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Monogenic and polygenic inheritance become instruments for clonal selection
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“Several studies have implicated activation of the NLRP3 inflammasome and increased IL-1β production as causal drivers of non-malignant disease observed in human CH with TET2 mutations and mouse models of CH with Tet2 mutations 78,97,99,103,105,113,129,188,189 .”
From Clonal haematopoiesis and dysregulation of the immune system (2023) · cites this paper as [97]
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“In monocytes and macrophages, the effects of genetic alterations in Tet2, Dnmt3a and Jak2 have been studied most extensively, revealing increased chemokine expression, hyperactivation of the inflammasome and increased IL-1β as common features 97,129-131,136,148,188 .”
From Clonal haematopoiesis and dysregulation of the immune system (2023) · cites this paper as [97]
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Cited by
Clonal haematopoiesis and dysregulation of the immune system
Belizaire, R., Wong, W. J., Robinette, M. L., & Ebert, B. L. (2023) · Nature Reviews Immunology · doi:10.1038/s41577-023-00843-3 · Cited by 161
Rodriguez-Meira, A., Norfo, R., Wen, S., Chédeville, A. L., Rahman, H., O’Sullivan, J., Wang, G., Louka, E., Kretzschmar, W. W., Paterson, A., et al. (2023) · Nature Genetics · doi:10.1038/s41588-023-01480-1 · Cited by 158
Huang, A. Y., Zhou, Z., Talukdar, M., Enyenihi, L., Miller, M. B., Chhouk, B., Rosen, I., Zheng, M., Zhou, M., Yang, A., et al. (2026) · Cell · doi:10.1016/j.cell.2026.03.040 · Cited by 15
Metadata
- Authors
- Loh, P.-R., Genovese, G., & McCarroll, S. A.
- Venue
- Nature
- Published
- 2020-06-24
- Volume
- 584
- Issue
- 7819
- Pages
- 136-141
- ISSN
- 0028-0836
- 1476-4687
- PMC
- PMC7415571
- Cited by
- 228
- References
- 20
- Language
- en
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