Cited by 290Neuroscience and Neuropharmacology ResearchNeurotransmitter Receptor Influence on BehaviorMemory and Neural Mechanisms

The DOI matches its Crossref record; 23 of the 23 references it cites were found in a registry or an index.

Reward behaviour is regulated by the strength of hippocampus–nucleus accumbens synapses

Open access

LeGates, Tara A., Kvarta, Mark D., Tooley, Jessica R., Francis, T. Chase, Lobo, Mary Kay, Creed, Meaghan C., Thompson, Scott M.·2018·Nature

DOI 10.1038/s41586-018-0740-8PMC PMC6292781

Open this paper in CoChat — free account

Abstract

Reward drives motivated behaviours and is essential for survival, and therefore there is strong evolutionary pressure to retain contextual information about rewarding stimuli. This drive may be abnormally strong, such as in addiction, or weak, such as in depression, in which anhedonia (loss of pleasure in response to rewarding stimuli) is a prominent symptom. Hippocampal input to the shell of the nucleus accumbens (NAc) is important for driving NAc activity 1,2 and activity-dependent modulation of the strength of this input may contribute to the proper regulation of goal-directed behaviours. However, there have been few robust descriptions of the mechanisms that underlie the induction or expression of long-term potentiation (LTP) at these synapses, and there is, to our knowledge, no evidence about whether such plasticity contributes to reward-related behaviour. Here we show that high-frequency activity induces LTP at hippocampus-NAc synapses in mice via canonical, but dopamine-independent, mechanisms. The induction of LTP at this synapse in vivo drives conditioned place preference, and activity at this synapse is required for conditioned place preference in response to a natural reward. Conversely, chronic stress, which induces anhedonia, decreases the strength of this synapse and impairs LTP, whereas antidepressant treatment is accompanied by a reversal of these stress-induced changes. We conclude that hippocampus-NAc synapses show activity-dependent plasticity and suggest that their strength may be critical for contextual reward behaviour.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Integrity signals

Registry

Crossref · 10.1038/s41586-018-0740-8

Cites

23 of 23 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

D 1 and D 2 Dopamine Receptor-regulated Gene Expression of Striatonigral and Striatopallidal Neurons
Gerfen, C. R., Engber, T. M., Mahan, L. C., Susel, Z., Chase, T. N., Monsma, F. J., & Sibley, D. R. (1990) · Science · doi:10.1126/science.2147780 · Cited by 2,967
Distinct roles for direct and indirect pathway striatal neurons in reinforcement
Kravitz, A. V., Tye, L. D., & Kreitzer, A. C. (2012) · Nature Neuroscience · doi:10.1038/nn.3100 · Cited by 972
Cell type-specific loss of BDNF signaling mimics optogenetic control of cocaine reward
Lobo, M. K., Covington, H. E., Chaudhury, D., Friedman, A. K., Sun, H., Damez-Werno, D., Dietz, D. M., Zaman, S., Koo, J. W., Kennedy, P. J., et al. (2010) · Science · doi:10.1126/science.1188472 · Cited by 880
Self-citation
Contrasting properties of two forms of long-term potentiation in the hippocampus
Nicoll, R. A., & Malenka, R. C. (1995) · Nature · doi:10.1038/377115a0 · Cited by 861
Synaptic interactions among excitatory afferents to nucleus accumbens neurons: hippocampal gating of prefrontal cortical input
O’Donnell, P., & Grace, A. (1995) · Journal of Neuroscience · doi:10.1523/jneurosci.15-05-03622.1995 · Cited by 760
Synaptic and Behavioral Profile of Multiple Glutamatergic Inputs to the Nucleus Accumbens
Britt, J. P., Benaliouad, F., McDevitt, R. A., Stuber, G. D., Wise, R. A., & Bonci, A. (2012) · Neuron · doi:10.1016/j.neuron.2012.09.040 · Cited by 716
A critical time window for dopamine actions on the structural plasticity of dendritic spines
Yagishita, S., Hayashi-Takagi, A., Ellis-Davies, G. C. R., Urakubo, H., Ishii, S., & Kasai, H. (2014) · Science · doi:10.1126/science.1255514 · Cited by 614
Distinct Roles of Synaptic Transmission in Direct and Indirect Striatal Pathways to Reward and Aversive Behavior
Hikida, T., Kimura, K., Wada, N., Funabiki, K., & Nakanishi, S. (2010) · Neuron · doi:10.1016/j.neuron.2010.05.011 · Cited by 592
Reversal of cocaine-evoked synaptic potentiation resets drug-induced adaptive behaviour
Pascoli, V., Turiault, M., & Lüscher, C. (2011) · Nature · doi:10.1038/nature10709 · Cited by 440
Dopamine Receptor Activation Is Required for Corticostriatal Spike-Timing-Dependent Plasticity
Pawlak, V., & Kerr, J. N. D. (2008) · Journal of Neuroscience · doi:10.1523/jneurosci.4402-07.2008 · Cited by 430

Show all 23 references

Sorted by citations

Items 201–290 of 290

Sex-specific mechanisms underlie long-term potentiation at hippocampus-nucleus accumbens synapsesPreprint
Copenhaver, A. E., & LeGates, T. A. (2024) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2024.01.15.575709 · Cited by 3
Self-citation
A ventral hippocampus to nucleus accumbens pathway regulates impulsivityPreprint
Klug, M. E., Décarie-Spain, L., Lauer, L. T., Kao, A. E., Moody, O. P., Morano, N. R., Huang, H., Arnold, D. B., Noble, E. E., & Kanoski, S. E. (2025) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2025.11.18.689154 · Cited by 3
Anxiety induced by systemic inflammation involves microglial engulfing of nucleus accumbens inputs and diminished excitability of dopamine D1 receptor neurons
Nakajima, S., Kabahizi, A., Aubailly, S., Naili-Douaouda, S., Tomita, A., Bosson, A., Alquier, T., Murphy‐Royal, C., & Fulton, S. E. (2025) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2025.106154 · Cited by 4
Methamphetamine conditioned place preference in adolescent mice: Interaction between sex and strain
Severino, L. N., Toussaint, A. B., Langa, R. M., McKenna, G., Bodziony, I., & Burghardt, N. S. (2026) · Journal of Psychopharmacology · doi:10.1177/02698811261420102 · Cited by 2
Transcriptional regulation of ventral hippocampus-nucleus accumbens circuit excitability drives cocaine seeking
Eagle, A. L., Sugimoto, C., Doyle, M. A., Anderson, D., Mousavi, S. L., Dykstra, M. M., Kuhn, H. M., Murray, B. S., Bastle, R. M., Simmons, S. C., et al. (2026) · Science Advances · doi:10.1126/sciadv.adv1236 · Cited by 4
Transcranial magneto-acoustic stimulation improves corticostriatal transmission in direct medium spiny neurons and rescues neuroplasticity of Parkinson’s disease model mice
Xu, Y., Zhang, S., Mi, J., Lu, X., An, Y., Liu, J., Sun, J., Wang, Y., & Xu, G. (2026) · npj Parkinson s Disease · doi:10.1038/s41531-026-01333-8 · Cited by 2
Protein phosphatase 2A deficiency in hippocampal CA1 inhibits priming effect of morphine on conditioned place preference in mice
Dai, J., Xie, R., Sun, Z., Kou, X., Zhang, J.-Q., Cui, Q., Liu, R., Gao, X., Wang, J., & Gao, J. (2023) · Cerebral Cortex · doi:10.1093/cercor/bhac527 · Cited by 2
Alcohol disrupts long-term potentiation at hippocampus-medium spiny neuron synapses in the medial shell of the nucleus accumbens
Copenhaver, A. E., Snider, S. A., Campbell, J. R., & LeGates, T. A. (2026) · Brain Research · doi:10.1016/j.brainres.2026.150577 · Cited by 2
Self-citation
Synaptic plasticity in fronto-insular circuits underlying stress susceptibility and resilience
Rocks, D., & Liston, C. M. (2024) · Neuroscience Research · doi:10.1016/j.neures.2024.12.006 · Cited by 2
Control of Parallel Hippocampal Output Pathways by Amygdalar Long-Range InhibitionPreprint
AlSubaie, R., Wee, R. W. S., Ritoux, A., Mishchanchuk, K., Passlack, J., Regester, D., & MacAskill, A. F. (2021) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2021.03.08.434367 · Cited by 2
Role of the Hippocampus in Decision Making Under UncertaintyPreprint
Attaallah, B., Petitet, P., Zambellas, R., Irani, S. R., Manohar, S., & Masud Husain, B. (2021) · SSRN Electronic Journal · doi:10.2139/ssrn.3912947 · Cited by 2
Internal state dependent control of feeding behaviour via hippocampal ghrelin signallingPreprint
Wee, R. W. S., Mishchanchuk, K., AlSubaie, R., & MacAskill, A. F. (2021) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2021.11.05.467326 · Cited by 2
Negative emotional behavior during fentanyl abstinence is mediated by adaptations in nucleus accumbens neuron subtypesPreprint
Fox, M. E., Wulff, A. B., Franco, D., Choi, E. Y., Calarco, C. A., Engeln, M., Turner, M. D., Chandra, R., Rhodes, V. M., Thompson, S. M., et al. (2022) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2022.05.15.491856 · Cited by 2
Self-citation
Ventral CA1 Population Codes for AnxietyPreprint
Lim, S. C., Fusi, S., & Hen, R. (2023) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2023.09.25.559358 · Cited by 3
vCA1 SST neurons represent avoidance states that guide anxiety-related behavioral choicesPreprint
Bratsch-Prince, J. X., Wei, M., Sureshbabu, S., Chhaya, V., Cano-Adamuz, N., Logas, K. R., & Kheirbek, M. A. (2026) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.64898/2026.03.02.709156 · Cited by 2
Chromatin accessibility and H3K9me3 landscapes reveal long-term epigenetic effects of fetal-neonatal iron deficiency in rat hippocampus
Liu, S. X., Ramakrishnan, A., Shen, L., Gewirtz, J. C., Georgieff, M., & Tran, P. V. (2024) · BMC Genomics · doi:10.1186/s12864-024-10230-4 · Cited by 1
Investigating the changes in volumes of the limbic system and hypothalamic-subnuclei in patients with depression
Shin, D., Han, K., Lee, S., Kim, B., Pyun, S., Tae, W., & Ham, B. (2024) · Psychiatry Research Neuroimaging · doi:10.1016/j.pscychresns.2024.111942 · Cited by 1
Specializations in Amygdalar and Hippocampal Innervation of the Primate Nucleus Accumbens Shell
Marshall, L. G., & Barbas, H. (2025) · Journal of Neuroscience · doi:10.1523/jneurosci.2425-24.2025 · Cited by 2
Downregulation of integrin α3 in ADHD mirrored in mutant mouse model by dopamine-dependent hippocampal AMPAR expression
Yao, X., Chen, R., Zhu, J., Hou, R., Xiang, S., Jia, T., Gu, Y., Wang, Z., Hu, H., Chen, H., et al. (2025) · Molecular Psychiatry · doi:10.1038/s41380-025-03399-x · Cited by 1
Decreased Oxytocin Mediates PVN–CA2 and PVN–PrL in Sleep Deprivation-Induced Social Memory Deficits
Liu, Y., Deng, Y., Gao, Y., Rao, B., Wang, Y., Zhang, Y., Yi, K., Cang, Y., Li, H., Bi, L., et al. (2025) · Research · doi:10.34133/research.1076 · Cited by 1
Heterosynaptic Interactions between the Dorsal and Ventral Hippocampus in Individual Medium Spiny Neurons of the Nucleus Accumbens Ventromedial Shell
Copenhaver, A. E., Vance, S., Snider, S. A., Befano, K., She, J. B., & LeGates, T. A. (2026) · Journal of Neuroscience · doi:10.1523/jneurosci.1225-25.2026 · Cited by 1
Self-citation
Dorsal CA1 projections to nucleus accumbens and lateral septum differentially regulate social and locomotor behavior
Han, Y., Besing, G.-L. K., Larivee, R., Guo, D. Y., Mukerjee, S., Erickson, K. R., Lewis, A. S., Nobis, W. P., Lyman, K. A., Siciliano, C. A., et al. (2026) · Cerebral Cortex · doi:10.1093/cercor/bhag059 · Cited by 1
Emotional shaping of spatial encoding along the dorsal ventral axis of the hippocampus
Silva, A., & Girardeau, G. (2026) · Frontiers in Systems Neuroscience · doi:10.3389/fnsys.2026.1888312 · Cited by 1
Altered Postnatal Chromatin Development in the Nucleus Accumbens Primes Enduring Stress Sensitivity
Rashford, R. L., Fang, L. Z., DeBerardine, M., Kim, H. J. J., Hirschfield, L. W., Cervi, E., Barrett, M. R., Thompson, J. M., Creed, M. C., & Peña, C. J. (2026) · Journal of Neuroscience · doi:10.1523/jneurosci.2217-25.2026 · Cited by 4
Self-citation
Endocannabinoid System: behavioral modulation in murine models by Cannabinoids type 2 receptors
Monteiro, R. F. M., Nascimento, M. V. L., Lima, K. T., Almeida, J. R. G., Ávila, P. E. S., & Bastos, G. D. N. T. (2021) · Research Society and Development · doi:10.33448/rsd-v10i13.21491 · Cited by 1
Neuronal Network Activation Induced by Forniceal Deep Brain Stimulation in Mice
Tang, B., Wu, Z., Wang, Q., & Tang, J. (2025) · Genes · doi:10.3390/genes16020210 · Cited by 1
Pro-resilient effects of environmental enrichment on social isolation: Behavioural and cytochrome c oxidase brain analysis in Wistar adult rats
Amador, P., López, M., Cuesta‐López, I., Jove, C. I., Tomás‐Zapico, C., & Begega, A. (2025) · Behavioural Brain Research · doi:10.1016/j.bbr.2025.115574 · Cited by 1
Chemogenetic inhibition of a monosynaptic projection from the basolateral amygdala to the ventral hippocampus selectively reduces appetitive, but not consummatory, alcohol drinking-related behaviorsPreprint
Bach, E. C., Ewin, S. E., Heaney, C. F., Carlson, H. N., Almonte, A. G., Chappell, A. M., Raab‐Graham, K. F., & Weiner, J. L. (2019) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/529719 · Cited by 1
Inhibition of the Ventral Hippocampus Increases Alcohol DrinkingPreprint
Griffin, W. C., Rinker, J. A., Woodward, J. J., Mulholland, P. J., & Becker, H. C. (2019) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/786178 · Cited by 1
Population dynamics underlying associative learning in the dorsal and ventral hippocampusPreprint
Biane, J. S., Ladow, M. A., Stefanini, F., Boddu, S. P., Fan, A., Hassan, S., Dundar, N., Apodaca-Montano, D. L., Woods, N. I., & Kheirbek, M. A. (2021) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2021.11.16.468862 · Cited by 1
Ventral hippocampal CCK interneurons gate context-reward memoryPreprint
Nguyen, R., Sivakumaran, S., Lambe, E. K., & Kim, J. C. (2023) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2023.04.27.538595 · Cited by 1
Hippocampal contextualization of social rewardsPreprint
Duarte, J. M., Li, K., Nguyen, R., & Ciocchi, S. (2023) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2023.05.12.540475 · Cited by 1
Predict key biomarkers of Alcohol Dependence in Nucleus accumbens by Weighted gene co-expression network analysisPreprint
Shi, X., Xu, B., He, T., Shi, J., & Zhang, L. (2024) · Research Square · doi:10.21203/rs.3.rs-4201908/v1 · Cited by 1
Representations of stimulus meaning in the hippocampusPreprint
Biane, J. S., Ladow, M. A., Fan, A., Choi, H. S., Zhou, L. Z., Hassan, S., Apodaca-Montano, D. L., Kwon, A. O., Bratsch-Prince, J. X., & Kheirbek, M. A. (2024) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2024.10.14.618280 · Cited by 1
When remembering is rewarding
Bray, N. (2018) · Nature reviews. Neuroscience · doi:10.1038/s41583-018-0110-4
Bulleyaconitine A inhibits morphine physical and psychological dependence via dynorphin A expressionPreprint
Zhao, M. J., Wang, M. Y., Ma, L., Ahmad, K. A., & Wang, Y. X. (2020) · doi:10.22541/au.159363388.81912664
Promoting Pleasant Memories with a Specialized Serotonergic Projection to the Hippocampus
Giorgi, A., & Maddaloni, G. (2021) · Journal of Neuroscience · doi:10.1523/jneurosci.1615-20.2020
The VTA-BLA-NAc circuit for sex reward inhibited by VTA GABAergic neurons under stress in male micePreprint
Sun, L., You, J., Cui, M., Sun, F., Wang, J., Wang, W., Wang, D., Liu, D., Xu, Z., Qiu, C., et al. (2021) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2021.01.20.427537
Different Encoding of Reward Location in Dorsal and Ventral HippocampusPreprint
Jarzębowski, P., Hay, Y. A., Grewe, B. F., & Paulsen, O. (2021) · SSRN Electronic Journal · doi:10.2139/ssrn.3919935
Rewarding and Antidepressant Properties of Ketamine and Ethanol: Effects on the BDNF and TrkB and p75 NTR ReceptorsPreprint
Contó, M. B., Pautassi, R. M., & Camarini, R. (2022) · SSRN Electronic Journal · doi:10.2139/ssrn.4001150
A Computational Theory of Learning Flexible Reward-Seeking Behavior with Place CellsPreprint
Gao, Y. (2022) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2022.04.23.489289
Faculty Opinions recommendation of Sustained rescue of prefrontal circuit dysfunction by antidepressant-induced spine formation.
Kolb, B. E. (2019) · Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature · doi:10.3410/f.735536620.793560172
Addiction
Savarese, A. M., & Crabbe, J. C. (2020) · Elsevier eBooks · doi:10.1016/b978-0-12-813866-3.00041-2
ATAC and histone H3K9me3 landscapes revealed the altered epigenome by fetal-neonatal iron deficiency in the adult male rat hippocampusPreprint
Liu, S. X., Ramakrishnan, A., Shen, L., Gewirtz, J. C., Georgieff, M., & Tran, P. V. (2022) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2022.06.07.495122
Dorsal Hippocampus To Nucleus Accumbens Projections Drive Reinforcement Via Activation of Accumbal Dynorphin NeuronsPreprint
Massaly, N., Ibrahim, K. M., Yoon, H. J., Sandoval, R., Williams, S. B., Frye, H. E., Post, W., Yu, W., Idowu, O., Zec, A., et al. (2022) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2022.08.08.503098
Sexually dimorphic neural encoding of threat discrimination in nucleus accumbens afferents drives suppression of reward behaviorPreprint
Muir, J., Tse, Y., Iyer, E., Sorensen, J., Eid, R., Cvetkovska, V., Wassef, K., Gostlin, S. K., Spencer, N., & Bagot, R. C. (2022) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2022.10.04.510865
Nucleoredoxin – a redox modulator of calcium calmodulin kinase 2a promoting the exploratory behavior in mice
Tran, N. B. (2022) · Publication Server of Goethe University Frankfurt am Main (Goethe University Frankfurt) · doi:10.21248/gups.71335
New Avenues for Treating Affective Dysfunction During Opioid Abstinence
Turner, J. R. (2023) · Biological Psychiatry · doi:10.1016/j.biopsych.2022.12.010
Smaller Subcortical Volume of the Accumbens and Caudate Precede Weight Gain in Youth with High Financial Adversity: Findings from the Abcd StudyPreprint
Adise, S., Mächel, C., Myers, K. P., Ottino‐González, J., McCormick, E. M., Millstein, J., Goran, M. I., & Sowell, E. R. (2024) · SSRN Electronic Journal · doi:10.2139/ssrn.4821280
The ventral hippocampal-nucleus accumbens shell circuit drives approach decisions under social novelty and learned cue approach-avoidance conflictPreprint
Patterson, D., Khan, N., Sassaninejad, K., Stewart, N. R., Collins, E., Yeates, D. C. M., Lee, A. C. H., & Ito, R. (2024) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2024.06.27.600935
Addiction
Savarese, A. M., & Crabbe, J. C. (2024) · Elsevier eBooks · doi:10.1016/b978-0-443-19176-3.00036-4
Cocaine, via ΔFosB, remodels gene expression and excitability in ventral hippocampusPreprint
Eagle, A. L., Doyle, M. A., Sugimoto, C., Dykstra, M. M., Kuhn, H. M., Murray, B. S., Bastle, R. M., He, J., Maze, I. S., Mazei‐Robison, M. S., et al. (2024) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2024.11.06.621895
α-Conotoxin TxIB Reversed Nicotine-Induced Locomotor Sensitization and Nicotine-Enhanced Dopaminergic Activity in Mice
Xu, W., Wang, M., Li, X., He, R., Ding, R., Bao, J., Zhangsun, D., & Luo, S. (2025) · Marine Drugs · doi:10.3390/md23030109
The Effect and Mechanism of Magnesium Valproate on Methamphetamine‐Addicted Rats
Li, Y., Wang, L., Sun, Y., & Wang, X. (2025) · Addiction Biology · doi:10.1111/adb.70084
The Hippocampus and Cortical Networks
Biesalski, H. K. (2025) · Springer eBooks · doi:10.1007/978-3-031-99121-9_11
Additional file 1 of Chromatin accessibility and H3K9me3 landscapes reveal long-term epigenetic effects of fetal-neonatal iron deficiency in rat hippocampus
Liu, S. X., Ramakrishnan, A., Shen, L., Gewirtz, J. C., Georgieff, M. K., & Tran, P. V. (2024) · Figshare · doi:10.6084/m9.figshare.25459510
Additional file 4 of Chromatin accessibility and H3K9me3 landscapes reveal long-term epigenetic effects of fetal-neonatal iron deficiency in rat hippocampus
Liu, S. X., Ramakrishnan, A., Shen, L., Gewirtz, J. C., Georgieff, M. K., & Tran, P. V. (2024) · Figshare · doi:10.6084/m9.figshare.26696277
Additional file 3 of Chromatin accessibility and H3K9me3 landscapes reveal long-term epigenetic effects of fetal-neonatal iron deficiency in rat hippocampus
Liu, S. X., Ramakrishnan, A., Shen, L., Gewirtz, J. C., Georgieff, M. K., & Tran, P. V. (2024) · Figshare · doi:10.6084/m9.figshare.26696274
Additional file 2 of Chromatin accessibility and H3K9me3 landscapes reveal long-term epigenetic effects of fetal-neonatal iron deficiency in rat hippocampus
Liu, S. X., Ramakrishnan, A., Shen, L., Gewirtz, J. C., Georgieff, M. K., & Tran, P. V. (2024) · Figshare · doi:10.6084/m9.figshare.25459657
Additional file 5 of Chromatin accessibility and H3K9me3 landscapes reveal long-term epigenetic effects of fetal-neonatal iron deficiency in rat hippocampus
Liu, S. X., Ramakrishnan, A., Shen, L., Gewirtz, J. C., Georgieff, M. K., & Tran, P. V. (2024) · Figshare · doi:10.6084/m9.figshare.26696280
Additional file 6 of Chromatin accessibility and H3K9me3 landscapes reveal long-term epigenetic effects of fetal-neonatal iron deficiency in rat hippocampus
Liu, S. X., Ramakrishnan, A., Shen, L., Gewirtz, J. C., Georgieff, M. K., & Tran, P. V. (2024) · Figshare · doi:10.6084/m9.figshare.26696286
TRP canonical 4 and/or 5 channel inhibition reduces aversion‐ and increases reward‐responding in chronically stressed mice
Poggi, G., Queisser, D., Senn, A., Sigrist, H., Kúkeľová, D., Madur, L., Cuomo-Haymour, N., Robert, M., Schmid, S., Portalés, A., et al. (2025) · British Journal of Pharmacology · doi:10.1111/bph.70305 · Cited by 1
Reinforced Hippocampus-Accumbens pathway marks a shift towards cognitive decline in agingPreprint
Ribera, A., Fernandes-Dias, B., Yugay, L., Deneuville, E., Dias‐Silva, M., Violain, M., Bouet, T., Bethus, I., Lopes, L. V., Vanhoutte, P., et al. (2026) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.64898/2026.01.19.700256
Triggering action potentials of a single neuron by multiphoton excitation elicits visually guided behavior
Wang, H., Xiao, Y., Tang, W., Lai, K., Ma, Q., Zhao, X., Li, B., Shi, H., & He, H. (2026) · Nature Communications · doi:10.1038/s41467-026-69446-5
Neurobiological links between Alzheimer’s disease and reward system dysfunction
Harutyunyan, H. S., Minasyan, R., Kalueff, A. V., & Yenkoyan, K. B. (2026) · Neuroscience · doi:10.1016/j.neuroscience.2026.03.028
It is a matter of size—manipulating body size with virtual reality modulates reward sensitivity
Pia, L., Freedberg, M., Pyasik, M. M., Boarini, R., Holcomb, A. N., Lanza, C. M., Zampini, M., & Schintu, S. (2026) · Scientific Reports · doi:10.1038/s41598-026-45811-8 · Cited by 1
Rôle des afférences thalamiques au noyau accumbens dans les comportements motivés chez le rat
Sicre, M. (2021) · theses.fr (ABES) · doi:10.70675/b8ead46dzaf07z4156zb06bzc3755176fcfc
Study of the therapeutic potentials of the induced augmentation in adult neurogenesis in a mouse model of chronic mild stress and depression
Eliwa, H. (2020) · theses.fr (ABES) · doi:10.70675/d246defdz6649z4d6fza1f9z50300ef2d10d
Dpp6 knockout mice exhibit increased ethanol conditioned place preference and acute ethanol‐induced anxiolytic behavior
Hernández, M., & Barkley‐Levenson, A. M. (2026) · Alcoholism Clinical and Experimental Research · doi:10.1111/acer.70282
On the developmental origin of CA1 pyramidal neuron diversity in the adult mouse hippocampus
Cavalieri, D. (2021) · theses.fr (ABES) · doi:10.70675/af05b2d4zc031z48d7z9ebaz859f489a8450
Différences sexuelles dans les synapses excitatrices de l’amygdale basolatérale de rat
Guily, P. (2021) · theses.fr (ABES) · doi:10.70675/3ce7db18z6a11z4e26z940fze421cc5e9733
New regulators in oxytocin and vasopressin release : role of the endolysosomal two-pore channels
Martucci, L. L. (2021) · theses.fr (ABES) · doi:10.70675/027d1ae2zd2ebz4677za019ze6ccd94cafe9
Hippocampal reactivations after aversive or rewarding experience : classical and deep learning approaches
Bryzgalov, D. V. (2021) · theses.fr (ABES) · doi:10.70675/c11854e0ze39ez4a3fza554zf56b05c49055 · Cited by 1
Conserved inhibitory motifs yield distinct hippocampal functions through regional circuit embeddingPreprint
Siwani, S., Thulin, A., França, A. S. C., Lindholm, A., Roman, E., & Kullander, K. (2026) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.64898/2026.05.06.718927
Synaptic Actions of Estradiol in the Brain’s Reward System: Linking Mechanisms to Behavior and Disease
LaChapelle-Sproat, M. V., Anderson, N. S., & LeGates, T. A. (2026) · Biological Psychiatry Global Open Science · doi:10.1016/j.bpsgos.2026.100757 · Cited by 1
Self-citation
Reward-tethered place cells support flexible magnitude coding and remapping in the hippocampusPreprint
Masala, N., Donahue, M. M., Boublil, B. L., Irizarry‐Martinez, G., Abouelatta, H., Miller, K. M., Sabariego, M., & Ewell, L. A. (2026) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.64898/2026.05.15.725501
Baseline Anhedonia Phenotypes Reveal Divergent Neurophysiological Effects of Intermittent Theta Burst Stimulation in Major Depressive Disorder
Wu, J., Deng, Z., Cheng, X., Qiu, N., Hu, L., Chen, Z., Yi, C., Pu, L., Yao, D., & Yan, H. (2026) · Biological Psychiatry Cognitive Neuroscience and Neuroimaging · doi:10.1016/j.bpsc.2026.05.004
Jiawei Sini San ameliorates cognitive deficits in CUMS depression rats by reshaping dendritic spines through regulating TRPC6-activated ROCK2-Cofilin signaling pathway
Zhang, T., Feng, H., Li, L., Wang, S. L., Wu, L., & Yan, C. (2026) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2026.121917
A ventral hippocampus to nucleus accumbens pathway regulates impulsivity in male but not female rats
Klug, M. E., Décarie-Spain, L., Lauer, L. T., Sortman, B. W., Mo, B., Kao, A. E., Moody, O. P., Morano, N. R., Huang, H., Arnold, D. B., et al. (2026) · Neuropsychopharmacology · doi:10.1038/s41386-026-02477-0 · Cited by 4
The Molecular Machinery of Synaptic Plasticity and Its Potential Role in the Aetiology of Schizophrenia
MORRIS, B. J. (2026) · Molecular Neurobiology · doi:10.1007/s12035-026-05954-1 · Cited by 1
Moderate hypoxia and cognitive training for cognitive impairment in mood disorders: a randomized controlled trialPreprint
Schandorff, J. M., Damgaard, V., Johansen, A., Macoveanu, J., Cramer, K., Madsen, A. B. F., Orum, B. E. R., Bruun, C. F., Meyer, M., Plavén‐Sigray, P., et al. (2026) · medRxiv · doi:10.64898/2026.07.10.26357722
Transsynaptic neural circuit mapping of ventral hippocampus motivational control systems
Klug, M. E., Shanmugam, M. V., Huang, H., Arnold, D., Hahn, J. D., & Kanoski, S. E. (2026) · Brain Structure and Function · doi:10.1007/s00429-026-03164-y
Differential Reward Circuitry Engagement During Anticipation in Highly Resilient World Trade Center Responders
Seeley, S. H., Schreiber, Z., Norbury, A., Morris, L. S., Monti, E., Cahn, L., Aaronson, C. J., Kowalchyk, M. L., DePierro, J. M., Murrough, J. W., et al. (2026) · Biological Psychiatry Cognitive Neuroscience and Neuroimaging · doi:10.1016/j.bpsc.2026.07.003
Hippocampus–Ventral Striatum Connectivity Is Associated With Binge Drinking Frequency in Adults
Elliott, B. L., Huque, Z. M., Ruiz, N. A., Ellman, L. M., & Murty, V. P. (2026) · Hippocampus · doi:10.1002/hipo.70113
Functional Integrity of Mesolimbic-Hippocampal Circuits Is Associated with Anhedonia in Individuals with Early Life Stress
O’Brien, K. J., Elliott, B. L., O’Shea, I. M., Schiffman, J. E., Mittal, V. A., Ellman, L. M., & Murty, V. P. (2026) · Journal of Neuroscience · doi:10.1523/jneurosci.0274-26.2026
Brain metabolic correlates of heroin addiction severity during abstinence and heroin versus social seeking: A PET study in rats
D’Ottavio, G., Sullivan, A., Pilz, E. M., Schoenborn, I., Solís, Ó., Gomez, J. L., Kahnt, T., Michaelides, M., & Shaham, Y. (2026) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2610087123
Cofilin 1 overexpression in the ventral hippocampus partially alleviates depressive-like behaviors in postmenopausal depression model mice through the dynamics of dendrites/dendritic spines in relevant brain regions
Yu, Z.-H., Chen, G., Ge, M.-J., Zhang, Z., Shen, J.-X., Pan, C., Han, F., Lu, Y.-P., & Xu, H. (2026) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2026.174261
Metformin alleviates type 2 diabetes-related depressive-like behaviors via AKAP150 signaling in NAc D1 medium spiny neurons
Deng, Q., Gao, S., Xue, S.-G., Zhang, S.-Q., Yang, J., Cui, Q., Zhang, C., & Zhou, H.-Y. (2026) · Pharmacological Research · doi:10.1016/j.phrs.2026.108446
The ventral hippocampus: computations, circuits and functions
Biane, J. S., Wagner-Carena, J., & Kheirbek, M. A. (2026) · Nature reviews. Neuroscience · doi:10.1038/s41583-026-01078-6 · Cited by 2
A consistent vigor network in Parkinson's disease: a potential target for brain stimulation effects
Kavian, Z., Sardouie, S. H., Arasteh, E., Mirian, M. S., Sreenivasan, V., Yazdani, M., & McKeown, M. J. (2026) · Frontiers in Human Neuroscience · doi:10.3389/fnhum.2026.1928519

Authors: LeGates, T. A., Kvarta, M. D., Tooley, J. R., Francis, T. C., Lobo, M. K., Creed, M. C., & Thompson, S. M.
Affiliations: University of Maryland, Baltimore (US)
Corresponding author: Thompson, Scott M.
ORCID: LeGates, Tara A.
Kvarta, Mark D.
Tooley, Jessica R.
Francis, T. Chase
Lobo, Mary Kay
Creed, Meaghan C.
Thompson, Scott M.
Venue: Nature
Publisher: Springer Science and Business Media LLC
Published: 2018-11-26
Volume: 564
Issue: 7735
Pages: 258-262
ISSN: 0028-0836 (ISSN-L)
1476-4687
DOI: 10.1038/s41586-018-0740-8
PMC: PMC6292781
OpenAlex: W2900803145
Cited by: 290
References: 23
Citations by year: 2026: 36 · 2025: 33 · 2024: 41 · 2023: 36 · 2022: 41 · 2021: 45 · 2020: 25 · 2019: 30 · 2018: 1
FWCI: 11.49
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: www.springer.com/tdm (tdm)
Locations: Nature (publishedVersion)
PubMed (publishedVersion)
Europe PMC (PubMed Central) (acceptedVersion)
PubMed Central (acceptedVersion)
RePEc: Research Papers in Economics (submittedVersion)
Funders: National Institute of Mental Health (R01MH106500, R01MH086828)
National Institute on Drug Abuse (R01DA038613)
Topics: Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
Keywords: hippocampus, nucleus accumbens, long-term potentiation, synaptic plasticity, conditioned place preference, anhedonia, chronic stress, antidepressant treatment, goal-directed behavior
MeSH terms: Animals, Chronic Disease, Conditioning, Psychological, Dopamine, Female, Goals, Hippocampus, Male, Neuronal Plasticity, Nucleus Accumbens, Reward, Stress, Psychological, Synapses, Long-Term Potentiation, Mice, Anhedonia

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Reward behaviour is regulated by the strength of hippocampus–nucleus accumbens synapses

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Self-check

Citations

Cites

Cited by

Related

Metadata

Record

About these checks