EV-TRACK: transparent reporting and centralizing knowledge in extracellular vesicle research
Open accessAbstract
We argue that the field of extracellular vesicle (EV) biology needs more transparent reporting to facilitate interpretation and replication of experiments. To achieve this, we describe EV-TRACK, a crowdsourcing knowledgebase (http://evtrack.org) that centralizes EV biology and methodology with the goal of stimulating authors, reviewers, editors and funders to put experimental guidelines into practice.
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All relevant data of the experiments were submitted to the EV-TRACK knowledgebase (EV-TRACK ID: EV200036).
“We have submitted all relevant data of our experiments to the EV-TRACK knowledgebase (EV-TRACK ID: EV200036) (Van Deun et al., 2017).”
From Small Extracellular Vesicles Have GST Activity and Ameliorate Senescence-Related Tissue Damage (2020) · cites this paper as Van Deun et al., 2017
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Effects of storage temperature on airway exosome integrity for diagnostic and functional analyses
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Why the need and how to approach the functional diversity of extracellular vesicles
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Self-citationExtracellular vesicles in the tumor microenvironment: old stories, but new tales
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Engineering Exosomes for Cancer Therapy
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Self-citationPlant-derived exosomal microRNAs inhibit lung inflammation induced by exosomes SARS-CoV-2 Nsp12
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Confounding factors of ultrafiltration and protein analysis in extracellular vesicle research
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Self-citationA compendium of single extracellular vesicle flow cytometry
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Self-citationMicroRNAs are minor constituents of extracellular vesicles that are rarely delivered to target cells
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Self-citationExtracellular vesicles as circulating cancer biomarkers: opportunities and challenges
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On the issue of transparency and reproducibility in nanomedicine
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Extracellular Vesicles From Epicardial Fat Facilitate Atrial Fibrillation
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Self-citationHyenne, V., Ghoroghi, S., Collot, M., Bons, J., Follain, G., Harlepp, S., Mary, B., Bauer, J., Mercier, L., Busnelli, I., et al. (2019) · Developmental Cell · doi:10.1016/j.devcel.2019.01.014 · Cited by 223 · see citing works
Self-citationVesiclepedia 2024: an extracellular vesicles and extracellular particles repository
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Self-citationDevelopment of Extracellular Vesicle Therapeutics: Challenges, Considerations, and Opportunities
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Exosomal microRNAs (exomiRs): Small molecules with a big role in cancer
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Characterizing Extracellular Vesicles and Their Diverse RNA Contents
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Self-citationHarnessing extracellular vesicle heterogeneity for diagnostic and therapeutic applications
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Hypoxia and extracellular vesicles: A review on methods, vesicular cargo and functions
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Exosome-Mediated Crosstalk between Keratinocytes and Macrophages in Cutaneous Wound Healing
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Therapeutic and Diagnostic Translation of Extracellular Vesicles in Cardiovascular Diseases
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Driedonks, T. A. P., Jiang, L., Carlson, B. W., Han, Z., Liu, G., Queen, S. E., Shirk, E. N., Gololobova, O. A., Liao, Z., Nyberg, L. H., et al. (2022) · Journal of Extracellular Biology · doi:10.1002/jex2.59 · Cited by 205 · see citing works
Self-citationSmall Extracellular Vesicles Have GST Activity and Ameliorate Senescence-Related Tissue Damage
Fafián-Labora, J. A., Rodríguez-Navarro, J. A., & O’Loghlen, A. (2020) · Cell Metabolism · doi:10.1016/j.cmet.2020.06.004 · Cited by 203 · see citing works
Emerging methods in biomarker identification for extracellular vesicle‐based liquid biopsy
Liang, Y., Lehrich, B. M., Zheng, S., & Lu, M. (2021) · Journal of Extracellular Vesicles · doi:10.1002/jev2.12090 · Cited by 198 · see citing works
Self-citationOligodendrocytes support axonal transport and maintenance via exosome secretion
Frühbeis, C., Kuo, W. P., Müller, C., Barth, K., Peris, L., Tenzer, S., Möbius, W., Werner, H. B., Nave, K., Fröhlich, D., et al. (2020) · PLoS Biology · doi:10.1371/journal.pbio.3000621 · Cited by 193 · see citing works
da Silva, A. M., Lázaro‐Ibáñez, E., Gunnarsson, A., Dhande, A., Daaboul, G. G., Peacock, B., Osteikoetxea, X., Salmond, N., Friis, K. P., Shatnyeva, O., et al. (2021) · Journal of Extracellular Vesicles · doi:10.1002/jev2.12130 · Cited by 191 · see citing works
A critical systematic review of extracellular vesicle clinical trials
Mizenko, R. R., Feaver, M., Bozkurt, B. T., Lowe, N. M., Nguyen, B., Huang, K., Wang, A., & Carney, R. P. (2024) · Journal of Extracellular Vesicles · doi:10.1002/jev2.12510 · Cited by 200 · see citing works
Li, K., Wong, D., Hong, K. Y., & Raffaı̈, R. L. (2018) · Methods in molecular biology · doi:10.1007/978-1-4939-7652-2_7 · Cited by 191 · see citing works
Lázaro‐Ibáñez, E., Lässer, C., Shelke, G. V., Crescitelli, R., Jang, S. C., Cvjetkovic, A., Rodríguez, A. G., & Lötvall, J. O. (2019) · Journal of Extracellular Vesicles · doi:10.1080/20013078.2019.1656993 · Cited by 189 · see citing works
Quantitative Proteomics Identifies Proteins Enriched in Large and Small Extracellular Vesicles
Lischnig, A., Bergqvist, M., Ochiya, T., & Lässer, C. (2022) · Molecular & Cellular Proteomics · doi:10.1016/j.mcpro.2022.100273 · Cited by 189 · see citing works
Abundantly Present miRNAs in Milk-Derived Extracellular Vesicles Are Conserved Between Mammals
van Herwijnen, M. J. C., Driedonks, T. A. P., Snoek, B. L., Kroon, A. M. T., Kleinjan, M., Jorritsma, R., Pieterse, C. M. J., Hoen, E. N. M. N., & Wauben, M. H. M. (2018) · Frontiers in Nutrition · doi:10.3389/fnut.2018.00081 · Cited by 189 · see citing works
Self-citationExtracellular vesicle analysis
Hendrix, A., Lippens, L., Pinheiro, C., Théry, C., Jaular, L. M., Lötvall, J. O., Lässer, C., Hill, A. F., & Witwer, K. W. (2023) · Nature Reviews Methods Primers · doi:10.1038/s43586-023-00240-z · Cited by 192 · see citing works
Self-citationMensa’, E., Guescini, M., Giuliani, A., Bacalini, M. G., Ramini, D., Corleone, G., Ferracin, M., Fulgenzi, G., Graciotti, L., Prattichizzo, F., et al. (2020) · Journal of Extracellular Vesicles · doi:10.1080/20013078.2020.1725285 · Cited by 186 · see citing works
- Authors
- EV-TRACK Consortium, Van Deun, J., Mestdagh, P., Agostinis, P., Akay, Ö., Anand, S., Anckaert, J., Martinez, Z. A., Baetens, T., Beghein, E., Bertier, L., Berx, G., Boere, J., Boukouris, S., Bremer, M., Buschmann, D., Byrd, J. B., Casert, C., Cheng, L., Cmoch, A., Daveloose, D., De Smedt, E., Demirsoy, S., Depoorter, V., Dhondt, B., Driedonks, T. A. P., Dudek, A., Elsharawy, A., Floris, I., Foers, A. D., Gärtner, K., Garg, A. D., Geeurickx, E., Gettemans, J., Ghazavi, F., Giebel, B., Kormelink, T. G., Hancock, G., Helsmoortel, H., Hill, A. F., Hyenne, V., Kalra, H., Kim, D., Kowal, J., Kraemer, S., Leidinger, P., Leonelli, C., Liang, Y., Lippens, L., Liu, S., Lo Cicero, A., Martin, S., Mathivanan, S., Mathiyalagan, P., Matusek, T., Milani, G., Monguió-Tortajada, M., Mus, L. M., Muth, D. C., Németh, A., Nolte-'t Hoen, E. N. M., O'Driscoll, L., Palmulli, R., Pfaffl, M. W., Primdal-Bengtson, B., Romano, E., Rousseau, Q., Sahoo, S., Sampaio, N., Samuel, M., Scicluna, B., Soen, B., Steels, A., Swinnen, J. V., Takatalo, M., Thaminy, S., Théry, C., Tulkens, J., Van Audenhove, I., van der Grein, S., Van Goethem, A., van Herwijnen, M. J., Van Niel, G., Van Roy, N., Van Vliet, A. R., Vandamme, N., Vanhauwaert, S., Vergauwen, G., Verweij, F., Wallaert, A., Wauben, M., Witwer, K. W., Zonneveld, M. I., De Wever, O., Vandesompele, J., & Hendrix, A.
- Affiliations
- Ghent University (BE)
- KU Leuven (BE)
- La Trobe University (AU)
- Utrecht University (NL)
- Essen University Hospital (DE)
- Technical University of Munich (DE)
- University of Michigan (US)
- Instytut Biologii Doświadczalnej im. Marcelego Nenckiego (PL)
- Damietta University (EG)
- University of Ottawa (CA)
- The University of Melbourne (AU)
- Helmholtz Munich (DE)
- Johns Hopkins University (US)
- Inserm (FR)
- Icahn School of Medicine at Mount Sinai (US)
- Universitätsklinikum Aachen (DE)
- Saarland University (DE)
- German Center for Neurodegenerative Diseases (DE)
- Centre National de la Recherche Scientifique (FR)
- University of Helsinki (FI)
- National Cancer Centre Japan (JP)
- Corresponding author
- Hendrix, An
- ORCID
- Van Deun, Jan
- Mestdagh, Pieter
- Agostinis, Patrizia
- Anand, Sushma
- Anckaert, Jasper
- Beghein, Els
- Bertier, Laurence
- Berx, Geert
- Boere, Janneke
- Buschmann, Dominik
- Byrd, James B
- Cheng, Lesley
- Depoorter, Victoria
- Dhondt, Bert
- Driedonks, Tom A P
- Elsharawy, Abdou
- Floris, Ilaria
- Foers, Andrew D
- Gärtner, Kathrin
- Garg, Abhishek D
- Geeurickx, Edward
- Gettemans, Jan
- Ghazavi, Farzaneh
- Giebel, Bernd
- Kormelink, Tom Groot
- Helsmoortel, Hetty
- Hill, Andrew F
- Hyenne, Vincent
- Kim, David
- Kraemer, Sandra
- Leidinger, Petra
- Liang, Yaxuan
- Lippens, Lien
- Martin, Shaun
- Mathivanan, Suresh
- Mathiyalagan, Prabhu
- Mus, Liselot M
- Muth, Dillon C
- Palmulli, Roberta
- Pfaffl, Michael W
- Romano, Erminia
- Sahoo, Susmita
- Samuel, Monisha
- Scicluna, Benjamin
- Steels, Anneleen
- Swinnen, Johannes V
- Takatalo, Maarit
- Théry, Clotilde
- Tulkens, Joeri
- Vandamme, Niels
- Vanhauwaert, Suzanne
- Vergauwen, Glenn
- Verweij, Frederik
- Wallaert, Annelynn
- Wauben, Marca
- Witwer, Kenneth W
- Zonneveld, Marijke I
- Vandesompele, Jo
- Hendrix, An
- Venue
- Nature Methods
- Published
- 2017-02-28
- Volume
- 14
- Issue
- 3
- Pages
- 228-232
- ISSN
- 1548-7091 (ISSN-L)
- 1548-7105
- OpenAlex
- W2594599876
- Cited by
- 1,284
- References
- 38
- Citations by year
- 2026: 133 · 2025: 131 · 2024: 178 · 2023: 169 · 2022: 139 · 2021: 160 · 2020: 154 · 2019: 107 · 2018: 80 · 2017: 32
- FWCI
- 41.75
- Type
- journal article
- Language
- en
- Open access
- green
- dspace.library.uu.nl
- Licence
- Locations
- Nature Methods (publishedVersion)
- PubMed (publishedVersion)
- Ghent University Academic Bibliography (Ghent University) (publishedVersion)
- Victoria University Research Repository (Victoria University) (submittedVersion)
- HAL (submittedVersion)
- Ghent University Academic Bibliography (Ghent University) (submittedVersion)
- Dépôt institutionnel de l'Université libre de Bruxelles (Université Libre de Bruxelles) (submittedVersion)
- Utrecht University Repository (Utrecht University) (submittedVersion, other-oa)
- Nova Science Publishers (Nova Science Publishers, Inc.) (submittedVersion)
- Lirias (KU Leuven) (submittedVersion)
- DZNE Pub (submittedVersion)
- RWTH Publications (RWTH Aachen) (submittedVersion)
- PuSH - Publication Server of Helmholtz Zentrum München (submittedVersion)
- Utrecht University Repository (Utrecht University) (submittedVersion)
- Funders
- Agence Nationale de la Recherche (ANR-10-LABX-0034)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Extracellular vesicles in disease
- Social Sciences › Decision Sciences › Information Systems and Management › Academic Publishing and Open Access
- Physical Sciences › Computer Science › Information Systems › Research Data Management Practices
- Keywords
- extracellular vesicles, research transparency, reporting guidelines, experimental method, replication
- MeSH terms
- Extracellular Vesicles, Databases, Bibliographic, Biomedical Research, Internationality
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