The DOI matches its Crossref record; 50 of the 50 references it cites were found in a registry or an index.
A circuit from hippocampal CA2 to lateral septum disinhibits social aggression
Open accessAbstract
Although the hippocampus is known to be important for declarative memory, it is less clear how hippocampal output regulates motivated behaviours, such as social aggression. Here we report that pyramidal neurons in the CA2 region of the hippocampus, which are important for social memory, promote social aggression in mice. This action depends on output from CA2 to the lateral septum, which is selectively enhanced immediately before an attack. Activation of the lateral septum by CA2 recruits a circuit that disinhibits a subnucleus of the ventromedial hypothalamus that is known to trigger attack. The social hormone arginine vasopressin enhances social aggression by acting on arginine vasopressin 1b receptors on CA2 presynaptic terminals in the lateral septum to facilitate excitatory synaptic transmission. In this manner, release of arginine vasopressin in the lateral septum, driven by an animal’s internal state, may serve as a modulatory control that determines whether CA2 activity leads to declarative memory of a social encounter and/or promotes motivated social aggression. Pyramidal neurons in the hippocampal CA2 region in mice promote social aggression via a disinhibitory circuit involving the lateral septum and ventromedial hypothalamus.
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Ultrasensitive fluorescent proteins for imaging neuronal activity
Chen, T.-W., Wardill, T. J., Sun, Y., Pulver, S. R., Renninger, S. L., Baohan, A., Schreiter, E. R., Kerr, R. A., Orger, M. B., Jayaraman, V., et al. (2013) · Nature · doi:10.1038/nature12354 · Cited by 6,474
de Nó, R. L. (1934) · Cited by 1,974
Natural neural projection dynamics underlying social behavior
Gunaydin, L. A., Grosenick, L., Finkelstein, J. C., Kauvar, I. V., Fenno, L. E., Adhikari, A., Lammel, S., Mirzabekov, J. J., Airan, R. D., Zalocusky, K. A., et al. (2014) · Cell · doi:10.1016/j.cell.2014.05.017 · Cited by 1,389
The connections of the septal region in the rat
Swanson, L. W., & Cowan, W. M. (1979) · Journal of Comparative Neurology · doi:10.1002/cne.901860408 · Cited by 1,135
Requirement for Hippocampal CA3 NMDA Receptors in Associative Memory Recall
Nakazawa, K., Quirk, M. C., Chitwood, R. A., Watanabe, M., Yeckel, M. F., Sun, L. D., Kato, A., Carr, C. A., Johnston, D., Wilson, M. A., et al. (2002) · Science · doi:10.1126/science.1071795 · Cited by 1,099
The hippocampal CA2 region is essential for social memory
Hitti, F. L., & Siegelbaum, S. A. (2014) · Nature · doi:10.1038/nature13028 · Cited by 976
Self-citationMapping of Brain Activity by Automated Volume Analysis of Immediate Early Genes
Renier, N., Adams, E. L., Kirst, C., Wu, Z., Azevedo, R., Kohl, J., Autry, A. E., Kadiri, L., Umadevi Venkataraju, K., Zhou, Y., et al. (2016) · Cell · doi:10.1016/j.cell.2016.05.007 · Cited by 918
Functional identification of an aggression locus in the mouse hypothalamus
Lin, D., Boyle, M. P., Dollar, P., Lee, H., Lein, E. S., Perona, P., & Anderson, D. J. (2011) · Nature · doi:10.1038/nature09736 · Cited by 914
Intact-brain analyses reveal distinct information carried by SNc dopamine subcircuits
Lerner, T. N., Shilyansky, C., Davidson, T. J., Evans, K. E., Beier, K. T., Zalocusky, K. A., Crow, A. K., Malenka, R. C., Luo, L., Tomer, R., et al. (2015) · Cell · doi:10.1016/j.cell.2015.07.014 · Cited by 794
Connections of the rat lateral septal complex 1Published on the World Wide Web on 2 June 1997. 1
Risold, P. Y., & Swanson, L. W. (1997) · Brain Research Reviews · doi:10.1016/s0165-0173(97)00009-x · Cited by 671
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Li, L., Durand-de Cuttoli, R., Aubry, A. V., Burnett, C. J., Cathomas, F., Parise, L. F., Chan, K. L., Morel, C., Yuan, C., Shimo, Y., et al. (2023) · Nature · doi:10.1038/s41586-022-05484-5 · Cited by 134
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Metadata
- Authors
- Leroy, F., Park, J., Asok, A., Brann, D. H., Meira, T., Boyle, L. M., Buss, E. W., Kandel, E. R., & Siegelbaum, S. A.
- Venue
- Nature
- Published
- 2018-12
- Volume
- 564
- Issue
- 7735
- Pages
- 213-218
- ISSN
- 0028-0836 (ISSN-L)
- 1476-4687
- OpenAlex
- W2902511506
- Cited by
- 283
- References
- 50
- FWCI
- 11.48
- Type
- journal article
- Language
- en
- Open access
- green
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- Leroy, F., Park, J., Asok, A., Brann, D. H., Meira, T., Boyle, L. M., Buss, E. W., Kandel, E. R., & Siegelbaum, S. A. (2018). A circuit from hippocampal CA2 to lateral septum disinhibits social aggression. Nature. https://doi.org/10.1038/s41586-018-0772-0
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