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Cited by 2,543Bone health and osteoporosis researchBone Metabolism and DiseasesMedical and Biological Sciences

Standardized nomenclature, symbols, and units for bone histomorphometry: A 2012 update of the report of the ASBMR Histomorphometry Nomenclature Committee

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Dempster, David W, Compston, Juliet E, Drezner, Marc K, Glorieux, Francis H, Kanis, John A, Malluche, Hartmut, Meunier, Pierre J, Ott, Susan M +2 more·2013·Journal of Bone and Mineral Research
DOI 10.1002/jbmr.1805PMC PMC3672237
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Abstract

Before publication of the original version of this report in 1987, practitioners of bone histomorphometry communicated with each other in a variety of arcane languages, which in general were unintelligible to those outside the field. The need for standardization of nomenclature had been recognized for many years,1 during which there had been much talk but no action. To satisfy this need, B Lawrence Riggs (ASBMR President, 1985 to 1986) asked A Michael Parfitt to convene an ASBMR committee to develop a new and unified system of terminology, suitable for adoption by the Journal of Bone and Mineral Research (JBMR) as part of its Instructions to Authors. The resulting recommendations were published in 19872 and were quickly adopted not only by JBMR but also by all respected journals in the bone field. The recommendations improved markedly the ability of histomorphometrists to communicate with each other and with nonhistomorphometrists, leading to a broader understanding and appreciation of histomorphometric data. In 2012, 25 years after the development of the standardized nomenclature system, Thomas L Clemens (Editor in Chief of JBMR) felt that it was time to revise and update the recommendations. The original committee was reconvened by David W Dempster, who appointed one new member, Juliet E Compston. The original document was circulated to the committee members and was extensively revised according to their current recommendations. The key revisions include omission of terminology used before 1987, recommendations regarding the parameters and technical information that should be included in all histomorphometry articles, recommendations on how to handle dynamic parameters of bone formation in settings of low bone turnover, and updating of references. It is generally agreed that a bone is an individual organ of the skeletal system, but the term "bone" has at least three meanings. The first is mineralized bone matrix excluding osteoid; this usage conforms rigorously to the definition of bone as a hard tissue. Osteoid is bone matrix that will be (but is not yet) mineralized, and is sometimes referred to as pre-bone. The second meaning of "bone," and the one we have adopted, is bone matrix, whether mineralized or not, ie, including both mineralized bone and osteoid. The third meaning of "bone" is a tissue including bone marrow and other soft tissue, as well as bone as just defined. We refer to the combination of bone and associated soft tissue or marrow as "bone tissue." "Tissue" is defined3 as "an aggregation of similarly specialized cells united in the performance of a particular function." In this sense, bone, bone marrow, and the contents of osteonal canals are certainly not the same tissue, but in a more general sense, most textbooks of histology recognize only four fundamental tissues—epithelium, nerve, muscle, and connective tissue4—of which the last-named includes bone and all its accompanying nonmineralized tissue. In current clinical and radiologic parlance, "trabecular" and "cortical" refer to contrasting structural types of bone. But "trabecular" does not appear in any standard textbook of anatomy or histology as a name for a type of bone; rather, "spongy" or "cancellous" is used. "Spongiosa" (primary or secondary) is best restricted to the stages of endochondral ossification; "cancellous" is most commonly used in textbooks4, 5 and is the term we have chosen. We retain the noun "trabecula" and its associated adjective "trabecular" to refer to an individual structural element of cancellous bone, in accordance with current practice in histology,4 pathology,6 and biomechanics.7 Etymologically, a trabecula is a beam or rod, and in young people plates rather than rods are the predominant structural elements, both in the spine8 and in the ilium,9 but no convenient alternative is available. The size, shape, and orientation of trabeculae (as just defined) vary considerably between different types of cancellous bone.9, 10 "Density" is a frequent source of confusion in discussions about bone. We propose that the term should be restricted as far as possible to its primary meaning in physics of mass per unit volume,11, 12 with a subsidiary meaning analogous to population density, which is applied mainly to cells. This precludes the use of "density" in its stereologic sense, as will be discussed later. Corresponding to the definitions given earlier, the volume to which mass is referred can be of mineralized bone, bone, bone tissue (cortical or cancellous), or a whole bone. Mineralized bone density is slightly less than true bone density, which excludes the volume of osteocyte lacunae and canaliculi.11 This volume is small and generally ignored; lacunar volume can be readily measured,13 but canalicular volume is inaccessible to light microscopy. Bone density reflects the volumetric proportion of osteoid; bone matrix volume, excluding lacunar and canalicular volume, has been referred to as absolute bone volume.14 B

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Research works printed but not linked: 12

  1. [11]Robinson RA Chemical analysis and electron microscopy of bone Rodahl K Nicholson JT Brown EM Bone as a tissue New York McGraw-Hill 186 250 1960
  2. [12]Courpron P Meunier P Bressot C Giroux JM Amount of bone in iliac crest biopsy. Significance of the trabecular bone volume Meunier PJ Bone histomorphometry. Second international workshop Paris Armour Montagu 39 53 1976
  3. [16]Vaughan JM The physiology of bone 2 Oxford The Clarendon Press 1976
  4. [20]Parfitt AM The stereologic basis of bone histomorphometry. Theory of quantitative microscopy and reconstruction of the third dimension Recker R Bone histomorphometry. Techniques and interpretations Boca Raton (FL) CRC Press 53 87 1983
  5. [29]Schenk RK Comments on terminology symbols Jaworski ZFG Proceedings of the First Workshop on Bone Morphometry Ottawa University of Ottawa Press 336 1976
  6. [30]Frost HM Bone histomorphometry: analysis of trabecular bone dynamics Recker R Bone histomorphometry. Techniques and interpretations Boca Raton (FL) CRC Press 109 31 1983
  7. [40]Duncan H Cortical porosis; a morphological evaluation Jaworski ZFG First Workshop on Bone Histomorphometry Ottawa University of Ottawa Press 78 1973
  8. [48]Parfitt AM Villanueva AR Mathews CHE Aswani JA Kinetics of matrix and mineral apposition in osteoporosis and renal osteodystrophy: relationship to rate of turnover and to cell morphology Jee WSS Parfitt AM Bone histomorphometry Third International Workshop Paris Armour-Montagu 213 9 1981
  9. [64]Lindsay R Cosman F Zhou H Nieves J Dempster DW Letter to the editor: double and quadruple tetracycline labeling of bone J Bone Miner Res in press 23255455
  10. [66]Parfitt AM The physiologic and clinical significance of bone histomorphometric data Recker R Bone histomorphometry. Techniques and interpretations Boca Raton (FL) CRC Press 143 223 1983
  11. [69]Jaworski ZFG Bone histomorphometry: outline of theory and practice Simmons OJ Kunin AS Skeletal research 2 New York Academic Press 237 76 1983
  12. [78]Frost HM Recker RR Bone histomorphometry: correction of the labeling ‘‘escape error Bone histomorphometry. Techniques and interpretations Boca Raton (FL) CRC Press 133 42 1983

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Authors
Dempster, D. W., Compston, J. E., Drezner, M. K., Glorieux, F. H., Kanis, J. A., Malluche, H., Meunier, P. J., Ott, S. M., Recker, R. R., & Parfitt, A. M.
Affiliations
  • Helen Hayes Hospital (US)
  • Cambridge University Hospitals NHS Foundation Trust (GB)
  • University of Wisconsin–Madison (US)
  • Shriners Hospitals for Children - Canada (CA)
  • Centre for Metabolic Bone Diseases, University of Sheffield Medical School, Sheffield, United Kingdom
  • University of Kentucky (US)
  • Inserm (FR)
  • University of Washington (US)
  • Creighton University (US)
  • University of Arkansas for Medical Sciences (US)
Corresponding author
Dempster, David W
ORCID
Venue
Journal of Bone and Mineral Research
Publisher
Oxford University Press (OUP)
Published
2012-11-29
Volume
28
Issue
1
Pages
2-17
ISSN
  • 0884-0431 (ISSN-L)
  • 1523-4681
DOI
10.1002/jbmr.1805
PMC
PMC3672237
OpenAlex
W2096425957
Cited by
2,543
References
85
Citations by year
2026: 122 · 2025: 158 · 2024: 205 · 2023: 163 · 2022: 184 · 2021: 227 · 2020: 267 · 2019: 225 · 2018: 220 · 2017: 202 · 2016: 182 · 2015: 175 · 2014: 155 · 2013: 53 · 2012: 1
FWCI
21.80
Type
journal article
Language
en
Open access
Licence
academic.oup.com/journals/pages/open_access/funder_policies/chorus/standard_publication_model (vor)
Locations
  • Journal of Bone and Mineral Research (publishedVersion)
  • PubMed (publishedVersion)
  • PubMed Central (acceptedVersion)
  • Research Bank (Australian Catholic University) (submittedVersion)
Funders
  • American Society for Bone and Mineral Research
  • National Institute of Arthritis and Musculoskeletal and Skin Diseases (R01AR027032)
Topics
  • Health Sciences › Medicine › Orthopedics and Sports Medicine › Bone health and osteoporosis research
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Bone Metabolism and Diseases
  • Health Sciences › Medicine › Anatomy › Medical and Biological Sciences
Keywords
bone histomorphometry, terminology standardization, terminology, bone formation, bone resorption, bone turnover, osteoid, bone matrix, low bone turnover
MeSH terms
Animals, Bone and Bones, Humans, Terminology as Topic, Reference Standards, Guidelines as Topic, Research Report

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