The DOI matches its Crossref record; 32 of the 32 references it cites were found in a registry or an index.
Broad-spectrum resistance to bacterial blight in rice using genome editing
Open accessAbstract
Bacterial blight of rice is an important disease in Asia and Africa. The pathogen,Xanthomonas oryzae pv.oryzae(Xoo), secretes one or more of six known transcription-activator-like effectors (TALes) that bind specific promoter sequences and induce, at minimum, one of the three host sucrose transporter genes SWEET11,SWEET13 and SWEET14, the expression of which is required for disease susceptibility. We used CRISPR–Cas9-mediated genome editing to introduce mutations in all three SWEET gene promoters. Editing was further informed by sequence analyses of TALe genes in 63 Xoo strains, which revealed multiple TALe variants for SWEET13 alleles. Mutations were also created in SWEET14, which is also targeted by two TALes from an African Xoo lineage. A total of five promoter mutations were simultaneously introduced into the rice line Kitaake and the elite mega varieties IR64 and Ciherang-Sub1. Paddy trials showed that genome-edited SWEET promoters endow rice lines with robust, broad-spectrum resistance.
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A Simple Cipher Governs DNA Recognition by TAL Effectors
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Sugar transporters for intercellular exchange and nutrition of pathogens
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Self-citationACT: the Artemis comparison tool
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Sucrose Efflux Mediated by SWEET Proteins as a Key Step for Phloem Transport
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Metadata
- Authors
- Oliva, R., Ji, C., Atienza-Grande, G., Huguet-Tapia, J. C., Perez-Quintero, A., Li, T., Eom, J.-S., Li, C., Nguyen, H., Liu, B., Auguy, F., Sciallano, C., Luu, V. T., Dossa, G. S., Cunnac, S., Schmidt, S. M., Slamet-Loedin, I. H., Vera Cruz, C., Szurek, B., Frommer, W. B., White, F. F., & Yang, B.
- Venue
- Nature Biotechnology
- Published
- 2019-10-28
- Volume
- 37
- Issue
- 11
- Pages
- 1344-1350
- ISSN
- 0733-222X (ISSN-L)
- 1087-0156
- 1546-1696
- OpenAlex
- W2982003255
- Cited by
- 851
- References
- 32
- FWCI
- 58.00
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- Oliva, R., Ji, C., Atienza-Grande, G., Huguet-Tapia, J. C., Perez-Quintero, A., Li, T., Eom, J.-S., Li, C., Nguyen, H., Liu, B., Auguy, F., Sciallano, C., Luu, V. T., Dossa, G. S., Cunnac, S., Schmidt, S. M., Slamet-Loedin, I. H., Vera Cruz, C., Szurek, B., . . . Yang, B. (2019). Broad-spectrum resistance to bacterial blight in rice using genome editing. Nature Biotechnology. https://doi.org/10.1038/s41587-019-0267-z
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
