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Cited by 1,266Neuroscience and Music PerceptionHearing, Cochlea, Tinnitus, GeneticsTactile and Sensory Interactions

Plasticity in the frequency representation of primary auditory cortex following discrimination training in adult owl monkeys

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Recanzone, GH, Schreiner, CE, Merzenich, MM·1993·The Journal of Neuroscience
DOI 10.1523/jneurosci.13-01-00087.1993PMC PMC6576321
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Abstract

Previous studies have shown that the tonotopic organization of primary auditory cortex is altered subsequent to restricted cochlear lesions (Robertson and Irvine, 1989) and that the topographic reorganization of the primary somatosensory cortex is correlated with changes in the perceptual acuity of the animal (Recanzone et al., 1992a-d). Here we report an increase in the cortical area of representation of a restricted frequency range in primary auditory cortex of adult owl monkeys that is correlated with the animal's performance at a frequency discrimination task. Monkeys trained for several weeks to discriminate small differences in the frequency of sequentially presented tonal stimuli revealed a progressive improvement in performance with training. At the end of the training period, the tonotopic organization of Al was defined by recording multiple-unit responses at 70-258 cortical locations. These responses were compared to those derived from three normal monkeys and from two monkeys that received the same auditory stimuli but that were engaged in a tactile discrimination task. The cortical representation, the sharpness of tuning, and the latency of the response were greater for the behaviorally relevant frequencies of trained monkeys when compared to the same frequencies of control monkeys. The cortical area of representation was the only studied parameter that was correlated with behavioral performance. These results demonstrate that attended natural stimulation can modify the tonotopic organization of Al in the adult primate, and that this alteration is correlated with changes in perceptual acuity.

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  • Early visual cortical areas are distinguished from primary somatosensory and auditory cortices, which in both monkeys and humans can show dramatic changes with perceptual learning.

    “Our results also further distinguish early visual cortical areas from primary somatosensory and auditory cortices, which in both monkeys and humans can show dramatic changes with perceptual learning5, 6, 37–39.”

    From Neural correlates of perceptual learning in a sensory-motor, but not a sensory, cortical area (2008) · cites this paper as [5]

  • Primary somatosensory and auditory cortices in monkeys and humans can show dramatic changes with perceptual learning.

    “primary somatosensory and auditory cortices, which in both monkeys and humans can show dramatic changes with perceptual learning5, 6, 37–39.”

    From Neural correlates of perceptual learning in a sensory-motor, but not a sensory, cortical area (2008) · cites this paper as [5]

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Research works printed but not linked: 3

  1. Merzenich MM, Recanzone G, Jenkins WM, Allard TT, Nudo RJ (1988) Cortical representational plasticity. In: Neurobiology of neocortex (Rakic P, Singer W, eds), pp 41-67. New York: Wiley.
  2. Merzenich MM, Recanzone GH, Jenkins WM, Nudo RJ (1990) How the brain functionally rewires itself. In: Natural and artificial parallel computations (Arbib M, Robinson JA, eds), pp 177-210. Cambridge, MA: MIT Press.
  3. von der Malsburg C, Singer W (1988) Principles of cortical network organization. In: Neurobiology of neocot-tex (Rakic P, Singer W, eds), pp 69-99. New York: Wiley.

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Authors
Recanzone, G., Schreiner, C., & Merzenich, M.
Affiliations
University of California, San Francisco (US)
Venue
The Journal of Neuroscience
Publisher
Society for Neuroscience
Published
1993-01-01
Volume
13
Issue
1
Pages
87-103
ISSN
  • 0270-6474 (ISSN-L)
  • 1529-2401
DOI
10.1523/jneurosci.13-01-00087.1993
PMC
PMC6576321
OpenAlex
W2169191420
Cited by
1,266
References
51
Citations by year
2026: 9 · 2025: 12 · 2024: 16 · 2023: 16 · 2022: 16 · 2021: 15 · 2020: 29 · 2019: 34 · 2018: 24 · 2017: 32 · 2016: 37 · 2015: 35 · 2014: 51 · 2013: 52 · 2012: 55
FWCI
14.83
Type
journal article
Language
en
Open access
Licence
Locations
  • Journal of Neuroscience (publishedVersion, cc-by-nc-sa)
  • PubMed Central (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • National Institutes of Health
  • Office of Naval Research
  • National Institute of General Medical Sciences (GM-0774)
  • National Institute of Neurological Disorders and Stroke (NS10414, R01NS010414)
Topics
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Neuroscience and Music Perception
  • Life Sciences › Neuroscience › Sensory Systems › Hearing, Cochlea, Tinnitus, Genetics
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Tactile and Sensory Interactions
Keywords
primary auditory cortex, tonotopic organization, frequency discrimination, owl monkey, cortical plasticity, frequency tuning, behavioral training
MeSH terms
Acoustic Stimulation, Animals, Auditory Cortex, Behavior, Animal, Discrimination Learning, Electrophysiology, Female, Male, Neuronal Plasticity, Psychometrics, Psychophysics, Aotidae

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