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Cited by 248

The DOI matches its Crossref record; 13 of the 13 references it cites were found in a registry or an index.

RETRACTED ARTICLE: Antibodies against endogenous retroviruses promote lung cancer immunotherapy

Open access
Ng, Kevin W., Boumelha, Jesse, Enfield, Katey S. S., Almagro, Jorge, Cha, Hongui, Pich, Oriol, Karasaki, Takahiro, Moore, David A., Salgado, Roberto, Sivakumar, Monica, Young, George, Molina-Arcas, Miriam, de Carné Trécesson, Sophie, Anastasiou, Panayiotis, Fendler, Annika, Au, Lewis, Shepherd, Scott T. C., Martínez-Ruiz, Carlos, Puttick, Clare, Black, James R. M., Watkins, Thomas B. K., Kim, Hyemin, Shim, Seohee, Faulkner, Nikhil, Attig, Jan, Veeriah, Selvaraju, Magno, Neil, Ward, Sophia, Frankell, Alexander M., Al Bakir, Maise, Lim, Emilia L., Hill, Mark S., Wilson, Gareth A., Cook, Daniel E., Birkbak, Nicolai J., Behrens, Axel, Yousaf, Nadia, Popat, Sanjay, Hackshaw, Allan, TRACERx Consortium, Rowan, Andrew, Huebner, Ariana, Campbell, Brittany B., Bailey, Chris, Lee, Claudia, Biswas, Dhruva, Colliver, Emma, Athanasopoulou, Foteini, Zhai, Haoran, Rane, Jayant K., Grigoriadis, Kristiana, Dietzen, Michelle, Leung, Michelle, Angelova, Mihaela, Lucas, Olivia, Al-Sawaf, Othman, Rosenthal, Rachel, Nicod, Jerome, Bunkum, Abigail, Toncheva, Antonia, Abbosh, Christopher, Richard, Corentin, Naceur-Lombardelli, Cristina, Gimeno-Valiente, Francisco, Lam, Jie Min, Thol, Kerstin, Thakkar, Krupa, Werner Sunderland, Mariana, Forster, Martin D., Kanu, Nnennaya, Prymas, Paulina, Bentham, Robert, Saghafinia, Sadegh, Quezada, Sergio A., Vanloo, Sharon, Zaccaria, Simone, Lee, Siow Ming, Hessey, Sonya, Liu, Wing Kin, Papadatos-Pastos, Dionysis, Wilson, James, Benafif, Sarah, Ahmad, Tanya, Borg, Elaine, Falzon, Mary, Khiroya, Reena, Marafioti, Teresa, Sharp, Abigail, Pilotti, Camilla, Dhanda, Harjot Kaur, Chan, Kitty, Gower, Nicole, Leslie, Rachel, Smith, Sean, Nicholson, Andrew G., Lim, Eric, Herrero, Javier, Castignani, Carla, Larose Cadieux, Elizabeth, Demeulemeester, Jonas, Van Loo, Peter, Peggs, Karl S., Veiga, Catarina, Royle, Gary, Collins-Fekete, Charles-Antoine, Procter, Alexander James, Nair, Arjun, Ahmed, Asia, Taylor, Magali N., Navani, Neal, Thakrar, Ricky M., Lawrence, David, Patrini, Davide, Nye, Emma, Stone, Richard Kevin, Chuter, David, MacKenzie, Mairead, Fraioli, Francesco, Ashford, Paul, Janes, Sam M., Tanić, Miljana, Beck, Stephan, Rice, Alexandra, Devaraj, Anand, Proli, Chiara, Kaniu, Daniel, Bhayani, Harshil, Chavan, Hema, Raubenheimer, Hilgardt, Ambrose, Lyn, Malima, Mpho, Fernandes, Nadia, De Sousa, Paulo, Shah, Pratibha, Booth, Sarah, Buderi, Silviu I., Jordan, Simon, Begum, Sofina, Boleti, Ekaterini, Stewart, Aengus, Magness, Alastair, Weeden, Clare E., Levi, Dina, Grönroos, Eva, Goldman, Jacki, Escudero, Mickael, Hobson, Philip, Vendramin, Roberto, Boeing, Stefan, Denner, Tamara, Barbè, Vittorio, Lu, Wei-Ting, Hill, William, Naito, Yutaka, Ramsden, Zoe, Grapa, Anca, Zhang, Hanyun, AbdulJabbar, Khalid, Pan, Xiaoxi, Gilbert, Kayleigh, Karamani, Angeliki, Chain, Benny, Pearce, David R., Karagianni, Despoina, Hoxha, Elena, Gálvez-Cancino, Felip, Stavrou, Georgia, Mastrokalos, Gerasimos, Lowe, Helen L., Matos, Ignacio, Reading, James L., Hartley, John A., Selvaraju, Kayalvizhi, Chen, Kezhong, Ensell, Leah, Shah, Mansi, Vasquez, Marcos, Litovchenko, Maria, Chervova, Olga, Pawlik, Piotr, Hynds, Robert E., López, Saioa, Gamble, Samuel, Ung, Seng Kuong Anakin, Bola, Supreet Kaur, Mourikis, Thanos P., Spanswick, Victoria, Wu, Yin, Martinoni Hoogenboom, Emilie, Monk, Fleur, Holding, James W., Choudhary, Junaid, Bhakhri, Kunal, Scarci, Marco, Hayward, Martin, Panagiotopoulos, Nikolaos, Gorman, Pat, Stephens, Robert C. M., Bandula, Steve, Wong, Yien Ning Sophia, Clark, Tristan, Cheyne, Heather, Khalil, Mohammed, Richardson, Shirley, Cruickshank, Tracey, Naidu, Babu, Matharu, Gurdeep, Shaw, Jacqui A., Riley, Joan, Primrose, Lindsay, Le Quesne, John, Blyth, Kevin G., Kerr, Alastair, Clipson, Alexandra, Chaturvedi, Anshuman, Dive, Caroline, Rothwell, Dominic G., Kilgour, Elaine, Tugwood, Jonathan, Priest, Lynsey, Oliveira, Pedro, Crosbie, Philip, Price, Gillian, Cave, Judith, Kerr, Keith M., Lindsay, Colin R., Blackhall, Fiona H., Krebs, Matthew G., Summers, Yvonne, Kirk, Alan, Thomas, Mathew, Asif, Mo, Kostoulas, Nikos, Bilancia, Rocco, Middleton, Gary, Shackcloth, Michael J., Leek, Angela, Hodgkinson, Jack Davies, Totten, Nicola, Dick, Craig, Robinson, Lily, Russell, Peter, Hewish, Madeleine, Danson, Sarah, Lester, Jason F., Gomes, Fabio, Brown, Kate, Carter, Mathew, Patel, Akshay J., Osman, Aya, Lacson, Christer, Langman, Gerald, Shackleford, Helen, Djearaman, Madava, Kadiri, Salma, Alzetani, Aiman, Richards, Jennifer, Scarlett, Lydia, Ingram, Papawadee, Chee, Serena, Austin, Silvia, Bajaj, Amrita, Nakas, Apostolos, Sodha-Ramdeen, Azmina, Fennell, Dean A., Ang, Keng, Tufail, Mohamad, Chowdhry, Mohammed Fiyaz, Scotland, Molly, Boyles, Rebecca, Rathinam, Sridhar, Wilson, Claire, Marrone, Domenic, Dulloo, Sean, Montero, Angeles, Smith, Elaine, Fontaine, Eustace, Granato, Felice, Doran, Helen, Novasio, Juliette, Rammohan, Kendadai, Joseph, Leena, Bishop, Paul, Shah, Rajesh, Moss, Stuart, Joshi, Vijay, Aerts, Hugo J. W. L., Kaufmann, Tom L., Schwarz, Roland F., Kisistok, Judit, Sokac, Mateo, Diossy, Miklos, Szallasi, Zoltan, Dijkstra, Krijn, Yuan, Yinyin, CAPTURE Consortium, Byrne, Fiona, Boos, Laura Amanda, Shum, Benjamin, Gerard, Camille L., Schmitt, Andreas M., Messiou, Christina, Cunningham, David, Chau, Ian, Starling, Naureen, Turner, Nicholas, Welsh, Liam, Jones, Robin L., Droney, Joanne, Banerjee, Susana, Tatham, Kate C., Jhanji, Shaman, Harrington, Kevin, Okines, Alicia, Reid, Alison, Young, Kate, Furness, Andrew J. S., Pickering, Lisa, Nicholson, Emma, Kumar, Sacheen, Wilkinson, Katalin A., Swerdlow, Anthony, Wilkinson, Robert J., Hiley, Crispin T., Litchfield, Kevin, McGranahan, Nicholas, Jamal-Hanjani, Mariam, Larkin, James, Lee, Se-Hoon, Turajlic, Samra, Swanton, Charles, Downward, Julian, Kassiotis, George·2023·Nature
DOI 10.1038/s41586-023-05771-9
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Abstract

B cells are frequently found in the margins of solid tumours as organized follicles in ectopic lymphoid organs called tertiary lymphoid structures (TLS) 1,2 . Although TLS have been found to correlate with improved patient survival and response to immune checkpoint blockade (ICB), the underlying mechanisms of this association remain elusive 1,2 . Here we investigate lung-resident B cell responses in patients from the TRACERx 421 (Tracking Non-Small-Cell Lung Cancer Evolution Through Therapy) and other lung cancer cohorts, and in a recently established immunogenic mouse model for lung adenocarcinoma 3 . We find that both human and mouse lung adenocarcinomas elicit local germinal centre responses and tumour-binding antibodies, and further identify endogenous retrovirus (ERV) envelope glycoproteins as a dominant anti-tumour antibody target. ERV-targeting B cell responses are amplified by ICB in both humans and mice, and by targeted inhibition of KRAS(G12C) in the mouse model. ERV-reactive antibodies exert anti-tumour activity that extends survival in the mouse model, and ERV expression predicts the outcome of ICB in human lung adenocarcinoma. Finally, we find that effective immunotherapy in the mouse model requires CXCL13-dependent TLS formation. Conversely, therapeutic CXCL13 treatment potentiates anti-tumour immunity and synergizes with ICB. Our findings provide a possible mechanistic basis for the association of TLS with immunotherapy response.

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Metadata

Authors
Ng, K. W., Boumelha, J., Enfield, K. S. S., Almagro, J., Cha, H., Pich, O., Karasaki, T., Moore, D. A., Salgado, R., Sivakumar, M., Young, G., Molina-Arcas, M., de Carné Trécesson, S., Anastasiou, P., Fendler, A., Au, L., Shepherd, S. T. C., Martínez-Ruiz, C., Puttick, C., Black, J. R. M., Watkins, T. B. K., Kim, H., Shim, S., Faulkner, N., Attig, J., Veeriah, S., Magno, N., Ward, S., Frankell, A. M., Al Bakir, M., Lim, E. L., Hill, M. S., Wilson, G. A., Cook, D. E., Birkbak, N. J., Behrens, A., Yousaf, N., Popat, S., Hackshaw, A., TRACERx Consortium, Rowan, A., Huebner, A., Campbell, B. B., Bailey, C., Lee, C., Biswas, D., Colliver, E., Athanasopoulou, F., Zhai, H., Rane, J. K., Grigoriadis, K., Dietzen, M., Leung, M., Angelova, M., Lucas, O., Al-Sawaf, O., Rosenthal, R., Nicod, J., Bunkum, A., Toncheva, A., Abbosh, C., Richard, C., Naceur-Lombardelli, C., Gimeno-Valiente, F., Lam, J. M., Thol, K., Thakkar, K., Werner Sunderland, M., Forster, M. D., Kanu, N., Prymas, P., Bentham, R., Saghafinia, S., Quezada, S. A., Vanloo, S., Zaccaria, S., Lee, S. M., Hessey, S., Liu, W. K., Papadatos-Pastos, D., Wilson, J., Benafif, S., Ahmad, T., Borg, E., Falzon, M., Khiroya, R., Marafioti, T., Sharp, A., Pilotti, C., Dhanda, H. K., Chan, K., Gower, N., Leslie, R., Smith, S., Nicholson, A. G., Lim, E., Herrero, J., Castignani, C., Larose Cadieux, E., Demeulemeester, J., Van Loo, P., Peggs, K. S., Veiga, C., Royle, G., Collins-Fekete, C.-A., Procter, A. J., Nair, A., Ahmed, A., Taylor, M. N., Navani, N., Thakrar, R. M., Lawrence, D., Patrini, D., Nye, E., Stone, R. K., Chuter, D., MacKenzie, M., Fraioli, F., Ashford, P., Janes, S. M., Tanić, M., Beck, S., Rice, A., Devaraj, A., Proli, C., Kaniu, D., Bhayani, H., Chavan, H., Raubenheimer, H., Ambrose, L., Malima, M., Fernandes, N., De Sousa, P., Shah, P., Booth, S., Buderi, S. I., Jordan, S., Begum, S., Boleti, E., Stewart, A., Magness, A., Weeden, C. E., Levi, D., Grönroos, E., Goldman, J., Escudero, M., Hobson, P., Vendramin, R., Boeing, S., Denner, T., Barbè, V., Lu, W.-T., Hill, W., Naito, Y., Ramsden, Z., Grapa, A., Zhang, H., AbdulJabbar, K., Pan, X., Gilbert, K., Karamani, A., Chain, B., Pearce, D. R., Karagianni, D., Hoxha, E., Gálvez-Cancino, F., Stavrou, G., Mastrokalos, G., Lowe, H. L., Matos, I., Reading, J. L., Hartley, J. A., Selvaraju, K., Chen, K., Ensell, L., Shah, M., Vasquez, M., Litovchenko, M., Chervova, O., Pawlik, P., Hynds, R. E., López, S., Gamble, S., Ung, S. K. A., Bola, S. K., Mourikis, T. P., Spanswick, V., Wu, Y., Martinoni Hoogenboom, E., Monk, F., Holding, J. W., Choudhary, J., Bhakhri, K., Scarci, M., Hayward, M., Panagiotopoulos, N., Gorman, P., Stephens, R. C. M., Bandula, S., Wong, Y. N. S., Clark, T., Cheyne, H., Khalil, M., Richardson, S., Cruickshank, T., Naidu, B., Matharu, G., Shaw, J. A., Riley, J., Primrose, L., Le Quesne, J., Blyth, K. G., Kerr, A., Clipson, A., Chaturvedi, A., Dive, C., Rothwell, D. G., Kilgour, E., Tugwood, J., Priest, L., Oliveira, P., Crosbie, P., Price, G., Cave, J., Kerr, K. M., Lindsay, C. R., Blackhall, F. H., Krebs, M. G., Summers, Y., Kirk, A., Thomas, M., Asif, M., Kostoulas, N., Bilancia, R., Middleton, G., Shackcloth, M. J., Leek, A., Hodgkinson, J. D., Totten, N., Dick, C., Robinson, L., Russell, P., Hewish, M., Danson, S., Lester, J. F., Gomes, F., Brown, K., Carter, M., Patel, A. J., Osman, A., Lacson, C., Langman, G., Shackleford, H., Djearaman, M., Kadiri, S., Alzetani, A., Richards, J., Scarlett, L., Ingram, P., Chee, S., Austin, S., Bajaj, A., Nakas, A., Sodha-Ramdeen, A., Fennell, D. A., Ang, K., Tufail, M., Chowdhry, M. F., Scotland, M., Boyles, R., Rathinam, S., Wilson, C., Marrone, D., Dulloo, S., Montero, A., Smith, E., Fontaine, E., Granato, F., Doran, H., Novasio, J., Rammohan, K., Joseph, L., Bishop, P., Shah, R., Moss, S., Joshi, V., Aerts, H. J. W. L., Kaufmann, T. L., Schwarz, R. F., Kisistok, J., Sokac, M., Diossy, M., Szallasi, Z., Dijkstra, K., Yuan, Y., CAPTURE Consortium, Byrne, F., Boos, L. A., Shum, B., Gerard, C. L., Schmitt, A. M., Messiou, C., Cunningham, D., Chau, I., Starling, N., Turner, N., Welsh, L., Jones, R. L., Droney, J., Banerjee, S., Tatham, K. C., Jhanji, S., Harrington, K., Okines, A., Reid, A., Young, K., Furness, A. J. S., Pickering, L., Nicholson, E., Kumar, S., Wilkinson, K. A., Swerdlow, A., Wilkinson, R. J., Hiley, C. T., Litchfield, K., McGranahan, N., Jamal-Hanjani, M., Larkin, J., Lee, S.-H., Turajlic, S., Swanton, C., Downward, J., & Kassiotis, G.
Venue
Nature
Publisher
Springer Science and Business Media LLC
Published
2023-04-12
Volume
616
Issue
7957
Pages
563-573
ISSN
  • 0028-0836 (ISSN-L)
  • 1476-4687
DOI
10.1038/s41586-023-05771-9
OpenAlex
W4365137750
Cited by
248
References
13
FWCI
25.57
Type
journal article
Language
en
Status
Retracted
Open access
hybrid

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Ng, K. W., Boumelha, J., Enfield, K. S. S., Almagro, J., Cha, H., Pich, O., Karasaki, T., Moore, D. A., Salgado, R., Sivakumar, M., Young, G., Molina-Arcas, M., de Carné Trécesson, S., Anastasiou, P., Fendler, A., Au, L., Shepherd, S. T. C., Martínez-Ruiz, C., Puttick, C., . . . Kassiotis, G. (2023). RETRACTED ARTICLE: Antibodies against endogenous retroviruses promote lung cancer immunotherapy. Nature. https://doi.org/10.1038/s41586-023-05771-9

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