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Cited by 325

The DOI matches its Crossref record; 58 of the 58 references it cites were found in a registry or an index.

Structural insights into the activation of metabotropic glutamate receptors

Open access
Koehl, Antoine, Hu, Hongli, Feng, Dan, Sun, Bingfa, Zhang, Yan, Robertson, Michael J., Chu, Matthew, Kobilka, Tong Sun, Laeremans, Toon, Steyaert, Jan, Tarrasch, Jeffrey, Dutta, Somnath, Fonseca, Rasmus, Weis, William I., Mathiesen, Jesper M., Skiniotis, Georgios, Kobilka, Brian K.·2019·Nature
DOI 10.1038/s41586-019-0881-4
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Abstract

Metabotropic glutamate receptors are family C G-protein-coupled receptors. They form obligate dimers and possess extracellular ligand-binding Venus flytrap domains, which are linked by cysteine-rich domains to their 7-transmembrane domains. Spectroscopic studies show that signalling is a dynamic process, in which large-scale conformational changes underlie the transmission of signals from the extracellular Venus flytraps to the G protein-coupling domains—the 7-transmembrane domains—in the membrane. Here, using a combination of X-ray crystallography, cryo-electron microscopy and signalling studies, we present a structural framework for the activation mechanism of metabotropic glutamate receptor subtype 5. Our results show that agonist binding at the Venus flytraps leads to a compaction of the intersubunit dimer interface, thereby bringing the cysteine-rich domains into close proximity. Interactions between the cysteine-rich domains and the second extracellular loops of the receptor enable the rigid-body repositioning of the 7-transmembrane domains, which come into contact with each other to initiate signalling. The activation mechanism of metabotropic glutamate receptor subtype 5, a member of the family C G-protein-coupled receptors, is characterized by a combination of cryo-electron microscopy, crystallography and signalling studies.

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Metadata

Authors
Koehl, A., Hu, H., Feng, D., Sun, B., Zhang, Y., Robertson, M. J., Chu, M., Kobilka, T. S., Laeremans, T., Steyaert, J., Tarrasch, J., Dutta, S., Fonseca, R., Weis, W. I., Mathiesen, J. M., Skiniotis, G., & Kobilka, B. K.
Venue
Nature
Publisher
Springer Science and Business Media LLC
Published
2019-01-23
Volume
566
Issue
7742
Pages
79-84
ISSN
  • 0028-0836 (ISSN-L)
  • 1476-4687
DOI
10.1038/s41586-019-0881-4
OpenAlex
W2911446286
Cited by
325
References
58
FWCI
13.39
Type
journal article
Language
en
Open access
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CoChat. (2026). Citation check: Structural insights into the activation of metabotropic glutamate receptors. https://app.cochat.ai/papers/10.1038/s41586-019-0881-4
The paper
Koehl, A., Hu, H., Feng, D., Sun, B., Zhang, Y., Robertson, M. J., Chu, M., Kobilka, T. S., Laeremans, T., Steyaert, J., Tarrasch, J., Dutta, S., Fonseca, R., Weis, W. I., Mathiesen, J. M., Skiniotis, G., & Kobilka, B. K. (2019). Structural insights into the activation of metabotropic glutamate receptors. Nature. https://doi.org/10.1038/s41586-019-0881-4

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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.