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Identification of a human hematopoietic stem cell subset that retains memory of inflammatory stressPreprint

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Txnip Enhances Fitness of Dnmt3a -Mutant Hematopoietic Stem Cells via p21

Zhang, C. R., Ostrander, E. L., Kukhar, O., Mallaney, C., Sun, J., Haussler, E., Celik, H., Koh, W. K., King, K. Y., Gontarz, P., et al. (2022) · Blood Cancer Discovery · doi:10.1158/2643-3230.bcd-21-0132 · Cited by 23

TET2 mutation as prototypic clonal hematopoiesis lesion

Guarnera, L., & Jha, B. K. (2024) · Seminars in Hematology · doi:10.1053/j.seminhematol.2024.01.013 · Cited by 24

DNMT3A Harboring Leukemia-Associated Mutations Directs Sensitivity to DNA Damage at Replication Forks

Venugopal, K., Feng, Y., Nowialis, P., Xu, H., Shabashvili, D. E., Berntsen, C. M., Kaur, P., Krajcik, K. I., Taragjini, C., Zaroogian, Z., et al. (2021) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-21-2863 · Cited by 22

Epigenetic and transcriptional control of interferon-β

Daman, A. W., & Josefowicz, S. Z. (2021) · The Journal of Experimental Medicine · doi:10.1084/jem.20210039 · Cited by 21

Modeling clonal hematopoiesis in umbilical cord blood cells by CRISPR/Cas9

Christen, F., Hablesreiter, R., Hoyer, K., Hennch, C., Maluck-Böttcher, A., Segler, A., Madadi, A., Frick, M., Bullinger, L., Briest, F., et al. (2021) · Leukemia · doi:10.1038/s41375-021-01469-x · Cited by 22

NSD family proteins: Rising stars as therapeutic targets

He, L., Cao, Y., & Sun, L. (2024) · Cell Insight · doi:10.1016/j.cellin.2024.100151 · Cited by 22

Activation of Notch and Myc Signaling via B-cell–Restricted Depletion of Dnmt3a Generates a Consistent Murine Model of Chronic Lymphocytic Leukemia

Biran, A., Yin, S., Kretzmer, H., ten Hacken, E., Parvin, S., Lucas, F. M., Uduman, M., Gutierrez, C., Dangle, N. J., Billington, L., et al. (2021) · Cancer Research · doi:10.1158/0008-5472.can-21-1273 · Cited by 21

Pre-existing stem cell heterogeneity dictates clonal responses to the acquisition of leukemic driver mutations

Singh, I., Fernández-Pérez, D., Sanchez, P. S., & Rodriguez-Fraticelli, A. (2025) · Cell stem cell · doi:10.1016/j.stem.2025.01.012 · Cited by 30

Srsf2P95H/+ co-operates with loss of TET2 to promote myeloid bias and initiate a chronic myelomonocytic leukemia-like disease in mice

Xu, J. J., Chalk, A. M., Wall, M., Langdon, W. Y., Smeets, M. F. M. A., & Walkley, C. R. (2022) · Leukemia · doi:10.1038/s41375-022-01727-6 · Cited by 23

Bidirectional interplay between metabolism and epigenetics in hematopoietic stem cells and leukemia

Zhang, Y. W., Schönberger, K., & Cabezas‐Wallscheid, N. (2023) · The EMBO Journal · doi:10.15252/embj.2022112348 · Cited by 24

Differential H4K16ac levels ensure a balance between quiescence and activation in hematopoietic stem cells

Rodrigues, C. P., & Akhtar, A. (2021) · Science Advances · doi:10.1126/sciadv.abi5987 · Cited by 21

Cell origin–dependent cooperativity of mutant Dnmt3a and Npm1 in clonal hematopoiesis and myeloid malignancy

SanMiguel, J. M., Eudy, E., Loberg, M. A., Miles, L. A., Stearns, T. M., Mistry, J. J., Rauh, M. J., Levine, R. L., & Trowbridge, J. J. (2022) · Blood Advances · doi:10.1182/bloodadvances.2022006968 · Cited by 19

Temporally discordant chromatin accessibility and DNA demethylation define short- and long-term enhancer regulation during cell fate specification

Guerin, L. N., Scott, T. J., Yap, J. A., Johansson, A., Puddu, F., Charlesworth, T., Yang, Y., Simmons, A. J., Lau, K. S., Ihrie, R. A., et al. (2025) · Cell Reports · doi:10.1016/j.celrep.2025.115680 · Cited by 21

Single-cell fate decisions of bipotential hematopoietic progenitors

Brand, M., & Morrissey, E. R. (2020) · Current Opinion in Hematology · doi:10.1097/moh.0000000000000592 · Cited by 19

Myelodysplasia Syndrome, Clonal Hematopoiesis and Cardiovascular Disease

Veiga, C. B., Lawrence, E., Murphy, A. J., Herold, M. J., & Dragoljevic, D. (2021) · Cancers · doi:10.3390/cancers13081968 · Cited by 20

Epigenetic Modification of Cytosines in Hematopoietic Differentiation and Malignant Transformation

An, J., & Ko, M. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24021727 · Cited by 21

GTAC enables parallel genotyping of multiple genomic loci with chromatin accessibility profiling in single cells

Turkalj, S., Jakobsen, N. A., Groom, A., Metzner, M., Riva, S. G., Gur, E., Usukhbayar, B., Salazar, M. A., Hentges, L. D., Mickute, G., et al. (2023) · Cell stem cell · doi:10.1016/j.stem.2023.04.012 · Cited by 19

Uncovering underlying physical principles and driving forces of cell differentiation and reprogramming from single-cell transcriptomics

Zhu, L., Yang, S., Zhang, K., Wang, H., Fang, X., & Wang, J. (2024) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2401540121 · Cited by 21

Ascorbate Inhibits Proliferation and Promotes Myeloid Differentiation in TP53-Mutant Leukemia

Smith-Díaz, C. C., Magon, N. J., McKenzie, J. L., Hampton, M. B., Vissers, M. C. M., & Das, A. B. (2021) · Frontiers in Oncology · doi:10.3389/fonc.2021.709543 · Cited by 20

Relevance of DNA methylation at enhancers for the acquisition of cell identities

Kreibich, E., & Krebs, A. R. (2023) · FEBS Letters · doi:10.1002/1873-3468.14686 · Cited by 19

Increased iron uptake by splenic hematopoietic stem cells promotes TET2-dependent erythroid regeneration

Tseng, Y.-J., Kageyama, Y., Murdaugh, R. L., Kitano, A., Kim, J. H., Hoegenauer, K. A., Tiessen, J., Smith, M. H., Uryu, H., Takahashi, K., et al. (2024) · Nature Communications · doi:10.1038/s41467-024-44718-0 · Cited by 21

HDAC1 is required for GATA-1 transcription activity, global chromatin occupancy and hematopoiesis

Yan, B., Yang, J., Kim, M. Y., Luo, H., Cesari, N., Yang, T., Strouboulis, J., Zhang, J., Hardison, R. C., Huang, S., et al. (2021) · Nucleic Acids Research · doi:10.1093/nar/gkab737 · Cited by 18

Erythropoiesis: insights from a genomic perspective

Ji, H. Y. (2024) · Experimental & Molecular Medicine · doi:10.1038/s12276-024-01311-1 · Cited by 22

Epigenetics of the antibody and autoantibody response

Moroney, J. B., Chupp, D. P., Xu, Z., Zan, H., & Casali, P. (2020) · Current Opinion in Immunology · doi:10.1016/j.coi.2020.09.004 · Cited by 17

Significance of targeting DNMT3A mutations in AML

Huang, G., Cai, X., & Li, D. (2024) · Annals of Hematology · doi:10.1007/s00277-024-05885-8 · Cited by 20

Single-cell multi-omics of human clonal hematopoiesis reveals that DNMT3A R882 mutations perturb early progenitor states through selective hypomethylation

Nam, A. S., Dusaj, N., Izzo, F., Murali, R., Myers, R. M., Mouhieddine, T. H., Sotelo, J., Benbarche, S., Waarts, M., Gaiti, F., et al. (2022) · Nature Genetics · doi:10.1038/s41588-022-01179-9 · Cited by 140

Single-Cell Analysis of Human Clonal Hematopoiesis Identifies Distinct Impact of DNMT3A and TET2 mutations on Hematopoietic Differentiation

Jakobsen, N. A., Turkalj, S., Stoilova, B., Metzner, M., Moore, R., Usukhbayar, B., Salazar, M. A., Kennedy, A., Newman, S., Kendrick, B. J. L., et al. (2022) · Blood · doi:10.1182/blood-2022-166474 · Cited by 3

Single-Cell Methylome and Transcriptome High-Resolution Maps Define the Effects of Epigenetic Modifiers on the Landscape of Hematopoietic Differentiation

Izzo, F., Poran, A., Lee, S. C.-W., Chaligné, R., Gaiti, F., Kothen-Hill, S., Schulman, R. C., Ki, M., Kenigsberg, E., Abdel-Wahab, O. I., et al. (2017) · Blood · doi:10.1182/blood.v130.suppl_1.559.559

Genome-wide DNA methylation profiles in hematopoietic stem and progenitor cells reveal overrepresentation of ETS transcription factor binding sites

Hogart, A., Lichtenberg, J., Ajay, S. S., Anderson, S., NIH Intramural Sequencing Center, Margulies, E. H., & Bodine, D. M. (2012) · Genome Research · doi:10.1101/gr.132878.111 · Cited by 101

Single-Cell Multi-Omics in Human Clonal Hematopoiesis Reveals That DNMT3A R882 Mutations Perturb Early Progenitor States through Selective Hypomethylation

Nam, A. S., Dusaj, N. N., Izzo, F., Murali, R., Mouhieddine, T. H., Myers, R. M., Sotelo, J., Benbarche, S., Gaiti, F., Tahri, S., et al. (2020) · Blood · doi:10.1182/blood-2020-142574 · Cited by 1