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Increased memory B cell potency and breadth after a SARS-CoV-2 mRNA boost
Open accessAbstract
The Omicron variant of SARS-CoV-2 infected many vaccinated and convalescent individuals 1–3 . Despite the reduced protection from infection, individuals who received three doses of an mRNA vaccine were highly protected from more serious consequences of infection 4 . Here we examine the memory B cell repertoire in a longitudinal cohort of individuals receiving three mRNA vaccine doses 5,6 . We find that the third dose is accompanied by an increase in, and evolution of, receptor-binding domain (RBD)-specific memory B cells. The increase is due to expansion of memory B cell clones that were present after the second dose as well as the emergence of new clones. The antibodies encoded by these cells showed significantly increased potency and breadth when compared with antibodies obtained after the second dose. Notably, the increase in potency was especially evident among newly developing clones of memory cells, which differed from persisting clones in targeting more conserved regions of the RBD. Overall, more than 50% of the analysed neutralizing antibodies in the memory compartment after the third mRNA vaccine dose neutralized the Omicron variant. Thus, individuals receiving three doses of an mRNA vaccine have a diverse memory B cell repertoire that can respond rapidly and produce antibodies capable of clearing even diversified variants such as Omicron. These data help to explain why a third dose of a vaccine that was not specifically designed to protect against variants is effective against variant-induced serious disease.
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“A booster serves as a re-exposure to the virus, which creates new antibodies as well as additional and improved memory B-cells responses to fight off future infections.”
From Effectiveness of COVID-19 vaccines against SARS-CoV-2 infection and severe outcomes in adults: a systematic review and meta-analysis of European studies published up to 22 January 2024 (2025) · cites this paper as [20]
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“It has even been found that booster exposure also improves the ability of the memory B-cells to recognise unknown variants such as the Omicron strain [18, 20].”
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Cites
Fast, scalable generation of high-quality protein multiple sequence alignments using Clustal Omega
Sievers, F., Wilm, A., Dineen, D., Gibson, T., Karplus, K., Li, W.-Z., Lopez, R., McWilliam, H., Remmert, M., Söding, J., et al. (2011) · Molecular Systems Biology · doi:10.1038/msb.2011.75 · Cited by 15,576
A new coronavirus associated with human respiratory disease in China
Wu, F., Zhao, S., Yu, B., Chen, Y.-M., Wang, W., Song, Z.-G., Hu, Y., Tao, Z.-W., Tian, J.-H., Pei, Y.-Y., et al. (2020) · Nature · doi:10.1038/s41586-020-2008-3 · Cited by 11,688
Khoury, D. S., Cromer, D., Reynaldi, A., Schlub, T. E., Wheatley, A. K., Juno, J. A., Subbarao, K., Kent, S. J., Triccas, J. A., & Davenport, M. P. (2021) · Nature Medicine · doi:10.1038/s41591-021-01377-8 · Cited by 3,742
Grifoni, A., Weiskopf, D., Ramirez, S. I., Mateus, J., Dan, J. M., Moderbacher, C. R., Rawlings, S. A., Sutherland, A., Premkumar, L., Jadi, R. S., et al. (2020) · Cell · doi:10.1016/j.cell.2020.05.015 · Cited by 3,595
Convergent Antibody Responses to SARS-CoV-2 in Convalescent Individuals
Robbiani, D. F., Gaebler, C., Muecksch, F., Lorenzi, J. C. C., Wang, Z., Cho, A., Agudelo, M., Barnes, C. O., Gazumyan, A., Finkin, S., et al. (2020) · Nature · doi:10.1038/s41586-020-2456-9 · Cited by 1,853
Self-citationA serological assay to detect SARS-CoV-2 seroconversion in humans
Amanat, F., Stadlbauer, D., Strohmeier, S., Nguyen, T. H. O., Chromikova, V., McMahon, M., Jiang, K., Arunkumar, G. A., Jurczyszak, D., Polanco, J., et al. (2020) · Nature Medicine · doi:10.1038/s41591-020-0913-5 · Cited by 1,769
Evolution of antibody immunity to SARS-CoV-2
Gaebler, C., Wang, Z., Lorenzi, J. C. C., Muecksch, F., Finkin, S., Tokuyama, M., Cho, A., Jankovic, M., Schaefer-Babajew, D., Oliveira, T. Y., et al. (2021) · Nature · doi:10.1038/s41586-021-03207-w · Cited by 1,674
Self-citationREGN-COV2, a Neutralizing Antibody Cocktail, in Outpatients with Covid-19
Weinreich, D. M., Sivapalasingam, S., Norton, T., Ali, S., Gao, H., Bhore, R., Musser, B. J., Soo, Y., Rofail, D., Im, J., et al. (2021) · New England Journal of Medicine · doi:10.1056/nejmoa2035002 · Cited by 1,642
SARS-CoV-2 neutralizing antibody structures inform therapeutic strategies
Barnes, C. O., Jette, C. A., Abernathy, M. E., Dam, K.-M. A., Esswein, S. R., Gristick, H. B., Malyutin, A. G., Sharaf, N. G., Huey-Tubman, K. E., Lee, Y. E., et al. (2020) · Nature · doi:10.1038/s41586-020-2852-1 · Cited by 1,599
Self-citationConSurf 2005: the projection of evolutionary conservation scores of residues on protein structures
Landau, M., Mayrose, I., Rosenberg, Y., Glaser, F., Martz, E., Pupko, T., & Ben‐Tal, N. (2005) · Nucleic Acids Research · doi:10.1093/nar/gki370 · Cited by 1,379
Cited by
Sorted by citations
Items 101–200 of 298
Zhao, T., Huang, X., & Shu, Y. (2023) · Human Vaccines & Immunotherapeutics · doi:10.1080/21645515.2023.2273155 · Cited by 14
What makes SARS‐CoV‐2 unique? Focusing on the spike protein
Qian, J., Zhang, S.-C., Wang, F., Li, J., & Zhang, J. (2024) · Cell Biology International · doi:10.1002/cbin.12130 · Cited by 16
Kuwata, T., Kaku, Y., Biswas, S., Matsumoto, K., Shimizu, M., Kawanami, Y., Uraki, R., Okazaki, K., Minami, R., Nagasaki, Y., et al. (2024) · EBioMedicine · doi:10.1016/j.ebiom.2024.105439 · Cited by 13
Hicks, P. D., Manzoni, T. B., Westover, J. B., Petch, R. J., Roper, B., Gowen, B. B., & Bates, P. F. (2024) · Vaccines · doi:10.3390/vaccines12121403 · Cited by 14
Pettini, E., Medaglini, D., & Ciabattini, A. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.1058748 · Cited by 14
Memory B cells anticipate SARS-CoV-2 variants through somatic hypermutation
Bruhn, M., Obara, M., Chiyyeadu, A., Costa, B., Salam, M. A., Ziegler, A., Waltl, I., Pavlou, A., Bonifacius, A., Hoffmann, M., et al. (2023) · Journal of Infection · doi:10.1016/j.jinf.2023.10.020 · Cited by 14
Longitudinal monitoring of mRNA-vaccine-induced immunity against SARS-CoV-2
Monzon‐Posadas, W. O., Zorn, J., Peters, K., Baum, M., Proksch, H., Schlüter, C. B., Menting, T., Pušnik, J., & Streeck, H. (2023) · Frontiers in Immunology · doi:10.3389/fimmu.2023.1066123 · Cited by 13
Seow, J., Shalim, Z. A., Graham, C., Kimuda, S., Pillai, A., Lechmere, T., Kurshan, A., Khimji, A. M., Snell, L. B., Nebbia, G., et al. (2023) · mBio · doi:10.1128/mbio.01206-23 · Cited by 10
Luczkowiak, J., Rivas, G. A., Labiod, N., Lasala, F., Rolo, M., Lora‐Tamayo, J., Mancheño‐Losa, M., Rial‐Crestelo, D., Pérez‐Rivilla, A., Folgueira, M. D., et al. (2022) · Journal of Medical Virology · doi:10.1002/jmv.28268 · Cited by 15
Maturation of SARS-CoV-2 Spike-specific memory B cells drives resilience to viral escape
Marzi, R., Bassi, J., Silacci-Fregni, C., Bartha, I., Muoio, F., Culap, K., Sprugasci, N., Lombardo, G., Saliba, C., Cameroni, E., et al. (2022) · iScience · doi:10.1016/j.isci.2022.105726 · Cited by 12
Ruhl, L., Kühne, J. F., Beushausen, K., Keil, J., Christoph, S., Sauer, J., & Falk, C. S. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2023.1120010 · Cited by 14
mRNA vaccines and hybrid immunity use different B cell germlines against Omicron BA.4 and BA.5
Andreano, E., Paciello, I., Pierleoni, G., Maccari, G., Antonelli, G., Abbiento, V., Pileri, P., Benincasa, L., Giglioli, G., Piccini, G., et al. (2023) · Nature Communications · doi:10.1038/s41467-023-37422-y · Cited by 14
Memory B cell differentiation from germinal centers
Inoue, T. (2023) · International Immunology · doi:10.1093/intimm/dxad017 · Cited by 13
Yang, X., Zhang, H., Bao, W., Fu, S., & Jin, H. (2022) · Vaccines · doi:10.3390/vaccines10122070 · Cited by 12
Bruhn, M., Obara, M., Chiyyeadu, A., Costa, B., Salam, A., Ziegler, A., Waltl, I., Pavlou, A., Bonifacius, A., Hoffmann, M., et al. (2024) · European Journal of Immunology · doi:10.1002/eji.202451056 · Cited by 12
Byrne, J., Gu, L., Leon, A. A. G., Gaillard, C. M., Saini, G., Alalwan, D., Tomás‐Cortázar, J., Kenny, G., Donohue, S., Reynolds, B., et al. (2024) · Frontiers in Immunology · doi:10.3389/fimmu.2024.1445653 · Cited by 12
Bredholt, G., Sævik, M., Søyland, H., Ueland, T., Zhou, F., Pathirana, R. D., Madsen, A., Vahokoski, J., Lartey, S. L., Halvorsen, B. L., et al. (2024) · Vaccine X · doi:10.1016/j.jvacx.2024.100564 · Cited by 13
The lymphatic system and COVID-19 vaccines
Miyasaka, M. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.1041025 · Cited by 12
Miyamoto, S., & Suzuki, T. (2024) · Vaccine · doi:10.1016/j.vaccine.2024.01.088 · Cited by 13
Hu, Y., Wu, Q., Chang, F., Yang, H. J., Zhang, X., Wang, Q., Chen, J., Teng, S., Liu, Y., Zheng, X., et al. (2024) · npj Vaccines · doi:10.1038/s41541-024-00997-8 · Cited by 11
Manzoni, T. B., Westover, J. B., Lundgreen, K. A., Hicks, P. D., Petch, R. J., Ort, J. T., Weissman, D., Fan, S. H. Y., Hensley, S. E., Pardi, N., et al. (2025) · Viruses · doi:10.3390/v17081095 · Cited by 11
Durable immune responses after BNT162b2 vaccination in home-dwelling old adults
Hansen, L., Brokstad, K. A., Bansal, A., Zhou, F., Bredholt, G., Onyango, T. B., Sandnes, H. H., Elyanow, R., Madsen, A., Trieu, M.-C., et al. (2023) · Vaccine X · doi:10.1016/j.jvacx.2023.100262 · Cited by 12
Devaux, C. A., & Fantini, J. (2023) · Pathogens · doi:10.3390/pathogens12050713 · Cited by 11
Persistent immune imprinting after XBB.1.5 COVID vaccination in humansPreprint
Tortorici, M. A., Addetia, A., Seo, A. J., Brown, J. T., Sprouse, K. R., Logue, J., Clark, E., Franko, N., Chu, H. Y., & Veesler, D. (2023) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2023.11.28.569129 · Cited by 11
Divergent B-cell repertoire remodelling by mRNA, DNA and live attenuated vaccines in fish
Porter, D., Collins, C., Mazzolini, A., Jouneau, L., Mhanna, V., Coiffier, C., Peruzzi, M., Jaszczyszyn, Y., Mariotti‐Ferrandiz, E., Huetz, F., et al. (2025) · npj Vaccines · doi:10.1038/s41541-025-01232-8 · Cited by 10
Naiditch, H., Betts, M. R., Larman, H. B., Levi, M., & Rosenberg, A. Z. (2025) · Frontiers in Immunology · doi:10.3389/fimmu.2024.1376654 · Cited by 10
Marcotte, H., Hammarström, L. L. G., & Pan‐Hammarström, Q. (2022) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-022-01146-0 · Cited by 10
Functional heterogeneity in the memory B-cell response
Henry, B., & Laidlaw, B. J. (2023) · Current Opinion in Immunology · doi:10.1016/j.coi.2022.102281 · Cited by 10
Mortari, E. P., Pulvirenti, F., Marcellini, V., Terreri, S., Salinas, A. F., Ferrari, S., Napoli, G. D., Guadagnolo, D., Sculco, E., Albano, C., et al. (2023) · Frontiers in Immunology · doi:10.3389/fimmu.2023.1194225 · Cited by 10
Asokan, M., Joan, R. F., Babji, S., Dayma, G., Nadukkandy, P., Subrahmanyam, V., Pandey, A., Malagi, G., Arya, P., Mahajan, V., et al. (2024) · The Lancet Regional Health - Southeast Asia · doi:10.1016/j.lansea.2024.100361 · Cited by 11
COVID-19 mRNA third dose induces a unique hybrid immunity-like antibody responsePreprint
Andreano, E., Paciello, I., Pierleoni, G., Piccini, G., Abbiento, V., Antonelli, G., Pileri, P., Manganaro, N., Pantano, E., Maccari, G., et al. (2022) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2022.05.09.491201 · Cited by 10
Influenza virus antibodies inhibit antigen-specific de novo B cell responses in mice
Goodwin, E. C., Gibbs, J. S., Yewdell, J. W., Eisenlohr, L. C., & Hensley, S. E. (2024) · Journal of Virology · doi:10.1128/jvi.00766-24 · Cited by 9
Molecular convergence of neutralizing antibodies in human revealed by repeated rabies vaccination
Fujisawa, M., Onodera, T., Kuroda, D., Kewcharoenwong, C., Sasaki, M., Itakura, Y., Yumoto, K., Nithichanon, A., Ito, N., Takeoka, S., et al. (2025) · npj Vaccines · doi:10.1038/s41541-025-01073-5 · Cited by 9
Tam, J. C. H., Sibayan, A. C., Seow, J., Graham, C., Kurshan, A., Merrick, B., Stanton, R. J., & Doores, K. J. (2025) · Cell Reports · doi:10.1016/j.celrep.2025.116000 · Cited by 12
Immunological memory to vaccines
Crotty, S. (2026) · Immunity · doi:10.1016/j.immuni.2026.02.019 · Cited by 9
Lin, F. J., Doss, A. M. A., Davis-Adams, H. G., Adams, L. J., Hanson, C. H., VanBlargan, L. A., Liang, C.-Y., Chen, R. E., Monroy, J. M., Wedner, H. J., et al. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.1033770 · Cited by 9
Borghi, M., Gallinaro, A., Pirillo, M. F., Canitano, A., Michelini, Z., Angelis, M. L. D., Cecchetti, S., Tinari, A., Falce, C., Mariotti, S., et al. (2023) · Frontiers in Immunology · doi:10.3389/fimmu.2023.1147953 · Cited by 9
Zheng, Y., Pan, J., Jin, M., Wang, J., Tung, T., Chen, S., Bi, X., Zhou, K., Chen, M., Wang, D., et al. (2023) · International Immunopharmacology · doi:10.1016/j.intimp.2023.110151 · Cited by 9
Wiehe, K. J., Saunders, K. O., Stalls, V., Cain, D. W., Venkatayogi, S., Beem, J. S. M., Berry, M., Evangelous, T. D., Henderson, R. C., Hora, B., et al. (2022) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2022.11.11.516143 · Cited by 9
Kardava, L., Lim, J., Buckner, C. M., de Assis, F. L., Zhang, X., Wang, W. J., Melnyk, M. L. S., Merhebi, O. E., Trihemasava, K., Teng, I., et al. (2025) · Cell Reports · doi:10.1016/j.celrep.2025.115557 · Cited by 8
Deimel, L. P., Nishimura, Y., Santos, G. S. S., Baharani, V. A., Hernandez, B., Oliveira, T. Y., MacLean, A. J., Canis, M., Shawraz, S., Gazumyan, A., et al. (2025) · Cell Reports · doi:10.1016/j.celrep.2025.116142 · Cited by 8
Self-citationMiyamoto, S., Kuroda, Y., Kanno, T., Ueno, A., Shiwa-Sudo, N., Iwata‐Yoshikawa, N., Sakai, Y., Nagata, N., Arashiro, T., Ainai, A., et al. (2023) · iScience · doi:10.1016/j.isci.2023.106694 · Cited by 6
Fedele, G., Schiavoni, I., Trentini, F., Leone, P., Olivetta, E., Fallucca, A., Fiore, S., Martino, A. D., Abrignani, S., Baldo, V., et al. (2023) · Frontiers in Immunology · doi:10.3389/fimmu.2023.1272119 · Cited by 7
Long-term COVID-19 vaccine- and Omicron infection-induced humoral and cell-mediated immunity
Belik, M., Reinholm, A., Kolehmainen, P., Heroum, J., Maljanen, S., Altan, E., Österlund, P., Laine, L., Ritvos, O., Pasternack, A. H., et al. (2024) · Frontiers in Immunology · doi:10.3389/fimmu.2024.1494432 · Cited by 9
Shrestha, L. B., Tungatt, K., Aggarwal, A., Stubis, A., Fewings, N., Fichter, C., Akerman, A., Rodrigo, C., Tedla, N. T., Lee, S. C. L., et al. (2024) · EBioMedicine · doi:10.1016/j.ebiom.2024.105461 · Cited by 8
Huang, W., Weng, S., Tzeng, H., Yen, F.-C., Chiang, Y.-S., & You, H. (2022) · Vaccines · doi:10.3390/vaccines10091550 · Cited by 8
Kale, A., Gaur, A., Menon, I., Chirmule, N. B., Bagwe, P., Jawa, R., Vijayanand, S., Patil, S., Suresh, S., & Jawa, V. (2023) · Journal of Pharmaceutical Sciences · doi:10.1016/j.xphs.2023.01.019 · Cited by 8
Steenhuis, M., Wouters, E., Schrezenmeier, H., Rispens, T., Tiberghien, P., Harvala, H., Feys, H. B., van der Schoot, C. E., & Collaborators, S. (2023) · Vox Sanguinis · doi:10.1111/vox.13480 · Cited by 8
Absolute concentration estimation of COVID-19 convalescent and post-vaccination IgG antibodies
Klegerman, M. E., Peng, T., Seferovich, I., Rahbar, M. H., Hessabi, M., Tahanan, A., Wanger, A. R., Grimes, C. Z., Ostrosky‐Zeichner, L., Koster, K. J., et al. (2024) · PLoS ONE · doi:10.1371/journal.pone.0311777 · Cited by 8
Li, J., Long, H., Chen, S., Zhang, Z., Li, S., Liu, Q., Liu, J., Cai, J., Luo, L., & Peng, Y. (2025) · Vaccines · doi:10.3390/vaccines13010052 · Cited by 7
Long-lasting antibody B-cell responses to SARS-CoV-2 three years after the onset of the pandemic
Molinos-Albert, L. M., Rubio, R., Martín-Pérez, C., Pradenas, E., Torres, C., Jiménez, A., Canyelles, M., Vidal, M., Barrios, D., Marfil, S., et al. (2025) · Cell Reports · doi:10.1016/j.celrep.2025.115498 · Cited by 7
Liu, H., Wei, P., Zhang, Q., Aviszus, K., Linderberger, J., Yang, J. J., Liu, J., Chen, Z., Waheed, H., Reynoso, L., et al. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms231911325 · Cited by 39
Ekström, N., Haveri, A., Solastie, A., Virta, C., Österlund, P., Nohynek, H., Nieminen, T. A., Ivaska, L., Tähtinen, P. A., Lempainen, J., et al. (2022) · Open Forum Infectious Diseases · doi:10.1093/ofid/ofac625 · Cited by 8
Qualitative monitoring of SARS-CoV-2 mRNA vaccination in humans using droplet microfluidics
Broketa, M., Sokal, A., Mor, M., Canales-Herrerías, P., Perima, A., Meola, A., Fernández, I., Iannascoli, B., Chenon, G., Vandenberghe, A., et al. (2023) · JCI Insight · doi:10.1172/jci.insight.166602 · Cited by 10
Approaches to evaluate the specific immune responses to SARS-CoV-2
López-Gomez, A., Pelaez-Prestel, H. F., & Juárez, I. (2023) · Vaccine · doi:10.1016/j.vaccine.2023.09.033 · Cited by 7
Painter, M. M., Johnston, T. S., Lundgreen, K. A., Santos, J. J. D. S., Qin, J. S., Goel, R. R., Apostolidis, S. A., Mathew, D., Fulmer, B., Williams, J. C., et al. (2023) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2023.02.05.527215 · Cited by 7
Raisinghani, N., Alshahrani, M., Gupta, G., & Verkhivker, G. M. (2024) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2024.07.09.602810 · Cited by 7
Xie, M.-X., Qiu, Y.-N., Zhao, X.-Y., Shi, J.-L., Liu, Y., Zhang, Q., He, J., Li, J.-Y., Liu, L., Sun, S., et al. (2025) · Nature Communications · doi:10.1038/s41467-025-65596-0 · Cited by 4
Self-citationThe characteristics of BCR‐CDR3 repertoire in COVID‐19 patients and SARS‐CoV‐2 vaccinated volunteers
Xiao, J., Luo, Y. Q., Li, Y., & Yao, X. (2024) · Journal of Medical Virology · doi:10.1002/jmv.29488 · Cited by 6
Ying, B., Liang, C.-Y., Desai, P., Scheaffer, S. M., Elbashir, S. M., Edwards, D. K., Thackray, L. B., & Diamond, M. (2024) · Journal of Virology · doi:10.1128/jvi.00574-24 · Cited by 8
Fujitani, M., Lu, X., Shinnakasu, R., Inoue, T., Kidani, Y., Seki, N. M., Ishida, S., Mitsuki, S., Ishihara, T., Aoki, M., et al. (2025) · Frontiers in Immunology · doi:10.3389/fimmu.2025.1550279 · Cited by 8
Effectiveness of COVID-19 Vaccination In Healthcare Workers in Shiga Prefecture, Japan
Chano, T., Yamashita, T., Fujimura, H., Kita, H., Ikemoto, T., Kume, S., Morita, S., Suzuki, T., & Kakuno, F. (2022) · Scientific Reports · doi:10.1038/s41598-022-22682-3 · Cited by 6
Changes in serum-neutralizing antibody potency and breadth post-SARS-CoV-2 mRNA vaccine boost
Nair, M. S., Ribeiro, R. M., Wang, M., Bowen, A. D., Liu, L., Guo, Y., Chang, J. Y., Wang, P., Sheng, Z., Sobieszczyk, M. E., et al. (2023) · iScience · doi:10.1016/j.isci.2023.106345 · Cited by 5
García‐Pérez, J., Bermejo, M., Ramírez‐García, A., Tarazona, E. D. L. T., Cascajero, A., de la Osa, M. C., Jiménez, P., Gómez, M. A., Calonge, E., Sancho‐López, A., et al. (2023) · Journal of Medical Virology · doi:10.1002/jmv.28679 · Cited by 7
Hayashi, H., Sun, J., Yanagida, Y., Otera, T., Tai, J. A., Nishikawa, T., Yamashita, K., Sakaguchi, N., Yoshida, S., Baba, S., et al. (2023) · Scientific Reports · doi:10.1038/s41598-023-40172-y · Cited by 6
Zhang, X., Li, M., Zhang, N., Li, Y., Teng, F., Li, Y., Zhang, X., Xu, X., Li, H., Zhu, Y., et al. (2024) · Advanced Science · doi:10.1002/advs.202402639 · Cited by 5
mRNA vaccines and hybrid immunity use different B cell germlines to neutralize Omicron BA.4 and BA.5Preprint
Andreano, E., Paciello, I., Pierleoni, G., Maccari, G., Antonelli, G., Abbiento, V., Pileri, P., Benincasa, L., Giglioli, G., Piccini, G., et al. (2022) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2022.08.04.502828 · Cited by 6
Hartley, G. E., Fryer, H. A., Gill, P. A., Boo, I., Bornheimer, S. J., Hogarth, P. M., Drummer, H. E., O’Hehir, R. E., Edwards, E. S. J., & van Zelm, M. C. (2023) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2023.09.15.557929 · Cited by 6
Kim, W. (2024) · Immune Network · doi:10.4110/in.2024.24.e28 · Cited by 5
Ma, C., Luo, C., Deng, F., Chen, Y., Chen, Y., Zhong, G., Zhan, Y., Nie, L., Huang, Y., Xia, Y., et al. (2024) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2024.167441 · Cited by 5
Adeleke, R. A., Sahler, J., Choi, A., Roth, K., Upadhye, V., Ezzatpour, S., Imbiakha, B., Khomandiak, S., Diaz, A. N., Whittaker, G. R., et al. (2025) · Science Advances · doi:10.1126/sciadv.adq4545 · Cited by 5
Structural serology of polyclonal antibody responses to mRNA-1273 and NVX-CoV2373 COVID-19 vaccines
Bangaru, S., Jackson, A. M., Copps, J., Fernández‐Quintero, M. L., Torres, J. L., Richey, S. T., Nogal, B., Sewall, L. M., de la Peña, A. T., Rehman, A., et al. (2025) · Cell Reports · doi:10.1016/j.celrep.2025.115986 · Cited by 6
Lien, C.-E., Liu, M.-C. J., Wang, N., Liu, L. T.-C., Wu, C.-C., Tang, W.-H., Lian, W., Huang, K.-Y. A., & Chen, C. (2023) · Vaccines · doi:10.3390/vaccines11121798 · Cited by 4
Watanabe, Y., Hosokawa, N., Yoshida, M., Miura, T., & Kawano, M. (2023) · Vaccines · doi:10.3390/vaccines11020287 · Cited by 5
Brazete, C. S., Brazete, J., Alves, F., Aguiar, A., Gonçalves, A. M., Cardoso, M., Sá, L., Gonçalves, E. M., Pinto, M. S. D. S., & Duarte, R. (2023) · Public Health · doi:10.1016/j.puhe.2023.02.015 · Cited by 5
Ho, V., Low, H. B., Cui, J., Juequn, Z., Shunmuganathan, B. D. O., Gupta, R., Tan, N. Y. J., Qian, X., Purushotorman, K., SCOPE Cohort Study Group, et al. (2024) · Aging Cell · doi:10.1111/acel.14099 · Cited by 4
Identification of B cell subsets based on antigen receptor sequences using deep learning
Lee, H., Shin, K., Lee, Y., Lee, S., Lee, S., Lee, E., Kim, S. W., Shin, H. Y., Kim, J. H., Chung, J., et al. (2024) · Frontiers in Immunology · doi:10.3389/fimmu.2024.1342285 · Cited by 7
Juárez, I., Pérez-Flores, I., Meneses, A. A., López-Gomez, A., Romero, N. C., Cubillo, B. R., de la Higuera, M. Á. M., Jiménez, B. P., Gonzalez-Garcia, R., Amorós-Pérez, B., et al. (2025) · Vaccines · doi:10.3390/vaccines13020123 · Cited by 5
Dhawan, M. K., Thakur, N., Sharma, M. K., & Rabaan, A. A. (2025) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2025.117936 · Cited by 5
Omicron-adapted vaccines might require longer follow-up to reveal true benefits
Tang, L., Zhang, R., Cui, M., & Peng, H. (2022) · The Lancet Microbe · doi:10.1016/s2666-5247(22)00292-0 · Cited by 5
Sheng, Z., Bimela, J. S., Wang, M., Li, Z., Guo, Y., & Ho, D. D. (2023) · Frontiers in Immunology · doi:10.3389/fimmu.2023.1190416 · Cited by 5
Al-Ramahi, J. S., Shahzad, M., Li, K., DeJarnette, S., Chaudhary, S. G., Lutfi, F. U., Ahmed, N., Balusu, R., Bansal, R., Abdelhakim, H., et al. (2023) · Leukemia & lymphoma/Leukemia and lymphoma · doi:10.1080/10428194.2023.2243355 · Cited by 5
Zeng, Z., Geng, X., Wen, X., Chen, Y., Zhu, Y., Dong, Z., Hao, L., Wang, T., Yang, J., Zhang, R., et al. (2023) · Frontiers in Microbiology · doi:10.3389/fmicb.2023.1232453 · Cited by 5
Zang, T. M., Kuffour, E. O., Baharani, V. A., Canis, M., Schmidt, F., DaSilva, J., Lercher, A., Chaudhary, P., Hoffmann, H.-H., Gazumyan, A., et al. (2023) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2317367120 · Cited by 4
Self-citationAirway and Systemic Immune Responses Following the Third COVID-19 Vaccination in COPD Patients
Southworth, T. W., Jackson, N. A., & Singh, D. (2023) · International Journal of COPD · doi:10.2147/copd.s433269 · Cited by 5
Memory B cell development in response to mRNA SARS-CoV-2 and nanoparticle immunization in mice
Wiatr, M., wang, Z., Canis, M., Hernandez, B., Gazumyan, A., Santos, G. S. S., Shawraz, S., lee, S., Bieniasz, P. D., Hatziioannou, T., et al. (2026) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2527869123 · Cited by 4
Self-citationPetropoulou, D., Tsilingiris, D., Karras, S. Ν., Ioannidis, A., Πετροπούλου, Γ., Chatzigeorgiou, A., Kassi, E. N., Karampela, Ι., Diamantopoulou, A., Panagiotopoulos, K., et al. (2026) · Metabolism Open · doi:10.1016/j.metop.2026.100446 · Cited by 4
Zhou, P., Hartweger, H., MacLean, A. J., Ramos, V., Yao, K.-H., Hernandez, B., wang, Z., Gazumyan, A., & Nussenzweig, M. C. (2026) · Immunity · doi:10.1016/j.immuni.2026.01.027 · Cited by 4
Self-citationVarese, A., Mazzitelli, B., Díaz, F. A. E., Kjolhede, M. V., Ojeda, D. S., Vellicce, A., Arto, P., Cícero, C. Y., Pascowsky, M., Figueras, L., et al. (2022) · The Journal of Infectious Diseases · doi:10.1093/infdis/jiac250 · Cited by 4
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Earnest, R., Chen, C. I., Chaguza, C., Hahn, A. M., Grubaugh, N. D., Wilson, M. S., & Team2, F. T. Y. C.-1. R. A. I. (2022) · Emerging infectious diseases · doi:10.3201/eid2812.220969 · Cited by 8
Li, S. C., & Kabeer, M. H. (2022) · Pharmaceutics · doi:10.3390/pharmaceutics14122653 · Cited by 4
Cheung, A. K. L., Lü, Y., Zhu, Y., Fung, T. Y., Zheng, Y., Zheng, Z., & Peng, H. (2023) · Journal of Medical Virology · doi:10.1002/jmv.28694 · Cited by 4
O’Reilly, S. R., Kenny, G., Alrawahneh, T., Francois, N., Gu, L., Angeliadis, M., d’Autume, V. D. M., Leon, A. G., Feeney, E. R., Yousif, O., et al. (2023) · PLoS ONE · doi:10.1371/journal.pone.0294262 · Cited by 4
Hildt, E. (2022) · Bundesgesundheitsblatt - Gesundheitsforschung - Gesundheitsschutz · doi:10.1007/s00103-022-03600-4 · Cited by 4
Singh, T., Miller, I. G., Venkatayogi, S., Webster, H. S., Heimsath, H. J., Eudailey, J., Dudley, D. M., Kumar, A., Mangan, R. J., Thein, A., et al. (2024) · mBio · doi:10.1128/mbio.03160-23 · Cited by 4
Finite neutralisation breadth of omicron after repeated vaccination
Zhu, Y., Lü, Y., Tang, L., Zhou, C.-L., Liang, R., Cui, M., Xu, Y., Zheng, Z., Cheng, Z., & Peng, H. (2022) · The Lancet Microbe · doi:10.1016/s2666-5247(22)00193-8 · Cited by 4
SARS-CoV-2 Antibody Responses to AZD1222 Vaccination in West AfricaPreprint
Abdullahi, A., Oladele, D. A., Owusu, M., Kemp, S. A., James, A. B., Salako, A. O., Fink, D., Sylverken, A. A., Ige, F. A., Onwuamah, C. K., et al. (2022) · Research Square · doi:10.21203/rs.3.rs-1834968/v1 · Cited by 4
Faliti, C. E., Anam, F. A., Cheedarla, N., Woodruff, M. C., Usman, S. Y., Runnstrom, M. C., Van, T. T. P., Kyu, S. Y., Ahmed, H., Morrison-Porter, A., et al. (2023) · medRxiv · doi:10.1101/2023.06.08.23291159 · Cited by 4
Long-term immune responses to SARS-CoV-2 Omicron BA.4/5 mRNA booster in people living with HIV
Augello, M., Bono, V., Rovito, R., Tavelli, A., Santoro, A., Tincati, C., Vergori, A., Azzini, A. M., Righi, E., Spiteri, G., et al. (2025) · Communications Medicine · doi:10.1038/s43856-025-00799-6 · Cited by 3
Yassim, A. S. M., Hisham, A. A. M., Daud, N. N. A. N., Anuar, N. D., Tan, T.-M., Suppıan, R., Asmaa, M. J. S., Asri, A. A. M., Azlan, M., Idris, N. S., et al. (2025) · Scientific Reports · doi:10.1038/s41598-025-05377-3 · Cited by 3
Metadata
- Authors
- Muecksch, F., Wang, Z., Cho, A., Gaebler, C., Ben Tanfous, T., DaSilva, J., Bednarski, E., Ramos, V., Zong, S., Johnson, B., Raspe, R., Schaefer-Babajew, D., Shimeliovich, I., Daga, M., Yao, K.-H., Schmidt, F., Millard, K. G., Turroja, M., Jankovic, M., Oliveira, T. Y., Gazumyan, A., Caskey, M., Hatziioannou, T., Bieniasz, P. D., & Nussenzweig, M. C.
- Affiliations
- Rockefeller University (US)
- Howard Hughes Medical Institute (US)
- Corresponding author
- Bieniasz, Paul D.
- Nussenzweig, Michel C.
- ORCID
- Muecksch, Frauke
- Wang, Zijun
- Cho, Alice
- Gaebler, Christian
- DaSilva, Justin
- Bednarski, Eva
- Ramos, Victor
- Zong, Shuai
- Johnson, Brianna
- Raspe, Raphael
- Schaefer-Babajew, Dennis
- Shimeliovich, Irina
- Daga, Mridushi
- Yao, Kai-Hui
- Schmidt, Fabian
- Millard, Katrina G.
- Turroja, Martina
- Oliveira, Thiago Y.
- Gazumyan, Anna
- Caskey, Marina
- Hatziioannou, Theodora
- Bieniasz, Paul D.
- Nussenzweig, Michel C.
- Venue
- Nature
- Published
- 2022-04-21
- Volume
- 607
- Issue
- 7917
- Pages
- 128-134
- ISSN
- 0028-0836 (ISSN-L)
- 1476-4687
- PMC
- PMC9259484
- OpenAlex
- W4224232962
- Cited by
- 297
- References
- 45
- Citations by year
- 2026: 27 · 2025: 39 · 2024: 65 · 2023: 86 · 2022: 80
- FWCI
- 33.12
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Locations
- Nature (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- RePEc: Research Papers in Economics (submittedVersion)
- Funders
- U.S. Department of Health & Human Services | National Institutes of Health (2U19AI111825, P01-AI138398-S1, UL1 TR001866, R01AI78788, R37-AI64003)
- Howard Hughes Medical Institute
- Topics
- Health Sciences › Medicine › Infectious Diseases › SARS-CoV-2 and COVID-19 Research
- Life Sciences › Immunology and Microbiology › Immunology › Immune responses and vaccinations
- Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
- Keywords
- SARS-CoV-2, Omicron variant, mRNA vaccines, booster vaccination, memory B cells, receptor binding domain, neutralizing antibodies, antibody potency, antibody breadth, B cell clones, longitudinal cohort
- MeSH terms
- COVID-19, SARS-CoV-2, COVID-19 Vaccines, mRNA Vaccines, Memory B Cells, Antibodies, Viral, Humans, Immunization, Secondary, RNA, Messenger, Antibodies, Neutralizing
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