Clonal hematopoiesis: Mutation-specific adaptation to environmental change
Open accessAbstract
Clonal hematopoiesis of indeterminate potential (CHIP) describes a widespread expansion of genetically variant hematopoietic cells that increases exponentially with age and is associated with increased risks of cancers, cardiovascular disease, and other maladies. Here, we discuss how environmental contexts associated with CHIP, such as old age, infections, chemotherapy, or cigarette smoking, alter tissue microenvironments to facilitate the selection and expansion of specific CHIP mutant clones. Further, we consider major remaining gaps in knowledge, including intrinsic effects, clone size thresholds, and factors affecting clonal competition, that will determine future application of this field in transplant and preventive medicine.
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Over a lifetime, repeated infections, autoimmune dysregulation, systemic disease that promotes inflammatory signals such as CVD, or other physiological stresses including metabolic stress or sleep deprivation may lead to systemic inflammation that provides cumulative, chronic positive selective pressure upon CH clones.
“Over a lifetime of an organism, repeated infections, autoimmune dysregulation, systemic disease that promotes inflammatory signals such as CVD, or other physiological stresses including metabolic stress or sleep deprivation may lead to systemic inflammation that provides cumulative, chronic positive selective pressure upon CH clones [67].”
From Clonal hematopoiesis and inflammation – the perpetual cycle (2023) · cites this paper as [67]
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Microbiome and Hemato-immune Aging
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TNF Receptors Choose HSC Fate in Supporting Dnmt3a -Mutant Clonal Hematopoiesis
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Clonal Hematopoietic Mutations in Plasma Cell Disorders: Clinical Subgroups and Shared Pathogenesis
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Risk of Clonal Hematopoiesis of Indeterminate Potential after Cancer Radiation TherapyPreprint
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- Authors
- Florez, M. A., Tran, B. T., Wathan, T. K., DeGregori, J., Pietras, E. M., & King, K. Y.
- Affiliations
- Baylor College of Medicine (US)
- University of Colorado Anschutz (US)
- Corresponding author
- King, Katherine Y.
- Venue
- Cell Stem Cell
- Publisher
- Elsevier BV
- Published
- 2022-06
- Volume
- 29
- Issue
- 6
- Pages
- 882-904
- ISSN
- 1875-9777 (ISSN-L)
- 1934-5909
- PMC
- PMC9202417
- OpenAlex
- W4281715700
- Cited by
- 129
- References
- 259
- Citations by year
- 2026: 29 · 2025: 35 · 2024: 38 · 2023: 20 · 2022: 7
- FWCI
- 4.46
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- www.elsevier.com/tdm/userlicense/1.0/ (tdm)
- www.elsevier.com/legal/tdmrep-license (tdm)
- www.elsevier.com/open-access/userlicense/1.0/ (vor, 366 d)
- doi.org/10.15223/policy-017 (stm-asf)
- doi.org/10.15223/policy-037 (stm-asf)
- doi.org/10.15223/policy-012 (stm-asf)
- doi.org/10.15223/policy-029 (stm-asf)
- doi.org/10.15223/policy-004 (stm-asf)
- Locations
- Cell stem cell (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institute on Aging (R01AG066544, R01AG067584)
- National Heart, Lung, and Blood Institute (F31HL156500, R01HL134880, R01HL136333, R35HL155672)
- National Cancer Institute (P01CA265748)
- National Institute of Allergy and Infectious Diseases (R01AI141716)
- National Institute of Diabetes and Digestive and Kidney Diseases (R01DK119394)
- Topics
- Health Sciences › Medicine › Hematology › Acute Myeloid Leukemia Research
- Health Sciences › Medicine › Hematology › Hematopoietic Stem Cell Transplantation
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Cancer Genomics and Diagnostics
- Keywords
- clonal hematopoiesis of indeterminate potential, clonal evolution, somatic mutations, hematopoietic stem cells, tissue microenvironment, aging, infection, chemotherapy, cigarette smoking, clonal competition, cancer risk, cardiovascular disease, hematopoietic stem cell transplantation
- MeSH terms
- Clonal Hematopoiesis, Hematopoiesis, Hematopoietic Stem Cells, Mutation, Risk Factors
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