A gut-derived metabolite alters brain activity and anxiety behaviour in mice

STAR: ultrafast universal RNA-seq aligner

Dobin, A., Davis, C. A., Schlesinger, F., Drenkow, J., Zaleski, C., Jha, S., Batut, P., Chaisson, M., & Gingeras, T. R. (2013) · Bioinformatics · doi:10.1093/bioinformatics/bts635 · Cited by 51,709

DADA2: High–resolution sample inference from Illumina amplicon data

Callahan, B. J., McMurdie, P. J., Rosen, M. J., Han, A. W., Johnson, A. J. A., & Holmes, S. P. (2016) · Nature Methods · doi:10.1038/nmeth.3869 · Cited by 35,698

Reproducible, interactive, scalable and extensible microbiome data science using QIIME 2

Bolyen, E., Rideout, J. R., Dillon, M. R., Bokulich, N. A., Abnet, C. C., Al-Ghalith, G. A., Alexander, H., Alm, E. J., Arumugam, M., Asnicar, F., et al. (2019) · Nature Biotechnology · doi:10.1038/s41587-019-0209-9 · Cited by 23,742

Salmon provides fast and bias-aware quantification of transcript expression

Patro, R., Duggal, G., Love, M. I., Irizarry, R. A., & Kingsford, C. (2017) · Nature Methods · doi:10.1038/nmeth.4197 · Cited by 12,700

Computer Visualization of Three-Dimensional Image Data Using IMOD

Kremer, J. R., Mastronarde, D. N., & McIntosh, J. R. (1996) · Journal of Structural Biology · doi:10.1006/jsbi.1996.0013 · Cited by 5,530

Automated electron microscope tomography using robust prediction of specimen movements

Mastronarde, D. N. (2005) · Journal of Structural Biology · doi:10.1016/j.jsb.2005.07.007 · Cited by 5,136

An RNA-Sequencing Transcriptome and Splicing Database of Glia, Neurons, and Vascular Cells of the Cerebral Cortex

Zhang, Y., Chen, K., Sloan, S. A., Bennett, M. L., Scholze, A. R., O'Keeffe, S., Phatnani, H. P., Guarnieri, P., Caneda, C., Ruderisch, N., et al. (2014) · The Journal of Neuroscience · doi:10.1523/jneurosci.1860-14.2014 · Cited by 4,875

Gut microbiota regulate motor deficits and neuroinflammation in a model of Parkinson's disease

Sampson, T. R., Debelius, J. W., Thron, T., Janssen, S., Shastri, G. G., Ilhan, Z. E., Challis, C., Schretter, C. E., Rocha, S., Gradinaru, V., et al. (2016) · Cell · doi:10.1016/j.cell.2016.11.018 · Cited by 3,622

Microbiota Modulate Behavioral and Physiological Abnormalities Associated with Neurodevelopmental Disorders

Hsiao, E. Y., McBride, S. W., Hsien, S., Sharon, G., Hyde, E. R., McCue, T., Codelli, J. A., Chow, J., Reisman, S. E., Petrosino, J. F., et al. (2013) · Cell · doi:10.1016/j.cell.2013.11.024 · Cited by 3,283

When to use the Bonferroni correction

Armstrong, R. A. (2014) · Ophthalmic and Physiological Optics · doi:10.1111/opo.12131 · Cited by 3,031

Bacterial peptidoglycan signalling in microglia: Activation by MDP via the NF-κB/MAPK pathway

Spielbauer, J., Glotfelty, E. J., Sarlus, H., Harris, R. A., Heijtz, R. D., & Karlsson, T. E. (2024) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2024.06.027 · Cited by 28

Copper induced intestinal inflammation response through oxidative stress induced endoplasmic reticulum stress in Takifugu fasciatus

Ma, S., Liu, Y., Zhao, C., Chu, P., Yin, S., & Wang, T. (2023) · Aquatic Toxicology · doi:10.1016/j.aquatox.2023.106634 · Cited by 28

Effect of gut microbiome on serotonin metabolism: a personalized treatment approach

Potter, K., Gayle, E. J., & Deb, S. (2023) · Naunyn-Schmiedeberg s Archives of Pharmacology · doi:10.1007/s00210-023-02762-5 · Cited by 27

Intervention in gut microbiota increases intestinal γ-aminobutyric acid and alleviates anxiety behavior: a possible mechanism via the action on intestinal epithelial cells

Ikegami, M., Narabayashi, H., Nakata, K., Yamashita, M., Sugi, Y., Fuji, Y., Matsufuji, H., Harata, G., Yoda, K., Miyazawa, K., et al. (2024) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2024.1421791 · Cited by 26

Taxonomic and Metabolic Signatures of Gut Microbiota for Assessing the Severity of Depression and Anxiety in Major Depressive Disorder Patients

Zhang, X., Hou, Y., Li, Y., Wei, W., Cai, X., Shao, H., Yuan, Y., & Zheng, X. (2022) · Neuroscience · doi:10.1016/j.neuroscience.2022.06.024 · Cited by 27

Ginkgo biloba extract protects against depression-like behavior in mice through regulating gut microbial bile acid metabolism

Zhou, J., Fan, Q., Cai, X., Zhang, Y., Hou, Y., Shuqi, C. A. O., Li, Z., Mengzhen, F. E. N. G., Qingqing, W. A. N. G., ZHANG, J., et al. (2023) · Chinese Journal of Natural Medicines · doi:10.1016/s1875-5364(23)60496-0 · Cited by 26

Bacteroides vulgatus alleviates dextran sodium sulfate-induced colitis and depression-like behaviour by facilitating gut-brain axis balance

Wu, X., Xu, J., Li, J., Deng, M., Shen, Z., Nie, K., Luo, W., Zhang, C., Ma, K., Chen, X., et al. (2023) · Frontiers in Microbiology · doi:10.3389/fmicb.2023.1287271 · Cited by 30

Issues for patchy tissues: defining roles for gut-associated lymphoid tissue in neurodevelopment and disease

Abo-Shaban, T., Sharna, S. S., Hosie, S., Lee, C. Y. Q., Balasuriya, G. K., McKeown, S. J., Franks, A. E., & Hill‐Yardin, E. L. (2022) · Journal of Neural Transmission · doi:10.1007/s00702-022-02561-x · Cited by 26

Blood-derived factors to brain communication in brain diseases

He, J., Zhang, Y., Guo, Y., Guo, J., Chen, X., Xu, S., Xu, X., Wu, C., Liu, C., Chen, J., et al. (2024) · 中国科学通报：英文版 · doi:10.1016/j.scib.2024.09.022 · Cited by 26

Quinoa Saponin Ameliorates Lipopolysaccharide-Induced Behavioral Disorders in Mice by Inhibiting Neuroinflammation, Modulating Gut Microbiota, and Counterbalancing Intestinal Inflammation

Lan, Y., Wang, X., Yan, F., Zhang, W., Zhao, S., Song, Y., Wang, S., Zhu, Z., Wang, Y., & Liu, X. (2025) · Journal of Agricultural and Food Chemistry · doi:10.1021/acs.jafc.5c00296 · Cited by 26

From psychosomatic medicine, brain–computer interface to brain–apparatus communication

Yao, D., Qin, Y. F., & Zhang, Y. (2022) · Brain-Apparatus Communication A Journal of Bacomics · doi:10.1080/27706710.2022.2120775 · Cited by 27

Multiple neuronal populations control the eating behavior in Hydra and are responsive to microbial signals

Giez, C., Pinkle, D., Giencke, Y., Wittlieb, J., Herbst, E., Spratte, T., Lachnit, T., Klimovich, A. V., Selhuber‐Unkel, C., & Bosch, T. C. G. (2023) · Current Biology · doi:10.1016/j.cub.2023.10.038 · Cited by 29

An engineered Escherichia coli Nissle strain prevents lethal liver injury in a mouse model of tyrosinemia type 1

Gu, P., Xie, L. X., Chen, T., Yang, Q. Z., Zhang, X., Liu, R., Guo, J., Wei, R., Li, D., Jiang, Y. Q., et al. (2023) · Journal of Hepatology · doi:10.1016/j.jhep.2023.10.037 · Cited by 24

Microbe-derived uremic solutes enhance thrombosis potential in the host

Nemet, I., Funabashi, M., Li, X. S., Dwidar, M., Sangwan, N., Skye, S. M., Romano, K. A., Čajka, T., Needham, B. D., Mazmanian, S. K., et al. (2023) · mBio · doi:10.1128/mbio.01331-23 · Cited by 24

The gut–brain connection: microbes’ influence on mental health and psychological disorders

Ataei, P., Kalantari, H., Bodnar, T. S., & Turner, R. J. (2026) · Frontiers in Microbiomes · doi:10.3389/frmbi.2025.1701608 · Cited by 33

Probiotics and Prebiotics in the Treatment of Autism Spectrum Disorder: A Narrative Review

Zhang, S., Han, F., Wang, Q., & Fan, F. (2024) · Journal of Integrative Neuroscience · doi:10.31083/j.jin2301020 · Cited by 29

Dysregulated meta-organismal metabolism of aromatic amino acids in alcohol-associated liver disease

Mrdjen, M., Huang, E., Pathak, V., Bellar, A., Welch, N., Dasarathy, J., Streem, D. W., McClain, C. J., Mitchell, M. C., Radaeva, S., et al. (2023) · Hepatology Communications · doi:10.1097/hc9.0000000000000284 · Cited by 23

Akkermansia muciniphila ameliorates colonic injury in mice with DSS-induced acute colitis by blocking macrophage pro-inflammatory phenotype switching via the HDAC5/DAB2 axis

Miao, Y., Wang, M., Sun, H. X., Zhang, Y., Zhou, W., Yang, W., Duan, L., Niu, L., Li, Z., Chen, J., et al. (2024) · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · doi:10.1016/j.bbamcr.2024.119751 · Cited by 23

Oral Supramolecular Adsorbent for Preventing Chemo‐Induced Gastrointestinal Mucositis and Microbial Dysbiosis and for Enhancing Chemoimmunotherapy

Tian, M., Fan, D., Liu, Z., Mu, X., Tao, Q., Yu, C., & Zhang, S. (2022) · Advanced Materials · doi:10.1002/adma.202205299 · Cited by 23

Propionic acid promotes neurite recovery in damaged multiple sclerosis neurons

Gisevius, B., Duscha, A., Poschmann, G., Stühler, K., Motte, J., Fisse, A. L., Augustyniak, S., Rehm, A., Renk, P., Böse, C., et al. (2024) · Brain Communications · doi:10.1093/braincomms/fcae182 · Cited by 26

Phlorizin ameliorates cognitive and behavioral impairments via the microbiota-gut-brain axis in high-fat and high-fructose diet-induced obese male mice

Zhang, S. Q., Wang, X., Liu, S., Hu, C. Y., & Meng, Y. (2024) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2024.09.008 · Cited by 24

Electrochemical sensor based on polydopamine-molecularly imprinted polymer for detection of 4-ethylphenyl sulfate “a novel gut metabolite”: Fabrication, characterization, and performance evaluation in human urine

Archana, Verma, D., Hashmi, S. Z. H., Lakshmi, G. B. V. S., Sajwan, R. K., Kumar, A., & Solanki, P. R. (2023) · Microchemical Journal · doi:10.1016/j.microc.2023.108964 · Cited by 22

The missing hallmark of health: psychosocial adaptation

López-Otín, C., & Kroemer, G. (2024) · Cell Stress · doi:10.15698/cst2024.03.294 · Cited by 27

Oral nano-antioxidants improve sleep by restoring intestinal barrier integrity and preventing systemic inflammation

Wu, Z., Liu, L., Li, L., Cao, X., Jia, W., Liao, X., Zhao, Z., Qi, H., Fan, G., Lu, H., et al. (2023) · National Science Review · doi:10.1093/nsr/nwad309 · Cited by 23

Zinc promotes microbial p-coumaric acid production that protects against cholestatic liver injury

Li, D., Wan, M., Xue, L.-F., Zhang, Z., Qiu, Y., Mei, F., Tang, N., Yu, C., Yao, Y., Chen, T., et al. (2024) · Cell Host & Microbe · doi:10.1016/j.chom.2024.11.002 · Cited by 22

The microbiome as a modulator of neurological health across the maternal-offspring interface

Orchanian, S. B., & Hsiao, E. Y. (2025) · Journal of Clinical Investigation · doi:10.1172/jci184314 · Cited by 23

Midgut and Head Transcriptomic Analysis of Silkworms Reveals the Physiological Effects of Artificial Diets

Li, J., Chen, C., & Zha, X. (2022) · Insects · doi:10.3390/insects13030291 · Cited by 21

Clinical and Preclinical Evidence for Gut Microbiome Mechanisms in Substance Use Disorders

Hofford, R. S., & Kiraly, D. D. (2023) · Biological Psychiatry · doi:10.1016/j.biopsych.2023.08.004 · Cited by 20

Correlation between gut microbiome and cognitive impairment in patients undergoing peritoneal dialysis

Wang, J., Wu, S., Zhang, J., Li, Y., Wu, Y., & Qi, X. (2023) · BMC Nephrology · doi:10.1186/s12882-023-03410-z · Cited by 20

Analysis of gut microbiota and depression and anxiety: Mendelian randomization from three datasets

Lai, Y., & Xiong, P. (2025) · General Hospital Psychiatry · doi:10.1016/j.genhosppsych.2025.03.012 · Cited by 20

Immune control of brain physiology

Kovacs, M., Dominguez-Belloso, A., Ali-Moussa, S., & Deczkowska, A. (2025) · Nature reviews. Immunology · doi:10.1038/s41577-025-01129-6 · Cited by 22

The immunomodulatory roles of the gut microbiome in autoimmune diseases of the central nervous system: Multiple sclerosis as a model

Hoffman, K. R., Brownell, Z., Doyle, W. J., & Ochoa‐Repáraz, J. (2022) · Journal of Autoimmunity · doi:10.1016/j.jaut.2022.102957 · Cited by 20

Intestinal activating transcription factor 4 regulates stress-related behavioral alterations via paraventricular thalamus in male mice

Yuan, F., Zhou, Z., Wu, S., Jiao, F., Chen, L., Fang, L., Yin, H., Hu, X., Jiang, X., Liu, K., et al. (2023) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2215590120 · Cited by 19

Nutrient regulation of development and cell fate decisions

Tu, W. B., Christofk, H. R., & Plath, K. (2023) · Development · doi:10.1242/dev.199961 · Cited by 23

Revised Aspects into the Molecular Bases of Hydroxycinnamic Acid Metabolism in Lactobacilli

de Felipe, F. L. (2023) · Antioxidants · doi:10.3390/antiox12061294 · Cited by 20

Intestinal 8 gingerol attenuates TBI-induced neuroinflammation by inhibiting microglia NLRP3 inflammasome activation in a PINK1/Parkin-dependent manner

Tang, X., Huang, L., Ma, W., Mingxin, H., Zeng, Z., Yu, Y., Qin, N., Zhou, F., Li, F., Gong, S., et al. (2025) · Phytomedicine · doi:10.1016/j.phymed.2025.156580 · Cited by 18

Microecologics and Exercise: Targeting the Microbiota–Gut–Brain Axis for Central Nervous System Disease Intervention

Peng, Z., Hou, T., Yang, K., Zhang, J., Mao, Y.-H., & Hou, X. (2025) · Nutrients · doi:10.3390/nu17111769 · Cited by 21

A Diet Supplemented with Polyphenols, Prebiotics and Omega-3 Fatty Acids Modulates the Intestinal Microbiota and Improves the Profile of Metabolites Linked with Anxiety in Dogs

Ephraim, E., Brockman, J. A., & Jewell, D. E. (2022) · Biology · doi:10.3390/biology11070976 · Cited by 22

Landscapes of Enteric Virome Signatures in Early-Weaned Piglets

Tao, S., Zou, H., Li, J., & Hong Kui, W. E. I. (2022) · Microbiology Spectrum · doi:10.1128/spectrum.01698-22 · Cited by 21

Microbial glutamate metabolism predicts intravenous cocaine self-administration in diversity outbred mice

Tran, T. D. B., Nguyen, H. T., Sodergren, E. J., Dickson, P. E., Wright, S. N., Philip, V. M., Weinstock, G. M., Chesler, E. J., Zhou, Y., & Bubier, J. A. (2022) · Neuropharmacology · doi:10.1016/j.neuropharm.2022.109409 · Cited by 20

Microbial and Metabolite Signatures of Stress Reactivity in Ulcerative Colitis Patients in Clinical Remission Predict Clinical Flare Risk

Jacobs, J. P., Sauk, J. S., Ahdoot, A., Liang, F., Katzka, W. R., Ryu, H. J., Khandadash, A., Lagishetty, V., Labus, J. S., Naliboff, B. D., et al. (2023) · Inflammatory Bowel Diseases · doi:10.1093/ibd/izad185 · Cited by 20

Intestinal microbiota via NLRP3 inflammasome dependent neuronal pyroptosis mediates anxiety-like behaviour in mice exposed to 3.5 GHz radiofrequency radiation

Zhou, G., Wang, X., Gao, P., Qin, T., Guo, L. T., Zhang, Z., Huang, Z., Lin, J., Jing, Y., Wang, H., et al. (2024) · The Science of The Total Environment · doi:10.1016/j.scitotenv.2024.172391 · Cited by 19

Fecal microbiome transplantation alleviates manganese-induced neurotoxicity by altering the composition and function of the gut microbiota via the cGAS–STING/NLRP3 pathway

Liu, J., Zhang, Z., Zhong, S., Zhang, X., Yang, J., Zhou, Q., Wang, D., Chang, X., & Wang, H. (2024) · The Science of The Total Environment · doi:10.1016/j.scitotenv.2024.175681 · Cited by 21

Intervention and research progress of gut microbiota-immune-nervous system in autism spectrum disorders among students

Zhou, M., Niu, B., Ma, J., Ge, Y., Han, Y., Wu, W., & Yue, C. (2025) · Frontiers in Microbiology · doi:10.3389/fmicb.2025.1535455 · Cited by 23

Microbial orchestration of neuroimmune crosstalk: from homeostasis to disease

Ouyang, H., Yang, Y., Zhang, X., Cui, Y., & Zhang, Y. (2025) · Frontiers in Immunology · doi:10.3389/fimmu.2025.1679286 · Cited by 21

The past, present, and future of research on neuroinflammation-induced mild cognitive impairment: A bibliometric analysis

Cai, M., Zhang, Y., Chen, S. X., Wu, Z., & Zhu, L. (2022) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2022.968444 · Cited by 20

Gut-associated functions are favored during microbiome assembly across a major part of C. elegans life

Zimmermann, J., Piecyk, A., Sieber, M., Petersen, C., Johnke, J., Moitinho‐Silva, L., Künzel, S., Bluhm, L., Traulsen, A., Kaleta, C., et al. (2024) · mBio · doi:10.1128/mbio.00012-24 · Cited by 18

α-synuclein overexpression and the microbiome shape the gut and brain metabolome in mice

Morais, L. H., Boktor, J. C., MahmoudianDehkordi, S., Kaddurah‐Daouk, R., & Mazmanian, S. K. (2024) · npj Parkinson s Disease · doi:10.1038/s41531-024-00816-w · Cited by 24

Toward a better understanding of T cell dysregulation in autism: An integrative review

Moreno, R. J., Amara, R. A., & Ashwood, P. (2024) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2024.10.009 · Cited by 18

Multidimensional mechanisms of anxiety and depression in Parkinson’s disease: Integrating neuroimaging, neurocircuits, and molecular pathways

Zhao, J., Jia, H., Ma, P., Zhu, D. Y., & Fang, Y. (2025) · Pharmacological Research · doi:10.1016/j.phrs.2025.107717 · Cited by 20

The microbiome-gut-brain axis in nutritional neuroscience

Schellekens, H., Ribeiro, G., Cuesta‐Marti, C., & Cryan, J. F. (2022) · Nutritional Neuroscience · doi:10.1080/1028415x.2022.2128007 · Cited by 17

Air pollution accelerates the development of obesity and Alzheimer’s disease: the role of leptin and inflammation - a mini-review

Campolim, C. M., Schimenes, B. C., Veras, M. M., Kim, Y., & Prada, P. O. (2024) · Frontiers in Immunology · doi:10.3389/fimmu.2024.1401800 · Cited by 20

Altered Gut Microbiota Contributes to Acute-Respiratory-Distress-Syndrome-Related Depression through Microglial Neuroinflammation

Zhu, B., Gu, Z., Hu, H., Huang, J., Zeng, Z., Liang, H., Yuan, Z., Huang, S., Qiu, Y., Sun, X., et al. (2025) · Research · doi:10.34133/research.0636 · Cited by 16

Plant-based fermented foods: General concepts, improvement of the quality, metabolites, and health-related functions

Çakmak, H., Düven, G., Subaşı, B. G., Buyukkestelli, H. I., Bravo‐Núñez, Á., Özyurt, V. H., Söğüt, E., & Şimşek, Ş. (2025) · Food Bioscience · doi:10.1016/j.fbio.2025.106960 · Cited by 18

Paraburkholderia sabiae administration alters zebrafish anxiety-like behavior via gut microbial taurine metabolism

Ichikawa, S., Abe, R., Fujimoto, H., Higashi, K., Zang, L., Nakayama, H., Matsuoka, I., & Shimada, Y. (2023) · Frontiers in Microbiology · doi:10.3389/fmicb.2023.1079187 · Cited by 16

Advances in synthetic biology toolboxes paving the way for mechanistic understanding and strain engineering of gut commensal Bacteroides spp. and Clostridium spp.

Tan, Y., Liang, J., Lai, M., Wan, S., Luo, X., & Li, F. (2023) · Biotechnology Advances · doi:10.1016/j.biotechadv.2023.108272 · Cited by 16

Association between gut microbiota and anxiety disorders: a bidirectional two-sample mendelian randomization study

Li, J., Fan, C., Wang, J., Tang, B., Cao, J., Hu, X., Zhao, X., & Feng, C. (2024) · BMC Psychiatry · doi:10.1186/s12888-024-05824-x · Cited by 20

Gut microbiota-dependent adaptor molecule recruits DNA methyltransferase to the TLR4 gene in colonic epithelial cells to suppress inflammatory reactions

Narabayashi, H., Koma, C., Nakata, K., Ikegami, M., Nakanishi, Y., Ogihara, J., Tsuda, M., Hosono, A., Hanazawa, S., & Takahashi, K. (2022) · Frontiers in Molecular Biosciences · doi:10.3389/fmolb.2022.1005136 · Cited by 17

The role of the intestinal microbiome in cognitive decline in patients with kidney disease

Wagner, C. A., Frey-Wagner, I. M., Ortíz, A., Unwin, R. J., Liabeuf, S., Suzumoto, Y., Iervolino, A., Stasi, A., Marzo, V. D., Gesualdo, L., et al. (2025) · Nephrology Dialysis Transplantation · doi:10.1093/ndt/gfae253 · Cited by 17

Research progress in the pathogenesis of sepsis-associated encephalopathy

Zhou, Y., Bai, L., Tang, W., Yang, W., & Sun, L. (2024) · Heliyon · doi:10.1016/j.heliyon.2024.e33458 · Cited by 17

Enteropathway: the metabolic pathway database for the human gut microbiota

Shiroma, H., Darzi, Y., Terajima, E., Nakagawa, Z., Tsuchikura, H., Tsukuda, N., Moriya, Y., Okuda, S., Goto, S., & Yamada, T. (2024) · Briefings in Bioinformatics · doi:10.1093/bib/bbae419 · Cited by 17

Relevance of gut microbiome research in food safety assessment

Garrido‐Romero, M., Pazos, F., Sánchez‐Martínez, E., Benito, C., Ruiz, J. Á. G., Borrego‐Yaniz, G., Bowes, C., Broll, H., Caminero, A., Caro, E., et al. (2024) · Gut Microbes · doi:10.1080/19490976.2024.2410476 · Cited by 16

The impact of gut microbiota on the occurrence, treatment, and prognosis of ischemic stroke

Chen, L., Wang, X., Wang, S., Liu, W., Song, Z., & Liao, H.-L. (2025) · Neurobiology of Disease · doi:10.1016/j.nbd.2025.106836 · Cited by 19

Interactions of the maternal microbiome with diet, stress, and infection influence fetal development

Puglisi, C. H., Kim, M. J., Aldhafeeri, M., Lewandowski, M., & Vuong, H. E. (2025) · FEBS Journal · doi:10.1111/febs.70031 · Cited by 17

Microbiome and Brain Development: A Tale of Two Systems

Cryan, J. F. (2025) · Annals of Nutrition and Metabolism · doi:10.1159/000544950 · Cited by 15

Do immune system and microbiome–gut–brain axis interactions associate with major depressive disorder?

Zhao, H., Tao, L., Tang, C. W., Cai, W., & Shen, W. (2025) · Journal of Translational Medicine · doi:10.1186/s12967-025-07176-w · Cited by 23

The gut microbiome shapes social behaviour across animal species

Griffiths, J. A., Nirmalkar, K., Wu, W., Krajmalnik‐Brown, R., & Mazmanian, S. K. (2025) · Nature Reviews Microbiology · doi:10.1038/s41579-025-01262-y · Cited by 19

The gut microbiota–oligodendrocyte axis: A promising pathway for modulating oligodendrocyte homeostasis and demyelination-associated disorders

Tang, W., Wang, Q., Sun, M., Liu, C., Huang, Y., Zhou, M., Zhang, X., Meng, Z., & Zhang, J. (2024) · Life Sciences · doi:10.1016/j.lfs.2024.122952 · Cited by 14

Targeting the gut–microbiota–brain axis in irritable bowel disease to improve cognitive function – recent knowledge and emerging therapeutic opportunities

Tang, H., Chen, X., Huang, S., Gang, Y., Wang, X., & Shen, G.-M. (2023) · Reviews in the Neurosciences · doi:10.1515/revneuro-2022-0155 · Cited by 14

The Role of Livestock Antibiotic Use in Microbiota Dysbiosis and Neuroinflammation

Silvestro, S., Biondo, C., Midiri, A., Lucia, B. P. A., & Mancuso, G. (2025) · Antibiotics · doi:10.3390/antibiotics14060608 · Cited by 17

Crosstalk between metabolic reprogramming and microbiota: implications for cancer progression and novel therapeutic opportunities

Li, X., Jia, Y., Li, Y., Hei, H., Zhang, S., & Qin, J. (2025) · Frontiers in Immunology · doi:10.3389/fimmu.2025.1582166 · Cited by 12

Mass spectrometry-based metabolomics approaches to interrogate host–microbiome interactions in mammalian systems

Kulkarni, A. S., Paiva, G. C. M., Jin, J., Laro, J. A., Peramuna, T., McCall, L., & Garg, N. (2025) · Natural Product Reports · doi:10.1039/d5np00021a · Cited by 12

Implications of Gut Microbiota-Derived Metabolites in Neurological Disorders

Dalal, N., Jaiswal, J., Kushwaha, M., Verma, H., Rana, P., Gupta, S., Panwar, R., Janmeda, P., Jain, P., Singh, A. K., et al. (2025) · ACS Chemical Neuroscience · doi:10.1021/acschemneuro.5c00414 · Cited by 12

Atp11b Deletion Affects the Gut Microbiota and Accelerates Brain Aging in Mice

Liu, C., Zhang, S., Shi, H., Zhou, H., Zhuang, J., Cao, Y., Ward, N., & Wang, J. (2022) · Brain Sciences · doi:10.3390/brainsci12060709 · Cited by 13

The gut-derived metabolites as mediators of the effect of healthy nutrition on the brain

Leyrolle, Q., Prado-Perez, L., & Layé, S. (2023) · Frontiers in Nutrition · doi:10.3389/fnut.2023.1155533 · Cited by 13

Gut Microbiota Regulates Epigenetic Remodelling in the Amygdala: A Role in Repeated Mild Traumatic Brain Injury (rMTBI)-Induced Anxiety

Jadhav, G., Dudhabhate, B. B., Kokare, D. M., & Sakharkar, A. J. (2023) · Molecular Neurobiology · doi:10.1007/s12035-023-03697-x · Cited by 12

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Heijtz, R. D., Wang, S., Anuar, F., Qian, Y., Björkholm, B., Samuelsson, A., Hibberd, M. L., Forssberg, H., & Pettersson, S. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1010529108 · Cited by 3,228

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