The DOI matches its Crossref record; 39 of the 41 references it cites were found in a registry or an index, and 1 are not checked yet.
The guidance receptor plexin D1 is a mechanosensor in endothelial cells
Open accessAbstract
Shear stress on arteries produced by blood flow is important for vascular development and homeostasis but can also initiate atherosclerosis 1. Endothelial cells that line the vasculature use molecular mechanosensors to directly detect shear stress profiles that will ultimately lead to atheroprotective or atherogenic responses 2. Plexins are key cell-surface receptors of the semaphorin family of cell-guidance signalling proteins and can regulate cellular patterning by modulating the cytoskeleton and focal adhesion structures 3-5. However, a role for plexin proteins in mechanotransduction has not been examined. Here we show that plexin D1 (PLXND1) has a role in mechanosensation and mechanically induced disease pathogenesis. PLXND1 is required for the response of endothelial cells to shear stress in vitro and in vivo and regulates the site-specific distribution of atherosclerotic lesions. In endothelial cells, PLXND1 is a direct force sensor and forms a mechanocomplex with neuropilin-1 and VEGFR2 that is necessary and sufficient for conferring mechanosensitivity upstream of the junctional complex and integrins. PLXND1 achieves its binary functions as either a ligand or a force receptor by adopting two distinct molecular conformations. Our results establish a previously undescribed mechanosensor in endothelial cells that regulates cardiovascular pathophysiology, and provide a mechanism by which a single receptor can exhibit a binary biochemical nature.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
The source backs part of the claim, not all of it — or backs it for a different population, condition or comparison.
In the citing paper
“Interestingly, a recent study also reported a semaphorin-independent mechanosensitive function for Plexin-D1, a paralog of Plexin-B1, to detect blood flow shear stress in endothelial cells62.”
From Regulation of cell distancing in peri-plaque glial nets by Plexin-B1 affects glial activation and amyloid compaction in Alzheimer’s disease (2024) · cites this paper as [62]
Experimental — accuracy not yet measured
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
NIH Image to ImageJ: 25 years of image analysis
Schneider, C. A., Rasband, W. S., & Eliceiri, K. W. (2012) · Nature Methods · doi:10.1038/nmeth.2089 · Cited by 64,638
EMAN2: An extensible image processing suite for electron microscopy
Tang, G., Peng, L., Baldwin, P. R., Mann, D. S., Jiang, W., Rees, I., & Ludtke, S. J. (2006) · Journal of Structural Biology · doi:10.1016/j.jsb.2006.05.009 · Cited by 2,914
Flow-mediated endothelial mechanotransduction
Davies, P. F. (1995) · Physiological Reviews · doi:10.1152/physrev.1995.75.3.519 · Cited by 2,802
Spontaneous Hypercholesterolemia and Arterial Lesions in Mice Lacking Apolipoprotein E
Zhang, S. H., Reddick, R. L., Piedrahita, J. A., & Maeda, N. (1992) · Science · doi:10.1126/science.1411543 · Cited by 2,237
A mechanosensory complex that mediates the endothelial cell response to fluid shear stress
Tzima, E., Irani-Tehrani, M., Kiosses, W. B., Dejana, E., Schultz, D., Engelhardt, B., Cao, G., DeLisser, H. M., & Schwartz, M. A. (2005) · Nature · doi:10.1038/nature03952 · Cited by 1,738
Self-citationMechanotransduction in vascular physiology and atherogenesis
Hahn, C. S., & Schwartz, M. A. (2008) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm2596 · Cited by 1,257
Piezo1 integration of vascular architecture with physiological force
Li, J., Hou, B., Tumova, S., Muraki, K., Bruns, A. F., Ludlow, M. J., Sedó, A., Hyman, A. J., McKeown, L., Young, R. S., et al. (2014) · Nature · doi:10.1038/nature13701 · Cited by 1,250
A time- and cost-efficient system for high-level protein production in mammalian cells
Aricescu, A. R., Lu, W., & Jones, E. Y. (2006) · Acta Crystallographica Section D Biological Crystallography · doi:10.1107/s0907444906029799 · Cited by 770
Self-citationKLF2 Is a Novel Transcriptional Regulator of Endothelial Proinflammatory Activation
SenBanerjee, S., Lin, Z., Atkins, G. B., Greif, D. M., Rao, R. M., Kumar, A., Feinberg, M. W., Chen, Z., Simon, D. I., Luscinskas, F. W., et al. (2004) · The Journal of Experimental Medicine · doi:10.1084/jem.20031132 · Cited by 734
Integrins in Mechanotransduction
Katsumi, A., Orr, A. W., Tzima, E., & Schwartz, M. A. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.r300038200 · Cited by 724
Self-citation
Cited by
Sorted by citations
A systems view of the vascular endothelium in health and disease
Augustin, H. G., & Koh, G. Y. (2024) · Cell · doi:10.1016/j.cell.2024.07.012 · Cited by 383
Flow-induced reprogramming of endothelial cells in atherosclerosis
Tamargo, I. A., Baek, K. I., Kim, Y., Park, C. J., & Jo, H. (2023) · Nature Reviews Cardiology · doi:10.1038/s41569-023-00883-1 · Cited by 306
Davis, M. J., Earley, S., Li, Y.-S., & Chien, S. (2023) · Physiological Reviews · doi:10.1152/physrev.00053.2021 · Cited by 273
The Importance of Mechanical Forces for in vitro Endothelial Cell Biology
Gordon, E. J., Schimmel, L., & Frye, M. (2020) · Frontiers in Physiology · doi:10.3389/fphys.2020.00684 · Cited by 177
Botts, S. R., Fish, J. E., & Howe, K. L. (2021) · Frontiers in Pharmacology · doi:10.3389/fphar.2021.787541 · Cited by 181
Molecular mechanisms of exercise contributing to tissue regeneration
Chen, J., Zhou, R. J., Ye, F., & Cheng, L. (2022) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-022-01233-2 · Cited by 185
Coronary heart disease and atrial fibrillation: a vicious cycle
Liang, F., & Wang, Y. (2020) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00702.2020 · Cited by 157
Endothelial mechanobiology in atherosclerosis
Wang, X., Shen, Y., Shang, M., Liu, X., & Munn, L. L. (2023) · Cardiovascular Research · doi:10.1093/cvr/cvad076 · Cited by 154
Extracellular Matrix Cues Regulate Mechanosensing and Mechanotransduction of Cancer Cells
Mierke, C. T. (2024) · Cells · doi:10.3390/cells13010096 · Cited by 146
Endothelial shear stress signal transduction and atherogenesis: From mechanisms to therapeutics
He, L., Zhang, C., Chen, Q., Wang, L., & Huang, Y. (2022) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2022.108152 · Cited by 141
Biophysical and Biochemical Roles of Shear Stress on Endothelium: A Revisit and New Insights
Cheng, C. K., Wang, N., Wang, L., & Huang, Y. (2025) · Circulation Research · doi:10.1161/circresaha.124.325685 · Cited by 126
Mechanosensing by Vascular Endothelium
Lim, X. R., & Harraz, O. F. (2023) · Annual Review of Physiology · doi:10.1146/annurev-physiol-042022-030946 · Cited by 123
Bibli, S., Hu, J., Looso, M., Weigert, A., Rațiu, C., Wittig, J., Drekolia, M. K., Tombor, L., Randriamboavonjy, V., Leisegang, M. S., et al. (2020) · Circulation · doi:10.1161/circulationaha.120.051877 · Cited by 107
The molecular mechanism of mechanotransduction in vascular homeostasis and disease
Yamashiro, Y., & Yanagisawa, H. (2020) · Clinical Science · doi:10.1042/cs20190488 · Cited by 106
Emerging roles of inflammation-mediated endothelial–mesenchymal transition in health and disease
Yoshimatsu, Y., & Watabe, T. (2022) · Inflammation and Regeneration · doi:10.1186/s41232-021-00186-3 · Cited by 97
Foote, C. A., Soares, R. N., Ramirez‐Perez, F. I., Ghiarone, T., Aroor, A., Manrique‐Acevedo, C., Padilla, J., & Martinez‐Lemus, L. (2022) · Comprehensive Physiology · doi:10.1002/j.2040-4603.2022.tb00232.x · Cited by 89
Majumdar, U., Manivannan, S., Basu, M., Ueyama, Y., Blaser, M. C., Cameron, E., McDermott, M. R., Lincoln, J., Cole, S. E., Wood, S. A., et al. (2021) · Science Advances · doi:10.1126/sciadv.abe3706 · Cited by 94
Mußbacher, M., Schossleitner, K., Kral-Pointner, J. B., Salzmann, M., Schrammel, A., & Schmid, J. A. (2022) · Current Atherosclerosis Reports · doi:10.1007/s11883-022-01023-9 · Cited by 86
Benincasa, G., Coscioni, E., & Claudio Napoli, A. (2022) · Biochemical Pharmacology · doi:10.1016/j.bcp.2022.115108 · Cited by 84
Mehta, V., Pang, K. L., Givens, C. S., Chen, Z., Huang, J., Sweet, D. T., Jo, H., Reader, J. S., & Tzima, E. (2021) · Science Advances · doi:10.1126/sciadv.abg5060 · Cited by 80
Self-citationNotch in mechanotransduction – from molecular mechanosensitivity to tissue mechanostasis
Stassen, O. M. J. A., Ristori, T., & Sahlgren, C. (2020) · Journal of Cell Science · doi:10.1242/jcs.250738 · Cited by 75
Neural signalling of gut mechanosensation in ingestive and digestive processes
Kim, M., Heo, G., & Kim, S. (2022) · Nature reviews. Neuroscience · doi:10.1038/s41583-021-00544-7 · Cited by 83
Viscoelasticity, Like Forces, Plays a Role in Mechanotransduction
Mierke, C. T. (2022) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2022.789841 · Cited by 86
Pressure and stiffness sensing together regulate vascular smooth muscle cell phenotype switching
Swiatlowska, P., Sit, B. H. M., Feng, Z., Marhuenda, E., Xanthis, I., Zingaro, S., Ward, M. J., Zhou, X., Xiao, Q., Shanahan, C. M., et al. (2022) · Science Advances · doi:10.1126/sciadv.abm3471 · Cited by 74
Activation of Smad2/3 signaling by low fluid shear stress mediates artery inward remodeling
Deng, H., Min, E., Baeyens, N., Coon, B. G., Hu, R., Zhuang, Z. W., Chen, M., Huang, B., Afolabi, T., Zarkada, G., et al. (2021) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2105339118 · Cited by 74
The spectrin cytoskeleton integrates endothelial mechanoresponses
Mylvaganam, S., Plumb, J. D., Yusuf, B., Li, R., Lu, C.-Y., Robinson, L. A., Freeman, S. A., & Grinstein, S. (2022) · Nature Cell Biology · doi:10.1038/s41556-022-00953-5 · Cited by 70
Mechanochemical control of epidermal stem cell divisions by B-plexins
Chen, J., Javed, A., Kaiser, L., Nava, M. M., Xu, R. C., Brandt, D. T., Zhao, D., Mayer, B., Fernández-Baldovinos, J., Zhou, L., et al. (2021) · Nature Communications · doi:10.1038/s41467-021-21513-9 · Cited by 73
A Hierarchical Mechanotransduction System: From Macro to Micro
Cao, R. Y., Tian, H., Tian, Y., & Fu, X. (2023) · Advanced Science · doi:10.1002/advs.202302327 · Cited by 67
The Mechanobiology of Endothelial-to-Mesenchymal Transition in Cardiovascular Disease
Islam, S., Boström, K. I., Carlo, D. D., Simmons, C. A., Tintut, Y., Yao, Y., & Hsu, J. J. (2021) · Frontiers in Physiology · doi:10.3389/fphys.2021.734215 · Cited by 59
Remodeling of the Microvasculature: May the Blood Flow Be With You
Santamarı́a, R., González-Álvarez, M., Delgado, R., Esteban, S., & Arroyo, A. G. (2020) · Frontiers in Physiology · doi:10.3389/fphys.2020.586852 · Cited by 56
Alves, C. J., Dariolli, R., Haydak, J. C., Kang, S., Hannah, T. C., Wiener, R. J., DeFronzo, S., Tejero, R., Gusella, G. L., Ramakrishnan, A., et al. (2021) · Nature Communications · doi:10.1038/s41467-021-26296-7 · Cited by 55
Early events in endothelial flow sensing
Tanaka, K., Joshi, D., Timalsina, S., & Schwartz, M. A. (2021) · Cytoskeleton · doi:10.1002/cm.21652 · Cited by 55
Decoding mechanical cues by molecular mechanotransduction
Swaminathan, V., & Gloerich, M. (2021) · Current Opinion in Cell Biology · doi:10.1016/j.ceb.2021.05.006 · Cited by 54
Li, Y., Kang, S., Halawani, D., Wang, Y., Alves, C. J., Ramakrishnan, A., Estill, M. S., Shen, L., Li, F., He, X., et al. (2022) · Genes & Development · doi:10.1101/gad.349063.121 · Cited by 53
Ligand-independent receptor clustering modulates transmembrane signaling: a new paradigm
Sánchez, M. F., & Tampé, R. (2022) · Trends in Biochemical Sciences · doi:10.1016/j.tibs.2022.08.002 · Cited by 49
Endothelial discoidin domain receptor 1 senses flow to modulate YAP activation
Liu, J., Zhao, C., Xiao, X., Li, A., Liu, Y., Zhao, J., Fan, L., Liang, Z., Pang, W., Yao, W., et al. (2023) · Nature Communications · doi:10.1038/s41467-023-42341-z · Cited by 43
From remodeling to quiescence: The transformation of the vascular network
Ouarné, M., Pena, A., & Franco, C. A. (2021) · Cells and Development · doi:10.1016/j.cdev.2021.203735 · Cited by 42
Huang, Y., Wang, M., Ni, H., Zhang, J., Li, A., Hu, B., Junqueira Alves, C., Wahane, S., Rios de Anda, M., Ho, L., et al. (2024) · Nature Neuroscience · doi:10.1038/s41593-024-01664-w · Cited by 42
“Interestingly, a recent study also reported a semaphorin-independent mechanosensitive function for Plexin-D1, a paralog of Plexin-B1, to detect blood flow shear stress in endothelial cells 62 .”
Dynamics of Endothelial Cell Generation and Turnover in Arteries During Homeostasis and Diseases
Li, Y., Liu, Z., Han, X., Liang, F., Zhang, Q., Huang, X., Shi, X., Huo, H., Han, M., Liu, X., et al. (2023) · Circulation · doi:10.1161/circulationaha.123.064301 · Cited by 43
Mechanisms of endothelial flow sensing
Aitken, C., Mehta, V., Schwartz, M. A., & Tzima, E. (2023) · Nature Cardiovascular Research · doi:10.1038/s44161-023-00276-0 · Cited by 42
Self-citationShear stress and pathophysiological PI3K involvement in vascular malformations
Abdelilah‐Seyfried, S., & Ola, R. (2024) · Journal of Clinical Investigation · doi:10.1172/jci172843 · Cited by 42
Plexin-B2 facilitates glioblastoma infiltration by modulating cell biomechanics
Huang, Y., Tejero, R., Lee, V. K., Brusco, C., Hannah, T. C., Bertucci, T. B., Alves, C. J., Katsyv, I., Kluge, M., Foty, R. A., et al. (2021) · Communications Biology · doi:10.1038/s42003-021-01667-4 · Cited by 45
Fang, F., Feng, T., Li, J., Zhang, H., Wang, Q., Chen, Y., Wang, G., Shen, Y., & Liu, X. (2022) · Genes & Diseases · doi:10.1016/j.gendis.2022.03.020 · Cited by 37
Neuronal guidance genes in health and diseases
Yuasa‐Kawada, J., Kinoshita-Kawada, M., Tsuboi, Y., & Wu, J. Y. (2022) · Protein & Cell · doi:10.1093/procel/pwac030 · Cited by 37
Xu, S. (2020) · Pharmacological Research · doi:10.1016/j.phrs.2020.104737 · Cited by 36
Fluid flow as a driver of embryonic morphogenesis
Daems, M., Peacock, H. M., & Jones, E. A. V. (2020) · Development · doi:10.1242/dev.185579 · Cited by 37
Self-citationShear stress control of vascular leaks and atheromas through Tie2 activation by VE‐PTP sequestration
Shirakura, K., Bałuk, P., Nottebaum, A. F., Ipe, U., Peters, K. G., McDonald, D. M., & Vestweber, D. (2023) · EMBO Molecular Medicine · doi:10.15252/emmm.202216128 · Cited by 36
Oscillatory shear stress promotes endothelial senescence and atherosclerosis via STING activation
Dong, M., Chen, M., Zhang, Y., He, X., Min, J., Tan, Y., Wei, H., Li, X., Chen, X., Zheng, L., et al. (2024) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2024.149979 · Cited by 34
Bibli, S., & Fleming, I. (2021) · Antioxidants and Redox Signaling · doi:10.1089/ars.2021.0162 · Cited by 33
Silvani, G., Romanov, V., Cox, C. D., & Martinac, B. (2021) · Frontiers in Bioengineering and Biotechnology · doi:10.3389/fbioe.2021.612151 · Cited by 32
Wu, B., Xu, W., Wu, K., Li, Y., Hu, M., Feng, C., Zhu, C., Zheng, J., Cui, X., Li, J., et al. (2024) · Nature Ecology & Evolution · doi:10.1038/s41559-024-02510-9 · Cited by 31
Maruyama, K., Naemura, K., Arima, Y., Uchijima, Y., Nagao, H., Yoshihara, K., Singh, M. K., Uemura, A., Matsuzaki, F., Yoshida, Y., et al. (2021) · iScience · doi:10.1016/j.isci.2021.102305 · Cited by 31
Axon guidance molecules in immunometabolic diseases
Nakanishi, Y., Kang, S., & Kumanogoh, A. (2022) · Inflammation and Regeneration · doi:10.1186/s41232-021-00189-0 · Cited by 30
Bosseboeuf, E., Chikh, A., Chaker, A. B., Mitchell, T. P., Vignaraja, D., Rajendrakumar, R., Khambata, R. S., Nightingale, T. D., Mason, J. C., RANDI, A. M., et al. (2023) · Science Signaling · doi:10.1126/scisignal.abo4863 · Cited by 31
Hamrangsekachaee, M., Wen, K., Bencherif, S. A., & Ebong, E. E. (2022) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00449.2022 · Cited by 34
Mechanosensory entities and functionality of endothelial cells
Mierke, C. T. (2024) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2024.1446452 · Cited by 36
Disturbed Flow Induces Atherosclerosis by Annexin A2-Mediated Integrin Activation
Demos, C., Williams, D., & Jo, H. (2020) · Circulation Research · doi:10.1161/circresaha.120.317909 · Cited by 30
Chikh, A., & Raimondi, C. (2024) · Biochemical Society Transactions · doi:10.1042/bst20230329 · Cited by 29
Yu, Z., Chen, Y., Li, J., Chen, C., Lu, H., Chen, S., Zhang, T., Guo, T., Zhu, Y., Jin, J., et al. (2024) · Journal of Nanobiotechnology · doi:10.1186/s12951-024-02334-6 · Cited by 29
Jing, L., Fan, S., Yao, X., & Zhang, Y. (2021) · Regenerative Biomaterials · doi:10.1093/rb/rbab066 · Cited by 29
Motor neurons use push-pull signals to direct vascular remodeling critical for their connectivity
Martins, L. F., Brambilla, I., Motta, A., de Pretis, S., Bhat, G. P., Badaloni, A., Malpighi, C., Amin, N. D., Imai, F., Almeida, R. D., et al. (2022) · Neuron · doi:10.1016/j.neuron.2022.09.021 · Cited by 30
Chalkias, A. F. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms242417522 · Cited by 27
Shu, J., Deng, H., Zhang, Y., Wu, F., & He, J. (2024) · Regenerative Biomaterials · doi:10.1093/rb/rbae016 · Cited by 29
Shear stress regulation of nanoparticle uptake in vascular endothelial cells
Zhang, H., Hu, Z., Wang, J., Xu, J., Wang, X., Zang, G., Qiu, J., & Wang, G. (2023) · Regenerative Biomaterials · doi:10.1093/rb/rbad047 · Cited by 26
Regulation of YAP Promotor Accessibility in Endothelial Mechanotransduction
Mannion, A. J., Zhao, H., Zhang, Y., von Wright, Y., Bergman, O., Roy, J., Saharinen, P., & Holmgren, L. (2024) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.123.320300 · Cited by 26
Zebrafish Vascular Development: General and Tissue-Specific Regulation
Nakajima, H., Chiba, A., Fukumoto, M., Morooka, N., & Mochizuki, N. (2021) · Journal of Lipid and Atherosclerosis · doi:10.12997/jla.2021.10.2.145 · Cited by 27
Vascular homeostasis in atherosclerosis: A holistic overview
Xu, S., Lyu, Q., Ilyas, I., Tian, X.-Y., & Weng, J. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.976722 · Cited by 26
Insights into the regulatory role of Plexin D1 signalling in cardiovascular development and diseases
Zhang, Y., Zhang, Y., Jia, D., Yang, H., Cheng, M.-D., Zhu, W., Xin, H., Li, P., & Zhang, Y. (2021) · Journal of Cellular and Molecular Medicine · doi:10.1111/jcmm.16509 · Cited by 25
A force-sensitive adhesion GPCR is required for equilibrioception
Yang, Z., Zhou, S., Zhang, Q., Song, Z.-C., Liu, W., Sun, Y., Wang, M.-W., Fu, X., Zhu, K., Guan, Y., et al. (2025) · Cell Research · doi:10.1038/s41422-025-01075-x · Cited by 24
The Hippo pathway mediates Semaphorin signaling
Meng, Z., Li, F.-L., Fang, C., Yeoman, B. M., Qiu, Y., Wang, Y., Cai, X., Lin, K. C., Yang, D., Luo, M., et al. (2022) · Science Advances · doi:10.1126/sciadv.abl9806 · Cited by 24
Hou, Z., Deng, L., Fang, F., Zhao, T., Zhang, Y., Li, G., Miao, M. Z., Zhang, Y., Yu, H., & Liu, X. (2025) · BMC Biology · doi:10.1186/s12915-025-02125-x · Cited by 24
Moving from lipids to leukocytes: inflammation and immune cells in atherosclerosis
Annink, M. E., Kraaijenhof, J. M., Stroes, E. S. G., & Kroon, J. (2024) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2024.1446758 · Cited by 22
Endothelial Mechanosensors for Atheroprone and Atheroprotective Shear Stress Signals
Li, H., Zhou, W.-Y., Xia, Y.-Y., & Zhang, J.-X. (2022) · Journal of Inflammation Research · doi:10.2147/jir.s355158 · Cited by 22
Wen, Y., Li, S., Bao, G., Wang, J., Liu, X., Hu, J., Zhao, F., Zhao, Z., Shi, B., & Luo, Y. (2022) · Frontiers in Veterinary Science · doi:10.3389/fvets.2022.926725 · Cited by 23
Endothelial PlexinD1 signaling instructs spinal cord vascularization and motor neuron development
Vieira, J. R., Shah, B., Dupraz, S., Paredes, I., Himmels, P., Schermann, G., Adler, H., Motta, A., Gärtner, L., Navarro-Aragall, A. G., et al. (2022) · Neuron · doi:10.1016/j.neuron.2022.12.005 · Cited by 21
Li, J., Hu, K., He, D., Zhou, L., Wang, Z., & Tao, Y. (2021) · Frontiers in Oncology · doi:10.3389/fonc.2020.604131 · Cited by 22
Jia, Z., Mei, J., Ding, W., Zhao, X., Wen, G., Yu, H., Qin, L., Piao, Z., Chen, W., & Tang, L. (2022) · Computer Methods and Programs in Biomedicine · doi:10.1016/j.cmpb.2022.107187 · Cited by 20
Zhou, S. M., Ou, H., Wu, Y., Qi, D., Pei, X., Yu, X., Hu, X., & Wu, E. (2023) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2023.108434 · Cited by 21
Matrix stiffness, endothelial dysfunction and atherosclerosis
Xu, Z., Chen, Y., Wang, Y., Han, W., Xu, W., Liao, X., Zhang, T., & Wang, G. (2023) · Molecular Biology Reports · doi:10.1007/s11033-023-08502-5 · Cited by 20
Life at the crossroads: the nuclear LINC complex and vascular mechanotransduction
Bougaran, P., & Bautch, V. L. (2024) · Frontiers in Physiology · doi:10.3389/fphys.2024.1411995 · Cited by 20
Angiorganoid: vitalizing the organoid with blood vessels
Ma, X., Li, H., Zhu, S., Hong, Z., Kong, W., Yuan, Q., Wu, R., Pan, Z., Zhang, J., Chen, Y., et al. (2022) · Vascular Biology · doi:10.1530/vb-22-0001 · Cited by 19
Hauger, P. C., & Hordijk, P. L. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25116047 · Cited by 21
Hagihara, K., Haraguchi, N., Nishimura, J., Yasueda, A., Fujino, S., Ogino, T., Takahashi, H., Miyoshi, N., Uemura, M., Matsuda, C., et al. (2022) · Annals of Surgical Oncology · doi:10.1245/s10434-022-11945-y · Cited by 17
Loss of SOX18/CLAUDIN5 disrupts the pulmonary endothelial barrier in ventilator-induced lung injury
Flores, A. G., Groß, C., Zemskov, E. A., Lü, Q., Tieu, K., Wang, T., & Black, S. M. (2022) · Frontiers in Physiology · doi:10.3389/fphys.2022.1066515 · Cited by 20
Wang, Y.-T., Tong, X., Shi, X., Keswani, T., Chatterjee, E., Chen, L., Li, G., Lee, K., Guo, T., & Yu, Y. (2023) · ACS Applied Materials & Interfaces · doi:10.1021/acsami.3c11188 · Cited by 17
Chan, J., Hannah, T., Sadia, S., Kolsteeg, C., Dixon, A., Wiener, R. J., Nguyen, H., Tipping, M. J., Ladeira, J. S., Franklin, P. F. D. C., et al. (2025) · Nature Communications · doi:10.1038/s41467-024-55056-6 · Cited by 18
Christie, S. M., Jing, H., Tracy, E., Buck, M., Yu, J. S., & Smith, A. W. (2021) · Journal of Biological Chemistry · doi:10.1016/j.jbc.2021.100965 · Cited by 17
Vascular Pathobiology: Atherosclerosis and Large Vessel Disease
Bonafiglia, Q. A., Bendeck, M. P., & Gotlieb, A. I. (2022) · Elsevier eBooks · doi:10.1016/b978-0-12-822224-9.00006-2 · Cited by 21
The role of semaphorins in small vessels of the eye and brain
Zhang, C., Hong, C., Wang, H., Chen, A.-Q., Zhou, Y., Wan, Y., Li, Y., & Hu, B. (2020) · Pharmacological Research · doi:10.1016/j.phrs.2020.105044 · Cited by 16
The emerging roles of semaphorin4D/CD100 in immunological diseases
Wang, L., Li, X., Song, Y., Song, D., & Huang, D. (2020) · Biochemical Society Transactions · doi:10.1042/bst20200821 · Cited by 16
Endothelial Krüppel-like factor 2/4: Regulation and function in cardiovascular diseases
Gao, J., Pan, H., Guo, X., Huang, Y., & Luo, J. (2025) · Cellular Signalling · doi:10.1016/j.cellsig.2025.111699 · Cited by 16
Vascular mechanical forces and vascular diseases
Liu, S., Cai, J., & Chen, Z. (2025) · Journal of Advanced Research · doi:10.1016/j.jare.2025.09.013 · Cited by 18
Endothelial Mechanosensors for Atheroprone and Atheroprotective Shear Stress Signals
Li, H., Zhou, W., Xia, Y., & Zhang, J. (2022) · Dove Medical Press (Taylor and Francis Group) · Cited by 15
NRP1 transduces mechanical stress inhibition via LATS1/YAP in hypertrophic scars
Li, M., Wang, P., Li, J., Zhou, F., Huang, S., Qi, S., & Shu, B. (2023) · Cell Death Discovery · doi:10.1038/s41420-023-01635-3 · Cited by 19
Plasma proteomics for prediction of subclinical coronary artery calcifications in primary prevention
Royer, P., Björnson, E., Adiels, M., Álvez, M. B., Fagerberg, L., Bäckhed, F., Uhlén, M., Gummesson, A., & Bergström, G. M. L. (2024) · American Heart Journal · doi:10.1016/j.ahj.2024.01.011 · Cited by 15
Guiding axon regeneration: Instructions from blood vessels
Acker‐Palmer, A. (2024) · Neuron · doi:10.1016/j.neuron.2023.11.017 · Cited by 14
De novo Fc-based receptor dimerizers differentially modulate PlexinB1 function
Sugano-Nakamura, N., Matoba, K., Hirose, M., Bashiruddin, N. K., Matsunaga, Y., Yamashita, K., Hirata, K., Yamamoto, M., Arimori, T., Suga, H., et al. (2022) · Structure · doi:10.1016/j.str.2022.07.008 · Cited by 15
Park, C.-S., Baek, K. I., Hung, R.-C., Choi, L., Jeong, K., Kim, P., Jahng, A. K., Kim, J., Kim, Y., Meselhe, M., et al. (2025) · Cardiovascular Research · doi:10.1093/cvr/cvaf233 · Cited by 13
Plexin D1 mediates disturbed flow-induced M1 macrophage polarization in atherosclerosis
Zhang, S., Zhang, Y., Zhang, P., Wei, Z., Ma, M., Wang, W. J., Tong, W., Tian, F., Hui, H., Tian, J., et al. (2023) · Heliyon · doi:10.1016/j.heliyon.2023.e17314 · Cited by 13
Zhou, W., Wang, F., Qian, X., Luo, S., Wang, Z., Gao, X., Kong, X., Zhang, J., & Chen, S. (2023) · International Immunopharmacology · doi:10.1016/j.intimp.2023.109842 · Cited by 13
Metadata
- Authors
- Mehta, V., Pang, K.-L., Rozbesky, D., Nather, K., Keen, A., Lachowski, D., Kong, Y., Karia, D., Ameismeier, M., Huang, J., Fang, Y., del Rio Hernandez, A., Reader, J. S., Jones, E. Y., & Tzima, E.
- Affiliations
- Centre for Human Genetics (GB)
- Imperial College London (GB)
- Duke University (US)
- University of Chicago (US)
- Corresponding author
- Tzima, Ellie
- ORCID
- Venue
- Nature
- Published
- 2020-02-05
- Volume
- 578
- Issue
- 7794
- Pages
- 290-295
- ISSN
- 0028-0836 (ISSN-L)
- 1476-4687
- PMC
- PMC7025890
- OpenAlex
- W3005314662
- Cited by
- 221
- References
- 41
- Citations by year
- 2026: 25 · 2025: 42 · 2024: 39 · 2023: 31 · 2022: 41 · 2021: 27 · 2020: 16
- FWCI
- 14.34
- Type
- journal article
- Language
- en
- Update notices
- correction (2022-05-03)
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Nature (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- RePEc: Research Papers in Economics (submittedVersion)
- UCL Discovery (University College London) (submittedVersion)
- Funders
- Wellcome Trust (203141/Z/16/Z, 107457/Z/15/Z, 100980, 100980/C/13/Z)
- Cancer Research UK (17721, A17721)
- British Heart Foundation (RE/13/1/30181, PG/16/29/32128)
- Medical Research Council (MR/M000141/1, MR/T000503/1)
- National Heart, Lung, and Blood Institute (R01HL136765, R01HL138223)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Cellular Mechanics and Interactions
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Axon Guidance and Neuronal Signaling
- Life Sciences › Immunology and Microbiology › Immunology › Atherosclerosis and Cardiovascular Diseases
- Keywords
- PlexinD1, mechanosensing, mechanotransduction, endothelial cells, shear stress, atherosclerosis, semaphorin receptors, neuropilin-1, VEGFR2
- MeSH terms
- Animals, Female, Membrane Glycoproteins, Receptors, Cell Surface, Stress, Mechanical, Integrins, Pliability, Neuropilin-1, Semaphorins, Vascular Endothelial Growth Factor Receptor-2, Mechanotransduction, Cellular, Endothelial Cells, Intracellular Signaling Peptides and Proteins, Atherosclerosis, Mice
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
