The DOI matches its Crossref record; 56 of the 56 references it cites were found in a registry or an index.
Human distal airways contain a multipotent secretory cell that can regenerate alveoli
Open accessAbstract
The human lung differs substantially from its mouse counterpart, resulting in a distinct distal airway architecture affected by disease pathology in chronic obstructive pulmonary disease. In humans, the distal branches of the airway interweave with the alveolar gas-exchange niche, forming an anatomical structure known as the respiratory bronchioles. Owing to the lack of a counterpart in mouse, the cellular and molecular mechanisms that govern respiratory bronchioles in the human lung remain uncharacterized. Here we show that human respiratory bronchioles contain a unique secretory cell population that is distinct from cells in larger proximal airways. Organoid modelling reveals that these respiratory airway secretory (RAS) cells act as unidirectional progenitors for alveolar type 2 cells, which are essential for maintaining and regenerating the alveolar niche. RAS cell lineage differentiation into alveolar type 2 cells is regulated by Notch and Wnt signalling. In chronic obstructive pulmonary disease, RAS cells are altered transcriptionally, corresponding to abnormal alveolar type 2 cell states, which are associated with smoking exposure in both humans and ferrets. These data identify a distinct progenitor in a region of the human lung that is not found in mouse that has a critical role in maintaining the gas-exchange compartment and is altered in chronic lung disease. Human respiratory bronchioles contain a unique population of secretory cells called respiratory airway secretory cells that are distinct from the cells in the larger proximal airways, and act as unidirectional progenitors for alveolar type 2 cells.
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Cites
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Guided construction of single cell reference for human and mouse lung
Guo, M., Morley, M. P., Jiang, C., Wu, Y., Li, G., Du, Y., Zhao, S., Wagner, A., Cakar, A. C., Kouril, M., et al. (2023) · Nature Communications · doi:10.1038/s41467-023-40173-5 · Cited by 197
Self-citationZhu, Y., Pan, X., Jia, Y., Yang, X., Song, X., Ding, J., Zhong, W., Feng, J., & Zhu, L. (2023) · Environmental Health Perspectives · doi:10.1289/ehp11969 · Cited by 49
Morphologically intact airways in lung fibrosis have an abnormal proteome
Herrera, J. A., Dingle, L. A., Monetero, M. A., Venkateswaran, R. V., Blaikley, J. F., Granato, F., Pearson, S., Lawless, C., & Thornton, D. J. (2023) · Respiratory Research · doi:10.1186/s12931-023-02400-x · Cited by 12
Metadata
- Authors
- Basil, M. C., Cardenas-Diaz, F. L., Kathiriya, J. J., Morley, M. P., Carl, J., Brumwell, A. N., Katzen, J., Slovik, K. J., Babu, A., Zhou, S., Kremp, M. M., McCauley, K. B., Li, S., Planer, J. D., Hussain, S. S., Liu, X., Windmueller, R., Ying, Y., Stewart, K. M., Oyster, M., Christie, J. D., Diamond, J. M., Engelhardt, J. F., Cantu, E., Rowe, S. M., Kotton, D. N., Chapman, H. A., & Morrisey, E. E.
- Venue
- Nature
- Published
- 2022-03-30
- Volume
- 604
- Issue
- 7904
- Pages
- 120-126
- ISSN
- 0028-0836 (ISSN-L)
- 1476-4687
- OpenAlex
- W4221078835
- Cited by
- 322
- References
- 56
- FWCI
- 36.93
- Type
- journal article
- Language
- en
- Open access
- green
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- Basil, M. C., Cardenas-Diaz, F. L., Kathiriya, J. J., Morley, M. P., Carl, J., Brumwell, A. N., Katzen, J., Slovik, K. J., Babu, A., Zhou, S., Kremp, M. M., McCauley, K. B., Li, S., Planer, J. D., Hussain, S. S., Liu, X., Windmueller, R., Ying, Y., Stewart, K. M., . . . Morrisey, E. E. (2022). Human distal airways contain a multipotent secretory cell that can regenerate alveoli. Nature. https://doi.org/10.1038/s41586-022-04552-0
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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