The DOI matches its Crossref record; 43 of the 43 references it cites were found in a registry or an index.
Escape of SARS-CoV-2 501Y.V2 from neutralization by convalescent plasma
Open accessPublished version of a preprint
Abstract
SARS-CoV-2 variants of concern (VOC) have arisen independently at multiple locations 1,2 and may reduce the efficacy of current vaccines that target the spike glycoprotein of SARS-CoV-2 3. Here, using a live-virus neutralization assay, we compared the neutralization of a non-VOC variant with the 501Y.V2 VOC (also known as B.1.351) using plasma collected from adults who were hospitalized with COVID-19 during the two waves of infection in South Africa, the second wave of which was dominated by infections with the 501Y.V2 variant. Sequencing demonstrated that infections of plasma donors from the first wave were with viruses that did not contain the mutations associated with 501Y.V2, except for one infection that contained the E484K substitution in the receptor-binding domain. The 501Y.V2 virus variant was effectively neutralized by plasma from individuals who were infected during the second wave. The first-wave virus variant was effectively neutralized by plasma from first-wave infections. However, the 501Y.V2 variant was poorly cross-neutralized by plasma from individuals with first-wave infections; the efficacy was reduced by 15.1-fold relative to neutralization of 501Y.V2 by plasma from individuals infected in the second wave. By contrast, cross-neutralization of first-wave virus variants using plasma from individuals with second-wave infections was more effective, showing only a 2.3-fold decrease relative to neutralization of first-wave virus variants by plasma from individuals infected in the first wave. Although we tested only one plasma sample from an individual infected with a SARS-CoV-2 variant with only the E484K substitution, this plasma sample potently neutralized both variants. The observed effective neutralization of first-wave virus by plasma from individuals infected with 501Y.V2 provides preliminary evidence that vaccines based on VOC sequences could retain activity against other circulating SARS-CoV-2 lineages.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“In contrast, mutations in B.1.351 and P.1 variants are associated with the more pronounced loss of neutralizing capacity.15,16,22,23,25”
From Impact of SARS-CoV-2 variants on the total CD4+ and CD8+ T cell reactivity in infected or vaccinated individuals (2021) · cites this paper as [25]
In the citing paper
“In addition, Beta and Delta are relatively poorly neutralized by convalescent sera obtained from unvaccinated individuals infected with non-VOC virus ( 7 – 9 , 21 ).”
From Increased risk of SARS-CoV-2 reinfection associated with emergence of Omicron in South Africa (2021) · cites this paper as [7]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
RNA-Based COVID-19 Vaccine BNT162b2 Selected for a Pivotal Efficacy Study
Walsh, E. E., Frenck, R., Falsey, A. R., Kitchin, N., Absalon, J., Gurtman, A., Lockhart, S., Neuzil, K., Mulligan, M. J., Bailey, R., et al. (2020) · doi:10.1101/2020.08.17.20176651 · Cited by 2,615
Tegally, H., Wilkinson, E., Giovanetti, M., Iranzadeh, A., Fonseca, V., Giandhari, J., Doolabh, D., Pillay, S., San, E. J., Msomi, N., et al. (2020) · doi:10.1101/2020.12.21.20248640 · Cited by 2,535
Self-citationDetection of a SARS-CoV-2 variant of concern in South Africa
Tegally, H., Wilkinson, E., Giovanetti, M., Iranzadeh, A., Fonseca, V., Giandhari, J., Doolabh, D., Pillay, S., San, E. J., Msomi, N., et al. (2021) · Nature · doi:10.1038/s41586-021-03402-9 · Cited by 2,510
Self-citationAntibody resistance of SARS-CoV-2 variants B.1.351 and B.1.1.7
Wang, P., Nair, M. S., Liu, L., Iketani, S., Luo, Y., Guo, Y., Wang, M., Yu, J., Zhang, B., Kwong, P. D., et al. (2021) · Nature · doi:10.1038/s41586-021-03398-2 · Cited by 2,312
Convergent Antibody Responses to SARS-CoV-2 in Convalescent Individuals
Robbiani, D. F., Gaebler, C., Muecksch, F., Lorenzi, J. C. C., Wang, Z., Cho, A., Agudelo, M., Barnes, C. O., Gazumyan, A., Finkin, S., et al. (2020) · Nature · doi:10.1038/s41586-020-2456-9 · Cited by 1,853
Self-citationEvolution of antibody immunity to SARS-CoV-2
Gaebler, C., Wang, Z., Lorenzi, J. C. C., Muecksch, F., Finkin, S., Tokuyama, M., Cho, A., Jankovic, M., Schaefer-Babajew, D., Oliveira, T. Y., et al. (2021) · Nature · doi:10.1038/s41586-021-03207-w · Cited by 1,674
Self-citationSARS-CoV-2 neutralizing antibody structures inform therapeutic strategies
Barnes, C. O., Jette, C. A., Abernathy, M. E., Dam, K.-M. A., Esswein, S. R., Gristick, H. B., Malyutin, A. G., Sharaf, N. G., Huey-Tubman, K. E., Lee, Y. E., et al. (2020) · Nature · doi:10.1038/s41586-020-2852-1 · Cited by 1,599
Genomics and epidemiology of the P.1 SARS-CoV-2 lineage in Manaus, Brazil
Faria, N. R., Mellan, T. A., Whittaker, C., Claro, I. M., Candido, D. D. S., Mishra, S., Crispim, M. A. E., Sales, F. C. S., Hawryluk, I., McCrone, J. T., et al. (2021) · Science · doi:10.1126/science.abh2644 · Cited by 1,461
Piccoli, L., Park, Y.-J., Tortorici, M. A., Czudnochowski, N., Walls, A. C., Beltramello, M., Silacci-Fregni, C., Pinto, D., Rosen, L. E., Bowen, J. E., et al. (2020) · Cell · doi:10.1016/j.cell.2020.09.037 · Cited by 1,395
Multiple SARS-CoV-2 variants escape neutralization by vaccine-induced humoral immunity
Garcia-Beltran, W. F., Lam, E. C., St. Denis, K., Nitido, A. D., Garcia, Z. H., Hauser, B. M., Feldman, J., Pavlovic, M. N., Gregory, D. J., Poznansky, M. C., et al. (2021) · Cell · doi:10.1016/j.cell.2021.03.013 · Cited by 1,353
Self-citation
Cited by
Sorted by citations
Items 301–400 of 657
Glöckner, S., Hornung, F., Baier, M., Weis, S., Pletz, M. W., Deinhardt‐Emmer, S., Löffler, B., & the CoNAN Study Group (2021) · Viruses · doi:10.3390/v13102003 · Cited by 19
Human-to-dog transmission of SARS-CoV-2, Colombia
Rivero, R., Garay, E., Botero, Y., Coll, H. A. S., Gastelbondo, B., Muñoz, M., Ballesteros, N., Castañeda, S., Patiño, L. H., Ramírez, J. D., et al. (2022) · Scientific Reports · doi:10.1038/s41598-022-11847-9 · Cited by 20
O’Kennedy, M. M., Abolnik, C., Smith, T., Motlou, T. P., Goosen, K., Sepotokele, K. M., Roth, R., du Preez, I., Truyts, A., Stark, H. C., et al. (2023) · Vaccine · doi:10.1016/j.vaccine.2023.02.050 · Cited by 20
Chernyshev, M., Sakharkar, M., Connor, R. I., Dugan, H. L., Sheward, D. J., Rappazzo, C. G., Stålmarck, A., Forsell, M. N. E., Wright, P. F., Corcoran, M., et al. (2023) · Nature Communications · doi:10.1038/s41467-023-37972-1 · Cited by 17
Pokhrel, S., Kraemer, B. R., Burkholz, S., & Mochly‐Rosen, D. (2021) · Scientific Reports · doi:10.1038/s41598-021-92641-x · Cited by 20
Hospital mortality in COVID-19 patients in Belgium treated with statins, ACE inhibitors and/or ARBs
Byttebier, G., Belmans, L., Alexander, M., Saxberg, B. E. H., Spiegeleer, B. M. J. D., Spiegeleer, A. D., Devreker, N., Praet, J. T. V., Vanhove, K., Reybrouck, R., et al. (2021) · Human Vaccines & Immunotherapeutics · doi:10.1080/21645515.2021.1920271 · Cited by 19
Wang, B., Goh, Y. S., Prince, T., Ngoh, E. Z. X., Salleh, S. N. M., Hor, P. X., Loh, C. Y., Fong, S., Hartley, C. S., Tan, S. Y., et al. (2021) · npj Vaccines · doi:10.1038/s41541-021-00389-2 · Cited by 19
Lien, C.-E., Kuo, T., Lin, Y., Lian, W., Lin, M., Liu, L. T.-C., Cheng, J., Chou, Y., & Chen, C. (2021) · Clinical Infectious Diseases · doi:10.1093/cid/ciab711 · Cited by 16
Wong, T. Y., Horspool, A. M., Russ, B. P., Ye, C., Lee, K. S., Winters, M. T., Bevere, J. R., Miller, O. A., Rader, N. A., Cooper, M., et al. (2022) · Journal of Virology · doi:10.1128/jvi.02184-21 · Cited by 17
Clark, N. M., Janaka, S. K., Hartman, W. R., Stramer, S. L., Goodhue, E., Weiss, J., Evans, D. T., & Connor, J. P. (2022) · PLoS ONE · doi:10.1371/journal.pone.0257930 · Cited by 23
Upadhyay, V., Patrick, C., Lucas, A., & Mallela, K. M. G. (2022) · Biochemistry · doi:10.1021/acs.biochem.2c00132 · Cited by 17
Smith, M. F., Holland, S. C., Lee, M. B., Hu, J. C., Pham, N. C., Sullins, R. A., Holland, L. A., Mu, T., Thomas, A. W., Fitch, R., et al. (2023) · mBio · doi:10.1128/mbio.03101-22 · Cited by 17
Biophysical principles predict fitness of SARS-CoV-2 variants
Wang, D., Huot, M., Mohanty, V., & Shakhnovich, E. I. (2024) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2314518121 · Cited by 19
An update on host immunity correlates and prospects of re-infection in COVID-19
Negi, N., Maurya, S. P., Singh, R., & Das, B. K. (2021) · International Reviews of Immunology · doi:10.1080/08830185.2021.2019727 · Cited by 20
Gabitzsch, E., Safrit, J. T., Verma, M., Rice, A., Sieling, P. A., Zakin, L., Shin, A., Morimoto, B., Adisetiyo, H., Wong, R. M. H., et al. (2020) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2020.12.08.416297 · Cited by 17
Structural and computational insights into the SARS-CoV-2 Omicron RBD-ACE2 interactionPreprint
Lan, J., He, X., Ren, Y., Wang, Z., Zhou, H., Fan, S., Zhu, C., Liu, D., Shao, B., Liu, T., et al. (2022) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2022.01.03.474855 · Cited by 16
Effect of time and titer in convalescent plasma therapy for COVID-19
de Candia, P., Prattichizzo, F., Garavelli, S., Grotta, R. L., Rosa, A. D., Pontarelli, A., Parrella, R., Ceriello, A., & Matarese, G. (2021) · iScience · doi:10.1016/j.isci.2021.102898 · Cited by 16
Advancements in Testing Strategies for COVID-19
Asghar, R., Rasheed, M., Hassan, J. U., Rafique, M., Khan, M., & Deng, Y. (2022) · Biosensors · doi:10.3390/bios12060410 · Cited by 17
Fonseca, P. L. C., Moreira, F. R. R., de Souza, R. M., Guimarães, N. R., Carvalho, N. D. O., Adelino, T., Alves, H. J., Alvim, L. B., Cândido, D. D. S., Coelho, H. P., et al. (2022) · Virus Evolution · doi:10.1093/ve/veac064 · Cited by 16
Yaqoob, T., Rani, M., Neffati, R., Janjua, N. K., Khan, S., Arshad, M., & Murtaza, G. (2022) · Materials Science and Engineering B · doi:10.1016/j.mseb.2022.116118 · Cited by 17
Modelling optimal lockdowns with waning immunity
Goenka, A., Liu, L., & Nguyen, M. (2022) · Economic Theory · doi:10.1007/s00199-022-01468-8 · Cited by 18
Clonal diversity predicts persistence of SARS-CoV-2 epitope-specific T-cell response
Zornikova, K. V., Khmelevskaya, A. A., Sheetikov, S. A., Kiryukhin, D. O., Shcherbakova, O. V., Titov, A., Zvyagin, I. V., & Efimov, G. A. (2022) · Communications Biology · doi:10.1038/s42003-022-04250-7 · Cited by 17
Richardson, S. I., Kgagudi, P., Manamela, N. P., Kaldine, H., Venter, E. M., Pillay, T., Lambson, B. E., van der Mescht, M. A., Hermanus, T., Balla, S. R., et al. (2022) · Cell Reports Medicine · doi:10.1016/j.xcrm.2022.100910 · Cited by 18
Riou, C., Bhiman, J. N., Ganga, Y., Sawry, S., Ayres, F., Baguma, R., Balla, S. R., Benede, N., Bernstein, M. P., Besethi, A. S., et al. (2024) · PLOS Global Public Health · doi:10.1371/journal.pgph.0002703 · Cited by 16
Self-citationFocosi, D., Franchini, M., Joyner, M. J., & Casadevall, A. (2022) · Vox Sanguinis · doi:10.1111/vox.13239 · Cited by 15
Wurtzer, S., Waldman, P., Levert, M., Mouchel, J., Gorgé, O., Boni, M., Maday, Y., Maréchal, V., & Moulin, L. (2021) · medRxiv · doi:10.1101/2021.03.10.21253291 · Cited by 16
Su, D., Li, X., He, C., Huang, X., Chen, M., Wang, Q., Qin, W., Liang, Y. S., Xu, R., Wu, J., et al. (2021) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2021.05.16.444369 · Cited by 15
Yurkovetskiy, L., Egri, S. B., Kurhade, C., Díaz-Salinas, M. A., Jaimes, J. A., Nyalile, T., Xie, X., Choudhary, M. C., Dauphin, A., Li, J. Z., et al. (2023) · SSRN Electronic Journal · doi:10.1101/2023.03.30.535005 · Cited by 18
Outbreaks of publications about emerging infectious diseases: the case of SARS-CoV-2 and Zika virus
Ipekci, A. M., Buitrago‐García, D., Meili, K. W., Krauer, F., Prajapati, N., Thapa, S., Wildisen, L., Araujo-Chaveron, L., Baumann, L., Shah, S., et al. (2021) · BMC Medical Research Methodology · doi:10.1186/s12874-021-01244-7 · Cited by 16
Fast SARS-CoV-2 Variant Detection Using Snapback Primer High-Resolution Melting
Lownik, J. C., Farrar, J. S., Way, G. W., McKay, A., Roychoudhury, P., Greninger, A. L., & Martin, R. (2021) · Diagnostics · doi:10.3390/diagnostics11101788 · Cited by 16
Fc engineered ACE2-Fc is a potent multifunctional agent targeting SARS-CoV2
Wines, B. D., Kurtovic, L., Trist, H. M., Esparon, S. E., López, E., Chappin, K., Chan, L., Mordant, F. L., Lee, W. S., Gherardin, N. A., et al. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.889372 · Cited by 15
SARS-COV-2/COVID-19: scenario, epidemiology, adaptive mutations, and environmental factors
Asghar, A., Imran, H. M., Bano, N., Maalik, S., Mushtaq, S., Hussain, A., Varjani, S., Aleya, L., Iqbal, H. M. N., & Bilal, M. (2022) · Environmental Science and Pollution Research · doi:10.1007/s11356-022-22333-0 · Cited by 16
SARS-CoV-2 Variants, Current Vaccines and Therapeutic Implications for COVID-19
Liang, H., Wu, Y., Yau, V., Yin, H.-X., Lowe, S., Bentley, R., Ahmed, M. A., Zhao, W., & Sun, C. (2022) · Vaccines · doi:10.3390/vaccines10091538 · Cited by 16
Shaheen, N., Mohamed, A., Attalla, A., Diab, R. A., Swed, S., Nashwan, A. J., Rababah, A. A., Hefnawy, M. T., Soliman, Y. Y., Abdelwahab, O. A., et al. (2022) · Infection and Drug Resistance · doi:10.2147/idr.s387551 · Cited by 16
Hsu, Y., Frank, M., Mukherjee, D., Shchurik, V., Makarov, A. A., & Mann, B. F. (2022) · Glycobiology · doi:10.1093/glycob/cwac077 · Cited by 17
A potent, broadly protective vaccine against SARS-CoV-2 variants of concern
Wang, Z., An, J., Liu, K., Yü, P., Fang, X. D., Li, J., Zhu, H., Zhu, Q., Huang, C., Zhang, C., et al. (2022) · npj Vaccines · doi:10.1038/s41541-022-00571-0 · Cited by 15
Ongoing evolution of SARS-CoV-2 drives escape from mRNA vaccine-induced humoral immunity
Roederer, A. L., Cao, Y., Denis, K. S., Sheehan, M. L., Li, C. J., Lam, E. C., Gregory, D. J., Poznansky, M. C., Iafrate, A. J., Canaday, D. H., et al. (2024) · Cell Reports Medicine · doi:10.1016/j.xcrm.2024.101850 · Cited by 18
Self-citationMolecular strategies for antibody binding and escape of SARS-CoV-2 and its mutations
Hendy, M. A., Kaufman, S., & Ponga, M. R. (2021) · Scientific Reports · doi:10.1038/s41598-021-01081-0 · Cited by 17
Margolin, E., Verbeek, M., de Moor, W. R. J., Chapman, R., Meyers, A., Schäfer, G., Williamson, A., & Rybicki, E. (2022) · Frontiers in Plant Science · doi:10.3389/fpls.2021.798822 · Cited by 15
Lyski, Z. L., Brunton, A. E., Strnad, M., Sullivan, P. E., Siegel, S. A. R., Tafesse, F., Slifka, M. K., & Messer, W. B. (2021) · The Journal of Infectious Diseases · doi:10.1093/infdis/jiab585 · Cited by 16
Adeyinka, D. A., Neudorf, C. O., Camillo, C. A., Marks, W. N., & Muhajarine, N. (2022) · JMIR Public Health and Surveillance · doi:10.2196/31968 · Cited by 16
The Landscape of Neutralizing Monoclonal Antibodies (nAbs) for Treatment and Prevention of COVID-19
Almeida-Oliveira, A., Freire, D. P. B., de Andrade, A. R., Marques, A. D. M., Madeira, L. D. S., Senna, J. P. M., da Silveira, I. A. F. B., & Fialho, B. D. C. (2023) · Journal of Pharmaceutical Innovation · doi:10.1007/s12247-023-09713-w · Cited by 17
Muir, L., Jaffer, A., Rees-Spear, C., Gopalan, V., Chang, F. Y., Fernando, R., Vaitkute, G., Roustan, C., Rosa, A., Earl, C. P., et al. (2021) · Kidney International Reports · doi:10.1016/j.ekir.2021.03.902 · Cited by 15
Cellular senescence as a source of SARS‐CoV‐2 quasispecies
Karakasiliοtis, I., Lаgopati, N., Evangelou, K., & Gorgoulis, V. G. (2021) · FEBS Journal · doi:10.1111/febs.16230 · Cited by 15
SARS-CoV-2 Variants: Mutations and Effective Changes
Park, G., & Hwang, B. H. (2021) · Biotechnology and Bioprocess Engineering · doi:10.1007/s12257-021-0327-3 · Cited by 17
Espinosa, L. A., Ramos, Y., Andújar, I., Alegre, E. O. T., Cabrera, G., Martin, A. M., Roche, D., Chinea, G., Béquet‐Romero, M., González, I., et al. (2021) · Analytical and Bioanalytical Chemistry · doi:10.1007/s00216-021-03721-w · Cited by 15
Ferreira, C. D. S., Dantés, H. G., Bellei, N., López, E. L., Crespo, K. A. N., O’Ryan, M., & Villegas, J. (2021) · Viruses · doi:10.3390/v13122391 · Cited by 16
Qiao, S., Zhang, S., Ge, J., & Wang, X. (2022) · FEBS Open Bio · doi:10.1002/2211-5463.13454 · Cited by 16
Giron, C. C., Laaksonen, A., & da Silva, F. L. B. (2022) · Journal of Biomolecular Structure and Dynamics · doi:10.1080/07391102.2022.2095305 · Cited by 18
Reimann, H., Kremer, A. N., Blumenberg, V., Schmidt, K. G., Aigner, M., Jacobs, B., Eisenhauer, N., Kämpf, A., Rösler, W., Kharboutli, S., et al. (2022) · Blood Advances · doi:10.1182/bloodadvances.2022007806 · Cited by 15
Tegally, H., Ramuth, M., Amoaka, D., Scheepers, C., Wilkinson, E., Giovanetti, M., Lessells, R. J., Giandhari, J., Ismail, A., Martin, D. P., et al. (2021) · medRxiv · doi:10.1101/2021.06.16.21259017 · Cited by 13
Self-citationRapid and Flexible RT-qPCR Surveillance Platforms To Detect SARS-CoV-2 Mutations
Spieß, K., Gunalan, V., Marving, E. L., Nielsen, S. H., Jørgensen, M. G. P., Fomsgaard, A. S., Nielsen, L., Alfaro‐Núñez, A., Karst, S. M., Mortensen, S., et al. (2023) · Microbiology Spectrum · doi:10.1128/spectrum.03591-22 · Cited by 24
The Immunopathobiology of SARS-CoV-2 Infection
Patel, M., Shahjin, F., Cohen, J. D., Hasan, M., Machhi, J., Chugh, H., Singh, S., Das, S., Kulkarni, T. A., Herskovitz, J., et al. (2021) · FEMS Microbiology Reviews · doi:10.1093/femsre/fuab035 · Cited by 15
SARS‐CoV‐2 R.1 lineage variants that prevailed in Tokyo in March 2021
Nagano, K., Sassa, C. T., Iwasaki, Y., Takatsuki, Y., Yuasa, S., Takahashi, Y., Nakajima, J., Sonobe, K., Ichimura, N., Nukui, Y., et al. (2021) · Journal of Medical Virology · doi:10.1002/jmv.27240 · Cited by 14
Yue, S., Li, Z., Lin, Y., Yang, Y., Yuan, M., Pan, Z., Li, H., Gao, L., Zhou, J., Tang, J., et al. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.751584 · Cited by 13
Insect protease inhibitors; promising inhibitory compounds against SARS-CoV-2 main protease
Hemmati, S. A., & Tabein, S. (2022) · Computers in Biology and Medicine · doi:10.1016/j.compbiomed.2022.105228 · Cited by 14
Evolutionary dynamics of the severe acute respiratory syndrome coronavirus 2 genomes
Qian, Z., Li, P., Tang, X., & Lü, J. (2022) · Medical Review · doi:10.1515/mr-2021-0035 · Cited by 14
Miteva, D., Kitanova, M., Batselova, H., Lazova, S., Chervenkov, L., Peshevska-Sekulovska, M., Sekulovski, M., Gulinac, M., Vasilev, G., Tomov, L., et al. (2023) · Vaccines · doi:10.3390/vaccines11071181 · Cited by 16
Erster, O., Mendelson, E., Kabat, A., Levy, V., Mannasse, B., Asraf, H., Azar, R., Ali, Y., Bucris, E. D., Bar-Ilan, D., et al. (2022) · Microbiology Spectrum · doi:10.1128/spectrum.02176-21 · Cited by 14
Saunders, K. O., Lee, E., Parks, R., Martinez, D. R., Li, D., Chen, H., Edwards, R. J., Gobeil, S., Barr, M., Mansouri, K., et al. (2021) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2021.02.17.431492 · Cited by 14
SARS-CoV-2 cell-to-cell spread occurs rapidly and is insensitive to antibody neutralizationPreprint
Jackson, L., Rodel, H. E., Hwa, S.-H., Cele, S., Ganga, Y., Tegally, H., Bernstein, M. P., Giandhari, J., COMMIT-KZN Team, Gosnell, B. I., et al. (2021) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2021.06.01.446516 · Cited by 16
Self-citationMor, O., Zuckerman, N. S., Hazan, I., Fluss, R., Ash, N., Ginish, N., Mendelson, E., Alroy-Preis, S., Freedman, L., & Huppert, A. (2022) · Journal of Clinical Epidemiology · doi:10.1016/j.jclinepi.2021.10.011 · Cited by 13
Gurung, A. B., Ali, M. A., Lee, J., Farah, M. A., Al‐Anazi, K. M., Al-Hemaid, F. M. A., & Sami, H. (2021) · Journal of King Saud University - Science · doi:10.1016/j.jksus.2021.101773 · Cited by 13
Shahab, M., Akter, S., Sarkar, M. M. H., Banu, T. A., Goswami, B., Chowdhury, S. F., Naser, S. R., Habib, M. A., Shaikh, A. A., Saki, M., et al. (2023) · Informatics in Medicine Unlocked · doi:10.1016/j.imu.2023.101281 · Cited by 13
Dorlass, E. G., Lourenço, K. L., Magalhães, R. D. M., Sato, H. I., Fiorini, A., Peixoto, R. B., Coelho, H. P., Telezynski, B. L., Scagion, G. P., Ometto, T., et al. (2021) · Genomics · doi:10.1016/j.ygeno.2021.10.015 · Cited by 13
Maturation of SARS-CoV-2 Spike-specific memory B cells drives resilience to viral escape
Marzi, R., Bassi, J., Silacci-Fregni, C., Bartha, I., Muoio, F., Culap, K., Sprugasci, N., Lombardo, G., Saliba, C., Cameroni, E., et al. (2022) · iScience · doi:10.1016/j.isci.2022.105726 · Cited by 12
COVID-19: A state of art on immunological responses, mutations, and treatment modalities in riposte
Gong, X., Khan, A., Wani, M. Y., Ahmad, A., & Duse, A. G. (2022) · Journal of Infection and Public Health · doi:10.1016/j.jiph.2022.12.019 · Cited by 15
Bui, N.-N., Lin, Y.-T., Huang, S.-H., & Lin, C. (2021) · Infection Genetics and Evolution · doi:10.1016/j.meegid.2021.105164 · Cited by 13
Immunology and Technology of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Vaccines
Pecetta, S., Kratochvil, S., Kato, Y., Vadivelu, K., & Rappuoli, R. (2022) · Pharmacological Reviews · doi:10.1124/pharmrev.120.000285 · Cited by 11
Brandys, P., Montagutelli, X., Merenkova, I., Barut, G. T., Thiel, V., Schork, N. J., Trüeb, B. S., Conquet, L., Deng, A., Antanasijevic, A., et al. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.912898 · Cited by 11
mRNA Vaccines Against COVID-19 as Trailblazers for Other Human Infectious Diseases
Brandi, R., Paganelli, A., D’Amelio, R., Giuliani, P., Lista, F. R., Salemi, S., & Paganelli, R. (2024) · Vaccines · doi:10.3390/vaccines12121418 · Cited by 13
Kostaki, E. G., Tseti, I. K., Tsiodras, S., Pavlakis, G. N., Sfikakis, P. P., & Paraskevis, D. N. (2021) · Life · doi:10.3390/life11050375 · Cited by 13
Chrysanthus, C. S. (2022) · International Journal of Clinical Virology · doi:10.29328/journal.ijcv.1001043 · Cited by 12
Farias, J. P., da Silva, P. D. S., Fogaça, M. M. C., Santana, I. V. R., Luiz, W. B., Birbrair, A., & Amorim, J. H. (2022) · Journal of Virology · doi:10.1128/jvi.00177-22 · Cited by 12
Zhang, Y., Tan, W., Lou, Z., Zhao, Y., Zhang, J., Liang, H., Li, N., Zhu, X., Ding, L., Huang, B., et al. (2022) · Vaccines · doi:10.3390/vaccines10071149 · Cited by 11
Hwa, S.-H., Snyman, J., Bernstein, M. P., Ganga, Y., Cele, S., Muema, D., Tan, C. W., Khan, K., Karim, F., Hanekom, W. A., et al. (2022) · The Journal of Infectious Diseases · doi:10.1093/infdis/jiac343 · Cited by 12
Self-citationSARS-CoV-2 variants of concern: a review
Sarkar, M. S., & Madabhavi, I. (2022) · Monaldi Archives for Chest Disease · doi:10.4081/monaldi.2022.2337 · Cited by 14
Ad26.COV2.S priming provided a solid immunological base for mRNA-based COVID-19 booster vaccination
Geers, D., Sablerolles, R. S. G., van Baarle, D., Kootstra, N. A., Rietdijk, W. J. R., Schmitz, K. S., Gommers, L., Bogers, S., Nieuwkoop, N. J., van Dijk, L. L. A., et al. (2022) · iScience · doi:10.1016/j.isci.2022.105753 · Cited by 12
Mabuka, T., Naidoo, N., Ncube, N., Yiga, T., Ross, M. D., Kurehwa, K., Nyathi, M. N., Silaji, A., Ndemera, T., Lemeke, T., et al. (2023) · JMIRx Med · doi:10.2196/34598 · Cited by 12
SARS-CoV-2 Portrayed against HIV: Contrary Viral Strategies in Similar Disguise
Duerr, R., Crosse, K. M., Valero-Jimenez, A. M., & Dittmann, M. (2021) · Microorganisms · doi:10.3390/microorganisms9071389 · Cited by 12
Ferguson, E. A., Brum, E., Chowdhury, A., Chowdhury, S., Kundegorski, M. E., Mahmud, A. S., Purno, N. H., Sania, A., Steenson, R., Tasneem, M., et al. (2022) · Epidemics · doi:10.1016/j.epidem.2022.100592 · Cited by 14
Neuroinvasion and neurotropism by SARS-CoV-2 variants in the K18-hACE2 mousePreprint
Seehusen, F., Clark, J. J., Sharma, P., Bentley, E. G., Kirby, A., Subramaniam, K. S., Wunderlin, S., Hughes, G. L., Patterson, E. I., Michael, B. D., et al. (2021) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2021.04.16.440173 · Cited by 12
Rapid surveillance platforms for key SARS-CoV-2 mutations in DenmarkPreprint
Spieß, K., Gunalan, V., Marving, E. L., Nielsen, S. H., Jørgensen, M. G. P., Fomsgaard, A. S., Nielsen, L., Alfaro‐Núñez, A., Karst, S. M., Mortensen, S., et al. (2021) · medRxiv · doi:10.1101/2021.10.25.21265484 · Cited by 12
Sanders, J., Messchendorp, A. L., de Vries, R. D., Baan, C. C., van Baarle, D., van Binnendijk, R. S., Diavatopoulos, D. A., Geers, D., Schmitz, K. S., GeurtsvanKessel, C. H., et al. (2022) · SSRN Electronic Journal · doi:10.2139/ssrn.4070419 · Cited by 12
Multiviral Quartet Nanocages Elicit Broad Anti-Coronavirus Responses for Proactive VaccinologyPreprint
Hills, R. A., Tan, T. K., Cohen, A. A., Keeffe, J. R., Keeble, A. H., Gnanapragasam, P. N. P., Storm, K. N., Hill, M. L., Liu, S., Gilbert‐Jaramillo, J., et al. (2023) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2023.02.24.529520 · Cited by 12
Evolution and viral properties of the SARS-CoV-2 BA.3.2 subvariant
Jule, Z., Roemer, C., Hossen, T., Sviridchik, V., Reedoy, K., Ganga, Y., Silangwe, S., Jackson, L., Norman, A., Karim, F., et al. (2026) · Virus Evolution · doi:10.1093/ve/veag011 · Cited by 10
Self-citationDeep dissection of the antiviral immune profile of patients with COVID-19
Atanackovic, D., Avila, S. V., Lutfi, F. U., de Miguel‐Pérez, D., Fan, X., Sanchez‐Petitto, G., Mause, E. R. V., Siglin, J., Baddley, J. W., Mannuel, H. D., et al. (2021) · Communications Biology · doi:10.1038/s42003-021-02852-1 · Cited by 10
Mutation profile of SARS-CoV-2 genome in a sample from the first year of the pandemic in Colombia
Gálvez, J. M., Chaparro-Solano, H. M., Pinzón-Rondón, Á. M., Albornóz, L. L., Oviedo, J. M. P., Zapata-Gómez, F. A., Patiño-Aldana, A. F., Hernandez-Rodríguez, A. D., Quiroz, M. A. D., & Ruiz-Sternberg, Á. M. (2021) · Infection Genetics and Evolution · doi:10.1016/j.meegid.2021.105192 · Cited by 11
Emergence of novel combinations of SARS-CoV-2 spike receptor binding domain variants in Senegal
Ahouidi, A. D., Rodgers, M. A., Padane, A., Lèye, N., Olivo, A., Mbow, M., Mboup, A., Diaw, P. A., Dia, A., Harris, B., et al. (2021) · Scientific Reports · doi:10.1038/s41598-021-02874-z · Cited by 11
Complexity of Viral Epitope Surfaces as Evasive Targets for Vaccines and Therapeutic Antibodies
Miller, N. L., Raman, R., Clark, T., & Sasisekharan, R. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.904609 · Cited by 12
Yu, Y., Liu, Y., Zhao, S., & He, D. (2022) · Mathematical Biosciences & Engineering · doi:10.3934/mbe.2022485 · Cited by 11
SARS-CoV-2 intra-host single-nucleotide variants associated with disease severity
Zhang, Y., Jiang, N., Qi, W., Li, T., Zhang, Y., Wu, J., Zhang, H., Zhou, M., Cui, P., Yu, T., et al. (2022) · Virus Evolution · doi:10.1093/ve/veac106 · Cited by 11
Architecture of the SARS-CoV-2-specific T cell repertoire
Zornikova, K. V., Sheetikov, S. A., Rusinov, A. Y., Iskhakov, R. N., & Васильевна, Б. А. (2023) · Frontiers in Immunology · doi:10.3389/fimmu.2023.1070077 · Cited by 10
Neck, S. D., Penrice-Randal, R., Clark, J. J., Sharma, P., Bentley, E. G., Kirby, A., Mega, D. F., Han, X., Owen, A., Hiscox, J. A., et al. (2023) · Viruses · doi:10.3390/v15081637 · Cited by 11
Schröder, S., Richter, A. M., Veith, T., Emanuel, J., Gudermann, L., Friedmann, K., Jeworowski, L. M., Mühlemann, B., Jones, T. C., Müller, M. A., et al. (2023) · Virology Journal · doi:10.1186/s12985-023-02154-4 · Cited by 10
Lustig, G., Ganga, Y., Rodel, H. E., Tegally, H., Khairallah, A., Jackson, L., Cele, S., Khan, K., Jule, Z., Reedoy, K., et al. (2023) · Virus Evolution · doi:10.1093/ve/vead075 · Cited by 12
Self-citationPotent Anti‐SARS‐CoV‐2 Efficacy of COVID‐19 Hyperimmune Globulin from Vaccine‐Immunized Plasma
Yu, D., Li, Y., Hong, L., Wu, J., Hu, Y., Peng, Y., Li, T., Hou, J., Huang, W., Guan, L., et al. (2022) · Advanced Science · doi:10.1002/advs.202104333 · Cited by 11
The changing health impact of vaccines in the COVID-19 pandemic: A modeling study
Cohen, J. A., Stuart, R. M., Panovska‐Griffiths, J., Mudimu, E., Abeysuriya, R., Kerr, C. C., Famulare, M., & Klein, D. J. (2023) · Cell Reports · doi:10.1016/j.celrep.2023.112308 · Cited by 14
Evaluation of mRNA-1273 against SARS-CoV-2 B.1.351 Infection in Nonhuman PrimatesPreprint
Corbett, K. S., Werner, A. P., Connell, S. O., Gagné, M., Lai, L., Moliva, J. I., Flynn, B. J., Choi, A., Koch, M. J., Foulds, K. E., et al. (2021) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2021.05.21.445189 · Cited by 11
Chen, X., Chen, Z., Azman, A. S., Sun, R., Lu, W., Zheng, N., Zhou, J., Wu, Q., Deng, X., Zhao, Z., et al. (2021) · SSRN Electronic Journal · doi:10.2139/ssrn.3858816 · Cited by 11
Metadata
- Authors
- Network for Genomic Surveillance in South Africa, Cele, S., COMMIT-KZN Team, Gazy, I., Jackson, L., Hwa, S.-H., Tegally, H., Lustig, G., Giandhari, J., Pillay, S., Wilkinson, E., Naidoo, Y., Karim, F., Ganga, Y., Khan, K., Bernstein, M., Balazs, A. B., Gosnell, B. I., Hanekom, W., Moosa, M.-Y. S., Lessells, R. J., de Oliveira, T., & Sigal, A.
- Affiliations
- Africa Health Research Institute (ZA)
- Hebrew University of Jerusalem (IL)
- Centre for the AIDS Programme of Research in South Africa (ZA)
- University of KwaZulu-Natal (ZA)
- Ragon Institute of MGH, MIT and Harvard (US)
- Max Planck Institute for Infection Biology (DE)
- Corresponding author
- Sigal, Alex
- ORCID
- Cele, Sandile
- Gazy, Inbal
- Jackson, Laurelle
- Hwa, Shi-Hsia
- Tegally, Houriiyah
- Lustig, Gila
- Giandhari, Jennifer
- Pillay, Sureshnee
- Wilkinson, Eduan
- Naidoo, Yeshnee
- Karim, Farina
- Ganga, Yashica
- Khan, Khadija
- Bernstein, Mallory
- Balazs, Alejandro B.
- Gosnell, Bernadett I.
- Hanekom, Willem
- Moosa, Mahomed-Yunus S.
- Lessells, Richard J.
- de Oliveira, Tulio
- Sigal, Alex
- Venue
- Nature
- Published
- 2021-03-29
- Volume
- 593
- Issue
- 7857
- Pages
- 142-146
- ISSN
- 0028-0836 (ISSN-L)
- 1476-4687
- PMC
- PMC9867906
- OpenAlex
- W3148277587
- Cited by
- 651
- References
- 31
- Citations by year
- 2026: 13 · 2025: 22 · 2024: 28 · 2023: 63 · 2022: 199 · 2021: 320
- FWCI
- 48.26
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Nature (publishedVersion)
- medRxiv (acceptedVersion, cc-by-nd)
- PubMed (publishedVersion)
- Research at the University of Copenhagen (University of Copenhagen) (publishedVersion, other-oa)
- PubMed Central (acceptedVersion)
- RePEc: Research Papers in Economics (submittedVersion)
- UCL Discovery (University College London) (submittedVersion)
- Griffith Research Online (submittedVersion, other-oa)
- Funders
- South African Medical Research Council
- Inyuvesi Yakwazulu-Natali
- National Health Laboratory Service
- Medical Research Council
- National Institute on Drug Abuse (DP2DA040254)
- Topics
- Health Sciences › Medicine › Infectious Diseases › SARS-CoV-2 and COVID-19 Research
- Health Sciences › Medicine › Infectious Diseases › COVID-19 Clinical Research Studies
- Life Sciences › Agricultural and Biological Sciences › Animal Science and Zoology › Animal Virus Infections Studies
- Keywords
- SARS-CoV-2, Beta variant, convalescent plasma, neutralizing antibodies, cross-neutralization, vaccine efficacy, spike protein, receptor binding domain, COVID-19 pandemic, South Africa
- MeSH terms
- COVID-19, SARS-CoV-2, COVID-19 Serotherapy, Animals, Antibodies, Viral, Cell Line, Chlorocebus aethiops, Humans, Immunization, Passive, Mutation, Neutralization Tests, South Africa, Time Factors, Vero Cells, Immune Evasion, Antibodies, Neutralizing
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review