The DOI matches its Crossref record; 11 of the 11 references it cites were found in a registry or an index.
Representational drift in primary olfactory cortex
Open accessAbstract
Perceptual constancy requires the brain to maintain a stable representation of sensory input. In the olfactory system, activity in primary olfactory cortex (piriform cortex) is thought to determine odour identity1–5. Here we present the results of electrophysiological recordings of single units maintained over weeks to examine the stability of odour-evoked responses in mouse piriform cortex. Although activity in piriform cortex could be used to discriminate between odorants at any moment in time, odour-evoked responses drifted over periods of days to weeks. The performance of a linear classifier trained on the first recording day approached chance levels after 32 days. Fear conditioning did not stabilize odour-evoked responses. Daily exposure to the same odorant slowed the rate of drift, but when exposure was halted the rate increased again. This demonstration of continuous drift poses the question of the role of piriform cortex in odour perception. This instability might reflect the unstructured connectivity of piriform cortex6–12, and may be a property of other unstructured cortices. All odours elicit a unique pattern of neuronal activity in primary olfactory cortex but these patterns drift over time, posing a problem for the perceptual constancy of odours.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
In situ click chemistry generation of cyclooxygenase-2 inhibitors
Bhardwaj, A., Kaur, J., Wuest, M., & Wuest, F. (2017) · Nature Communications · doi:10.1038/s41467-016-0009-6 · Cited by 7,448
Genome-wide atlas of gene expression in the adult mouse brain
Lein, E. S., Hawrylycz, M. J., Ao, N., Ayres, M., Bensinger, A., Bernard, A., Boe, A. F., Boguski, M. S., Brockway, K. S., Byrnes, E. J., et al. (2007) · Nature · doi:10.1038/nature05453 · Cited by 5,572
McClelland, J. L., McNaughton, B. L., & O'Reilly, R. C. (1995) · Psychological Review · doi:10.1037/0033-295x.102.3.419 · Cited by 5,256
Recanzone, G., Schreiner, C., & Merzenich, M. (1993) · The Journal of Neuroscience · doi:10.1523/jneurosci.13-01-00087.1993 · Cited by 1,266
Neuropixels 2.0: A miniaturized high-density probe for stable, long-term brain recordings.
Steinmetz, N. A., Aydin, C., Lebedeva, A., Okun, M., Pachitariu, M., Bauza, M., Beau, M., Bhagat, J., Böhm, C., Broux, M., et al. (2021) · Science · doi:10.1126/science.abf4588 · Cited by 1,173
Squire, L. R., Genzel, L., Wixted, J. T., & Morris, R. G. (2015) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a021766 · Cited by 700
Dynamic Reorganization of Neuronal Activity Patterns in Parietal Cortex
Driscoll, L. N., Pettit, N. L., Minderer, M., Chettih, S. N., & Harvey, C. D. (2017) · Cell · doi:10.1016/j.cell.2017.07.021 · Cited by 445
Neuronal code for extended time in the hippocampus
Mankin, E. A., Sparks, F. T., Slayyeh, B., Sutherland, R. J., Leutgeb, S., & Leutgeb, J. K. (2012) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1214107109 · Cited by 371
Single-Unit Stability Using Chronically Implanted Multielectrode Arrays
Dickey, A. S., Suminski, A., Amit, Y., & Hatsopoulos, N. G. (2009) · Journal of Neurophysiology · doi:10.1152/jn.90920.2008 · Cited by 234
Causes and consequences of representational drift
Rule, M. E., O’Leary, T., & Harvey, C. D. (2019) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2019.08.005 · Cited by 227
Cited by
Neuropixels 2.0: A miniaturized high-density probe for stable, long-term brain recordings.
Steinmetz, N. A., Aydin, C., Lebedeva, A., Okun, M., Pachitariu, M., Bauza, M., Beau, M., Bhagat, J., Böhm, C., Broux, M., et al. (2021) · Science · doi:10.1126/science.abf4588 · Cited by 1,173
“Moreover, high-quality signals can be recorded for more than 8 weeks even with relatively rigid and large devices, such as wire tetrodes ( 35 , 36 ), Utah arrays ( 37 , 38 ), traditional silicon probes ( 39 – 41 ), and Neuropixels probes ( 6 , 25 , 42 ).”
A brain atlas of synapse protein lifetime across the mouse lifespan
Bulovaite, E., Qiu, Z., Kratschke, M., Zgraj, A., Fricker, D. G., Tuck, E. J., Gokhale, R., Koniaris, B., Jami, S. A., Merino-Serrais, P., et al. (2022) · Neuron · doi:10.1016/j.neuron.2022.09.009 · Cited by 111
Selection of experience for memory by hippocampal sharp wave ripples
Yang, W., Sun, C., Huszár, R., Hainmueller, T., Kiselev, K., & Buzsáki, G. (2024) · Science · doi:10.1126/science.adk8261 · Cited by 95
Transforming a head direction signal into a goal-oriented steering command
Westeinde, E. A., Kellogg, E., Dawson, P. M., Lu, J., Hamburg, L., Midler, B., Druckmann, S., & Wilson, R. I. (2022) · doi:10.1101/2022.11.10.516039 · Cited by 85
Transforming a head direction signal into a goal-oriented steering command
Westeinde, E. A., Kellogg, E., Dawson, P. M., Lu, J., Hamburg, L., Midler, B., Druckmann, S., & Wilson, R. I. (2024) · Nature · doi:10.1038/s41586-024-07039-2 · Cited by 85
Evolving the olfactory system with machine learning
Wang, P. Y., Sun, Y., Axel, R., Abbott, L. F., & Yang, G. R. (2021) · Neuron · doi:10.1016/j.neuron.2021.09.010 · Cited by 54
Self-citationFalandays, J. B., Yoshimi, J., Warren, W. H., & Spivey, M. J. (2024) · Cognitive Neurodynamics · doi:10.1007/s11571-023-09988-2 · Cited by 19
Metadata
- Authors
- Schoonover, C. E., Ohashi, S. N., Axel, R., & Fink, A. J. P.
- Venue
- Nature
- Published
- 2021-06-09
- Volume
- 594
- Issue
- 7864
- Pages
- 541-546
- ISSN
- 0028-0836 (ISSN-L)
- 1476-4687
- OpenAlex
- W3167740220
- Cited by
- 313
- References
- 11
- FWCI
- 24.12
- Type
- journal article
- Language
- en
- Open access
- green
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
