Udagawa, Nobuyuki

Origin of osteoclasts: mature monocytes and macrophages are capable of differentiating into osteoclasts under a suitable microenvironment prepared by bone marrow-derived stromal cells.

Udagawa, N., Takahashi, N., Akatsu, T., Tanaka, H., Sasaki, T., Nishihara, T., Koga, T., Martin, T. J., & Suda, T. (1990) · Proceedings of the National Academy of Sciences

Bone Metabolism and DiseasesOsteomyelitis and Bone Disorders Research

Cited by 1,048

Coupling of bone resorption and formation by RANKL reverse signalling

Ikebuchi, Y., Aoki, S., Honma, M., Hayashi, M., Sugamori, Y., Khan, M., Kariya, Y., Kato, G., Tabata, Y., Penninger, J. M., et al. (2018) · Nature

Bone Metabolism and DiseasesBone health and osteoporosis research

Cited by 557

Wnt5a-Ror2 signaling between osteoblast-lineage cells and osteoclast precursors enhances osteoclastogenesis

Maeda, K., Kobayashi, Y., Udagawa, N., Uehara, S., Ishihara, A., Mizoguchi, T., Kikuchi, Y., Takada, I., Kato, S., Kani, S., et al. (2012) · Nature Medicine

Bone Metabolism and DiseasesWnt/β-catenin signaling in development and cancer

Cited by 542

Interleukin-18 (Interferon-γ–inducing Factor) Is Produced by Osteoblasts and Acts Via Granulocyte/Macrophage Colony-stimulating Factor and Not Via Interferon-γ to Inhibit Osteoclast Formation

Udagawa, N., Horwood, N. J., Elliott, J., Mackay, A., Owens, J., Okamura, H., Kurimoto, M., Chambers, T. J., Martin, T. J., & Gillespie, M. T. (1997) · The Journal of Experimental Medicine

Bone Metabolism and DiseasesRheumatoid Arthritis Research and Therapies

Cited by 378

The Murine Glucagon-Like Peptide-1 Receptor Is Essential for Control of Bone Resorption

Yamada, C., Yamada, Y., Tsukiyama, K., Yamada, K., Udagawa, N., Takahashi, N., Tanaka, K., Drucker, D. J., Seino, Y., & Inagaki, N. (2008) · Endocrinology

Bone Metabolism and DiseasesBone health and osteoporosis research

Cited by 318

Transforming Growth Factor β Affects Osteoclast Differentiation via Direct and Indirect Actions

Quinn, J. M. W., Itoh, K., Udagawa, N., Häusler, K., Yasuda, H., Shima, N., Mizuno, A., Higashio, K., Takahashi, N., Suda, T., et al. (2001) · Journal of Bone and Mineral Research

Bone Metabolism and DiseasesTGF-β signaling in diseases

Cited by 278

Bone Morphogenetic Protein 2 Stimulates Osteoclast Differentiation and Survival Supported by Receptor Activator of Nuclear Factor-κB Ligand

Itoh, K., Udagawa, N., Katagiri, T., Iemura, S., Ueno, N., Yasuda, H., Higashio, K., Quinn, J. M. W., Gillespie, M. T., Martin, T. J., et al. (2001) · Endocrinology

Bone Metabolism and DiseasesTGF-β signaling in diseases

Cited by 250

Gastric Inhibitory Polypeptide as an Endogenous Factor Promoting New Bone Formation after Food Ingestion

Tsukiyama, K., Yamada, Y., Yamada, C., Harada, N., Kawasaki, Y., Ogura, M., Bessho, K., Li, M., Amizuka, N., Sato, M., et al. (2006) · Molecular Endocrinology

Bone Metabolism and DiseasesBone health and osteoporosis research

Cited by 198

Osteoprotegerin regulates bone formation through a coupling mechanism with bone resorption.

Nakamura, M., Udagawa, N., Matsuura, S., Mogi, M., Nakamura, H., Horiuchi, H., Saito, N., Hiraoka, B. Y., Kobayashi, Y., Takaoka, K., et al. (2003) · Endocrinology

Bone Metabolism and DiseasesBone health and osteoporosis research

Cited by 191

Astrocytic phagocytosis is a compensatory mechanism for microglial dysfunction

Konishi, H., Okamoto, T., Hara, Y., Komine, O., Tamada, H., Maeda, M., Osako, F., Kobayashi, M., Nishiyama, A., Kataoka, Y., et al. (2020) · The EMBO Journal

Neuroinflammation and Neurodegeneration MechanismsPhagocytosis and Immune Regulation

Cited by 179

Action of RANKL and OPG for Osteoclastogenesis

Kobayashi, Y., Udagawa, N., & Takahashi, N. (2009) · Critical Reviews™ in Eukaryotic Gene Expression

Bone Metabolism and DiseasesOsteomyelitis and Bone Disorders Research

Cited by 176

Importance of membrane- or matrix-associated forms of M-CSF and RANKL/ODF in osteoclastogenesis supported by SaOS-4/3 cells expressing recombinant PTH/PTHrP receptors.

Itoh, K., Udagawa, N., Matsuzaki, K., Takami, M., Amano, H., Shinki, T., Ueno, Y., Takahashi, N., & Suda, T. (2000) · Journal of Bone and Mineral Research

Bone Metabolism and DiseasesRheumatoid Arthritis Research and Therapies

Cited by 90

Protein kinase N3 promotes bone resorption by osteoclasts in response to Wnt5a-Ror2 signaling

Uehara, S., Udagawa, N., Mukai, H., Ishihara, A., Maeda, K., Yamashita, T., Murakami, K., Nishita, M., Nakamura, T., Kato, S., et al. (2017) · Science Signaling

Bone Metabolism and DiseasesWnt/β-catenin signaling in development and cancer

Cited by 83

Stimulation of Bone Formation in Cortical Bone of Mice Treated with a Receptor Activator of Nuclear Factor-κB Ligand (RANKL)-binding Peptide That Possesses Osteoclastogenesis Inhibitory Activity

Furuya, Y., Inagaki, A., Khan, M., Mori, K., Penninger, J. M., Nakamura, M., Udagawa, N., Aoki, K., Ohya, K., Uchida, K., et al. (2013) · Journal of Biological Chemistry

Bone Metabolism and DiseasesBone health and osteoporosis research

Cited by 77

Osteoprotegerin reduces the serum level of receptor activator of NF-κB ligand derived from osteoblasts.

Nakamichi, Y., Udagawa, N., Kobayashi, Y., Nakamura, M., Yamamoto, Y., Yamashita, T., Mizoguchi, T., Sato, M., Mogi, M., Penninger, J. M., et al. (2007) · The Journal of Immunology

Bone Metabolism and DiseasesNF-κB Signaling Pathways

Cited by 50

Calcitonin receptor down-regulation relates to calcitonin resistance in mature mouse osteoclasts.

Wada, S., Udagawa, N., Nagata, N., Martin, T. J., & Findlay, D. M. (1996) · Endocrinology

Bone Metabolism and DiseasesBone health and osteoporosis research

Cited by 47

Wnt16 regulates osteoclast differentiation in conjunction with Wnt5a

Kobayashi, Y., Thirukonda, G. J., Nakamura, Y., Koide, M., Yamashita, T., Uehara, S., Kato, H., Udagawa, N., & Takahashi, N. (2015) · Biochemical and Biophysical Research Communications

Bone Metabolism and DiseasesWnt/β-catenin signaling in development and cancer

Cited by 47

Osteocytic Osteolysis in PTH-treated Wild-type and Rankl −/− Mice Examined by Transmission Electron Microscopy, Atomic Force Microscopy, and Isotope Microscopy

Hongo, H., Hasegawa, T., Saito, M., Tsuboi, K., Yamamoto, T., Sasaki, M., Abe, M., Henrique Luiz de Freitas, P., Yurimoto, H., Udagawa, N., et al. (2020) · Journal of Histochemistry & Cytochemistry

Bone Metabolism and DiseasesBone health and osteoporosis research

Cited by 12