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Loop extrusion as a mechanism for formation of DNA damage repair foci
Open accessPublished version of a preprint
Abstract
The repair of DNA double-strand breaks (DSBs) is essential for safeguarding genome integrity. When a DSB forms, the PI3K-related ATM kinase rapidly triggers the establishment of megabase-sized, chromatin domains decorated with phosphorylated histone H2AX (γH2AX), which act as seeds for the formation of DNA-damage response foci 1. It is unclear how these foci are rapidly assembled to establish a 'repair-prone' environment within the nucleus. Topologically associating domains are a key feature of 3D genome organization that compartmentalize transcription and replication, but little is known about their contribution to DNA repair processes 2,3. Here we show that topologically associating domains are functional units of the DNA damage response, and are instrumental for the correct establishment of γH2AX-53BP1 chromatin domains in a manner that involves one-sided cohesin-mediated loop extrusion on both sides of the DSB. We propose a model in which H2AX-containing nucleosomes are rapidly phosphorylated as they actively pass by DSB-anchored cohesin. Our work highlights the importance of chromosome conformation in the maintenance of genome integrity and demonstrates the establishment of a chromatin modification by loop extrusion.
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“The cohesin complex is an important architectural protein that organizes the 3D genome and is also important in DSB repair”
From Neuronal DNA double-strand breaks lead to genome structural variations and 3D genome disruption in neurodegeneration (2023) · cites this paper as [32]
In the citing paper
“A recent study proposed that DSBs can act as roadblocks to loop extrusion32.”
From Neuronal DNA double-strand breaks lead to genome structural variations and 3D genome disruption in neurodegeneration (2023) · cites this paper as [32]
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Cites
Megabase Chromatin Domains Involved in DNA Double-Strand Breaks in Vivo
Rogakou, E. P., Boon, C., Redon, C., & Bonner, W. M. (1999) · The Journal of Cell Biology · doi:10.1083/jcb.146.5.905 · Cited by 2,422
Formation of chromosomal domains by loop extrusion
Fudenberg, G., Imakaev, M., Lu, C., Goloborodko, A., Abdennur, N., & Mirny, L. A. (2016) · Cell Reports · doi:10.1016/j.celrep.2016.04.085 · Cited by 2,003
Cohesin Loss Eliminates All Loop Domains
Rao, S. S. P., Huang, S.-C., Glenn St Hilaire, B., Engreitz, J. M., Perez, E. M., Kieffer-Kwon, K.-R., Sanborn, A. L., Johnstone, S. E., Bascom, G. D., Bochkov, I. D., et al. (2017) · Cell · doi:10.1016/j.cell.2017.09.026 · Cited by 1,883
Two independent modes of chromatin organization revealed by cohesin removal
Schwarzer, W., Abdennur, N., Goloborodko, A., Pekowska, A., Fudenberg, G., Loe-Mie, Y., Fonseca, N. A., Huber, W., Haering, C. H., Mirny, L., et al. (2017) · Nature · doi:10.1038/nature24281 · Cited by 1,196
MDC1 is a mediator of the mammalian DNA damage checkpoint
Stewart, G. S., Wang, B., Bignell, C. R., Taylor, A. M. R., & Elledge, S. J. (2003) · Nature · doi:10.1038/nature01446 · Cited by 874
A compendium of chromatin contact maps reveals spatially active regions in the human genome
Schmitt, A. D., Hu, M., Jung, I., Xu, Z., Qiu, Y., Tan, C. L., Li, Y., Lin, S., Lin, Y., Barr, C. L., et al. (2016) · Cell Reports · doi:10.1016/j.celrep.2016.10.061 · Cited by 866
Wutz, G., Várnai, C., Nagasaka, K., Cisneros, D. A., Stocsits, R. R., Tang, W., Schoenfelder, S., Jessberger, G., Muhar, M., Hossain, M. J., et al. (2017) · The EMBO Journal · doi:10.15252/embj.201798004 · Cited by 864
DNA loop extrusion by human cohesin
Davidson, I. F., Bauer, B., Goetz, D., Tang, W., Wutz, G., & Peters, J.-M. (2019) · Science · doi:10.1126/science.aaz3418 · Cited by 863
The cohesin release factor WAPL restricts chromatin loop extension
Haarhuis, J. H. I., van der Weide, R. H., Blomen, V. A., Yáñez-Cuna, J. O., Amendola, M., van Ruiten, M. S., Krijger, P. H. L., Teunissen, H., Medema, R. H., van Steensel, B., et al. (2017) · Cell · doi:10.1016/j.cell.2017.04.013 · Cited by 793
Real-time imaging of DNA loop extrusion by condensin
Ganji, M., Shaltiel, I. A., Bisht, S., Kim, E., Kalichava, A., Haering, C. H., & Dekker, C. (2018) · Science · doi:10.1126/science.aar7831 · Cited by 793
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Chi, Y., Lü, Y., Wu, J., Li, G., Li, X., Wu, Y., Zhao, X., Wen, J., Sha, X., Lu, G., et al. (2025) · Nano Letters · doi:10.1021/acs.nanolett.4c06402 · Cited by 4
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Irvin, E. M., & Wang, H. (2023) · DNA repair · doi:10.1016/j.dnarep.2023.103528 · Cited by 4
Yin, Z., Cui, S., Xue, S., Xie, Y., Wang, Y., Zhao, C., Zhang, Z., Wu, T., Hou, G., Wang, W., et al. (2023) · Biology · doi:10.3390/biology12081058 · Cited by 3
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Xia, L., Zhang, W., Liu, M. M., Shen, Y., Zhang, J., Wang, D., Wang, F., Zhang, Z., Zhong, Y., Huang, Y., et al. (2026) · Reproductive Biology and Endocrinology · doi:10.1186/s12958-026-01547-8 · Cited by 1
Wen, J., Xiang, Q., Guo, J., Zhou, X., Chen, Y., Huang, Y., & Rao, C. (2025) · Fitoterapia · doi:10.1016/j.fitote.2025.106841 · Cited by 1
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Fu, X., Zhu, Y., Lu, X., Gao, X., Xin, L., Ren, Y., Liu, X., Ge, L., Hao, J., Yao, Z., et al. (2025) · Cell Death and Disease · doi:10.1038/s41419-025-08300-w · Cited by 2
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Smirnov, A. V., Ryzhkova, A. S., & Yunusova, A. (2024) · Vavilov Journal of Genetics and Breeding · doi:10.18699/vjgb-24-65 · Cited by 1
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Xu, K., Zong-yuan, Y., Sun, C., Gou, C., Zhu, J., Wang, J., Bo, X., Yu, G., Li, H., & Chen, H. (2025) · Advanced Science · doi:10.1002/advs.202504571 · Cited by 1
Hirose, E., Yokoya, A., Kawamura, K., & Suzuki, K. (2023) · Journal of Radiation Research · doi:10.1093/jrr/rrac093 · Cited by 1
Simmons, J. R., Kemp, J. D. J., & Labrador, M. (2026) · G3 Genes Genomes Genetics · doi:10.1093/g3journal/jkag185 · Cited by 1
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Zou, R. S., Marín-González, A., Liu, Y., Liu, H. B., Shen, L. L., Dveirin, R. K., Luo, J. X. J., Kalhor, R., & Ha, T. (2022) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2022.01.18.476836 · Cited by 1
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Cohen, S., Cheradame, L., Pratt, K. J. B., Collins, S. E., Barillas, A., Carlson, A., Ramani, V., Legube, G., Villeda, S., Mullins, R. D., et al. (2024) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2024.10.22.619740 · Cited by 1
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Thakur, B. L., Basak, P., Khurana, S., Sharma, S., Lai, Y.-H., Nguyen, T., Ramanarayanan, V., Zhao, X., Batista, P. J., Stracker, T. H., et al. (2026) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.64898/2026.06.05.730358 · Cited by 1
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Sun, Y., Xu, X., Lin, L., Xu, K., Zheng, Y., Ren, C., Tao, H., Wang, X., Zhao, H., Tu, W.-W., et al. (2023) · Figshare · doi:10.6084/m9.figshare.22688787
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Optimal information transmission in a non-Markovian auto-regulatory gene expression system
Wang, Z., Chen, M., Zhang, Z., Yang, X., Zhou, T., Shi, C., & Zhang, J. (2025) · Biosystems · doi:10.1016/j.biosystems.2025.105675
Sun, Y., Xu, X., Lin, L., Xu, K., Zheng, Y., Ren, C., Tao, H., Wang, X., Zhao, H., Tu, W., et al. (2023) · Figshare · doi:10.6084/m9.figshare.22688790
Qu, H., Wang, Y., Yan, Q., Fan, C., Zhang, X., Wang, D., Guo, C., Chen, P., Shi, L., Liao, Q., et al. (2024) · Figshare · doi:10.6084/m9.figshare.25678615
Sun, Y., Xu, X., Lin, L., Xu, K., Zheng, Y., Ren, C., Tao, H., Wang, X., Zhao, H., Tu, W., et al. (2023) · Figshare · doi:10.6084/m9.figshare.22688784
Sun, Y., Xu, X., Lin, L., Xu, K., Zheng, Y., Ren, C., Tao, H., Wang, X., Zhao, H., Tu, W., et al. (2023) · Figshare · doi:10.6084/m9.figshare.22688793
Nested TAD hierarchy defines cohesion zones on replicated chromosomes
Takács, Z., Mylarshchikov, D. E., Kolesnikova, S., Langer, C. C. H., Goloborodko, A. A., & Gerlich, D. W. (2026) · The EMBO Journal · doi:10.1038/s44318-026-00902-0
Impact of low replication stress on the replication program of cancer and non-tumor cells
Courtot, L. (2020) · theses.fr (ABES) · doi:10.70675/74d8bf42zeebdz4323zb869zec66e6e29157
Dynamic and maintenance of constitutive heterochromatin in response to UV exposure
Berens, P. J. T. (2022) · theses.fr (ABES) · doi:10.70675/15fdfdfdz434fz4d53z9e63za9a6b512c718
Gene coregulation in cis within the 3D genome – A single-molecule imaging study
Kerlin, M. A. (2021) · theses.fr (ABES) · doi:10.70675/95774cf6z713dz4df5z92b1z76204ad8b669
Rocher, V. (2021) · theses.fr (ABES) · doi:10.70675/217850a9z3e46z4daazadc6zb1bce2ccfe54
Self-citationLa recombinaison méiotique dans le contexte de l’organisation des chromosomes chez la souris
Biot, M. (2022) · theses.fr (ABES) · doi:10.70675/b9afe47czb451z4b8fz9aa0z31eb4db88f97
Interplay between facultative heterochromatin and the DNA double-strand break repair response
Pobega, E. (2023) · theses.fr (ABES) · doi:10.70675/01445f06z7f68z431bza921zc3fd03c8d5a9
Distinct conformational dynamics of human Cohesin SMC1A and SMC3 ATPase domains
Gomes, M. V. (2021) · theses.fr (ABES) · doi:10.70675/b0a37a44z9d12z495azbd91z8bc22047db45
Metadata
- Authors
- Arnould, C., Rocher, V., Finoux, A.-L., Clouaire, T., Li, K., Zhou, F., Caron, P., Mangeot, P. E., Ricci, E. P., Mourad, R., Haber, J. E., Noordermeer, D., & Legube, G.
- Affiliations
- Centre National de la Recherche Scientifique (FR)
- Brandeis University (US)
- Lyon 1 Université (FR)
- Corresponding author
- Legube, Gaëlle
- ORCID
- Venue
- Nature
- Published
- 2021-02-17
- Volume
- 590
- Issue
- 7847
- Pages
- 660-665
- ISSN
- 0028-0836 (ISSN-L)
- 1476-4687
- PMC
- PMC7116834
- OpenAlex
- W3132847906
- Cited by
- 341
- References
- 56
- Citations by year
- 2026: 43 · 2025: 64 · 2024: 66 · 2023: 67 · 2022: 62 · 2021: 33
- FWCI
- 17.97
- Type
- journal article
- Language
- en
- Open access
- green
- doi.org
- Licence
- Locations
- Nature (publishedVersion)
- bioRxiv (Cold Spring Harbor Laboratory) (acceptedVersion, cc-by-nc-nd)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- HAL (submittedVersion, other-oa)
- HAL (submittedVersion)
- RePEc: Research Papers in Economics (submittedVersion)
- Funders
- Fondation Innovations en Infectiologie
- European Commission (ERC-2014, ERC-2014-CoG)
- Agence Nationale de la Recherche (ANR18, ANR-11-LABX-0048, ANR-14-CE10-0002, ANR-13-BSV8-0013, ANR-18-CE12-0015)
- Institut National Du Cancer
- Université de Lyon (ANR-11-LABX-0048)
- Laboratoire d'Excellence Ecofect (ANR-11-LABX-0048)
- National Institutes of Health
- National Institute of General Medical Sciences (T32GM007122, GM127029, R35GM127029)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › DNA Repair Mechanisms
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Genomics and Chromatin Dynamics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Chromatin Remodeling and Cancer
- Keywords
- loop extrusion, DNA double-strand break repair, topologically associating domains, cohesin, γH2AX, 53BP1, ATM kinase, chromatin domains, 3D genome organization, genome stability, H2AX phosphorylation
- MeSH terms
- Tumor Suppressor p53-Binding Protein 1, Cohesins, Cell Line, Chromosomal Proteins, Non-Histone, DNA, DNA Repair, Histones, Humans, Nucleic Acid Conformation, Nucleosomes, Phosphorylation, Saccharomyces cerevisiae, Genome, Cell Cycle Proteins, Saccharomyces cerevisiae Proteins, DNA Breaks, Double-Stranded
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