The DOI matches its Crossref record; 72 of the 72 references it cites were found in a registry or an index.
Construction of a human cell landscape at single-cell level
Abstract
Single-cell analysis is a valuable tool for dissecting cellular heterogeneity in complex systems 1. However, a comprehensive single-cell atlas has not been achieved for humans. Here we use single-cell mRNA sequencing to determine the cell-type composition of all major human organs and construct a scheme for the human cell landscape (HCL). We have uncovered a single-cell hierarchy for many tissues that have not been well characterized. We established a 'single-cell HCL analysis' pipeline that helps to define human cell identity. Finally, we performed a single-cell comparative analysis of landscapes from human and mouse to identify conserved genetic networks. We found that stem and progenitor cells exhibit strong transcriptomic stochasticity, whereas differentiated cells are more distinct. Our results provide a useful resource for the study of human biology.
Overview
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“By leveraging a recent human pan-tissue scRNA-Seq data (a.k.a. Human Cell Landscape; HCL) [12], we can identify cell-type specific/selective E3 ligases to facilitate the development of tumor-specific/selective PROTACs.”
From Proteolysis targeting chimeras (PROTACs) are emerging therapeutics for hematologic malignancies (2020) · cites this paper as [12]
Citations
Cites
Cytoscape: A software Environment for integrated models of biomolecular interaction networks
Shannon, P., Markiel, A., Ozier, O., Baliga, N. S., Wang, J. T., Ramage, D., Amin, N., Schwikowski, B., & Ideker, T. (2003) · Genome Research · doi:10.1101/gr.1239303 · Cited by 51,888
Self-citationSTAR: ultrafast universal RNA-seq aligner
Dobin, A., Davis, C. A., Schlesinger, F., Drenkow, J., Zaleski, C., Jha, S., Batut, P., Chaisson, M., & Gingeras, T. R. (2013) · Bioinformatics · doi:10.1093/bioinformatics/bts635 · Cited by 51,709
SCANPY: large-scale single-cell gene expression data analysis
Wolf, F. A., Angerer, P., & Theis, F. J. (2018) · Genome Biology · doi:10.1186/s13059-017-1382-0 · Cited by 8,881
Highly parallel genome-wide expression profiling of individual cells using nanoliter droplets.
Macosko, E. Z., Basu, A., Satija, R., Nemesh, J., Shekhar, K., Goldman, M., Tirosh, I., Bialas, A. R., Kamitaki, N., Martersteck, E. M., et al. (2015) · Cell · doi:10.1016/j.cell.2015.05.002 · Cited by 7,110
Spatial reconstruction of single-cell gene expression data
Satija, R., Farrell, J. A., Gennert, D., Schier, A. F., & Regev, A. (2015) · Nature Biotechnology · doi:10.1038/nbt.3192 · Cited by 7,055
Scenic: single-cell regulatory network inference and clustering.
Aibar, S., González-Blas, C. B., Moerman, T., Huynh-Thu, V. A., Imrichova, H., Hulselmans, G., Rambow, F., Marine, J.-C., Geurts, P., Aerts, J., et al. (2017) · Nature Methods · doi:10.1038/nmeth.4463 · Cited by 6,520
The single-cell transcriptional landscape of mammalian organogenesis
Cao, J., Spielmann, M., Qiu, X., Huang, X., Ibrahim, D. M., Hill, A. J., Zhang, F., Mundlos, S., Christiansen, L., Steemers, F. J., et al. (2019) · Nature · doi:10.1038/s41586-019-0969-x · Cited by 4,490
circlize implements and enhances circular visualization in R
Gu, Z., Gu, L., Eils, R., Schlesner, M., & Brors, B. (2014) · Bioinformatics · doi:10.1093/bioinformatics/btu393 · Cited by 4,290
La Manno, G., Soldatov, R., Zeisel, A., Braun, E., Hochgerner, H., Petukhov, V., Lidschreiber, K., Kastriti, M. E., Lönnerberg, P., Furlan, A., et al. (2018) · Nature · doi:10.1038/s41586-018-0414-6 · Cited by 4,118
mRNA-Seq whole-transcriptome analysis of a single cell
Tang, F., Barbacioru, C., Wang, Y., Nordman, E., Lee, C., Xu, N., Wang, X., Bodeau, J., Tuch, B. B., Siddiqui, A., et al. (2009) · Nature Methods · doi:10.1038/nmeth.1315 · Cited by 3,969
Research works printed but not linked: 1
- Cao, J. et al. Comprehensive single-cell transcriptional profiling of a multicellular organism. Science 357, 661–667 (2017). · DOI · Paper page
Cited by
Sorted by citations
Items 701–800 of 1,002
Spatial transcriptomic analyses highlight distinct erythroid niches in mice and humans
Han, X., Ren, K., Wang, P., Bi, H., Li, E., Aydemir, I., Ji, A., Cai, W., Soleimanisardoo, L., Wai, C. M., et al. (2026) · Nature Genetics · doi:10.1038/s41588-026-02671-2 · Cited by 3
Self-citationRefTM: reference-guided topic modeling of single-cell chromatin accessibility data
Zhang, Z., Chen, S., & Lin, Z. (2022) · Briefings in Bioinformatics · doi:10.1093/bib/bbac540 · Cited by 3
Tumor-derived Endothelial Cell: Important Etiological Factors in Endometriosis
Dong, Y., Zhang, M., OuYang, J., Zhou, W., & Yu, B. (2023) · Archives of Medical Research · doi:10.1016/j.arcmed.2023.102891 · Cited by 3
New generative methods for single-cell transcriptome data in bulk RNA sequence deconvolution
Nishikawa, T., Lee, M. F. R., & Amau, M. (2024) · Scientific Reports · doi:10.1038/s41598-024-54798-z · Cited by 3
Gong, L., Xiong, C., Liu, Y., Cai, L., & Gao, Z. (2024) · Computers in Biology and Medicine · doi:10.1016/j.compbiomed.2024.108225 · Cited by 3
Jian, S., & Li, H. (2024) · Lupus · doi:10.1177/09612033241292705 · Cited by 4
Wu, A., Li, H., Gao, M. Q., Liang, J. B., Huang, J., Farrés, J., Cao, D., & Li, G. (2024) · Frontiers in Immunology · doi:10.3389/fimmu.2024.1488042 · Cited by 3
Huang, M., & Li, Y. (2024) · ACM International Conference on Bioinformatics, Computational Biology, and Health Informatics (ACM-BCB) · doi:10.1145/3698587.3701374 · Cited by 2
Meng, J., Han, M., Huang, Y., Li, L., Ju, Y., Lv, D., Chen, X., Yuan, L., & Zhang, G. (2025) · Genomics Proteomics & Bioinformatics · doi:10.1093/gpbjnl/qzaf066 · Cited by 3
Full-length spatial transcriptome strategy based on robust and low-cost target tissue capture
Zhou, Y., Ge, Q., Li, M., Qi, T., Li, Z., Sheng, Y., Pan, M., Liu, Q., Zhao, X., & Lu, Z. (2025) · Biosensors and Bioelectronics · doi:10.1016/j.bios.2025.118018 · Cited by 3
Self-citationDecoding cell fate: integrated experimental and computational analysis at the single-cell level
Zhou, Y., Hou, S., Miao, X., Zhang, G., Li, Z., Zhang, D., Lin, Y., & Lin, Y. (2025) · Bioinformatics · doi:10.1093/bioinformatics/btaf603 · Cited by 4
Self-citationDeconvolution of Focal Segmental Glomerulosclerosis Pathophysiology Using Transcriptomics Techniques
Deleersnijder, D., Craenenbroeck, A. H. V., & Sprangers, B. (2021) · Glomerular Diseases · doi:10.1159/000518404 · Cited by 4
Chen, D., Luo, Y., & Cheng, G. (2022) · Clinical and Translational Discovery · doi:10.1002/ctd2.162 · Cited by 3
Hypoxia controls expression of kidney-pathogenic MUC1 variants
Naas, S., Krüger, R., Knaup, K. X., Naas, J., Grampp, S., Schiffer, M., Wiesener, M. S., & Schödel, J. (2023) · Life Science Alliance · doi:10.26508/lsa.202302078 · Cited by 3
Lin, J., Zhang, Q., Xie, T., Wu, Z., Hou, Y., Song, Y., Lin, Y., & Lin, J. (2024) · Small Methods · doi:10.1002/smtd.202301659 · Cited by 3
Self-citationWang, Z., Wang, W., Li, W., Yao, Y., Liu, W., & Tang, Z. (2024) · The Innovation Life · doi:10.59717/j.xinn-life.2024.100075 · Cited by 3
Self-citationHe, K., & Gong, G. (2024) · International Immunopharmacology · doi:10.1016/j.intimp.2024.113344 · Cited by 3
SIngle cell level Genotyping Using scRna Data (SIGURD)
Graßhoff, M., Kalmer, M., Chatain, N., Kricheldorf, K., Maurer, A., Weiskirchen, R., Koschmieder, S., & Costa, I. G. (2024) · Briefings in Bioinformatics · doi:10.1093/bib/bbae604 · Cited by 3
Utkina, M. V., Shcherbakova, A. S., Deviatiiarov, R. M., Ryabova, A., Loguinova, M. Y., Trofimov, V., Kuznetsova, A. A., Petropavlovskiy, M., Salimkhanov, R. K., Maksimov, D. O., et al. (2025) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2024.1469955 · Cited by 4
Next-Generation Barcoding for Single-Cell Omics
Li, T., Gu, Z., & Zhou, G. (2025) · Analytical Chemistry · doi:10.1021/acs.analchem.5c03587 · Cited by 3
Bioinformatics mining for gene expression data
Guo, A. (2020) · Scientia Sinica Vitae · doi:10.1360/ssv-2020-0260 · Cited by 3
Insights from Initial Variant Detection by Sequencing Single Sperm in Cattle
Yang, L., Gao, Y., Boschiero, C., Li, L., Zhang, H., Ma, L., & Liu, G. E. (2021) · Dairy · doi:10.3390/dairy2040050 · Cited by 3
Self-citationCharacterizing collaborative transcription regulation with a graph-based deep learning approach
Zhang, Z., Feng, F., Yao, Y., & Liu, J. (2022) · PLoS Computational Biology · doi:10.1371/journal.pcbi.1010162 · Cited by 3
Wan, Z., Li, X., Sun, J., Li, X., Liu, Z., Dong, H., Zhou, Q., Qiu, H., Xu, J., Yang, T., et al. (2022) · Frontiers in Cardiovascular Medicine · doi:10.3389/fcvm.2022.892000 · Cited by 3
Self-citationKidney Development: Recent Insights from Technological Advances
Röck, R., Rizzo, L., & Lienkamp, S. S. (2022) · Physiology · doi:10.1152/physiol.00041.2021 · Cited by 4
How developmental cell atlases inform stem cell embryo models
Haniffa, M. A., Maartens, A. P., & Teichmann, S. A. (2023) · Nature Methods · doi:10.1038/s41592-023-02072-x · Cited by 3
Bues, J., Biočanin, M., Pezoldt, J., Dainese, R., Chrisnandy, A., Rezakhani, S., Saelens, W., Gardeux, V., Gupta, R., Russeil, J., et al. (2020) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2020.05.19.103812 · Cited by 3
Human Developmental Cell Atlas: milestones achieved and the roadmap aheadPreprint
Haniffa, M. A., Taylor, D. M., Linnarsson, S., Aronow, B. J., Bader, G. D., Cámara, P. G., Camp, J. G., Chédotal, A., Copp, A. J., Etchevers, H., et al. (2020) · Research Square · doi:10.21203/rs.3.rs-73986/v1 · Cited by 3
Self-citationZhang, Z., Zamojski, M., Smith, G. R., Willis, T. L., Yianni, V., Mendelev, N., Pinças, H., Seenarine, N., Amper, M. A. S., Vasoya, M., et al. (2021) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2021.06.18.449034 · Cited by 3
Hematopoiesis at single cell resolution spanning human development and maturationPreprint
Li, H., Ezike, J., Afanassiev, A., Greenstreet, L., Zhang, S. X., Whangbo, J., Butty, V. L., Moiso, E., Connelly, G. G., Morris, V., et al. (2021) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2021.08.25.457678 · Cited by 4
Liau, E. S., Jin, S., Chen, Y., Liu, W.-S., Yong, L. W., Tsai, C.-T., Calon, M., Yu, J., Su, Y., Nedelec, S., et al. (2021) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2021.09.29.462340 · Cited by 3
Self-citationBarr, K., Rhodes, K., & Gilad, Y. (2022) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2022.07.20.500831 · Cited by 3
Lo, E. K. W., Velazquez, J. J., Peng, D., Kwon, C., Ebrahimkhani, M. R., & Cahan, P. (2022) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2022.09.07.506886 · Cited by 3
How CRISPR Is Revolutionizing the Generation of New Models for Cancer ResearchPreprint
Rivera, F. J. S., & Dow, L. E. (2023) · Cold Spring Harbor Perspectives in Medicine · doi:10.1101/cshperspect.a041384 · Cited by 4
ProjectSVR: Mapping single-cell RNA-seq data to reference atlases by supported vector regressionPreprint
Gao, J., Guo, S., & Zhang, Y.-W. (2023) · bioRxiv · doi:10.1101/2023.07.31.551202 · Cited by 6
Decoding cell identity with multi-scale explainable deep learningPreprint
Zhu, J., Zhang, Z., Xiang, Y., Xie, B., Dong, X., Xie, L., Zhou, P., Yao, R., Wang, X., Li, Y., et al. (2024) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2024.02.05.578922 · Cited by 3
A spatial single-cell type multiplex map of human spermatogenesisPreprint
Hikmet, F., Méar, L., Gustavsson, J., Miranda, G., Zhang, C., Katona, B., Schutten, R., Oksvold, P., von Feilitzen, K., Forsberg, M., et al. (2024) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2024.10.21.619380 · Cited by 3
Atrophy in multiple system atrophy relates to mitochondrial and oligodendrocytic processesPreprint
Chougar, L., Tremblay, C., Delva, A., Filiatrault, M., Vo, A., Hansen, J. Y., Farahani, A., Mišić, B., Khalafi, P., Castonguay, C.-E., et al. (2025) · medRxiv · doi:10.1101/2025.01.22.25320961 · Cited by 3
Wang, S. K., Li, J., Nair, S., Korasaju, R., Chen, Y., Zhang, Y., Kundaje, A. B., Liu, Y., Wang, N., & Chang, H. Y. (2025) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2025.03.21.644670 · Cited by 3
Self-citationLiu, D., Song, B., Li, Z., Zhang, S., Fabiha, T., Zhao, J., Inoki, A., Piccand, J., Soh, C.-L., Dixon, G., et al. (2025) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.64898/2025.12.23.696311 · Cited by 4
Li, X., Liu, Y., Zhou, F., Guo, W., Chen, G., Tao, J., Huang, J., Qiu, J., Chen, H., Ren, B. X., et al. (2025) · Cancer Letters · doi:10.1016/j.canlet.2025.217751 · Cited by 4
Self-citationThomas, M., Brabenec, R., Gregor, L., Andreu-Sanz, D., Carlini, E., Müller, P. J., Gottschlich, A., Simnica, D., Kobold, S., & Marr, C. (2025) · Computers in Biology and Medicine · doi:10.1016/j.compbiomed.2025.110332 · Cited by 2
Wang, X., Mei, Y., Wang, X., Wu, H., Wang, R., Zhang, P., Zhang, G., Li, J., Jiang, M., Fang, X., et al. (2025) · Clinical and Translational Medicine · doi:10.1002/ctm2.70461 · Cited by 3
Self-citationNetwork based simultaneous embedding of cells and marker genes from scRNA-seq studies
Bhattacharya, N., Chakraborti, S., Kumari, S., Mathew, B., Halder, A., Gujral, S., Gupta, K., Mittal, A., Sinha, D., Nelson, C. C., et al. (2025) · Briefings in Bioinformatics · doi:10.1093/bib/bbaf537 · Cited by 2
Lv, B., Jiang, M., Zhang, G., Guo, D., Yu, J., Fang, X., Haoyu, T., Guo, H., Han, Y., Guo, Y., et al. (2025) · American Journal of Respiratory Cell and Molecular Biology · doi:10.1165/rcmb.2025-0134oc · Cited by 3
Self-citationProjectSVR: mapping single-cell RNA-seq data to reference atlases by supported vector regression
Gao, J., Fang, J., Zhu, Q., Li, G., Bi, Z., Hu, Y., Hong, B., Zhang, Y., Guo, S., & Wang, H. (2025) · Briefings in Bioinformatics · doi:10.1093/bib/bbaf586 · Cited by 6
A systematic characterization of fibroblast subtypes and heterogeneity
Zhu, X. H., Kang, H., Zhao, Z., & Jia, P. (2025) · iScience · doi:10.1016/j.isci.2025.113915 · Cited by 2
ADAM5 is required for sperm-zona pellucida binding and sperm oviduct migration
Mashiko, D., Tonai, S., & Ikawa, M. (2025) · Biology of Reproduction · doi:10.1093/biolre/ioaf254 · Cited by 2
Wang, M., Xu, L., Alu, A., Li, P., Liu, J., Chen, S., He, X., Han, X., Li, Y., Pu, Q., et al. (2025) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-025-02471-w · Cited by 2
Self-citationChougar, L., Tremblay, C., Delva, A., Filiatrault, M., Vo, A., Hansen, J. Y., Farahani, A., Mišić, B., Khalafi, P., Castonguay, C.-E., et al. (2025) · npj Parkinson s Disease · doi:10.1038/s41531-025-01227-1 · Cited by 5
Bae, E.-J., Ham, S., Jeong, Y. W., Yang, W. S., Shin, J., Lee, W.-J., Ahn, W. J., Yoon, Y.-S., Lee, H.-J., Lee, S. H., et al. (2026) · Nature Communications · doi:10.1038/s41467-026-68870-x · Cited by 2
Dynamic lung single-cell atlas of domesticated and wild pigs
Huang, F., & Xiao, Y. (2026) · Science China Life Sciences · doi:10.1007/s11427-025-3150-6 · Cited by 3
Self-citationYang, Y., Zhang, L., Gao, L., Ming, Y., Zhang, T., Ye, Z., Liu, W. K., Xiong, Q., Xu, X., Xu, F., et al. (2026) · Cancer Letters · doi:10.1016/j.canlet.2026.218414 · Cited by 2
Self-citationJiang, S., Leng, P., Li, Y., Song, L., Xu, X., & Yang, L. (2026) · Applied Biochemistry and Biotechnology · doi:10.1007/s12010-026-05655-4 · Cited by 2
Family single-cell atlases reveal pig pregnancy and fetal growth restriction critical cell types
Cai, L., Zhang, Q., Yao, T., Zou, X., Xie, L., Yang, S., Xiao, Y., Huang, F., Peng, Z., Yang, J., et al. (2026) · Science · doi:10.1126/science.adu7265 · Cited by 2
Self-citationAICellType: a large language model-based platform for accurate cell type annotation
Cheng, C., Fang, S., Zuo, Q., Sun, J., Hu, X., Liu, X., & Jin, M. (2026) · Briefings in Bioinformatics · doi:10.1093/bib/bbag151 · Cited by 2
Wang, F., Ren, J., Zhou, Y., Huo, W., Liu, H., Qin, M., Jing, Y., Yin, Z., Shi, T., Shan, H., et al. (2026) · Nature Communications · doi:10.1038/s41467-026-72642-y · Cited by 2
Self-citationChoi, J., Lee, W., Yoon, J.-K., Choi, S. M., Lee, C., Moon, H., Cho, S., Chung, J.-H., Yang, H., & Kim, J. (2022) · BMC Bioinformatics · doi:10.1186/s12859-022-04676-0 · Cited by 2
Suzuki, I. (2022) · Developmental Neurobiology · doi:10.1002/dneu.22893 · Cited by 2
Biomimetic hydrogel blanket for conserving and recovering intrinsic cell properties
Um, S., Seo, Y., Seo, H., Lee, K., Park, S. H., Jeon, J. H., Lim, J. Y., Ok, M., Kim, Y.-C., Kim, H., et al. (2022) · Biomaterials Research · doi:10.1186/s40824-022-00327-w · Cited by 2
Zhao, K., Zhang, D., Xu, X., Wang, S., Liu, Z., Ren, X., Zhang, X., Lü, Z., Ren, S., & Qin, C. (2023) · Asian journal of urology · doi:10.1016/j.ajur.2022.12.004 · Cited by 2
Self-citationRevolutionizing the Life Sciences by Developing a Holographic Digital Mannequin
Cong, B., Liu, X., Zhang, S., Ni, Z., & Wang, L. (2023) · Engineering · doi:10.1016/j.eng.2023.05.004 · Cited by 2
Shi, J., Zhang, Y., Xu, L., & Wang, F. (2024) · Frontiers in Genetics · doi:10.3389/fgene.2024.1467682 · Cited by 2
collectNET: a web server for integrated inference of cell–cell communication network
Pan, Y., Gao, Z., Cui, X., Li, Z., & Jiang, R. (2024) · Database · doi:10.1093/database/baae098 · Cited by 2
IGFBP7+ subpopulation and IGFBP7 risk score in astrocytoma: insights from scRNA-Seq and bulk RNA-Seq
Zhao, L., Shao, W., Xiahou, Z., Ren, L., Liu, C., Song, Y., Xu, H. Y., Wang, Z., & Jin, X. (2024) · Frontiers in Immunology · doi:10.3389/fimmu.2024.1434300 · Cited by 2
Senescent T Cells: The Silent Culprit in Acute Myeloid Leukemia Progression?
Zhang, X., & Liu, L. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms252312550 · Cited by 2
Kalmer, M., Graßhoff, M., Maié, T., Pannen, K., Toledo, M. A. S., Vieri, M., Olschok, K., Lemanzyk, R., Lazarevic, J., Junge, B., et al. (2025) · Blood Advances · doi:10.1182/bloodadvances.2024012600 · Cited by 4
Li, C., Liao, J., Chen, B., & Wang, Q. (2025) · Critical Reviews in Oncology/Hematology · doi:10.1016/j.critrevonc.2025.104677 · Cited by 2
Brash, J. T., Diez-Pinel, G., Rinaldi, L., Castellan, R. F. P., Fantin, A., & Ruhrberg, C. (2025) · Angiogenesis · doi:10.1007/s10456-025-09971-x · Cited by 2
Jiang, Y., Yu, J., Kang, Z., & Peng, Y. (2025) · Discover Oncology · doi:10.1007/s12672-025-02357-x · Cited by 2
Liao, L., Madan, E., Palma, A. M., Kim, H., Kumar, A., Bhoopathi, P., Winn, R. A., Trevino, J., Fisher, P. B., Brakebusch, C., et al. (2025) · BMC Bioinformatics · doi:10.1186/s12859-025-06173-6 · Cited by 2
Elnahas, O., Ead, W. M., Qiu, Y., & Lu, J. G. (2025) · BMC Bioinformatics · doi:10.1186/s12859-025-06151-y · Cited by 2
Sun, C., Li, T., Jin, X., Xiu, Z., Su, H., Yang, H., Liu, M., & Wu, K. (2025) · Clinical and Translational Medicine · doi:10.1002/ctm2.70415 · Cited by 1
From impossible to possible: the lessons from the control of recent COVID-19 outbreaks in China
Tai, L., Wong, K., Wang, L., & Di, L. (2021) · International Journal of Biological Sciences · doi:10.7150/ijbs.58906 · Cited by 3
Wu, Y. J., Wu, Y., Liu, K., Liu, H., Wang, S., Huang, J., & Ding, H. (2021) · Frontiers in Genetics · doi:10.3389/fgene.2021.775470 · Cited by 2
Self-citationTowards the detection of copy number variation from single sperm sequencing in cattle
Yang, L., Gao, Y., Oswalt, A., Fang, L., Boschiero, C., Neupane, M., Sattler, C. G., Li, C., Seroussi, E., Xu, L., et al. (2022) · BMC Genomics · doi:10.1186/s12864-022-08441-8 · Cited by 2
Self-citationDecOT: Bulk Deconvolution With Optimal Transport Loss Using a Single-Cell Reference
Liu, G., Liu, X., & Ma, L. (2022) · Frontiers in Genetics · doi:10.3389/fgene.2022.825896 · Cited by 3
Sharma, M., Jha, I. P., Chawla, S., Pandey, N., Chandra, O., Mishra, S. V., & Kumar, V. (2022) · Briefings in Bioinformatics · doi:10.1093/bib/bbac241 · Cited by 2
In search of a Drosophila core cellular network with single-cell transcriptome data
Yang, M. Y., Harrison, B. R., & Promislow, D. (2022) · G3 Genes Genomes Genetics · doi:10.1093/g3journal/jkac212 · Cited by 2
Sun, Y., Huang, Z., Chen, W., Zhang, Y., Lei, H.-T., Huang, Q.-J., Lun, Z., Qu, L., & Zheng, L. (2024) · Biomolecules · doi:10.3390/biom14050516 · Cited by 3
van de Grift, Y. B. C., Heijmans, N., & van Amerongen, R. (2020) · Journal of Mammary Gland Biology and Neoplasia · doi:10.1007/s10911-020-09474-z · Cited by 2
Single-cell analysis reveals the function of lung progenitor cells in COVID-19 patientsPreprint
Zhao, Z., Zhao, Y., Zhou, Y., Wang, X., Zhang, T., & Zuo, W. (2020) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2020.07.13.200188 · Cited by 2
Self-citationA global overview of single-cell type selectivity and pleiotropy in complex diseases and traitsPreprint
Xue, C., Jiang, L., Long, Q., Chen, Y., Li, X., & Li, M. (2020) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2020.11.18.388488 · Cited by 2
Self-citationSingle-cell RNA sequencing identifies heterogeneous cell subtypes within gingival tissuePreprint
Qian, S., Huang, Q., Shi, J., Zhou, L., Zhao, Y. C., Li, B., & Lai, H. (2020) · doi:10.21203/rs.3.rs-101475/v1 · Cited by 2
Xiong, L., Tian, K., Li, Y., & Zhang, Q. C. (2021) · Research Square · doi:10.21203/rs.3.rs-398163/v1 · Cited by 2
Self-citationZhang, Z., Zhang, Y., Ma, Y., Xiang, S., Shen, J., Zhao, Y., Wu, X., Li, M., Yang, X., Kaboli, P. J., et al. (2020) · Research Square · doi:10.21203/rs.3.rs-131689/v1 · Cited by 2
Multiview Graph Learning for single-cell RNA sequencing dataPreprint
Karaaslanli, A., Saha, S., Aviyente, S., & Maiti, T. (2021) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2021.11.05.467476 · Cited by 2
Yu, H., Ai, N., Peng, P., Ke, Y., Chen, X., Li, Y., Zhao, T., Jiang, S., Liu, J., & Jiang, L. (2021) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2021.11.02.466852 · Cited by 2
Li, J., Wang, J., Zhang, P., Wang, R., Mei, Y., Sun, Z., Fei, L., Jiang, M., Ma, L., Weigao, E., et al. (2022) · Research Square · doi:10.21203/rs.3.rs-1544073/v1 · Cited by 2
Self-citationLatent human herpesvirus 6 is reactivated in chimeric antigen receptor T cellsPreprint
Lareau, C. A., Yin, Y., Maurer, K., Sandor, K. D., Yagnik, G., Peña, J., Crawford, J. C., Spanjaart, A. M., Gutierrez, J. C., Haradhvala, N. J., et al. (2022) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2022.08.12.503683 · Cited by 2
Li, J., Shyr, Y., & Liu, Q. (2023) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2023.10.13.562261 · Cited by 2
A human commons cell atlas reveals cell type specificity for OAS1 isoformsPreprint
Gálvez-Merchán, Á., Booeshaghi, A. S., & Pachter, L. S. (2024) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2024.03.23.586412 · Cited by 4
scELMo: Embeddings from Language Models are Good Learners for Single-cell Data AnalysisPreprint
Zhao, H., Liu, T., Chen, T., Zheng, W., & Luo, X. (2024) · Research Square · doi:10.21203/rs.3.rs-4014784/v1 · Cited by 2
Pan, X., Saunders, R. A., Replogle, J. M., Weissman, J. S., & Zhuang, X. (2026) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.64898/2026.05.16.725005 · Cited by 3
Huang, Y., Shao, M., Wang, Y., & Huang, H. (2022) · ImmunoMedicine · doi:10.1002/imed.1031 · Cited by 1
Self-citationCharacterization and verification of CD81 as a potential target in lung squamous cell carcinoma
Ye, X., Deng, J., Dong, C., Pan, X., & Lu, Y. (2023) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2023.149344 · Cited by 1
Dong, J., Li, M., & Wang, F. (2023) · IEEE International Conference on Medical Artificial Intelligence (MedAI) · doi:10.1109/medai59581.2023.00022 · Cited by 1
Luo, Y., & Liang, H. (2024) · Genome Medicine · doi:10.1186/s13073-024-01393-6 · Cited by 1
Annotation of single-cell clusters using marker genes within and across species
Kundu, S., Chau, T., Maroof, D. S., & Li, S. (2025) · Elsevier eBooks · doi:10.1016/b978-0-443-23736-2.00015-0 · Cited by 1
Wu, J., Li, Z., Zhou, W., Hu, Z., Gao, K., Yang, J., & Zhang, W. (2025) · Oncology Letters · doi:10.3892/ol.2025.14904 · Cited by 1
Self-citation
Metadata
- Authors
- Han, X., Zhou, Z., Fei, L., Sun, H., Wang, R., Chen, Y., Chen, H., Wang, J., Tang, H., Ge, W., Zhou, Y., Ye, F., Jiang, M., Wu, J., Xiao, Y., Jia, X., Zhang, T., Ma, X., Zhang, Q., Bai, X., Lai, S., Yu, C., Zhu, L., Lin, R., Gao, Y., Wang, M., Wu, Y., Zhang, J., Zhan, R., Zhu, S., Hu, H., Wang, C., Chen, M., Huang, H., Liang, T., Chen, J., Wang, W., Zhang, D., & Guo, G.
- Affiliations
- First Affiliated Hospital Zhejiang University (CN)
- Zhejiang University (CN)
- Women's Hospital, School of Medicine, Zhejiang University (CN)
- Second Affiliated Hospital of Zhejiang University (CN)
- Annoroad Gene Technology (China) (CN)
- Chinese Academy of Sciences (CN)
- Corresponding author
- Han, Xiaoping
- Guo, Guoji
- ORCID
- Han, Xiaoping
- Fei, Lijiang
- Sun, Huiyu
- Wang, Renying
- Chen, Yao
- Chen, Haide
- Wang, Jingjing
- Zhou, Yincong
- Ye, Fang
- Jiang, Mengmeng
- Wu, Junqing
- Xiao, Yanyu
- Zhang, Tingyue
- Ma, Xiaojie
- Zhang, Qi
- Bai, Xueli
- Lai, Shujing
- Yu, Chengxuan
- Zhu, Lijun
- Lin, Rui
- Gao, Yuchi
- Wang, Min
- Wu, Yiqing
- Zhang, Jianming
- Zhan, Renya
- Zhu, Saiyong
- Hu, Hailan
- Wang, Changchun
- Chen, Ming
- Huang, He
- Liang, Tingbo
- Chen, Jianghua
- Wang, Weilin
- Zhang, Dan
- Guo, Guoji
- Venue
- Nature
- Published
- 2020-03-25
- Volume
- 581
- Issue
- 7808
- Pages
- 303-309
- ISSN
- 0028-0836 (ISSN-L)
- 1476-4687
- OpenAlex
- W3013151148
- Cited by
- 1,087
- References
- 72
- Citations by year
- 2026: 91 · 2025: 163 · 2024: 159 · 2023: 186 · 2022: 203 · 2021: 198 · 2020: 86
- FWCI
- 56.76
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Nature (publishedVersion)
- PubMed (publishedVersion)
- RePEc: Research Papers in Economics (submittedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Single-cell and spatial transcriptomics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Genomics and Phylogenetic Studies
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gene Regulatory Network Analysis
- Keywords
- single-cell atlas, human cell types, cellular heterogeneity, human organs, fetal development, stem/progenitor cells, cell identity
- MeSH terms
- Adult, Animals, Cell Differentiation, Cell Line, Cell Separation, Cells, China, Ethnicity, Fetus, Hematopoietic Stem Cells, Humans, Immunity, Islets of Langerhans, Organ Specificity, RNA, Messenger, Stochastic Processes, Databases, Factual, Sequence Analysis, RNA, Asian People, Mice, Induced Pluripotent Stem Cells, Embryoid Bodies, Single-Cell Analysis
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review