The DOI matches its Crossref record; 39 of the 39 references it cites were found in a registry or an index.
RETRACTED ARTICLE: Parkin and PINK1 mitigate STING-induced inflammation
Open accessAbstract
Although serum from patients with Parkinson's disease contains elevated levels of numerous pro-inflammatory cytokines including IL-6, TNF, IL-1β, and IFNγ, whether inflammation contributes to or is a consequence of neuronal loss remains unknown 1. Mutations in parkin, an E3 ubiquitin ligase, and PINK1, a ubiquitin kinase, cause early onset Parkinson's disease 2,3. Both PINK1 and parkin function within the same biochemical pathway and remove damaged mitochondria from cells in culture and in animal models via mitophagy, a selective form of autophagy 4. The in vivo role of mitophagy, however, is unclear, partly because mice that lack either PINK1 or parkin have no substantial Parkinson's-disease-relevant phenotypes 5-7. Mitochondrial stress can lead to the release of damage-associated molecular patterns (DAMPs) that can activate innate immunity 8-12, suggesting that mitophagy may mitigate inflammation. Here we report a strong inflammatory phenotype in both Prkn-/- and Pink1-/- mice following exhaustive exercise and in Prkn-/-;mutator mice, which accumulate mutations in mitochondrial DNA (mtDNA)13,14. Inflammation resulting from either exhaustive exercise or mtDNA mutation is completely rescued by concurrent loss of STING, a central regulator of the type I interferon response to cytosolic DNA 15,16. The loss of dopaminergic neurons from the substantia nigra pars compacta and the motor defect observed in aged Prkn-/-;mutator mice are also rescued by loss of STING, suggesting that inflammation facilitates this phenotype. Humans with mono- and biallelic PRKN mutations also display elevated cytokines. These results support a role for PINK1- and parkin-mediated mitophagy in restraining innate immunity.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
The source backs part of the claim, not all of it — or backs it for a different population, condition or comparison.
In the citing paper
“Multiple studies have revealed that loss of PRKN and PINK1 dysregulated mitophagy and increased mitochondria stress, leading to mito-inflammation,267 which was recently suggested to be involved in PD pathology in PINK1 and PRKN deficient mice.268”
From Role of neuroinflammation in neurodegeneration development (2023) · cites this paper as [268]
Experimental — accuracy not yet measuredThe source backs part of the claim, not all of it — or backs it for a different population, condition or comparison.
In the citing paper
“Knockout of STING reverses motor deficit and neuron loss in aged PRKN knockout PD mouse model.268”
From Role of neuroinflammation in neurodegeneration development (2023) · cites this paper as [268]
Experimental — accuracy not yet measuredThe source backs part of the claim, not all of it — or backs it for a different population, condition or comparison.
In the citing paper
“peripheral dysregulation of IFN production is linked with the pathogenesis of CNS neurodegenerative conditions.”
From Interferon signaling modulates Down syndrome-associated Alzheimer’s disease pathology in a mouse model (2025) · cites this paper as [84]
Experimental — accuracy not yet measuredThe cited source says what the claim attributes to it.
In the citing paper
“Together with previous studies in models of Alzheimer’s disease53, Parkinson’s disease54,55, amyotrophic lateral sclerosis and frontotemporal dementia56, and Nieman–Pick’s disease57, our study reveals notable convergence on cGAS–STING signalling in chronic neurodegenerative conditions.”
From cGAS–STING drives ageing-related inflammation and neurodegeneration (2023) · cites this paper as [54]
In the citing paper
“Genetic and pharmacological restorations of autophagic/mitophagic clearance in animal models of these diseases ameliorate disease-defining pathologies and behavioral deficits (Fang et al., 2019; Ravikumar et al., 2004; Sliter et al., 2018).”
From NAD+ in Brain Aging and Neurodegenerative Disorders (2019) · cites this paper as Sliter et al., 2018
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
A role for mitochondria in nlrp3 inflammasome activation
Zhou, R., Yazdi, A. S., Menu, P., & Tschopp, J. (2011) · Nature · doi:10.1038/nature09663 · Cited by 5,602
Mutations in the parkin gene cause autosomal recessive juvenile parkinsonism
Kitada, T., Asakawa, S., Hattori, N., Matsumine, H., Yamamura, Y., Minoshima, S., Yokochi, M., Mizuno, Y., & Shimizu, N. (1998) · Nature · doi:10.1038/33416 · Cited by 5,227
Skyline: an open source document editor for creating and analyzing targeted proteomics experiments
MacLean, B., Tomazela, D. M., Shulman, N., Chambers, M., Finney, G. L., Frewen, B., Kern, R., Tabb, D. L., Liebler, D. C., & MacCoss, M. J. (2010) · Bioinformatics · doi:10.1093/bioinformatics/btq054 · Cited by 4,697
STING is an endoplasmic reticulum adaptor that facilitates innate immune signalling
Ishikawa, H., & Barber, G. N. (2008) · Nature · doi:10.1038/nature07317 · Cited by 3,576
Inflammasomes: mechanism of action, role in disease, and therapeutics
Guo, H., Callaway, J. B., & Ting, J. P.-Y. (2015) · Nature Medicine · doi:10.1038/nm.3893 · Cited by 3,340
Nakahira, K., Haspel, J. A., Rathinam, V. A. K., Lee, S.-J., Dolinay, T., Lam, H. C., Englert, J. A., Rabinovitch, M., Cernadas, M., Kim, H. P., et al. (2011) · Nature Immunology · doi:10.1038/ni.1980 · Cited by 3,049
Premature ageing in mice expressing defective mitochondrial DNA polymerase
Trifunovic, A., Wredenberg, A., Falkenberg, M., Spelbrink, J. N., Rovio, A. T., Bruder, C. E., Bohlooly-Y, M., Gidlöf, S., Oldfors, A., Wibom, R., et al. (2004) · Nature · doi:10.1038/nature02517 · Cited by 2,734
Regulation and function of the cGAS–STING pathway of cytosolic DNA sensing
Chen, Q., Sun, L., & Chen, Z. J. (2016) · Nature Immunology · doi:10.1038/ni.3558 · Cited by 2,333
The Roles of PINK1, Parkin, and Mitochondrial Fidelity in Parkinson’s Disease
Pickrell, A. M., & Youle, R. J. (2015) · Neuron · doi:10.1016/j.neuron.2014.12.007 · Cited by 2,310
Self-citationMitochondrial DNA mutations, oxidative stress, and apoptosis in mammalian aging
Kujoth, G. C., Hiona, A., Pugh, T. D., Someya, S., Panzer, K., Wohlgemuth, S. E., Hofer, T., Seo, A. Y., Sullivan, R., Jobling, W. A., et al. (2005) · Science · doi:10.1126/science.1112125 · Cited by 2,165
Cited by
Sorted by citations
Items 801–900 of 1,001
Mitochondria-dependent innate immunity: A potential therapeutic target in Flavivirus infection
Losarwar, S., Pancholi, B., Babu, R., & Garabadu, D. (2025) · International Immunopharmacology · doi:10.1016/j.intimp.2025.114551 · Cited by 16
Mitochondria – the CEO of the cell
Lee-Glover, L. P., Picard, M. A., & Shutt, T. E. (2025) · Journal of Cell Science · doi:10.1242/jcs.263403 · Cited by 16
Will genotype drive treatment options?
Brüggemann, N., & Klein, C. (2019) · Movement Disorders · doi:10.1002/mds.27699 · Cited by 15
Self-citationPINK1/Parkin in Neurodegenerative Disorders
Pandey, M., Saleem, S., Nautiyal, H., Pottoo, F. H., & Javed, M. N. (2020) · Advances in medical diagnosis, treatment, and care (AMDTC) book series · doi:10.4018/978-1-7998-1317-0.ch011 · Cited by 15
Delineating the Role of Mitophagy Inducers for Alzheimer Disease Patients
Wang, W., Han, R., He, H., Wang, Z., Luan, X., Li, J., Feng, L., Chen, S., Aman, Y., & Xie, C. (2021) · Aging and Disease · doi:10.14336/ad.2020.0913 · Cited by 15
Association Between Metabolic Syndrome and Mild Parkinsonian Signs Progression in the Elderly
Peng, Z., Zhou, R., Liu, D., Cui, M., Yu, K., Yang, H., Li, L., Liu, J., Chen, Y., Hong, W., et al. (2021) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2021.722836 · Cited by 15
Induction of transposable element expression is central to innate sensingPreprint
Rookhuizen, D. C., Bonté, P., Ye, M., Hoyler, T., Gentili, M., Burgdorf, N., Durand, S., Aprahamian, F., Kroemer, G., Manel, N., et al. (2021) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2021.09.10.457789 · Cited by 16
Mercado, G., Käufer, C., Richter, F., & Peelaerts, W. (2024) · Journal of Parkinson s Disease · doi:10.3233/jpd-240195 · Cited by 16
Strategies to rescue mitochondria in Parkinson’s disease: The significance of mitochondrial transfer
Liang, J., Su, Z., Su, G., Rasheed, M., Tang, S., Sunniya, H., Maazouzi, M., Cui, Y., Wang, J., Wang, X., et al. (2025) · Ageing Research Reviews · doi:10.1016/j.arr.2025.102856 · Cited by 14
Li, A., Huang, S., Cao, S., Lin, J., Zhao, L., Yu, F., Huang, M., Yang, L., Xin, J., Wen, J., et al. (2025) · EMBO Molecular Medicine · doi:10.1038/s44321-025-00323-2 · Cited by 14
Wang, B., Zhou, C., Wu, Q., Lin, P., Pu, Q., Qin, S., Gao, P., Wang, Z., Liu, Y., Arel, J., et al. (2022) · Immunology · doi:10.1111/imm.13482 · Cited by 13
Sun, R., Liu, J., Yu, M., Xia, M., Zhang, Y., Sun, X., Xu, Y., & Cui, X. (2022) · Drug Design Development and Therapy · doi:10.2147/dddt.s369111 · Cited by 14
Alternative pathways driven by STING: From innate immunity to lipid metabolism
Vila, I. K., Guha, S., Kalucka, J. M., Olagnier, D. P., & Laguette, N. (2022) · Cytokine & Growth Factor Reviews · doi:10.1016/j.cytogfr.2022.08.006 · Cited by 15
MITA/STING-mediated antiviral immunity and autoimmunity: the evolution, mechanism, and intervention
Zhong, B., & Shu, H. (2022) · Current Opinion in Immunology · doi:10.1016/j.coi.2022.102248 · Cited by 13
Thymic stromal lymphopoietin induces platelet mitophagy and promotes thrombosis in Kawasaki disease
Fu, L., MacKeigan, D. T., Gong, Q., Che, D., Xu, Y., Pi, L., Sun, C., Yu, H., Chen, K., Zhou, H., et al. (2022) · British Journal of Haematology · doi:10.1111/bjh.18531 · Cited by 14
Neuron-periphery mitochondrial stress communication in aging and diseases
Li, J., Cui, J., & Tian, Y. (2022) · Life Medicine · doi:10.1093/lifemedi/lnac051 · Cited by 14
Cell type- and region-specific translatomes in an MPTP mouse model of Parkinson's disease
Huang, Q., Chen, C., Chen, W., Cai, C., Xing, H., Li, J., Li, M., & Ma, S. (2023) · Neurobiology of Disease · doi:10.1016/j.nbd.2023.106105 · Cited by 14
Qu, J., Liu, N., Gao, L., Hu, J. M., Sun, M., & Yu, D. (2023) · Frontiers in Neuroscience · doi:10.3389/fnins.2023.1223747 · Cited by 17
The critical roles of STING in mitochondrial homeostasis
Zou, S., Wang, B., Yi, K., Su, D., Chen, Y., Li, N., & Geng, Q. (2023) · Biochemical Pharmacology · doi:10.1016/j.bcp.2023.115938 · Cited by 17
Trafficking and effect of released DNA on cGAS-STING signaling pathway and cardiovascular disease
Zhou, Z., Ouyang, C., Chen, Q., Ren, Z., Guo, X., Lei, M., Liu, C., & Yang, X. (2023) · Frontiers in Immunology · doi:10.3389/fimmu.2023.1287130 · Cited by 15
Rösing, S., Ullrich, F., Meisterfeld, S., Schmidt, F., Mlitzko, L., Croon, M., Nattrass, R. G., Eberl, N., Mahlberg, J., Schlee, M., et al. (2024) · Nature Communications · doi:10.1038/s41467-024-45535-1 · Cited by 15
Song, M., Qiang, Y., Wang, S., Shan, S., Zhang, L., Liu, C., Song, F., & Zhao, X. (2024) · Ecotoxicology and Environmental Safety · doi:10.1016/j.ecoenv.2024.116280 · Cited by 14
In sickness and in health—Type I interferon and the brain
Cao, W. (2024) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2024.1403142 · Cited by 15
Organellophagy regulates cell death:A potential therapeutic target for inflammatory diseases
Duan, Y., Yao, R.-Q., Ling, H., Zheng, L., Fan, Q. W., Li, Q., Wang, L., Zhou, Q.-Y., Wu, L.-M., Dai, X., et al. (2024) · Journal of Advanced Research · doi:10.1016/j.jare.2024.05.012 · Cited by 16
The role of mitochondria in cytokine and chemokine signalling during ageing
Kalykaki, M., Rubio‐Tomás, T., & Tavernarakis, N. (2024) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2024.111993 · Cited by 14
Ekholm‐Reed, S., Baker, R., Campos, A. R., Stouffer, D. G., Henze, M., Wolf, D. A., Loring, J. F., Thomas, E. A., & Reed, S. I. (2019) · Communications Biology · doi:10.1038/s42003-019-0366-x · Cited by 14
Prevention of ribosome collision-induced neuromuscular degeneration by SARS CoV-2–encoded Nsp1
Wang, X., Rimal, S., Tantray, I., Geng, J., Bhurtel, S., Khaket, T. P., Li, W., Han, Z., & Lu, B. (2022) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2202322119 · Cited by 14
The STING Signaling: A Novel Target for Central Nervous System Diseases
Song, M. S., Ren, J., Zhu, Z., Yi, Z., Wang, C., Liang, L., Tian, J., Mao, G., Mao, G., & Chen, M. (2025) · Cellular and Molecular Neurobiology · doi:10.1007/s10571-025-01550-4 · Cited by 13
Microvesicles carrying EV71 virions cross BBB through endocytic pathway to induce brain injury
Tian, X., Liu, B., Li, L., Yuan, M., You, Q., Zhang, R., Chen, D., Cheng, M., Zheng, N., He, M., et al. (2025) · Cell Communication and Signaling · doi:10.1186/s12964-025-02195-y · Cited by 14
Advances in mesenchymal stem cells and their derivatives for promoting peripheral nerve regeneration
Wei, S., Dong, J., Hu, Q., Bai, J., Gao, X., Shan, H., Sheng, L., Dai, J., Tao, L., Yan, B., et al. (2025) · Burns & Trauma · doi:10.1093/burnst/tkaf027 · Cited by 14
Mitophagy in the mechanisms of treatment resistance in solid tumors
Yan, X. S., Ding, H., Ren, M., & Zang, L. (2025) · Oncology Reviews · doi:10.3389/or.2025.1607983 · Cited by 13
IRGM1, a guardian of mitochondrial DAMP–mediated autoinflammation
Kaufman, B. A., & Mora, A. L. (2021) · Nature Immunology · doi:10.1038/s41590-021-00877-6 · Cited by 13
The Role of Rab Proteins in Mitophagy: Insights into Neurodegenerative Diseases
Shafique, A., Brughera, M., Lualdi, M., & Alberio, T. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24076268 · Cited by 15
de Fàbregues, O., Sellés, M. C., Ramos-Vicente, D., Roch, G., Vila, M., & Bové, J. (2023) · Neurobiology of Disease · doi:10.1016/j.nbd.2023.106308 · Cited by 12
Tian, G., Huang, C., Li, Z., Lü, Z., Feng, C., Yu, Z., Li, G., Liu, P., Hu, G., Gao, X., et al. (2023) · Veterinary Microbiology · doi:10.1016/j.vetmic.2023.109891 · Cited by 13
What Can Inflammation Tell Us about Therapeutic Strategies for Parkinson’s Disease?
Xue, J., Tao, K., Wang, W., & Wang, X. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25031641 · Cited by 19
Mitochondria: a breakthrough in combating rheumatoid arthritis
Li, S., Huo, C., Liu, A., & Zhu, Y. (2024) · Frontiers in Medicine · doi:10.3389/fmed.2024.1439182 · Cited by 13
Therapeutic Targets in Innate Immunity to Tackle Alzheimer’s Disease
Serradas, M. L., Ding, Y., Martorell, P., Kulińska, I., & Castro‐Gomez, S. (2024) · Cells · doi:10.3390/cells13171426 · Cited by 16
Skeldon, A. M., Wang, L., Sgarioto, N., Beveridge, R. E., Chan, S. Y. T., Dorich, S., Dumais, V., Fradet, N., Gaudreault, S., LeGros, P., et al. (2025) · Communications Chemistry · doi:10.1038/s42004-025-01481-7 · Cited by 13
Ryan, T. A., & Tumbarello, D. A. (2021) · Neural Regeneration Research · doi:10.4103/1673-5374.306074 · Cited by 13
Wang, X., Liu, Y., Han, X., Zou, G., Zhu, W., Shen, H. C., & Liu, H. (2021) · Bioorganic & Medicinal Chemistry Letters · doi:10.1016/j.bmcl.2021.128101 · Cited by 13
Autophagic regulation of neuroinflammation in ischemic stroke
Zheng, Y., Zhou, Z., Han, F., & Chen, Z. (2021) · Neurochemistry International · doi:10.1016/j.neuint.2021.105114 · Cited by 13
Advances in Human Mitochondria-Based Therapies
Zhong, G., Venkatesan, J. K., Madry, H., & Cucchiarini, M. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms24010608 · Cited by 13
Mitochondrial DNA in innate immune responses against infectious diseases
Das, P., & Chakrabarti, O. (2020) · Biochemical Society Transactions · doi:10.1042/bst20200687 · Cited by 12
Elzinga, S. E., Koubek, E. J., Hayes, J. M., Carter, A., Mendelson, F. E., Webber‐Davis, I. F., Lentz, S. I., & Feldman, E. L. (2023) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2023.1167688 · Cited by 12
The many faces of the zinc finger protein 335 in brain development and immune system
Li, D., Quan, Z., Ni, J., Li, H., & Qing, H. (2023) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2023.115257 · Cited by 11
Critical roles of parkin and PINK1 in coxsackievirus B3-induced viral myocarditis
Jin, U., Park, S., Lee, B. G., Kim, J.-B., Kim, J.-B., Joe, E.-H., Woo, H. G., & Park, S. M. (2023) · Microbes and Infection · doi:10.1016/j.micinf.2023.105211 · Cited by 13
Alterations of PINK1-PRKN signaling in mice during normal aging
Baninameh, Z., Watzlawik, J. O., Hou, X., Richardson, T., Kurchaba, N. W., Yan, T., Florio, D. N. D., Fairweather, D., Kang, L., Nguyen, J. H., et al. (2024) · Autophagy Reports · doi:10.1080/27694127.2024.2434379 · Cited by 12
Yang, F., Gao, Y., Xie, S., Yang, W., Wang, Q., Ye, W., Sun, L., Zhou, J., & Feng, X. (2025) · Food & Function · doi:10.1039/d4fo06043a · Cited by 12
Song, J., Zhang, L., Li, C., Maimaiti, M., Sun, J. P., Hu, J., Li, L., Zhang, X., Wang, C., & Hu, H. (2022) · Computational and Structural Biotechnology Journal · doi:10.1016/j.csbj.2022.04.002 · Cited by 12
Harutyunyan, T. A. (2023) · Mutagenesis · doi:10.1093/mutage/gead031 · Cited by 12
Bao, H., Zhang, Q., Li, Y., & Nie, C. (2023) · Journal of Biochemical and Molecular Toxicology · doi:10.1002/jbt.23530 · Cited by 12
Self-citationThe UAF1–USP1 Deubiquitinase Complex Stabilizes cGAS and Facilitates Antiviral Responses
Yu, Z., Li, T., Ma, C., Song, H., Wang, J., Chai, L., Wang, C., Wang, M., Wang, C., Yan, R., et al. (2023) · The Journal of Immunology · doi:10.4049/jimmunol.2200462 · Cited by 11
Post-translational modification and mitochondrial function in Parkinson’s disease
Luo, S., Wang, D., & Zhang, Z. (2024) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2023.1329554 · Cited by 14
Self-citationIslam, M. N., Mishra, V. K., Munalisa, R., Parveen, F., Ali, S. F., Akter, K., Ahmed, T., Ho, T., & Huang, C. (2024) · Molecular & Cellular Toxicology · doi:10.1007/s13273-023-00424-4 · Cited by 11
Zong, Y., Yang, Y., Zhao, J., Li, L., Luo, D., Hu, J., Gao, Y., Xie, X., Shen, L., Chen, S., et al. (2024) · Computers in Biology and Medicine · doi:10.1016/j.compbiomed.2024.108511 · Cited by 13
Wang, K., He, L., Liu, X., & Wu, M. (2024) · Chemosphere · doi:10.1016/j.chemosphere.2024.142651 · Cited by 11
TBK1-Zyxin signaling controls tumor-associated macrophage recruitment to mitigate antitumor immunity
Zhou, R., Wang, M., Li, X., Liu, Y., Yao, Y., Wang, A., Chen, C., Zhang, Q. Y., Wu, Q., Zhang, Q., et al. (2024) · The EMBO Journal · doi:10.1038/s44318-024-00244-9 · Cited by 10
Therapeutic potential of Parkin and its regulation in Parkinson’s disease
Safreena, N., Nair, I. C., & Chandra, G. (2024) · Biochemical Pharmacology · doi:10.1016/j.bcp.2024.116600 · Cited by 11
Li, L.-J., Liang, S., Sun, X., Zhu, J., Niu, X.-Y., Du, X.-Y., Huang, Y., & Liu, R. (2025) · Journal of Neuroinflammation · doi:10.1186/s12974-025-03333-6 · Cited by 14
The mitochondrial LONP1 protease: molecular targets and role in pathophysiology
Tang, P. C., Qun, Z., Li, Y., Wang, J., & She, M. (2025) · Molecular Biology Reports · doi:10.1007/s11033-025-10500-8 · Cited by 12
Self-citationTherapeutic modulation of cGAS-STING pathway in neurodegeneration
Sharma, V., Verma, R., Sharma, P., & Singh, T. G. (2025) · Brain Research · doi:10.1016/j.brainres.2025.149784 · Cited by 12
Deciphering the dual role and prognostic potential of PINK1 across cancer types
Radin, D., Dai, K., & Leonardi, D. (2020) · Neural Regeneration Research · doi:10.4103/1673-5374.295314 · Cited by 10
Ma, H., Gai, C., Chai, Y., Feng, W.-D., Cheng, C., Zhang, J., Zhang, Y., Yang, L., Guo, Z., Gao, Y.-S., et al. (2020) · Frontiers in Pharmacology · doi:10.3389/fphar.2020.577017 · Cited by 10
Leaked Mitochondrial C1QBP Inhibits Activation of the DNA Sensor cGAS
Song, K., Wu, Y., Fu, B., Wang, L., Hao, W., Hua, F., Sun, Y., Dorf, M. E., & Li, S. (2021) · The Journal of Immunology · doi:10.4049/jimmunol.2100392 · Cited by 11
In Vivo Investigation of Glucose Metabolism in Idiopathic and PRKN‐Related Parkinson's Disease
Borsche, M., Märtens, A., Hörmann, P., Brückmann, T., Lohmann, K., Tunç, S., Klein, C., Hiller, K., & Balck, A. (2023) · Movement Disorders · doi:10.1002/mds.29333 · Cited by 10
Self-citationEdmunds, L. R., Huckestein, B. R., Kahn, M., Zhang, D., Chu, Y., Zhang, Y., Wendell, S. G., Shulman, G. I., & Jurczak, M. J. (2019) · Physiological Reports · doi:10.14814/phy2.14281 · Cited by 11
Autophagy in the normal and diseased cornea
Teixeira, K. L. D., Gh., M. S., Romano, J., Norouzi, F., & Laurie, G. W. (2022) · Experimental Eye Research · doi:10.1016/j.exer.2022.109274 · Cited by 11
Zhong, H., Pan, R., Ouyang, Y., Xiao, T., Gu, W., Yang, H., Wang, H., Li, H., Peng, T., & Chen, P. (2026) · Molecular Cancer · doi:10.1186/s12943-026-02571-3 · Cited by 13
A Mitochondrial Perspective on Noncommunicable Diseases
Zheng, Y., Zhang, J., Zhu, X., Wei, Y., Zhao, W., Si, S., & Li, Y. (2023) · Biomedicines · doi:10.3390/biomedicines11030647 · Cited by 11
Self-citationMembrane traffic governs the STING inflammatory signalling
Taguchi, T. (2023) · The Journal of Biochemistry · doi:10.1093/jb/mvad064 · Cited by 11
Mitochondrial dysfunction at the cornerstone of inflammatory exacerbation in aged macrophages
Maurmann, R. M., Schmitt, B. L., Mosalmanzadeh, N., & Pence, B. D. (2023) · Exploration of Immunology · doi:10.37349/ei.2023.00112 · Cited by 12
Targeting Mitophagy as a Potential Therapeutic Approach for Age‐Related Bone Diseases
Zhang, K., Li, Q., Zhang, Y., Nuerlan, G., Li, Y., Mao, J., & Gong, S. (2024) · Advanced Therapeutics · doi:10.1002/adtp.202400078 · Cited by 10
Self-citationNanoparticle targeting cGAS-STING signaling in disease therapy
Zhou, L., Huang, Y., Wu, Y., & Tang, S. (2024) · Nano Research · doi:10.1007/s12274-024-6714-x · Cited by 11
Kong, L., Li, S., Fu, Y., Cai, Q., Zhai, Z., Liang, J., & Ma, T. (2025) · Food and Chemical Toxicology · doi:10.1016/j.fct.2025.115355 · Cited by 11
mTORC1 syndrome (TorS): unifying paradigm for PASC, ME/CFS and PAIS
Bar‐Tana, J. (2025) · Journal of Translational Medicine · doi:10.1186/s12967-025-06220-z · Cited by 10
Urolithin A alleviates radiation pneumonitis by activating PINK1/PRKN-mediated Mitophagy
Zhang, A., Luo, S., Li, P., Meng, L., Huang, L., Cheng, H., Zhao, C., Tu, H., & Gong, X. (2025) · International Immunopharmacology · doi:10.1016/j.intimp.2025.114671 · Cited by 10
Ding, J., Hu, H., Zhu, Y., Xu, X., Yin, B., Yang, M., Zhou, H., Huang, T., Li, M., Kou, Y., et al. (2025) · Journal for ImmunoTherapy of Cancer · doi:10.1136/jitc-2025-011776 · Cited by 10
Histone deacetylase 6: A new player in oxidative stress‑associated disorders and cancers (Review)
Qu, F., Zhao, Q., & Jin, Y. (2025) · International Journal of Molecular Medicine · doi:10.3892/ijmm.2025.5578 · Cited by 11
Guo, M., Li, B., Feng, G., Su, X., Wang, X., Han, X., Yang, M., Bai, L., Zhu, X., Fan, H., et al. (2023) · Materials & Design · doi:10.1016/j.matdes.2023.111808 · Cited by 10
Acosta-Galeana, I., Hernandez-Martinez, R., Reyes-Cruz, T., Chiquete, E., & Buendia, J. D. J. A. (2023) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2023.1193636 · Cited by 10
Animal Models for the Study of Nucleic Acid Immunity: Novel Tools and New Perspectives
Vila, I. K., Frétaud, M., Vlachakis, D., Laguette, N., & Langevin, C. (2020) · Journal of Molecular Biology · doi:10.1016/j.jmb.2020.08.016 · Cited by 11
Regioselectivity of aminomethylation in 3-acetyl-7-hydroxycoumarins: Mannich bases and Betti bases
Gao, F., Tao, D., Ju, C., Yang, B., Bao, X.-Q., Zhang, D., Zhang, T., & Li, L. (2021) · New Journal of Chemistry · doi:10.1039/d1nj01584b · Cited by 10
Supramolecular organizing centers at the interface of inflammation and neurodegeneration
Sušjan, P., Ramuta, T. Ž., Boršić, E., Orehek, S., & Hafner‐Bratkovič, I. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.940969 · Cited by 11
Progress in Parkinson's disease animal models of genetic defects: Characteristics and application
Zhang, C., Chen, S., Li, X., Xu, Q., Lin, Y., Lin, F., Yuan, M., Zi, Y., & Cai, J. (2022) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2022.113768 · Cited by 9
Parkinson’s disease-associated genetic variants synergistically shape brain networksPreprint
Chen, Z., Wu, B., Li, G., Zhou, L., Zhang, L., & Liu, J. (2022) · medRxiv · doi:10.1101/2022.12.25.22283938 · Cited by 10
The odyssey of cGAS: From cytosol to nucleus
Hao, W., Li, W., Wang, L., & Li, S. (2023) · Cytokine & Growth Factor Reviews · doi:10.1016/j.cytogfr.2023.09.004 · Cited by 11
Mitophagy in yeast: known unknowns and unknown unknowns
Abeliovich, H. (2023) · Biochemical Journal · doi:10.1042/bcj20230279 · Cited by 11
The PM20D1-NADA pathway protects against Parkinson’s disease
Yang, Y., Chen, S., Zhang, L., Zhang, G., Liu, Y., Li, Y., Zou, L., Meng, L., Tian, Y., Dai, L., et al. (2024) · Cell Death and Differentiation · doi:10.1038/s41418-024-01356-9 · Cited by 9
Self-citationParkin activates innate immunity and promotes antitumor immune responses
Perego, M., Yeon, M., Agarwal, E., Milcarek, A. T., Bertolini, I., Camisaschi, C., Ghosh, J. C., Tang, H., Grandvaux, N., Ruscetti, M. A., et al. (2024) · Journal of Clinical Investigation · doi:10.1172/jci180983 · Cited by 9
Yan, Q., Gao, Y., Wu, D., Liu, Q.-Q., Su, C., Liu, G., Yang, L., Zhao, M., & Yao, J. (2024) · Frontiers in Pharmacology · doi:10.3389/fphar.2024.1509482 · Cited by 10
Guan, X., Li, H., Zhang, L., & Zhi, H. (2025) · Inflammation Research · doi:10.1007/s00011-025-01993-x · Cited by 10
How does autophagy impact neurological function?
Fleming, A., López, A., Rob, M., Ramakrishna, S., Park, S. J., Li, X., & Rubinsztein, D. C. (2025) · The Neuroscientist · doi:10.1177/10738584251324459 · Cited by 9
Miro1: A potential target for treating neurological disorders
Zeng, L., Yang, J., Zhang, C.-H., Zhu, J., Zhong, S., Liu, X., Xie, H., Wang, L., Chen, L., Zhong, M., et al. (2025) · Neuroscience · doi:10.1016/j.neuroscience.2025.05.019 · Cited by 9
Solving the Amyloid Paradox: Unveiling the Complex Pathogenicity of Amyloid Fibrils
Sulatsky, M. I., Stepanenko, O. V., Stepanenko, O. V., & Sulatskaya, A. I. (2025) · Aggregate · doi:10.1002/agt2.70078 · Cited by 9
Mitochondrial DNA: leakage, recognition and associated human diseases
Takamatsu, H. (2025) · The Journal of Biochemistry · doi:10.1093/jb/mvaf037 · Cited by 9
The STING pathway drives noninflammatory neurodegeneration in NGLY1 deficiency
Yang, K., Torres-Ramirez, G., Dobbs, N., Han, J., Asahina, M., Fujinawa, R., Song, K., Liu, Y., Lin, W., Oviedo, A., et al. (2025) · The Journal of Experimental Medicine · doi:10.1084/jem.20242296 · Cited by 9
Stressful situations: Molecular insights on mitochondrial quality control pathways
Romanelli, S., & Trempe, J. (2025) · Journal of Biological Chemistry · doi:10.1016/j.jbc.2025.110483 · Cited by 11
Deficiency of cGAS signaling protects against sepsis-associated encephalopathy
Tan, C., Xu, F., Xie, Q., & Li, F. (2021) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2021.09.003 · Cited by 9
Parkin Inhibits RANKL-Induced Osteoclastogenesis and Ovariectomy-Induced Bone Loss
Hou, W., Chen, M., Ye, C., Chen, E., Li, W., & Zhang, W. (2022) · Biomolecules · doi:10.3390/biom12111602 · Cited by 9
Metadata
- Authors
- Sliter, D. A., Martinez, J., Hao, L., Chen, X., Sun, N., Fischer, T. D., Burman, J. L., Li, Y., Zhang, Z., Narendra, D. P., Cai, H., Borsche, M., Klein, C., & Youle, R. J.
- Affiliations
- National Institutes of Health (US)
- University of Lübeck (DE)
- Corresponding author
- Youle, Richard J.
- ORCID
- Venue
- Nature
- Published
- 2018-08-22
- Volume
- 561
- Issue
- 7722
- Pages
- 258-262
- ISSN
- 0028-0836 (ISSN-L)
- 1476-4687
- PMC
- PMC7362342
- OpenAlex
- W2887997888
- Cited by
- 1,287
- References
- 39
- Citations by year
- 2026: 68 · 2025: 177 · 2024: 190 · 2023: 185 · 2022: 180 · 2021: 197 · 2020: 157 · 2019: 115 · 2018: 16
- FWCI
- 82.18
- Type
- journal article
- Language
- en
- Status
- Retracted
- Open access
- green
- www.ncbi.nlm.nih.gov
- Licence
- Locations
- Nature (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- RePEc: Research Papers in Economics (submittedVersion)
- Funders
- National Institutes of Health
- National Institute on Alcohol Abuse and Alcoholism (DFG FOR2488)
- National Institute of Neurological Disorders and Stroke (Z01NS002859, ZIANS002859)
- National Institute of Environmental Health Sciences (1ZIAES10328601, ZIAES103286)
- Topics
- Health Sciences › Medicine › Clinical Neurology › Parkinson's Disease Mechanisms and Treatments
- Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
- Life Sciences › Immunology and Microbiology › Immunology › interferon and immune responses
- Keywords
- Parkin, PINK1, STING, mitophagy, Parkinson's disease, neuroinflammation, mitochondrial DNA mutations, exhaustive exercise, innate immunity, dopaminergic neurons, substantia nigra pars compacta, motor impairment, type I interferon response, cytosolic DNA, E3 ubiquitin ligase
- MeSH terms
- Alarmins, STING Protein, PTEN-Induced Putative Kinase, Animals, DNA, Mitochondrial, Humans, Immunity, Innate, Inflammation, Membrane Proteins, Mice, Inbred C57BL, Parkinson Disease, Physical Conditioning, Animal, Protein Kinases, Stress, Physiological, Ubiquitin-Protein Ligases, Mice, Receptor, Interferon alpha-beta, Mitophagy
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
