, M. A., et al. (2025) · PLoS ONE · doi:10.1371/journal.pone.0332237 · Cited by 4
Clinical significance of miR‑372 and miR‑495 in acute myeloid leukemia
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Ouyang, H., Zhou, Z., Zheng, Q., & Zhang, J. (2020) · International Journal of Medical Sciences · doi:10.7150/ijms.41812 · Cited by 5
Epigenetic modifiers in normal and aberrent erythropoeisis
Sundaravel, S., Steidl, U. G., & Wickrema, A. (2020) · Seminars in Hematology · doi:10.1053/j.seminhematol.2020.12.005 · Cited by 4
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Clonal hematopoiesis and its role in the development of hematological diseases
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Zhang, X., Zhang, K., Zhang, J., Chang, W., Zhao, Y., & Suo, X. (2023) · European Journal Of Haematology · doi:10.1111/ejh.14134 · Cited by 4
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Guo, J. F., Wu, Z., Jia, Y. H., Cao, H., Qin, Q., Sun, T., Zhou, X., Pan, X. M., Hua, C., Mao, C., et al. (2023) · Open Research (University of Surrey) · doi:10.1002/viw.20230050 · Cited by 4
Dynamics of clonal hematopoiesis and risk of hematologic malignancy
Arends, C. M., & Jaiswal, S. (2024) · International Journal of Hematology · doi:10.1007/s12185-024-03829-6 · Cited by 4
Chen, J., Liu, X., Zhang, Z., Su, R., Geng, Y., Guo, Y., Zhang, Y., & Su, M. (2024) · Laboratory Investigation · doi:10.1016/j.labinv.2024.102127 · Cited by 5
Clinical Trials of Repurposing Medicines in Acute Myeloid Leukemia
Andresen, V., & Gjertsen, B. T. (2019) · The Cancer Journal · doi:10.1097/ppo.0000000000000363 · Cited by 4
Vinogradov, A. V., Rezaykin, A. V., Sazonov, S. V., Sergeev, A. G., & Капитонова, М. Ю. (2020) · Medical news of the North Caucasus · doi:10.14300/mnnc.2020.15006 · Cited by 4
Yoshida, K., Misumi, M., Kusunoki, Y., & Yamada, M. (2020) · British Journal of Haematology · doi:10.1111/bjh.17296 · Cited by 4
Hsu, Y.-C., Huang, S., Chang, L., Chen, Y.-M., Chang, Y.-H., Lin, J.-W., Lin, C.-C., Chen, C., Chen, H., Chiu, H., et al. (2022) · PubMed Central · Cited by 4
Freeman, S. D., & Craddock, C. (2020) · Journal of Clinical Oncology · doi:10.1200/jco.19.03161 · Cited by 4
Tian, S., Jenkinson, G., Ferrer, A., Yan, H., Morales‐Rosado, J. A., Wang, K. L., Lasho, T. L., Yan, B. B., Baheti, S., Olson, J. E., et al. (2025) · Genomics Proteomics & Bioinformatics · doi:10.1093/gpbjnl/qzaf040 · Cited by 3
Boddicker, N. J., Shanafelt, T. D., Parikh, S. A., Rabe, K. G., Griffin, R., Norman, A. D., Yao, Y., Tian, S., Ma, T., O’Brien, D. R., et al. (2025) · Blood Cancer Journal · doi:10.1038/s41408-025-01385-8 · Cited by 3
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Nadar, S., Dohadwala, T. K., Kumaresan, N., Ahamed, S. I., & Fatima, S. (2025) · Clinical Hematology International · doi:10.46989/001c.146275 · Cited by 5
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Fu, J., Fu, Q., Wang, J., Wang, Q., Zhang, L., Chi, H., Zhang, L., Sun, L., Huang, Y., He, T., et al. (2026) · Arthritis & Rheumatology · doi:10.1002/art.70126 · Cited by 3
Sobieralski, P., Wasąg, B., Leszczyńska, A., Żuk, M., & Bieniaszewska, M. (2023) · Frontiers in Oncology · doi:10.3389/fonc.2023.1224590 · Cited by 3
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Zhao, Y., Zhang, W., Ma, Y., & Zhang, X. (2024) · UroPrecision · doi:10.1002/uro2.52 · Cited by 3
Dutta, S., Akhade, V. S., Choudhury, S. R., & Rao, M. R. S. (2024) · Frontiers in RNA Research · doi:10.3389/frnar.2024.1334464 · Cited by 3
Müskens, K. F., Wieringa, N., van Bergen, M. G. J. M., Bense, J. E., Pas, B. M. T., de Pagter, A. P. J., Lankester, A. C., Bierings, M., Neuberg, D. S., Haitjema, S., et al. (2025) · Blood Cancer Discovery · doi:10.1158/2643-3230.bcd-24-0136 · Cited by 5
Metadata
- Authors
- Abelson, S., Collord, G., Ng, S. W. K., Weissbrod, O., Mendelson Cohen, N., Niemeyer, E., Barda, N., Zuzarte, P. C., Heisler, L., Sundaravadanam, Y., Luben, R., Hayat, S., Wang, T. T., Zhao, Z., Cirlan, I., Pugh, T. J., Soave, D., Ng, K., Latimer, C., Hardy, C., Raine, K., Jones, D., Hoult, D., Britten, A., McPherson, J. D., Johansson, M., Mbabaali, F., Eagles, J., Miller, J. K., Pasternack, D., Timms, L., Krzyzanowski, P., Awadalla, P., Costa, R., Segal, E., Bratman, S. V., Beer, P., Behjati, S., Martincorena, I., Wang, J. C. Y., Bowles, K. M., Quirós, J. R., Karakatsani, A., La Vecchia, C., Trichopoulou, A., Salamanca-Fernández, E., Huerta, J. M., Barricarte, A., Travis, R. C., Tumino, R., Masala, G., Boeing, H., Panico, S., Kaaks, R., Krämer, A., Sieri, S., Riboli, E., Vineis, P., Foll, M., McKay, J., Polidoro, S., Sala, N., Khaw, K.-T., Vermeulen, R., Campbell, P. J., Papaemmanuil, E., Minden, M. D., Tanay, A., Balicer, R. D., Wareham, N. J., Gerstung, M., Dick, J. E., Brennan, P., Vassiliou, G. S., & Shlush, L. I.
- Affiliations
- University Health Network (CA)
- University of Cambridge (GB)
- University of Toronto (CA)
- Weizmann Institute of Science (IL)
- Clalit Health Services (IL)
- Ontario Institute for Cancer Research (CA)
- Wellcome Sanger Institute (GB)
- Centre international de recherche sur le cancer (FR)
- European Bioinformatics Institute (GB)
- University of East Anglia (GB)
- Gobierno del Principado de Asturias (ES)
- National and Kapodistrian University of Athens (GR)
- Hellenic Health Foundation (GR)
- Instituto Murciano de Investigación Biosanitaria (ES)
- Instituto de Salud Pública de Navarra (ES)
- University of Oxford (GB)
- Istituto per lo Studio e la Prevenzione Oncologica (IT)
- German Institute of Human Nutrition (DE)
- Federico II University Hospital (IT)
- German Cancer Research Center (DE)
- Fondazione IRCCS Istituto Nazionale dei Tumori (IT)
- Imperial College London (GB)
- Italian institute for Genomic Medicine (IT)
- Institut d'Investigació Biomédica de Bellvitge (ES)
- Utrecht University (NL)
- Memorial Sloan Kettering Cancer Center (US)
- World Health Organization (CH)
- Wellcome/MRC Cambridge Stem Cell Institute (GB)
- Corresponding author
- Gerstung, Moritz
- Dick, John E.
- Brennan, Paul
- Vassiliou, George S.
- Shlush, Liran I.
- ORCID
- Abelson, Sagi
- Collord, Grace
- Ng, Stanley W. K.
- Weissbrod, Omer
- Barda, Noam
- Zuzarte, Philip C.
- Heisler, Lawrence
- Sundaravadanam, Yogi
- Luben, Robert
- Hayat, Shabina
- Zhao, Zhen
- Cirlan, Iulia
- Pugh, Trevor J.
- Soave, David
- Ng, Karen
- Latimer, Calli
- Raine, Keiran
- Jones, David
- Britten, Abigail
- McPherson, John D.
- Johansson, Mattias
- Eagles, Jenna
- Miller, Jessica K.
- Krzyzanowski, Paul
- Awadalla, Philip
- Costa, Rui
- Segal, Eran
- Bratman, Scott V.
- Beer, Philip
- Behjati, Sam
- Wang, Jean C. Y.
- Bowles, Kristian M.
- Karakatsani, Anna
- Trichopoulou, Antonia
- Huerta, José M.
- Barricarte, Aurelio
- Travis, Ruth C.
- Tumino, Rosario
- Masala, Giovanna
- Boeing, Heiner
- Panico, Salvatore
- Kaaks, Rudolf
- Krämer, Alwin
- Sieri, Sabina
- Vineis, Paolo
- Foll, Matthieu
- McKay, James
- Polidoro, Silvia
- Sala, Núria
- Khaw, Kay-Tee
- Vermeulen, Roel
- Campbell, Peter J.
- Papaemmanuil, Elli
- Minden, Mark D.
- Tanay, Amos
- Balicer, Ran D.
- Wareham, Nicholas J.
- Gerstung, Moritz
- Dick, John E.
- Brennan, Paul
- Vassiliou, George S.
- Shlush, Liran I.
- Venue
- Nature
- Published
- 2018-07
- Volume
- 559
- Issue
- 7714
- Pages
- 400-404
- ISSN
- 0028-0836 (ISSN-L)
- 1476-4687
- PMC
- PMC6485381
- OpenAlex
- W2830196912
- Cited by
- 850
- References
- 49
- Citations by year
- 2026: 52 · 2025: 83 · 2024: 95 · 2023: 116 · 2022: 122 · 2021: 116 · 2020: 143 · 2019: 91 · 2018: 29
- FWCI
- 67.70
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Nature (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- RISalud Institutional Health Repository of Andalucía (submittedVersion, public-domain)
- HAL (submittedVersion)
- RePEc: Research Papers in Economics (submittedVersion)
- Dipòsit Digital de la Universitat de Barcelona (Universitat de Barcelona) (submittedVersion, public-domain)
- Utrecht University Repository (Utrecht University) (submittedVersion, other-oa)
- eScholarship (California Digital Library) (submittedVersion)
- Spiral (Imperial College London) (submittedVersion)
- Apollo (University of Cambridge) (submittedVersion)
- Utrecht University Repository (Utrecht University) (submittedVersion)
- Apollo
- Funders
- World Health Organization
- Leukemia and Lymphoma Society
- Wellcome Trust (WT 098051, WT095663MA)
- Cancer Research UK (23015, 14136, 16491, 21777)
- National Institute for Health and Care Research (NF-SI-0512-10114, NF-SI-0512-10135, NF-SI-0617-10149)
- Generalitat de Catalunya
- Associazione Italiana per la Ricerca sul Cancro
- Clalit Health Services
- Abisch-Frenkel-Stiftung
- Hellenic Health Foundation
- Medical Research Council (MC_UU_12015/1, MC_PC_13048, MC_PC_12009, MR/N003284/1)
- Agència de Gestió d'Ajuts Universitaris i de Recerca
- Instituto de Salud Carlos III (RD12/0036/0018)
- European Regional Development Fund
- National Cancer Institute (P30CA008748)
- Topics
- Health Sciences › Medicine › Hematology › Acute Myeloid Leukemia Research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Cancer Genomics and Diagnostics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Retinoids in leukemia and cellular processes
- Keywords
- acute myeloid leukemia, somatic mutations, clonal expansion, variant allele frequency
- MeSH terms
- Adult, Age Factors, Aged, Female, Health, Humans, Male, Middle Aged, Models, Genetic, Mutation, Leukemia, Myeloid, Acute, Prevalence, Mutagenesis, Disease Progression, Risk Assessment, Genetic Predisposition to Disease, Electronic Health Records
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