The DOI matches its Crossref record; 211 of the 211 references it cites were found in a registry or an index.
The NK cell–cancer cycle: advances and new challenges in NK cell–based immunotherapies
Open accessAbstract
Natural killer (NK) cells belong to the innate immune system and contribute to protecting the host through killing of infected, foreign, stressed or transformed cells. Additionally, via cellular cross-talk, NK cells orchestrate antitumor immune responses. Hence, significant efforts have been undertaken to exploit the therapeutic properties of NK cells in cancer. Current strategies in preclinical and clinical development include adoptive transfer therapies, direct stimulation, recruitment of NK cells into the tumor microenvironment (TME), blockade of inhibitory receptors that limit NK cell functions, and therapeutic modulation of the TME to enhance antitumor NK cell function. In this Review, we introduce the NK cell–cancer cycle to highlight recent advances in NK cell biology and to discuss the progress and problems of NK cell–based cancer immunotherapies. In this Review, Smyth and colleagues provide an overview of recent advances in NK cell biology and discuss the progress and problems of NK cell–based cancer immunotherapies.
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1 retracted
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Turning cold tumors hot: from molecular mechanisms to clinical applications
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CAR-T and CAR-NK as cellular cancer immunotherapy for solid tumors
Peng, L., Sferruzza, G., Yang, L., Zhou, L., & Chen, S. (2024) · Cellular & Molecular Immunology · doi:10.1038/s41423-024-01207-0 · Cited by 373
Immunobiology and immunotherapy of HCC: spotlight on innate and innate-like immune cells
Ruf, B., Heinrich, B., & Greten, T. F. (2021) · Cellular & Molecular Immunology · doi:10.1038/s41423-020-00572-w · Cited by 312
Natural killer cell homing and trafficking in tissues and tumors: from biology to application
Ran, G. H., Lin, Y. Q., Tian, L., Zhang, T., Yan, D. M., Yu, J. H., & Deng, Y. C. (2022) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-022-01058-z · Cited by 282
Metadata
- Authors
- Bald, T., Krummel, M. F., Smyth, M. J., & Barry, K. C.
- Venue
- Nature Immunology
- Published
- 2020-07-20
- Volume
- 21
- Issue
- 8
- Pages
- 835-847
- ISSN
- 1529-2908 (ISSN-L)
- 1529-2916
- OpenAlex
- W3043781639
- Cited by
- 506
- References
- 211
- FWCI
- 17.05
- Type
- journal article
- Language
- en
- Open access
- green
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