Legube, Gaëlle

Transcriptionally active chromatin recruits homologous recombination at DNA double-strand breaks

Aymard, F., Bugler, B., Schmidt, C. K., Guillou, E., Caron, P., Briois, S., Iacovoni, J. S., Daburon, V., Miller, K. M., Jackson, S. P., et al. (2014) · Nature Structural & Molecular Biology

DNA Repair MechanismsGenomics and Chromatin Dynamics

Cited by 668

Human HDAC1 and HDAC2 function in the DNA-damage response to promote DNA nonhomologous end-joining

Miller, K. M., Tjeertes, J. V., Coates, J., Legube, G., Polo, S. E., Britton, S., & Jackson, S. P. (2010) · Nature Structural & Molecular Biology

DNA Repair MechanismsHistone Deacetylase Inhibitors Research

Cited by 629

High‐resolution profiling of γH2AX around DNA double strand breaks in the mammalian genome

Iacovoni, J. S., Caron, P., Lassadi, I., Nicolas, E., Massip, L., Trouche, D., & Legube, G. (2010) · The EMBO Journal

DNA Repair MechanismsGenomics and Chromatin Dynamics

Cited by 515

Genome Editing in Primary Cells and in Vivo Using Viral-Derived Nanoblades Loaded with Cas9-SgRNA Ribonucleoproteins

Mangeot, P. E., Risson, V., Fusil, F., Marnef, A., Laurent, E., Blin, J., Mournetas, V., Massouridès, E., Sohier, T. J. M., Corbin, A., et al. (2019) · Nature Communications

CRISPR and Genetic EngineeringVirus-based gene therapy research

Cited by 346

Loop extrusion as a mechanism for formation of DNA damage repair foci

Arnould, C., Rocher, V., Finoux, A.-L., Clouaire, T., Li, K., Zhou, F., Caron, P., Mangeot, P. E., Ricci, E. P., Mourad, R., et al. (2021) · Nature

DNA Repair MechanismsGenomics and Chromatin Dynamics

Cited by 341

Genome-wide mapping of long-range contacts unveils clustering of DNA double-strand breaks at damaged active genes

Aymard, F., Aguirrebengoa, M., Guillou, E., Javierre, B. M., Bugler, B., Arnould, C., Rocher, V., Iacovoni, J. S., Biernacka, A., Skrzypczak, M., et al. (2017) · Nature Structural & Molecular Biology

DNA Repair MechanismsGenomics and Chromatin Dynamics

Cited by 263

Screen identifies bromodomain protein ZMYND8 in chromatin recognition of transcription-associated DNA damage that promotes homologous recombination

Gong, F., Chiu, L.-Y., Cox, B., Aymard, F., Clouaire, T., Leung, J. W., Cammarata, M., Perez, M., Agarwal, P., Brodbelt, J. S., et al. (2015) · Genes & Development

DNA Repair MechanismsGenomics and Chromatin Dynamics

Cited by 247

Cohesin Protects Genes against γH2AX Induced by DNA Double-Strand Breaks

Caron, P., Aymard, F., Iacovoni, J. S., Briois, S., Canitrot, Y., Bugler, B., Massip, L., Losada, A., & Legube, G. (2012) · PLoS Genetics

DNA Repair MechanismsGenomics and Chromatin Dynamics

Cited by 135