Thompson, Scott M.

NMDAR inhibition-independent antidepressant actions of ketamine metabolites

Zanos, P., Moaddel, R., Morris, P. J., Georgiou, P., Fischell, J., Elmer, G. I., Alkondon, M., Yuan, P., Pribut, H. J., Singh, N. S., et al. (2016) · Nature

Treatment of Major DepressionNeuroscience and Neuropharmacology Research

Cited by 1,609

Harnessing psilocybin: antidepressant-like behavioral and synaptic actions of psilocybin are independent of 5-HT2R activation in mice

Hesselgrave, N., Troppoli, T. A., Wulff, A. B., Cole, A. B., & Thompson, S. M. (2021) · Proceedings of the National Academy of Sciences

Psychedelics and Drug StudiesTreatment of Major Depression

Cited by 378

Reward behaviour is regulated by the strength of hippocampus–nucleus accumbens synapses

LeGates, T. A., Kvarta, M. D., Tooley, J. R., Francis, T. C., Lobo, M. K., Creed, M. C., & Thompson, S. M. (2018) · Nature

Neuroscience and Neuropharmacology ResearchNeurotransmitter Receptor Influence on Behavior

Cited by 290

An excitatory synapse hypothesis of depression

Thompson, S. M., Kallarackal, A. J., Kvarta, M. D., Van Dyke, A. M., LeGates, T. A., & Cai, X. (2015) · Trends in Neurosciences

Treatment of Major DepressionNeuroscience and Neuropharmacology Research

Cited by 265

Chronic Stress Induces a Selective Decrease in AMPA Receptor-Mediated Synaptic Excitation at Hippocampal Temporoammonic-CA1 Synapses

Kallarackal, A. J., Kvarta, M. D., Cammarata, E., Jaberi, L., Cai, X., Bailey, A. M., & Thompson, S. M. (2013) · The Journal of Neuroscience

Neuroscience and Neuropharmacology ResearchTreatment of Major Depression

Cited by 181

Local potentiation of excitatory synapses by serotonin and its alteration in rodent models of depression

Cai, X., Kallarackal, A. J., Kvarta, M. D., Goluskin, S., Gaylor, K., Bailey, A. M., Lee, H.-K., Huganir, R. L., & Thompson, S. M. (2013) · Nature Neuroscience

Neuroscience and Neuropharmacology ResearchTreatment of Major Depression

Cited by 180

Convergent Mechanisms Underlying Rapid Antidepressant Action

Zanos, P., Thompson, S. M., Duman, R. S., Zarate, C. A., & Gould, T. D. (2018) · CNS Drugs

Treatment of Major DepressionNeuroscience and Neuropharmacology Research

Cited by 171

Long-term potentiation of exogenous glutamate responses at single dendritic spines

Bagal, A. A., Kao, J. P. Y., Tang, C.-M., & Thompson, S. M. (2005) · Proceedings of the National Academy of Sciences

Neuroscience and Neuropharmacology ResearchMemory and Neural Mechanisms

Cited by 169

Antidepressant-relevant concentrations of the ketamine metabolite (2 R ,6 R )-hydroxynorketamine do not block NMDA receptor function

Lumsden, E. W., Troppoli, T. A., Myers, S. J., Zanos, P., Aracava, Y., Kehr, J., Lovett, J., Kim, S., Wang, F.-H., Schmidt, S., et al. (2019) · Proceedings of the National Academy of Sciences

Treatment of Major DepressionNeuroscience and Neuropharmacology Research

Cited by 158

Estradiol Induces Hypothalamic Dendritic Spines by Enhancing Glutamate Release: A Mechanism for Organizational Sex Differences

Schwarz, J. M., Liang, S.-L., Thompson, S. M., & McCarthy, M. M. (2008) · Neuron

Neuroscience and Neuropharmacology ResearchSexual Differentiation and Disorders

Cited by 139

Molecular Pharmacology and Neurobiology of Rapid-Acting Antidepressants

Gould, T. D., Zarate, C. A., & Thompson, S. M. (2019) · Annual Review of Pharmacology and Toxicology

Treatment of Major DepressionNeuroscience and Neuropharmacology Research

Cited by 133

Rapid Antidepressant Action and Restoration of Excitatory Synaptic Strength After Chronic Stress by Negative Modulators of Alpha5-Containing GABAA Receptors

Fischell, J., Van Dyke, A. M., Kvarta, M. D., LeGates, T. A., & Thompson, S. M. (2015) · Neuropsychopharmacology

Treatment of Major DepressionNeuroscience and Neuropharmacology Research

Cited by 122

NMDA Receptor Activation-Dependent Antidepressant-Relevant Behavioral and Synaptic Actions of Ketamine

Zanos, P., Brown, K. A., Georgiou, P., Yuan, P., Zarate, C. A., Thompson, S. M., & Gould, T. D. (2023) · The Journal of Neuroscience

Treatment of Major DepressionNeuroscience and Neuropharmacology Research

Cited by 115

A negative allosteric modulator for α5 subunit-containing GABA receptors exerts a rapid and persistent antidepressant-like action without the side effects of the NMDA receptor antagonist ketamine in mice

Zanos, P., Nelson, M. E., Highland, J. N., Krimmel, S. R., Georgiou, P., Gould, T. D., & Thompson, S. M. (2017) · eNeuro

Treatment of Major DepressionNeuroscience and Neuropharmacology Research

Cited by 106

Corticosterone mediates the synaptic and behavioral effects of chronic stress at rat hippocampal temporoammonic synapses

Kvarta, M. D., Bradbrook, K. E., Dantrassy, H. M., Bailey, A. M., & Thompson, S. M. (2015) · Journal of Neurophysiology

Stress Responses and CortisolNeuroscience and Neuropharmacology Research

Cited by 86

(R)‐Ketamine exerts antidepressant actions partly via conversion to (2R,6R)‐hydroxynorketamine, while causing adverse effects at sub‐anaesthetic doses

Zanos, P., Highland, J. N., Liu, X., Troppoli, T. A., Georgiou, P., Lovett, J., Morris, P. J., Stewart, B. W., Thomas, C. J., Thompson, S. M., et al. (2019) · British Journal of Pharmacology

Treatment of Major DepressionTryptophan and brain disorders

Cited by 82

Beyond the serotonin deficit hypothesis: Communicating a neuroplasticity framework of major depressive disorder

Page, C. E., Epperson, C. N., Novick, A. M., Duffy, K. A., & Thompson, S. M. (2024) · Molecular Psychiatry

Treatment of Major DepressionNeurotransmitter Receptor Influence on Behavior

Cited by 80

Differential control of GABA release at synapses from distinct interneurons in rat hippocampus

Poncer, J. C., McKinney, R. A., Gáhwiler, B. H., & Thompson, S. M. (2000) · The Journal of Physiology

Neuroscience and Neuropharmacology ResearchNeural dynamics and brain function

Cited by 78

(2R,6R)-hydroxynorketamine rapidly potentiates hippocampal glutamatergic transmission through a synapse-specific presynaptic mechanism

Riggs, L. M., Aracava, Y., Zanos, P., Fischell, J., Albuquerque, E. X., Pereira, E. F. R., Thompson, S. M., & Gould, T. D. (2020) · Neuropsychopharmacology

Treatment of Major DepressionNeuroscience and Neuropharmacology Research

Cited by 66

Plasticity of synapses and reward circuit function in the genesis and treatment of depression

Thompson, S. M. (2023) · Neuropsychopharmacology

Treatment of Major DepressionNeurotransmitter Receptor Influence on Behavior

Cited by 40

Negative Allosteric Modulation of Gamma-Aminobutyric Acid A Receptors at α5 Subunit–Containing Benzodiazepine Sites Reverses Stress-Induced Anhedonia and Weakened Synaptic Function in Mice

Troppoli, T. A., Zanos, P., Georgiou, P., Gould, T. D., Rudolph, U., & Thompson, S. M. (2022) · Biological Psychiatry

Treatment of Major DepressionNeuroscience and Neuropharmacology Research

Cited by 29