The DOI matches its Crossref record; 34 of the 35 references it cites were found in a registry or an index.
Coupling of bone resorption and formation by RANKL reverse signalling
Abstract
Receptor activator of nuclear factor-kappa B (RANK) ligand (RANKL) binds RANK on the surface of osteoclast precursors to trigger osteoclastogenesis. Recent studies have indicated that osteocytic RANKL has an important role in osteoclastogenesis during bone remodelling; however, the role of osteoblastic RANKL remains unclear. Here we show that vesicular RANK, which is secreted from the maturing osteoclasts, binds osteoblastic RANKL and promotes bone formation by triggering RANKL reverse signalling, which activates Runt-related transcription factor 2 (Runx2). The proline-rich motif in the RANKL cytoplasmic tail is required for reverse signalling, and a RANKL(Pro29Ala) point mutation reduces activation of the reverse signalling pathway. The coupling of bone resorption and formation is disrupted in RANKL(Pro29Ala) mutant mice, indicating that osteoblastic RANKL functions as a coupling signal acceptor that recognizes vesicular RANK. RANKL reverse signalling is therefore a potential pharmacological target for avoiding the reduced bone formation associated with inhibition of osteoclastogenesis.
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In the citing paper
“However, a recent study demonstrated that vesicular RANK binds to RANKL on the osteoblast surface (and possibly on osteocytes) and triggers the mTOR-dependent stimulation of Runx2238 (Fig. 5).”
From Bone remodeling: an operational process ensuring survival and bone mechanical competence (2022) · cites this paper as [238]
In the citing paper
“This finding suggests a previously unknown scenario in which actively resorbing osteoclasts promote the differentiation of neighboring osteoblast precursors into mature bone-forming cells.”
From Bone remodeling: an operational process ensuring survival and bone mechanical competence (2022) · cites this paper as [238]
In the citing paper
“RANKL monomers expressed on osteoblasts are not activated by RANK238 or by OPG, as indicated by the deletion of RANK or OPG failing to reduce bone formation.245”
From Bone remodeling: an operational process ensuring survival and bone mechanical competence (2022) · cites this paper as [238]
In the citing paper
“The physiological importance of the messages shuttled by EVs has been confirmed by the observation that osteoblasts do not efficiently deposit bone ECM when RANKL reverse signaling is suppressed.238”
From Bone remodeling: an operational process ensuring survival and bone mechanical competence (2022) · cites this paper as [238]
In the citing paper
“RANKL clustering on early osteoblasts may therefore be required for the activation of RANKL reverse signaling in resorption lacunae, similar to the effect of shuttling RANK in osteoclast EVs during bone remodeling (Fig. 5) or that of an anti-RANKL antibody-containing leucine zippers, which induce trimer formation.238”
From Bone remodeling: an operational process ensuring survival and bone mechanical competence (2022) · cites this paper as [238]
In the citing paper
“Osteosarcoma tumours arise during puberty, when many progenitor cells undergo differentiation in response to signalling via, for example, FGF2 (ref.96 ), RANKL 96,97 and IGF1 (ref.98 ).”
From Osteosarcoma (2022) · cites this paper as [97]
Citations
Cites
Ceramide Triggers Budding of Exosome Vesicles into Multivesicular Endosomes
Trajković, K., Hsu, C., Chiantia, S., Rajendran, L., Wenzel, D., Wieland, F., Schwille, P., Brügger, B., & Simons, M. (2008) · Science · doi:10.1126/science.1153124 · Cited by 3,760
2016 update of the PRIDE database and its related tools
Vizcaíno, J. A., Csordás, A., del‐Toro, N., Dianes, J. A., Griss, J., Lavidas, I., Mayer, G., Pérez‐Riverol, Y., Reisinger, F., Ternent, T., et al. (2015) · Nucleic Acids Research · doi:10.1093/nar/gkv1145 · Cited by 3,440
OPGL is a key regulator of osteoclastogenesis, lymphocyte development and lymph node organogenesis.
Kong, Y.-Y., Yoshida, H., Sarosi, I., Tan, H.-L., Timms, E., Capparelli, C., Morony, S., Oliveira-dos-Santos, A. J., Van, G., Itie, A., et al. (1999) · Nature · doi:10.1038/16852 · Cited by 3,351
Self-citationDempster, D. W., Compston, J. E., Drezner, M. K., Glorieux, F. H., Kanis, J. A., Malluche, H., Meunier, P. J., Ott, S. M., Recker, R. R., & Parfitt, A. M. (2013) · Journal of Bone and Mineral Research · doi:10.1002/jbmr.1805 · Cited by 2,543
Suda, T., Takahashi, N., Udagawa, N., Jimi, E., Gillespie, M. T., & Martin, T. J. (1999) · Endocrine Reviews · doi:10.1210/edrv.20.3.0367 · Cited by 2,345
Self-citationBiology of Bone Tissue: Structure, Function, and Factors That Influence Bone Cells
Florencio-Silva, R., Sasso, G. R. D. S., Sasso-Cerri, E., Simões, M. J., & Cerri, P. S. (2015) · BioMed Research International · doi:10.1155/2015/421746 · Cited by 2,044
Evidence for osteocyte regulation of bone homeostasis through RANKL expression
Nakashima, T., Hayashi, M., Fukunaga, T., Kurata, K., Oh-hora, M., Feng, J. Q., Bonewald, L. F., Kodama, T., Wutz, A., Wagner, E. F., et al. (2011) · Nature Medicine · doi:10.1038/nm.2452 · Cited by 1,778
Self-citationMatrix-embedded cells control osteoclast formation
Xiong, J., Onal, M., Jilka, R. L., Weinstein, R. S., Manolagas, S. C., & O'Brien, C. A. (2011) · Nature Medicine · doi:10.1038/nm.2448 · Cited by 1,304
EV-TRACK: transparent reporting and centralizing knowledge in extracellular vesicle research
EV-TRACK Consortium, Van Deun, J., Mestdagh, P., Agostinis, P., Akay, Ö., Anand, S., Anckaert, J., Martinez, Z. A., Baetens, T., Beghein, E., et al. (2017) · Nature Methods · doi:10.1038/nmeth.4185 · Cited by 1,284
Regulation of osteoblast differentiation by transcription factors
Komori, T. (2006) · Journal of Cellular Biochemistry · doi:10.1002/jcb.20958 · Cited by 1,027
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Items 101–200 of 560
Pieters, B. C. H., Cappariello, A., van den Bosch, M. H. J., van Lent, P. L. E. M., Teti, A. M., & van de Loo, F. A. J. (2019) · Frontiers in Immunology · doi:10.3389/fimmu.2019.01901 · Cited by 50
Takafuji, Y., Tatsumi, K., Ishida, M., Kawao, N., Okada, K., & Kaji, H. (2020) · Bone · doi:10.1016/j.bone.2020.115298 · Cited by 50
Qu, X., Sun, Z., Wang, Y., & Ong, H. S. (2021) · PeerJ · doi:10.7717/peerj.12510 · Cited by 48
[Retracted] Exosome: Function and Application in Inflammatory Bone Diseases
Hu, Y., Wang, Y., Chen, T., Hao, Z., Cai, L., & Li, J. (2021) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2021/6324912 · Cited by 49
RetractedEpigenetic regulation of bone remodeling and bone metastasis
Sharma, G., Sultana, A., Abdullah, K. M., Pothuraju, R., Nasser, M. W., Batra, S. K., & Siddiqui, J. A. (2022) · Seminars in Cell and Developmental Biology · doi:10.1016/j.semcdb.2022.11.002 · Cited by 49
H‐type blood vessels participate in alveolar bone remodeling during murine tooth extraction healing
Yan, Z., Wang, X., Zhou, Y., Wang, Z., Wang, Z., Jin, L., Yin, H., Xia, K., Tan, Y., Feng, S., et al. (2020) · Oral Diseases · doi:10.1111/odi.13321 · Cited by 46
Signaling pathways affected by mutations causing osteogenesis imperfecta
Etich, J., Rehberg, M., Eckes, B., Sengle, G., Semler, O., & Zaucke, F. (2020) · Cellular Signalling · doi:10.1016/j.cellsig.2020.109789 · Cited by 50
Macrophages as Emerging Key Players in Mitochondrial Transfers
Pang, Y., Zhang, C., & Gao, J. (2021) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2021.747377 · Cited by 47
Evidence of the static magnetic field effects on bone-related diseases and bone cells
Yang, J., Feng, Y., Li, Q., & Zeng, Y. H. (2022) · Progress in Biophysics and Molecular Biology · doi:10.1016/j.pbiomolbio.2022.11.006 · Cited by 45
The hidden secrets of soluble RANKL in bone biology
Elango, J., Bao, B., & Wu, W. (2021) · Cytokine · doi:10.1016/j.cyto.2021.155559 · Cited by 47
Strategies of Macrophages to Maintain Bone Homeostasis and Promote Bone Repair: A Narrative Review
Hu, Y., Huang, J., Chen, C., Wang, Y., Hao, Z., Chen, T., Wang, J., & Li, J. (2022) · Journal of Functional Biomaterials · doi:10.3390/jfb14010018 · Cited by 44
Chen, L., Zhang, Z., & Liu, X. (2024) · Journal of Inflammation Research · doi:10.2147/jir.s492415 · Cited by 44
Wu, H., Li, Y., Shi, L., Liu, Y., & Shen, J. Q. (2025) · Advanced Healthcare Materials · doi:10.1002/adhm.202403206 · Cited by 43
Liu, T., Li, B., Zheng, X., Jiang, S., Zhou, Z., Xu, W., Zheng, H., Wang, C.-D., Zhang, X., & Jiang, L. (2019) · Frontiers in Endocrinology · doi:10.3389/fendo.2019.00360 · Cited by 42
Takafuji, Y., Tatsumi, K., Kawao, N., Okada, K., Muratani, M., & Kaji, H. (2020) · Calcified Tissue International · doi:10.1007/s00223-020-00772-6 · Cited by 42
Liu, L., Chen, H., Zhao, X., Han, Q., Xu, Y., Liu, Y., Zhang, A., Li, Y., Zhang, W., Chen, B., et al. (2024) · Materials Today Bio · doi:10.1016/j.mtbio.2024.101410 · Cited by 42
RANKL and RANK in extracellular vesicles: surprising new players in bone remodeling
Holliday, L. S., Patel, S. S., & Jr Rody Wellington, J. (2021) · Extracellular Vesicles and Circulating Nucleic Acids · doi:10.20517/evcna.2020.02 · Cited by 41
Engineered exosomes: a promising strategy for tendon-bone healing
Qin, B., Bao, D., Liu, Y., Zeng, S., Deng, K., Liu, H., & Fu, S. (2023) · Journal of Advanced Research · doi:10.1016/j.jare.2023.11.011 · Cited by 42
Duan, L., Liang, Y., Xu, X. G., Wang, J., Li, X., Sun, D., Deng, Z., Li, W., & Wang, D. (2020) · Arthritis Research & Therapy · doi:10.1186/s13075-020-02374-x · Cited by 40
Chondroprotection and Molecular Mechanism of Action of Phytonutraceuticals on Osteoarthritis
Сухих, С. А., Носкова, С., Ivanova, S. A., Ulrikh, E., Izgaryshev, A., & Babich, O. (2021) · Molecules · doi:10.3390/molecules26082391 · Cited by 40
Rodrigues, J., Sarmento, B. F. C. C., & Pereira, C. L. (2022) · In vitro models · doi:10.1007/s44164-022-00008-x · Cited by 41
Lu, S., Cao, J., Song, Z., Gong, F., Yang, P., Ge, J., He, Y., Han, Z., Hou, G., Zhang, Z., et al. (2025) · Nature Communications · doi:10.1038/s41467-025-63456-5 · Cited by 39
Gong, X., Sun, S., Yang, Y., Huang, X., Gao, X., Jin, A., Xu, H., Wang, X., Liu, Y., Liu, J., et al. (2020) · Journal of Bone and Mineral Research · doi:10.1002/jbmr.4744 · Cited by 38
Crosstalk between muscle and bone
Kaji, H. (2023) · Journal of Bone and Mineral Metabolism · doi:10.1007/s00774-023-01472-5 · Cited by 38
Role of Biomolecules in Osteoclasts and Their Therapeutic Potential for Osteoporosis
Zhao, X., Patil, S., Xu, F., Lin, X., & Qian, A. (2021) · Biomolecules · doi:10.3390/biom11050747 · Cited by 38
Park‐Min, K., & Lorenzo, J. A. (2022) · Bone · doi:10.1016/j.bone.2022.116576 · Cited by 39
Balanta‐Melo, J., Torres‐Quintana, M. A., Bemmann, M., Vega, C., González, C., Kupczik, K., Toro‐Ibacache, V., & Buvinic, S. (2018) · Journal of Oral Rehabilitation · doi:10.1111/joor.12747 · Cited by 37
Liu, J., Tang, Y., Yang, W., Tao, B., He, Y., Shen, X., Shen, T., Lin, C., & Cai, K. (2019) · Biomaterials Science · doi:10.1039/c8bm01611a · Cited by 38
Phan, Q. T., Tan, W. H., Liu, R., Sundaram, S., Buettner, A., Kneitz, S., Cheong, B., Vyas, H., Mathavan, S., Schartl, M., et al. (2020) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2006093117 · Cited by 37
Tamura, T., Yoshioka, Y., Sakamoto, S., Ichikawa, T., & Ochiya, T. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21186680 · Cited by 37
Orthodontic retention: what's on the horizon?
Littlewood, S., Dalci, O., Dolce, C., Holliday, L. S., & Naraghi, S. (2021) · BDJ · doi:10.1038/s41415-021-2937-8 · Cited by 36
Cell surface-bound La protein regulates the cell fusion stage of osteoclastogenesis
Whitlock, J. M., Leikina, E., Melikov, K., de Castro, L. F., Mattijssen, S., Maraia, R. J., Collins, M. T., & Chernomordik, L. (2023) · Nature Communications · doi:10.1038/s41467-023-36168-x · Cited by 36
Ma, J., Zhu, L., Zhou, Z., Song, T., Yang, L., Xu, Y., Chen, A., & Ye, T. W. (2020) · Cell Proliferation · doi:10.1111/cpr.12955 · Cited by 35
Niu, Y., Yang, H., Yu, Z., Gao, C., Ji, S., Yan, J., Han, L., Huo, Q., Xu, M. J., & Liu, Y. (2022) · ACS Nano · doi:10.1021/acsnano.1c08269 · Cited by 35
Teissier, T., Temkin, V., Pollak, R. D., & Cox, L. S. (2022) · Frontiers in Physiology · doi:10.3389/fphys.2022.812157 · Cited by 35
HSP90β promotes osteoclastogenesis by dual-activation of cholesterol synthesis and NF-κB signaling
Cheng, H.-M., Xing, M., Zhou, Y.-P., Zhang, W., Liu, Z., Li, L., Zheng, Z., Ma, Y., Li, P., Liu, X., et al. (2023) · Cell Death & Differentiation · doi:10.1038/s41418-022-01071-3 · Cited by 34
Traditional Chinese medicine in osteoporosis: from pathogenesis to potential activity
Cao, G., Hu, S., Ning, Y., Dou, X., Ding, C., Wang, L., Wang, Z., Sang, X., Yang, Q., Shi, J., et al. (2024) · Frontiers in Pharmacology · doi:10.3389/fphar.2024.1370900 · Cited by 34
Autophagy-dependent mitochondrial function regulates osteoclast differentiation and maturation
Aoki, S., Shimizu, K., & Ito, K. (2020) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2020.04.155 · Cited by 34
Self-citationWeivoda, M. M., Lee, S., & Monroe, D. G. (2020) · Bone · doi:10.1016/j.bone.2020.115757 · Cited by 34
Muraca, M., & Cappariello, A. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21228682 · Cited by 35
Research progress of the mechanisms and applications of ginsenosides in promoting bone formation
Li, Z., Li, Y., Liu, C., Gu, Y., & Han, G. (2024) · Phytomedicine · doi:10.1016/j.phymed.2024.155604 · Cited by 33
Meng, B., Wu, D., Cheng, Y., Huang, P., Liu, Y., Gan, L., Liu, C., & Cao, Y. (2020) · Scandinavian Journal of Immunology · doi:10.1111/sji.12874 · Cited by 33
Nakazawa, Y., Nishiyama, N., Koizumi, H., Kanemaru, K., Nakahashi-Oda, C., & Shibuya, A. (2021) · eLife · doi:10.7554/elife.61999 · Cited by 33
Wang, Y., Mei, X., Bian, Y., Hu, T., Weng, X., Liang, R., & Wei, M. (2020) · Nanoscale · doi:10.1039/d0nr03387a · Cited by 32
Simão, M., & Cancela, M. L. (2021) · Biochemical Society Transactions · doi:10.1042/bst20200672 · Cited by 32
Cytokines and Bone: Osteoimmunology
Lorenzo, J. (2020) · Handbook of experimental pharmacology · doi:10.1007/164_2019_346 · Cited by 32
Li, X., Li, S., Fu, X., & Wang, Y. (2024) · Bioactive Materials · doi:10.1016/j.bioactmat.2023.11.019 · Cited by 31
Liu, L., Xiang, C., Li, T., Zhao, Z., Xiao, T., & Ouyang, Z. (2024) · Life Sciences · doi:10.1016/j.lfs.2024.122592 · Cited by 31
Hu, H., Zhang, Z.-Y., Luo, Z. X., Ti, H., Wu, J., Nie, H., Yuan, Z., Wu, X. L., Zhang, K.-Y., Shi, S., et al. (2025) · Cell Death Discovery · doi:10.1038/s41420-025-02633-3 · Cited by 40
Li, H., Zhou, J., Zhu, M., Ying, S., Li, L., Chen, D., Li, J., & Song, J. (2020) · Journal of Biomedical Materials Research Part A · doi:10.1002/jbm.a.37102 · Cited by 31
Staufer, O., Bücher, J. E. H., Fichtler, J., Schröter, M., Platzman, I., & Spatz, J. P. (2022) · Advanced Science · doi:10.1002/advs.202200201 · Cited by 31
Ahmed, A. S. I., Sheng, M. H. ‐., Lau, K. ‐. W., Wilson, S. M., Wongworawat, M. D., Tang, X., Ghahramanpouri, M., Nehme, A., Xu, Y., Abdipour, A., et al. (2022) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00413.2021 · Cited by 30
FOXO3 Mediates Tooth Movement by Regulating Force-Induced Osteogenesis
Jin, A., Hong, Y., Yang, Y., Xu, H., Huang, X., Gao, X., Gong, X., Dai, Q., & Jiang, L. (2021) · Journal of Dental Research · doi:10.1177/00220345211021534 · Cited by 29
The extended chondrocyte lineage: implications for skeletal homeostasis and disorders
Tsang, K. Y., & Cheah, K. S. E. (2019) · Current Opinion in Cell Biology · doi:10.1016/j.ceb.2019.07.011 · Cited by 29
Ma, J., Jing, J., Wang, J., Mo, Y., Li, Q., Lin, J., Chen, L., Shao, L., Miossec, P., & Dai, L. (2019) · Arthritis & Rheumatology · doi:10.1002/art.40868 · Cited by 28
Deng, Z., Zhang, R., Li, M., Wang, S., Fu, G., Jin, J., Wang, Z., Ma, Y., & Zheng, Q. (2020) · Biomaterials Science · doi:10.1039/d0bm01256d · Cited by 28
Qin, X., Niu, Z.-C., Han, X.-L., Yang, Y. S., Wei, Q., Gao, X., An, R., Han, L., Yang, W., Chai, L., et al. (2021) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2021.113815 · Cited by 28
Wang, L., Yang, H., Huang, J., Pei, S., Wang, L., Feng, J. Q., Jing, D., Zhao, H., Kronenberg, H. M., Moore, D. C., et al. (2021) · Bone Research · doi:10.1038/s41413-020-00129-7 · Cited by 28
New insights into the role of glycosaminoglycans in the endosteal bone microenvironment
Salbach‐Hirsch, J., Rauner, M., Hofbauer, C., & Hofbauer, L. C. (2021) · Biological Chemistry · doi:10.1515/hsz-2021-0174 · Cited by 31
Ateeq, H., Zia, A., Husain, Q., Khan, M. S., & AHMAD, M. M. (2022) · Journal of Diabetes & Metabolic Disorders · doi:10.1007/s40200-021-00960-7 · Cited by 28
Self-citationRANKL inhibition: a new target of treating diabetes mellitus?
Xing, B., Yu, J., Zhang, H., & Li, Y. (2023) · Therapeutic Advances in Endocrinology and Metabolism · doi:10.1177/20420188231170754 · Cited by 28
Liang, Q.-L., Xu, H., Yu, L., Ding, M.-R., Li, Y., Qi, G.-F., Zhang, K., Wang, L., Wang, H., & Cui, X. (2023) · Biomaterials · doi:10.1016/j.biomaterials.2023.122331 · Cited by 28
Liu, J., Wang, B., Chen, H., Yu, X., Cao, X., & Zhang, H. (2024) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2024.117231 · Cited by 29
Beyond resorption: osteoclasts as drivers of bone formation
Xiang, Q., Li, L., Ji, W., Gawlitta, D., Walboomers, X. F., & van den Beucken, J. J. J. P. (2024) · Cell Regeneration · doi:10.1186/s13619-024-00205-x · Cited by 29
Hou, J. F., Tamura, Y., Lu, H., Takahashi, Y., Kasugai, S., Nakata, H., & Kuroda, S. (2022) · Nanomaterials · doi:10.3390/nano12111850 · Cited by 27
The Cells of Bone and Their Interactions
Ansari, N., & Sims, N. A. (2019) · Handbook of experimental pharmacology · doi:10.1007/164_2019_343 · Cited by 29
Long, J., Wang, Y., Lu, M., Etxabide, A., Zhou, Y., Gu, P., Song, P., Min, L., Luo, Y. W., Nand, A. V., et al. (2023) · ACS Applied Materials & Interfaces · doi:10.1021/acsami.3c03047 · Cited by 26
Ye, P., Yang, Y., Qu, Y., Yang, W., Tan, J., Zhang, C., Sun, D., Zhang, J., Zhao, W., Guo, S., et al. (2024) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2024.134091 · Cited by 25
Krüppel‐like factors family in health and disease
Xiang, T., Yang, C. H., Deng, Z., Sun, D., Luo, F., & Chen, Y. (2024) · MedComm · doi:10.1002/mco2.723 · Cited by 25
Huang, C., Zheng, Y., Bai, J., Shi, C., Shi, X., Shan, H., & Zhou, X. (2020) · Journal of Orthopaedic Translation · doi:10.1016/j.jot.2020.10.011 · Cited by 25
Zeng, J., Peng, Y., Wang, D., Ayesha, K., & Chen, S. (2023) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2023.1123065 · Cited by 31
Wang, R., Wang, Y., Niu, Y., He, D., Jin, S., Li, Z., Zhu, L., Chen, L., Wu, X., Ding, C., et al. (2023) · ACS Central Science · doi:10.1021/acscentsci.3c00794 · Cited by 25
Emerging therapeutic targets for osteoporosis
Gennari, L., Merlotti, D., Falchetti, A., Eller-Vainicher, C., Cosso, R., & Chiodini, I. (2020) · Expert Opinion on Therapeutic Targets · doi:10.1080/14728222.2020.1726889 · Cited by 25
Genetic disorders associated with the RANKL/OPG/RANK pathway
Xue, J., Ikegawa, S., & Guo, L. Z. (2020) · Journal of Bone and Mineral Metabolism · doi:10.1007/s00774-020-01148-4 · Cited by 25
The induction of RANKL molecule clustering could stimulate early osteoblast differentiation
Sone, E., Noshiro, D., Ikebuchi, Y., Nakagawa, M., Khan, M., Tamura, Y., Ikeda, M., Oki, M., Murali, R., Fujimori, T., et al. (2019) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2018.12.093 · Cited by 24
Self-citationWang, M., Jun, J., Xin, Z., Jiahao, Z., & Jie, G. (2024) · Journal of Cellular and Molecular Medicine · doi:10.1111/jcmm.18231 · Cited by 24
Sumida, R., Maeda, T., Kawahara, I., Yusa, J., & Kato, Y. (2019) · Experimental and Therapeutic Medicine · doi:10.3892/etm.2019.7560 · Cited by 25
Li, S., Liu, Q., Wu, D., He, T., Yuan, J., Qiu, H., Tickner, J. C., Zheng, S. G., Li, X., Xu, J., et al. (2020) · Cell Death and Disease · doi:10.1038/s41419-020-02947-3 · Cited by 24
Integration of mechanics and biology in computer simulation of bone remodeling
Pant, A., Paul, E., Niebur, G. L., & Vahdati, A. (2021) · Progress in Biophysics and Molecular Biology · doi:10.1016/j.pbiomolbio.2021.05.001 · Cited by 24
Dhawan, U., Jaffery, H., Salmerón‐Sánchez, M., & Dalby, M. J. (2021) · Current Opinion in Biotechnology · doi:10.1016/j.copbio.2021.10.010 · Cited by 25
Liu, Z., Yin, Y., Wang, Z., Xie, L., Deng, P., Wang, D., Ji, N., Zhao, H., Han, X., Chen, Q., et al. (2021) · Bone · doi:10.1016/j.bone.2021.116301 · Cited by 24
Broad application prospects of bone turnover markers in pediatrics
Zhang, Y., Huang, X., Li, C., Zhang, J., Yu, X., Li, Y., Zhou, W., & Fan, Y. (2022) · Journal of Clinical Laboratory Analysis · doi:10.1002/jcla.24656 · Cited by 28
Yang, L., Chen, S., Shang, T., Zhao, R., Yuan, B., Zhu, X., Raucci, M. G., Yang, X., Zhang, X., Santin, M., et al. (2020) · ACS Applied Materials & Interfaces · doi:10.1021/acsami.0c09004 · Cited by 24
Liu, X., Zhou, Z., Zeng, W., Zeng, Q., & Zhang, X. (2023) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2023.1277686 · Cited by 25
de Castro, L. F., Whitlock, J. M., Michel, Z. D., Pan, K. S., Taylor, J., Szymczuk, V. L., Boyce, B. F., Martín, D., Kram, V., Galisteo, R., et al. (2024) · Bone Research · doi:10.1038/s41413-023-00311-7 · Cited by 25
Dong, Q., Li, D., Zhang, K., Shi, H., Cai, M., Li, Y., Zhao, R., & Qin, D. (2025) · Journal of Endocrinology · doi:10.1530/joe-25-0234 · Cited by 25
Teng, X., Wei, L., Han, L., Min, D., & Du, Y. (2020) · BMC Cancer · doi:10.1186/s12885-020-07046-2 · Cited by 23
The mechanism of oxytocin and its receptors in regulating cells in bone metabolism
Fei-xiang, L., Yanchen, F., Li, X., Yunke, Z., Jinxin, M., Jianru, W., & Zi-xuan, L. (2023) · Frontiers in Pharmacology · doi:10.3389/fphar.2023.1171732 · Cited by 24
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Chang, W., Tian, B., Qin, Q., Li, D., Zhang, Y., Zhou, C., Wu, B., Zhang, M., Shan, H., Ni, Y., et al. (2024) · ACS Nano · doi:10.1021/acsnano.4c12064 · Cited by 22
Neto, E., Leitão, L., Mateus, J. C., Sousa, D. M., Alves, C. J., Aroso, M., Monteiro, A. C., Conceição, F., Oreffo, R. O. C., West, J. J., et al. (2022) · Cell & Bioscience · doi:10.1186/s13578-022-00864-w · Cited by 25
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Riquelme‐Guzmán, C., Tsai, S. L., Paz, K. C., Nguyen, C., Oriola, D., Schuez, M., Jan Brugués, A., Currie, J. D., & Sandoval‐Guzmán, T. (2022) · eLife · doi:10.7554/elife.79966 · Cited by 24
Metadata
- Authors
- Ikebuchi, Y., Aoki, S., Honma, M., Hayashi, M., Sugamori, Y., Khan, M., Kariya, Y., Kato, G., Tabata, Y., Penninger, J. M., Udagawa, N., Aoki, K., & Suzuki, H.
- Affiliations
- University of Tokyo Hospital (JP)
- Tokyo Medical and Dental University (JP)
- Kyoto University (JP)
- Institute of Molecular Biotechnology (AT)
- Matsumoto Dental University (JP)
- Corresponding author
- Honma, Masashi
- ORCID
- Venue
- Nature
- Published
- 2018-09-05
- Volume
- 561
- Issue
- 7722
- Pages
- 195-200
- ISSN
- 0028-0836 (ISSN-L)
- 1476-4687
- OpenAlex
- W2890611509
- Cited by
- 557
- References
- 35
- Citations by year
- 2026: 37 · 2025: 71 · 2024: 85 · 2023: 63 · 2022: 75 · 2021: 78 · 2020: 83 · 2019: 53 · 2018: 12
- FWCI
- 20.10
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- Locations
- Nature (publishedVersion)
- PubMed (publishedVersion)
- RePEc: Research Papers in Economics (submittedVersion)
- Funders
- Japan Society for the Promotion of Science (17K19776, 16K11818, 18H02918, 16H05445, 17F17124, 18K04734, 16K20419, 16H06261, 16H05508)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Bone Metabolism and Diseases
- Health Sciences › Medicine › Orthopedics and Sports Medicine › Bone health and osteoporosis research
- Health Sciences › Medicine › Rheumatology › Osteomyelitis and Bone Disorders Research
- Keywords
- RANK, osteoclasts, osteoblasts, bone resorption, bone formation, bone remodeling, Runx2, proline-rich motif, osteoclastogenesis
- MeSH terms
- Animals, Bone Resorption, Cell Differentiation, Cross-Linking Reagents, Female, Male, Mice, Inbred C57BL, Osteoblasts, Osteoclasts, Osteogenesis, Signal Transduction, Amino Acid Substitution, Cytoplasmic Vesicles, Core Binding Factor Alpha 1 Subunit, Mice, RANK Ligand, Receptor Activator of Nuclear Factor-kappa B
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