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Identifying G-Quadruplex-DNA-Disrupting Small Molecules

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Structural Basis of Pyridostatin and Its Derivatives Specifically Binding to G-Quadruplexes

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Single-cell mapping of DNA G-quadruplex structures in human cancer cells

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The Relevance of G-Quadruplexes for DNA Repair

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The human AP-endonuclease 1 (APE1) is a DNA G-quadruplex structure binding protein and regulatesKRASexpression in pancreatic ductal adenocarcinoma cells

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A new G-quadruplex-specific photosensitizer inducing genome instability in cancer cells by triggering oxidative DNA damage and impeding replication fork progression

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G-quadruplexes promote the motility in MAZ phase-separated condensates to activate CCND1 expression and contribute to hepatocarcinogenesis

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An Upstream G-Quadruplex DNA Structure Can Stimulate Gene Transcription

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The Emerging Roles of Multimolecular G-Quadruplexes in Transcriptional Regulation and Chromatin Organization

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Discovery of a Novel G-Quadruplex and Histone Deacetylase (HDAC) Dual-Targeting Agent for the Treatment of Triple-Negative Breast Cancer

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Optical control of gene expression using a DNA G-quadruplex targeting reversible photoswitch

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Structured Waters Mediate Small Molecule Binding to G-Quadruplex Nucleic Acids

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A Smart Small Molecule as Specific Fluorescent Probe for Sensitive Recognition of Mitochondrial G-Quadruplexes

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A Phenotypic Approach to the Discovery of Potent G-Quadruplex Targeted Drugs

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DNA G-Quadruplexes as Targets for Natural Product Drug Discovery

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Advancements in molecular disassembly of optical probes: a paradigm shift in sensing, bioimaging, and therapeutics

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G-Quadruplex Assembly by Ribosomal DNA: Emerging Roles in Disease Pathogenesis and Cancer Biology

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G-quadruplexes in helminth parasites

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Chemically modified CRISPR-Cas9 enables targeting of individual G-quadruplex and i-motif structures, revealing ligand-dependent transcriptional perturbation

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G4mismatch: Deep neural networks to predict G-quadruplex propensity based on G4-seq data

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Structure of the Major G-Quadruplex in the Human EGFR Oncogene Promoter Adopts a Unique Folding Topology with a Distinctive Snap-Back Loop

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G-quadruplex-driven molecular disassembly and type I-to-type II photophysical conversion of a heavy-atom-free photosensitizer for site-specific oxidative damage

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METTL3 Is Suppressed by Circular RNA circMETTL3/miR-34c-3p Signaling and Limits the Tumor Growth and Metastasis in Triple Negative Breast Cancer

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EndoQuad: a comprehensive genome-wide experimentally validated endogenous G-quadruplex database

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Activation-induced cytidine deaminase localizes to G-quadruplex motifs at mutation hotspots in lymphoma

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G-quadruplex-mediated genomic instability drives SNVs in cancer

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Side-by-side comparison of G-quadruplex (G4) capture efficiency of the antibody BG4 versus the small-molecule ligands TASQs

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Integrative genomic analyses of promoter G-quadruplexes reveal their selective constraint and association with gene activation

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Identification of G-quadruplex-interacting proteins in living cells using an artificial G4-targeting biotin ligase

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Remodeling of the Conformational Dynamics of Noncanonical DNA Structures by Monomeric and Aggregated α-Synuclein

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Searching for G-Quadruplex-Binding Proteins in Plants: New Insight into Possible G-Quadruplex Regulation

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G-quadruplex structures regulate long-range transcriptional reprogramming to promote drug resistance in ovarian cancer cells

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Selective c-MYC G4 DNA recognition based on a fluorescent light-up probe with disaggregation-induced emission characteristics

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Prediction of G4 formation in live cells with epigenetic data: a deep learning approach

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Promising G-Quadruplex-Targeted Dibenzoquinoxaline Type-1 Photosensitizer Triggers DNA Damage in Triple-Negative Breast Cancer Cells

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Novel Roles of G-quadruplexes on Enhancers in human chromatinPreprint

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Affinity Chromatography‐Based Assays for the Screening of Potential Ligands Selective for G‐Quadruplex Structures

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Metal centers and aromatic moieties in Schiff base complexes: impact on G-quadruplex stabilization and oncogene downregulation

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Genetic variations in G-quadruplex forming sequences affect the transcription of human disease-related genes

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Human Rev1 relies on insert-2 to promote selective binding and accurate replication of stabilized G-quadruplex motifs

Ketkar, A. D., Smith, L., Johnson, C., Richey, A., Berry, M., Hartman, J. H., Maddukuri, L., Reed, M. R., Gunderson, J. E. C., Leung, J. W. C., et al. (2021) · Nucleic Acids Research · doi:10.1093/nar/gkab041 · Cited by 16

Precise detection of G-quadruplexs in living systems: principles, applications, and perspectives

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Solution structures and effects of a platinum compound successively bound MYC G-quadruplex

Liu, W.-T., Zhu, B., Liu, L.-Y., Xia, X., Jang, J., Dickerhoff, J., Yang, D.-Z., & Mao, Z.-W. (2024) · Nucleic Acids Research · doi:10.1093/nar/gkae649 · Cited by 11

An overview on nucleic-acid G-quadruplex prediction: from rule-based methods to deep neural networks

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A G-Quadruplex-Binding Small Molecule and the HDAC Inhibitor SAHA (Vorinostat) Act Synergistically in Gemcitabine-Sensitive and Resistant Pancreatic Cancer Cells

Ahmed, A. A., & Neidle, S. (2020) · Molecules · doi:10.3390/molecules25225407 · Cited by 14

Fabrication of bifunctional G-quadruplex-hemin DNAzymes for colorimetric detection of apurinic/apyrimidinic endonuclease 1 and microRNA-21

Huang, X., He, Z., Zhou, K., Zhi, H., & Yang, J. (2021) · The Analyst · doi:10.1039/d1an01603b · Cited by 14

Molecular engineering of a wash-free, clover-like G-quadruplex fluorescent probe that exploits a new mechanism of disaggregation-and-binding-induced emission

Wang, X., & Hu, M.-H. (2023) · Sensors and Actuators B Chemical · doi:10.1016/j.snb.2023.134075 · Cited by 14

Modulating gene expression in breast cancer via DNA secondary structure and the CRISPR toolbox

Kretzmann, J. A., Irving, K. L., Smith, N. M., & Evans, C. W. (2021) · NAR Cancer · doi:10.1093/narcan/zcab048 · Cited by 14

Loss of DHX36/G4R1, a G4 resolvase, drives genome instability and regulates innate immune gene expression in cancer cells

Bartosik, A. R., Hou, P., Tang, S., Vaughn, J. P., Smaldino, P. J., Ratan, A., Mayo, M. W., & Wang, Y. (2025) · Nucleic Acids Research · doi:10.1093/nar/gkaf621 · Cited by 13

Targeting KRAS Regulation with PolyPurine Reverse Hoogsteen Oligonucleotides

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In vivo detection of DNA secondary structures using permanganate/S1 footprinting with direct adapter ligation and sequencing (PDAL-Seq)

Lahnsteiner, A., Craig, S. J. C., Kamali, K., Weissensteiner, B., McGrath, B. C., Risch, A., & Makova, K. D. (2024) · Methods in enzymology on CD-ROM/Methods in enzymology · doi:10.1016/bs.mie.2023.12.003 · Cited by 13

DNA 5mC methylation inhibits the formation of G-quadruplex structures in the genome

Niu, K., Xiang, L., Zhang, X., Li, X., Yao, T., Li, J., Zhang, C., Liu, J., Peng, Y., Xu, G., et al. (2025) · Genome biology · doi:10.1186/s13059-025-03678-4 · Cited by 13

Good Vibrations Report on the DNA Quadruplex Binding of an Excited State Amplified Ruthenium Polypyridyl IR Probe

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Analysis of Nucleotide Variations in Human G-Quadruplex Forming Regions Associated with Disease States

Neupane, A., Chariker, J. H., & Rouchka, E. C. (2023) · Genes · doi:10.3390/genes14122125 · Cited by 11

Improved simultaneous mapping of epigenetic features and 3D chromatin structure via ViCAR

Flynn, S. M., Dhir, S., Herka, K., Doyle, C., Melidis, L., Simeone, A., Hui, W. W. I., Tavares, R. D. C. A., Schoenfelder, S., Tannahill, D., et al. (2024) · Genome biology · doi:10.1186/s13059-024-03377-6 · Cited by 11

Natural compounds from Juncus plants interacting with telomeric and oncogene G-quadruplex structures as potential anticancer agents

Platella, C., Capasso, D., Riccardi, C., Musumeci, D., DellaGreca, M., & Montesarchio, D. (2021) · Organic & Biomolecular Chemistry · doi:10.1039/d1ob01995c · Cited by 12

New telomere to telomere assembly of human chromosome 8 reveals a previous underestimation of G-quadruplex forming sequences and inverted repeats.

Brázda, V., Bohálová, N., & Bowater, R. (2021) · Gene · doi:10.1016/j.gene.2021.146058 · Cited by 12

Nonselective Intercalation of G-Quadruplex-Targeting Ligands into Double-Stranded DNA Quantified by Single-Molecule Stretching

Liu, T., Wu, Y., Qin, L., Luo, Q., Li, W., Cheng, Y., Tu, Y., & You, H. (2023) · The Journal of Physical Chemistry B · doi:10.1021/acs.jpcb.3c03031 · Cited by 12

Recent advances in supramolecular self‐assembly and biological applications of luminescent alkynylplatinum( II ) polypyridine complexes

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Prediction of strand-specific and cell-type-specific G-quadruplexes based on high-resolution CUT&Tag data

Cui, Y., Liu, H., Ming, Y., Zhang, Z., Liu, L., & Liu, R. (2023) · Briefings in Functional Genomics · doi:10.1093/bfgp/elad024 · Cited by 10

A non-B DNA binding peptidomimetic channel alters cellular functions

Paul, R., Dutta, D., Mukhopadhyay, T. K., Müller, D., Lala, B., Datta, A., Schwalbe, H., & Dash, J. (2024) · Nature Communications · doi:10.1038/s41467-024-49534-0 · Cited by 10

CUT&Tag reveals unconventional G-quadruplex landscape in Mycobacterium tuberculosis in response to oxidative stress

Maurizio, I., Ruggiero, E., Zanin, I., Conflitti, M., Nicoletto, G., Provvedi, R., & Richter, S. N. (2025) · Nature Communications · doi:10.1038/s41467-025-62485-4 · Cited by 10

Identification and functional characterization of G-quadruplexes in plants

Ma, X., Feng, Y., Luo, Z., & Zhang, W. (2022) · Trends in Plant Science · doi:10.1016/j.tplants.2022.03.015 · Cited by 10

G-quadruplex DNA structures mediate non-autonomous instruction of breast tumour microenvironmentsPreprint

Hunold, P., Hoehne, M. N., Kiljan, M., van Ray, O., Herter, J., Herter-Sprie, G., & Hänsel-Hertsch, R. (2023) · bioRxiv · doi:10.1101/2023.01.16.524243 · Cited by 1

G-quadruplexes: a promising target for cancer therapy

Kosiol, N., Juranek, S., Brossart, P., Heine, A., & Paeschke, K. (2021) · Molecular Cancer · doi:10.1186/s12943-021-01328-4 · Cited by 561

DNA G-quadruplex structures in human cancer cells

Hui, W. I. (2022) · Apollo (University of Cambridge) · doi:10.17863/cam.90676

G-quadruplex structures are key modulators of somatic structural variants in cancers

Zhang, R. (2023) · Data Archiving and Networked Services (DANS) · doi:10.17632/t3hds48yz9

The Relevance of G-Quadruplexes in Gene Promoters and the First Introns Associated with Transcriptional Regulation in Breast Cancer

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