Neuropilin-1 is a T cell memory checkpoint limiting long-term antitumor immunity
Open accessAbstract
Robust CD8+ T cell memory is essential for long-term protective immunity but is often compromised in cancer, where T cell exhaustion leads to loss of memory precursors. Immunotherapy via checkpoint blockade may not effectively reverse this defect, potentially underlying disease relapse. Here we report that mice with a CD8+ T cell-restricted neuropilin-1 (NRP1) deletion exhibited substantially enhanced protection from tumor rechallenge and sensitivity to anti-PD1 immunotherapy, despite unchanged primary tumor growth. Mechanistically, NRP1 cell-intrinsically limited the self-renewal of the CD44+PD1+TCF1+TIM3- progenitor exhausted T cells, which was associated with their reduced ability to induce c-Jun/AP-1 expression on T cell receptor restimulation, a mechanism that may contribute to terminal T cell exhaustion at the cost of memory differentiation in wild-type tumor-bearing hosts. These data indicate that blockade of NRP1, a unique 'immune memory checkpoint', may promote the development of long-lived tumor-specific T mem that are essential for durable antitumor immunity.
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The C-terminal motif of the cleaved S1 subunit can bind to neuropillin-1 (NRP-1), which negatively influences T cell memory.
“Interestingly, the C-terminal motif of the cleaved S1 subunit can bind to neuropillin-1 (NRP-1),67,68 which negatively influences T cell memory.69”
From COVID-19 mRNA vaccines: Platforms and current developments (2022) · cites this paper as [69]
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Subramanian, A., Tamayo, P., Mootha, V. K., Mukherjee, S., Ebert, B. L., Gillette, M. A., Paulovich, A., Pomeroy, S. L., Golub, T. R., Lander, E. S., et al. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0506580102 · Cited by 53,625 · see citing works
limma powers differential expression analyses for RNA-sequencing and microarray studies
Ritchie, M. E., Phipson, B., Wu, D., Hu, Y., Law, C. W., Shi, W., & Smyth, G. K. (2015) · Nucleic Acids Research · doi:10.1093/nar/gkv007 · Cited by 40,458 · see citing works
PD-1 and PD-L1 Immune Checkpoint Blockade to Treat Breast Cancer
Hartkopf, A. D., Taran, F., Wallwiener, M., Walter, C. B., Krämer, B., Grischke, E., & Brucker, S. Y. (2016) · Breast Care · doi:10.1159/000453569 · Cited by 30,989 · see citing works
Safety, activity, and immune correlates of anti–PD-1 antibody in cancer
Topalian, S. L., Hodi, F. S., Brahmer, J. R., Gettinger, S. N., Smith, D. C., McDermott, D. F., Powderly, J. D., Carvajal, R. D., Sosman, J. A., Atkins, M. B., et al. (2012) · New England Journal of Medicine · doi:10.1056/nejmoa1200690 · Cited by 12,628 · see citing works
Smyth, G. K. (2004) · Statistical Applications in Genetics and Molecular Biology · doi:10.2202/1544-6115.1027 · Cited by 11,829 · see citing works
Mootha, V. K., Lindgren, C. M., Eriksson, K.-F., Subramanian, A., Sihag, S., Lehar, J., Puigserver, P., Carlsson, E., Ridderstråle, M., Laurila, E., et al. (2003) · Nature Genetics · doi:10.1038/ng1180 · Cited by 10,197 · see citing works
voom: precision weights unlock linear model analysis tools for RNA-seq read counts
Law, C. W., Chen, Y., Shi, W., & Smyth, G. K. (2014) · Genome Biology · doi:10.1186/gb-2014-15-2-r29 · Cited by 6,155 · see citing works
Molecular and cellular insights into T cell exhaustion
Wherry, E. J., & Kurachi, M. (2015) · Nature Reviews Immunology · doi:10.1038/nri3862 · Cited by 4,652 · see citing works
Self-citationCre reporter strains produced by targeted insertion of EYFP and ECFP into the ROSA26 locus
Srinivas, S., Watanabe, T., Lin, C.-S., William, C. M., Tanabe, Y., Jessell, T. M., & Costantini, F. (2001) · BMC Developmental Biology · doi:10.1186/1471-213x-1-4 · Cited by 3,121 · see citing works
Smart-seq2 for sensitive full-length transcriptome profiling in single cells
Picelli, S., Björklund, Å. K., Faridani, O. R., Sagasser, S., Winberg, G., & Sandberg, R. (2013) · Nature Methods · doi:10.1038/nmeth.2639 · Cited by 2,358 · see citing works
Miller, B. C., Sen, D. R., Al Abosy, R., Bi, K., Virkud, Y. V., LaFleur, M. W., Yates, K. B., Lako, A., Felt, K., Naik, G. S., et al. (2019) · Nature Immunology · doi:10.1038/s41590-019-0312-6 · Cited by 2,087 · see citing works
Defining CD8+ T cells that provide the proliferative burst after PD-1 therapy
Im, S. J., Hashimoto, M., Gerner, M. Y., Lee, J., Kissick, H. T., Burger, M. C., Shan, Q., Hale, J. S., Lee, J., Nasti, T. H., et al. (2016) · Nature · doi:10.1038/nature19330 · Cited by 2,070 · see citing works
Siddiqui, I., Schaeuble, K., Chennupati, V., Fuertes Marraco, S. A., Calderon-Copete, S., Pais Ferreira, D., Carmona, S. J., Scarpellino, L., Gfeller, D., Pradervand, S., et al. (2019) · Immunity · doi:10.1016/j.immuni.2018.12.021 · Cited by 1,679 · see citing works
Epigenetic stability of exhausted T cells limits durability of reinvigoration by PD-1 blockade
Pauken, K. E., Sammons, M. A., Odorizzi, P. M., Manne, S., Godec, J., Khan, O., Drake, A. M., Chen, Z., Sen, D. R., Kurachi, M., et al. (2016) · Science · doi:10.1126/science.aaf2807 · Cited by 1,348 · see citing works
Self-citationKaech, S. M., & Ahmed, R. (2001) · Nature Immunology · doi:10.1038/87720 · Cited by 1,277 · see citing works
The future of cancer treatment: immunomodulation, CARs and combination immunotherapy
Khalil, D. N., Smith, E. L., Brentjens, R. J., & Wolchok, J. D. (2016) · Nature Reviews Clinical Oncology · doi:10.1038/nrclinonc.2016.25 · Cited by 1,151 · see citing works
Molecular and functional profiling of memory CD8 T cell differentiation.
Kaech, S., Hemby, S., Kersh, E., & Ahmed, R. (2002) · Cell · doi:10.1016/s0092-8674(02)01139-x · Cited by 1,081 · see citing works
Utzschneider, D. T., Charmoy, M., Chennupati, V., Pousse, L., Ferreira, D., Calderon-Copete, S. P., Danilo, M., Alfei, F., Hofmann, M., Wieland, D., et al. (2016) · Immunity · doi:10.1016/j.immuni.2016.07.021 · Cited by 1,026 · see citing works
The epigenetic landscape of T cell exhaustion
Sen, D. R., Kaminski, J., Barnitz, R. A., Kurachi, M., Gerdemann, U., Yates, K. B., Tsao, H.-W., Godec, J., LaFleur, M. W., Brown, F. D., et al. (2016) · Science · doi:10.1126/science.aae0491 · Cited by 986 · see citing works
Overwijk, W. W., Theoret, M. R., Finkelstein, S. E., Surman, D. R., de Jong, L. A., Vyth‐Dreese, F. A., Dellemijn, T. A. M., Antony, P. A., Spiess, P. J., Palmer, D. C., et al. (2003) · The Journal of Experimental Medicine · doi:10.1084/jem.20030590 · Cited by 927 · see citing works
JNK is involved in signal integration during costimulation of T lymphocytes
Su, B., Jacinto, E., Hibi, M., Kallunki, T., Karin, M., & Ben‐Neriah, Y. (1994) · Cell · doi:10.1016/0092-8674(94)90056-6 · Cited by 907 · see citing works
c-Jun overexpression in CAR T cells induces exhaustion resistance
Lynn, R. C., Weber, E. W., Sotillo, E., Gennert, D., Xu, P., Good, Z., Anbunathan, H., Lattin, J., Jones, R., Tieu, V., et al. (2019) · Nature · doi:10.1038/s41586-019-1805-z · Cited by 891 · see citing works
The Transcription Factor NFAT Promotes Exhaustion of Activated CD8 + T Cells
Martinez, G. J., Pereira, R. M., Äijö, T., Kim, E. Y., Marangoni, F., Pipkin, M. E., Togher, S., Heissmeyer, V., Zhang, Y. C., Crotty, S., et al. (2015) · Immunity · doi:10.1016/j.immuni.2015.01.006 · Cited by 857 · see citing works
A requirement for neuropilin-1 in embryonic vessel formation
Kawasaki, T., Kitsukawa, T., Bekku, Y., Matsuda, Y., Sanbo, M., Yagi, T., & Fujisawa, H. (1999) · Development · doi:10.1242/dev.126.21.4895 · Cited by 828 · see citing works
Neuropilin-1 conveys semaphorin and VEGF signaling during neural and cardiovascular development.
Gu, C.-H., Rodríguez, E., Reimert, D. V., Shu, T., Fritzsch, B., Richards, L. J., Kolodkin, A., & Ginty, D. (2003) · Developmental Cell · doi:10.1016/s1534-5807(03)00169-2 · Cited by 756 · see citing works
An intra-tumoral niche maintains and differentiates stem-like CD8 T cells
Jansen, C. S., Prokhnevska, N., Master, V., Sanda, M., Carlisle, J., Bilen, M., Cardenas, M., Wilkinson, S., Lake, R., Sowalsky, A., et al. (2019) · Nature · doi:10.1038/s41586-019-1836-5 · Cited by 724 · see citing works
Kitsukawa, T., Shimizu, M., Sanbo, M., Hirata, T., Taniguchi, M., Bekku, Y., Yagi, T., & Fujisawa, H. (1997) · Neuron · doi:10.1016/s0896-6273(00)80392-x · Cited by 709 · see citing works
Fares, C. M., Allen, E. M. V., Drake, C. G., Allison, J. P., & Hu‐Lieskovan, S. (2019) · American Society of Clinical Oncology Educational Book · doi:10.1200/edbk_240837 · Cited by 648 · see citing works
Interferon-γ Drives Treg Fragility to Promote Anti-tumor Immunity
Overacre-Delgoffe, A. E., Chikina, M., Dadey, R. E., Yano, H., Brunazzi, E. A., Shayan, G., Horne, W., Moskovitz, J. M., Kolls, J. K., Sander, C., et al. (2017) · Cell · doi:10.1016/j.cell.2017.05.005 · Cited by 627 · see citing works
Self-citationThe TCF1-Bcl6 axis counteracts type I interferon to repress exhaustion and maintain T cell stemness
Wu, T., Ji, Y., Moseman, E. A., Xu, H. C., Manglani, M., Kirby, M., Anderson, S. M., Handon, R., Kenyon, E., Elkahloun, A. G., et al. (2016) · Science Immunology · doi:10.1126/sciimmunol.aai8593 · Cited by 614 · see citing works
Stability and function of regulatory T cells is maintained by a neuropilin-1–semaphorin-4a axis
Delgoffe, G. M., Woo, S.-R., Turnis, M. E., Gravano, D. M., Guy, C., Overacre, A. E., Bettini, M. L., Vogel, P., Finkelstein, D., Bonnevier, J., et al. (2013) · Nature · doi:10.1038/nature12428 · Cited by 587 · see citing works
Self-citationDoering, T. A., Crawford, A., Angelosanto, J., Paley, M., Ziegler, C. G. K., & Wherry, E. J. (2012) · Immunity · doi:10.1016/j.immuni.2012.08.021 · Cited by 542 · see citing works
Antigen-independent memory CD8 T cells do not develop during chronic viral infection
Wherry, E. J., Barber, D. L., Kaech, S. M., Blattman, J. N., & Ahmed, R. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0407192101 · Cited by 495 · see citing works
Man, K., Gabriel, S. S., Liao, Y., Gloury, R., Preston, S., Henstridge, D. C., Pellegrini, M., Zehn, D., Berberich‐Siebelt, F., Febbraio, M. A., et al. (2017) · Immunity · doi:10.1016/j.immuni.2017.11.021 · Cited by 489 · see citing works
Frontline: Neuropilin‐1: a surface marker of regulatory T cells
Bruder, D., Probst-Kepper, M., Westendorf, A., Geffers, R., Beissert, S., Loser, K., von Boehmer, H., Buer, J., & Hansen, W. (2004) · European Journal of Immunology · doi:10.1002/eji.200324799 · Cited by 475 · see citing works
CXCR5+ follicular cytotoxic T cells control viral infection in B cell follicles
Leong, Y. A., Chen, Y., Hong, S. L., Wu, D., Man, K., Deleage, C., Minnich, M., Meckiff, B. J., Wei, Y.-B., Hou, Z.-H., et al. (2016) · Nature Immunology · doi:10.1038/ni.3543 · Cited by 449 · see citing works
Yang, C. Y., Best, J. A., Knell, J., Yang, E., Sheridan, A. D., Jesionek, A. K., Li, H. S., Rivera, R. R., Lind, K. C., D’Cruz, L. M., et al. (2011) · Nature Immunology · doi:10.1038/ni.2158 · Cited by 411 · see citing works
Maekawa, Y., Minato, Y., Ishifune, C., Kurihara, T., Kitamura, A., Kojima, H., Yagita∥, H., Sakata‐Yanagimoto, M., Saito, T., Taniuchi, I., et al. (2008) · Nature Immunology · doi:10.1038/ni.1649 · Cited by 269 · see citing works
Multifaceted Role of Neuropilins in the Immune System: Potential Targets for Immunotherapy
Roy, S., Bag, A. K., Singh, R. K., Talmadge, J. E., Batra, S. K., & Datta, K. (2017) · Frontiers in Immunology · doi:10.3389/fimmu.2017.01228 · Cited by 237 · see citing works
Jadhav, R., Im, S., Hu, B., Hashimoto, M., Li, P., Lin, J., Leonard, W., Greenleaf, W., Ahmed, R., & Goronzy, J. (2019) · Proceedings of the National Academy of Sciences of the United States of America · doi:10.1073/pnas.1903520116 · Cited by 203 · see citing works
Repression of the DNA-binding inhibitor Id3 by Blimp-1 limits the formation of memory CD8+ T cells
Ji, Y., Pós, Z., Rao, M., Klebanoff, C. A., Yu, Z., Sukumar, M., Reger, R. N., Palmer, D. C., Borman, Z. A., Muranski, P. J., et al. (2011) · Nature Immunology · doi:10.1038/ni.2153 · Cited by 201 · see citing works
The function and dysfunction of memory CD 8+ T cells in tumor immunity
Reading, J. L., Gálvez‐Cancino, F., Swanton, C., Lladser, Á., Peggs, K. S., & Quezada, S. A. (2018) · Immunological Reviews · doi:10.1111/imr.12657 · Cited by 182 · see citing works
Smart-seq2 for sensitive full-length transcriptome profiling in single cells
Picelli, S., Björklund, Å. K., Faridani, O. R., Sagasser, S., Winberg, G., & Sandberg, R. (2013) · F1000Research · doi:10.7490/f1000research.1094785.1 · Cited by 173 · see citing works
Regulation of antitumour CD8 T-cell immunity and checkpoint blockade immunotherapy by Neuropilin-1
Leclerc, M., Voilin, E., Gros, G., Corgnac, S., de Montpréville, V., Validire, P., Bismuth, G., & Mami‐Chouaib, F. (2019) · Nature Communications · doi:10.1038/s41467-019-11280-z · Cited by 153 · see citing works
Battaglia, A., Buzzonetti, A., Monego, G., Peri, L., Ferrandina, G., Fanfani, F., Scambia, G., & Fattorossi, A. (2008) · Immunology · doi:10.1111/j.1365-2567.2007.02737.x · Cited by 112 · see citing works
CD8 T-Cell Memory Differentiation during Acute and Chronic Viral Infections
Kalia, V., Sarkar, S., & Ahmed, R. (2010) · Advances in experimental medicine and biology · doi:10.1007/978-1-4419-6451-9_7 · Cited by 85 · see citing works
Battaglia, A., Buzzonetti, A., Baranello, C., Ferrandina, G., Martinelli, E., Fanfani, F., Scambia, G., & Fattorossi, A. (2009) · Cancer Immunology and Immunotherapy · doi:10.1007/s00262-008-0646-7 · Cited by 83 · see citing works
Induction of Postsurgical Tumor Immunity and T-Cell Memory by a Poorly Immunogenic Tumor
Zhang, P., Côté, A. L., de Vries, V. C., Usherwood, E. J., & Turk, M. J. (2007) · Cancer Research · doi:10.1158/0008-5472.can-07-1264 · Cited by 80 · see citing works
Wang, Y.-F., Hu, J., Li, Y.-D., Xiao, M., Wang, H.-Q., Tian, Q., Li, Z.-R., Tang, J.-F., Hu, L., Tan, Y., et al. (2019) · Frontiers in Immunology · doi:10.3389/fimmu.2019.00169 · Cited by 79 · see citing works
Byrne, K. T., Côté, A. L., Zhang, P., Steinberg, S. M., Guo, Y., Allie, R., Zhang, W., Ernstoff, M. S., Usherwood, E. J., & Turk, M. J. (2011) · Journal of Clinical Investigation · doi:10.1172/jci44849 · Cited by 77 · see citing works
Gullicksrud, J. A., Li, F.-Y., Xing, S.-J., Zeng, Z., Peng, W.-Q., Badovinac, V., Harty, J., & Xue, H.-H. (2017) · Journal of Immunology · doi:10.4049/jimmunol.1700595 · Cited by 65 · see citing works
Ito, D., Nojima, S., Nishide, M., Okuno, T., Takamatsu, H., Kang, S., Kimura, T., Yoshida, Y., Morimoto, K., Maeda, Y., et al. (2015) · The Journal of Immunology · doi:10.4049/jimmunol.1403038 · Cited by 53 · see citing works
Local Induction of Immunosuppressive CD8+ T Cells in the Gut-Associated Lymphoid Tissues
Fleissner, D., Hansen, W., Geffers, R., Buer, J., & Westendorf, A. (2010) · PLoS ONE · doi:10.1371/journal.pone.0015373 · Cited by 30 · see citing works
Immunological consequences of tumor excision: From active immunity to immunological memory
Bursuker, I., & North, R. J. (1986) · International Journal of Cancer · doi:10.1002/ijc.2910370216 · Cited by 22 · see citing works
Jackson, S. R., Berrien-Elliott, M., Yuan, J.-Y., Hsueh, E., & Teague, R. (2014) · PLoS ONE · doi:10.1371/journal.pone.0110707 · Cited by 20 · see citing works
Self-reactivity as the necessary cost of maintaining a diverse memory T-cell repertoire
Singh, N. J. (2016) · Pathogens and Disease · doi:10.1093/femspd/ftw092 · Cited by 11 · see citing works
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Scharping, N. E., Rivadeneira, D. B., Menk, A. V., Vignali, P. D. A., Ford, B. R., Rittenhouse, N. L., Peralta, R., Wang, Y., Wang, Y., DePeaux, K., et al. (2021) · Nature Immunology · doi:10.1038/s41590-020-00834-9 · Cited by 897 · see citing works
IL-2 regulates tumor-reactive CD8+ T cell exhaustion by activating the aryl hydrocarbon receptor
Liu, Y., Zhou, N., Zhou, L., Wang, J., Zhou, Y., Zhang, T., Fang, Y., Deng, J., Gao, Y., Liang, X., et al. (2021) · Nature Immunology · doi:10.1038/s41590-020-00850-9 · Cited by 372 · see citing works
COVID-19 mRNA vaccines: Platforms and current developments
Szabó, G. T., Mahiny, A. J., & Vlatkovic, I. (2022) · Molecular Therapy · doi:10.1016/j.ymthe.2022.02.016 · Cited by 308 · see citing works
Stem-like exhausted and memory CD8+ T cells in cancer
Gebhardt, T., Park, S. L., & Parish, I. A. (2023) · Nature reviews. Cancer · doi:10.1038/s41568-023-00615-0 · Cited by 216 · see citing works
Neuropilin-1: a checkpoint target with unique implications for cancer immunology and immunotherapy
Chuckran, C. A., Liu, C., Bruno, T. C., Workman, C. J., & Vignali, D. A. (2020) · Journal for ImmunoTherapy of Cancer · doi:10.1136/jitc-2020-000967 · Cited by 147 · see citing works
Self-citationHirai, T., Yang, Y., Zenke, Y., Li, H., Chaudhri, V. K., Diaz, J. S. D. L. C., Zhou, P. Y., Nguyen, B. A., Bartholin, L., Workman, C. J., et al. (2020) · Immunity · doi:10.1016/j.immuni.2020.10.022 · Cited by 120 · see citing works
Self-citationLi, H., Wang, M., Huang, B., Zhu, S., Zhou, J., Chen, D., Cui, R., Zhang, M., & Sun, Z. (2021) · Nature Communications · doi:10.1038/s41467-021-27485-0 · Cited by 113 · see citing works
Feng, Y., Ma, W., Zang, Y., Guo, Y., Li, Y., Zhang, Y., Dong, X., Liu, Y., Zhan, X., Pan, Z., et al. (2024) · Nature Communications · doi:10.1038/s41467-024-54710-3 · Cited by 116 · see citing works
Choi, J., Sun, I., Hwang, H. S., Yoon, H. Y., & Kim, K. (2022) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2022.114344 · Cited by 98 · see citing works
The GPCR–Gαs–PKA signaling axis promotes T cell dysfunction and cancer immunotherapy failure
Wu, V. H., Yung, B. S., Faraji, F., Saddawi‐Konefka, R., Wang, Z., Wenzel, A. T., Song, M., Pagadala, M. S., Clubb, L. M., Chiou, J., et al. (2023) · Nature Immunology · doi:10.1038/s41590-023-01529-7 · Cited by 98 · see citing works
Self-citationResident memory T cells form during persistent antigen exposure leading to allograft rejection
Abou‐Daya, K. I., Tieu, R., Zhao, D., Rammal, R., Sacirbegovic, F., Williams, A. L., Shlomchik, W. D., Oberbarnscheidt, M. H., & Lakkis, F. G. (2021) · Science Immunology · doi:10.1126/sciimmunol.abc8122 · Cited by 92 · see citing works
Neuropilin-1 mediates lung tissue-specific control of ILC2 function in type 2 immunity
Zhang, J., Qiu, J., Zhou, W., Cao, J., Hu, X., Mi, W., Su, B., He, B., Qiu, J., & Shen, L. (2022) · Nature Immunology · doi:10.1038/s41590-021-01097-8 · Cited by 82 · see citing works
Hu, Y., Hudson, W. H., Kissick, H. T., Medina, C. B., Baptista, A. P., Ma, C., Liao, W., Germain, R. N., Turley, S. J., Zhang, N., et al. (2022) · The Journal of Experimental Medicine · doi:10.1084/jem.20211574 · Cited by 81 · see citing works
Targeted Anti‐Tumor Immunotherapy Using Tumor Infiltrating Cells
Xie, Y., Xie, F., Zhang, L., Zhou, X., Huang, J., Wang, F., Jin, J., Zhang, L., Zeng, L., & Zhou, F. (2021) · Advanced Science · doi:10.1002/advs.202101672 · Cited by 71 · see citing works
Lutz, V., Hellmund, V. M., Picard, F. S. R., Raifer, H., Ruckenbrod, T., Klein, M., Bopp, T., Savai, R., Duewell, P., Keber, C. U., et al. (2023) · Cancer Immunology Research · doi:10.1158/2326-6066.cir-22-0398 · Cited by 70 · see citing works
IFNγ-induction of TH1-like regulatory T cells controls antiviral responses
Gocher, A. M., Cui, J., Szymczak-Workman, A. L., Vignali, K. M., Latini, J., Pieklo, G. P., Kimball, J. C., Avery, L., Cipolla, E., Huckestein, B. R., et al. (2023) · Nature Immunology · doi:10.1038/s41590-023-01453-w · Cited by 70 · see citing works
Self-citationMechanisms of CD8+ T cell exclusion and dysfunction in cancer resistance to anti-PD-(L)1.
Mortaezaee, K., & Majidpoor, J. (2023) · Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie · doi:10.1016/j.biopha.2023.114824 · Cited by 65 · see citing works
Cellular landscape of tumour microenvironment in prostate cancer
Feng, D., Xiong, Q., Wei, Q., & Yang, L. (2022) · Immunology · doi:10.1111/imm.13456 · Cited by 61 · see citing works
Antigen-driven EGR2 expression is required for exhausted CD8+ T cell stability and maintenance
Wagle, M. V., Vervoort, S. J., Kelly, M. J., Byl, W. V. D., Peters, T. J., Martin, B. P., Martelotto, L. G., Nüssing, S., Ramsbottom, K. M., Torpy, J., et al. (2021) · Nature Communications · doi:10.1038/s41467-021-23044-9 · Cited by 59 · see citing works
NRP1 promotes prostate cancer progression via modulating EGFR-dependent AKT pathway activation
Zhang, P., Chen, L., Zhou, F., He, Z., Wang, G., & Luo, Y. (2023) · Cell Death and Disease · doi:10.1038/s41419-023-05696-1 · Cited by 59 · see citing works
Strategies to reinvigorate exhausted CD8+ T cells in tumor microenvironment
Guan, Q., Han, M., Guo, Q., Yan, F., Wang, M., Ning, Q., & Xi, D. (2023) · Frontiers in Immunology · doi:10.3389/fimmu.2023.1204363 · Cited by 54 · see citing works
Targeting neuropilin-1 interactions is a promising anti-tumor strategy
Liu, S., Zhong, L.-P., He, J., & Zhao, Y.-X. (2020) · Chinese Medical Journal · doi:10.1097/cm9.0000000000001200 · Cited by 43 · see citing works
Role of Neuropilin 1 in COVID-19 Patients with Acute Ischemic Stroke
Al-Thomali, A. W., Al-Kuraishy, H. M., Al-Gareeb, A. I., Albuhadily, A. K., WAARD, M. M. D., Sabatier, J., Khalil, A. A. K., Saad, . M., & Batiha, G. E. (2022) · Biomedicines · doi:10.3390/biomedicines10082032 · Cited by 49 · see citing works
Engaging stemness improves cancer immunotherapy
Dianat‐Moghadam, H., Sharifi, M., Salehi, R., Keshavarz, M., Shahgolzari, M., & Amoozgar, Z. (2022) · Cancer Letters · doi:10.1016/j.canlet.2022.216007 · Cited by 45 · see citing works
Diselenide‐Based Dual‐Responsive Prodrug as Pyroptosis Inducer Potentiates Cancer Immunotherapy
Wan, S., Ye, M., Yang, Q., Zhang, T., Zhang, M., Ma, X., Xu, J., Wang, S., Wu, Z., Yang, L., et al. (2022) · Advanced Healthcare Materials · doi:10.1002/adhm.202202135 · Cited by 45 · see citing works
A widespread viral entry mechanism: The C-end Rule motif–neuropilin receptor interaction
Balistreri, G., Yamauchi, Y., & Teesalu, T. (2021) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2112457118 · Cited by 42 · see citing works
Chuckran, C. A., Cillo, A., Moskovitz, J., Overacre-Delgoffe, A., Somasundaram, A. S., Shan, F., Magnon, G., Kunning, S., Abécassis, I., Zureikat, A., et al. (2021) · Science Translational Medicine · doi:10.1126/scitranslmed.abf8495 · Cited by 37 · see citing works
Self-citationTargeting Neuropilin-1 with Nanobodies Reduces Colorectal Carcinoma Development
Vlaeminck, Y. D., Bonelli, S., Awad, R. M., Dewilde, M., Rizzolio, S., Lecocq, Q., Bolli, E., Santos, A. R., Laoui, D., Schoonooghe, S., et al. (2020) · Cancers · doi:10.3390/cancers12123582 · Cited by 37 · see citing works
Targeting metabotropic glutamate receptor 4 for cancer immunotherapy
Wan, Z., Sun, R., Liu, Y., Li, S., Sun, J., Li, J., Zhu, J., Moharil, P., Zhang, B., Ren, P., et al. (2021) · Science Advances · doi:10.1126/sciadv.abj4226 · Cited by 35 · see citing works
Zou, C., Xu, F., Shen, J., & Xu, S. (2022) · Journal of Oncology · doi:10.1155/2022/3997562 · Cited by 35 · see citing works
Barnkob, M. B., Michaels, Y. S., André, V., Macklin, P. S., Gileadi, U., Valvo, S., Rei, M., Kulicke, C. A., Chen, J., Jain, V., et al. (2024) · Nature Communications · doi:10.1038/s41467-024-47424-z · Cited by 34 · see citing works
Gui, Z., Ye, Y.-Q., Li, Y., Ren, Z., Wei, N., Liu, L., Wang, H., & Zhang, M. (2024) · Translational Oncology · doi:10.1016/j.tranon.2024.102001 · Cited by 34 · see citing works
Zhang, X.-L., Wu, D., Tian, Y., Chen, X.-D., Lan, J., Wei, F.-L., Li, Y., Luo, Y., & Sun, X.-B. (2022) · Pharmaceutical Biology · doi:10.1080/13880209.2022.2142615 · Cited by 31 · see citing works
Chakravarti, M., Dhar, S., Bera, S., Sinha, A., Roy, K., Sarkar, A., Dasgupta, S., Bhuniya, A., Saha, A., Das, J., et al. (2023) · Cancer Research · doi:10.1158/0008-5472.can-22-3864 · Cited by 29 · see citing works
Knockdown of integrin β1 inhibits proliferation and promotes apoptosis in bladder cancer cells
Wang, J., Wang, J., Liu, Y., Ji, B., Ding, B., Wang, Y., & Ren, M.-H. (2024) · BioFactors · doi:10.1002/biof.2150 · Cited by 28 · see citing works
Dong, Y., Hao, L., Shi, Z.-J., Fang, K., Yu, H., Zang, G.-H., Fan, T., & Han, C.-H. (2022) · Journal of Oncology · doi:10.1155/2022/7261486 · Cited by 28 · see citing works
Neuropilin (NRPs) Related Pathological Conditions and Their Modulators
Broz, M., Kolarič, A., Jukič, M., & Bren, U. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23158402 · Cited by 27 · see citing works
Stem-like CD8+ T cells in cancer
Steiner, C., Denlinger, N., Huang, X.-P., & Yang, Y.-P. (2024) · Frontiers in Immunology · doi:10.3389/fimmu.2024.1426418 · Cited by 26 · see citing works
Potential mechanisms of cancer stem‐like progenitor T‐cell bio‐behaviours
Ni, L. (2024) · Clinical and Translational Medicine · doi:10.1002/ctm2.1817 · Cited by 26 · see citing works
Li, X., Chen, T., Li, X., Zhang, H., Li, Y., Zhang, S., Luo, S., & Zheng, T. (2024) · Experimental Hematology and Oncology · doi:10.1186/s40164-024-00564-w · Cited by 27 · see citing works
Neuropilin-1, a myeloid cell-specific protein, is an inhibitor of HIV-1 infectivity
Wang, S., Zhao, L., Zhang, X., Zhang, J., Shang, H., & Liang, G. (2022) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2114884119 · Cited by 25 · see citing works
Role of semaphorins, neuropilins and plexins in cancer progression
Fernández‐Nogueira, P., Linzoain-Agos, P., Cueto‐Remacha, M., la Guia-Lopez, I. D., Recalde‐Percaz, L., Parcerisas, A., Gascón, P., Carbó, N., Gutiérrez-Uzquiza, Á., Fuster, G., et al. (2024) · Cancer Letters · doi:10.1016/j.canlet.2024.217308 · Cited by 24 · see citing works
Neuropilin-1: A Multifaceted Target for Cancer Therapy
Varanasi, S. M., Gulani, Y., Rachamala, H. K., Mukhopadhyay, D., & Angom, R. S. (2025) · Current Oncology · doi:10.3390/curroncol32040203 · Cited by 25 · see citing works
Chen, C., Ma, J., Pi, C., Huang, W., Zhang, T., Fu, C., Liu, W., & Yang, Y. (2023) · Cell Discovery · doi:10.1038/s41421-023-00568-6 · Cited by 22 · see citing works
Stimuli-Responsive Polymeric Nanomedicine for Enhanced Cancer Immunotherapy
Kim, C. H., Lee, E. S., Ko, H., Son, S., Kim, S. H., Lee, C. H., Na, H., Shin, J. M., & Park, J. H. (2024) · Chemistry of Materials · doi:10.1021/acs.chemmater.3c02472 · Cited by 22 · see citing works
Jun, an Oncological Foe or Friend?
Jafri, Z., Li, Y., Zhang, J., O’Meara, C. H., & Khachigian, L. M. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms26020555 · Cited by 21 · see citing works
NRP1 instructs IL-17-producing ILC3s to drive colitis progression
Wang, Y., Wang, J., Liu, G., Yi, X., Wu, J., Cao, H., Zhang, L., Zhou, P., Fan, Y., Yu, Y., et al. (2025) · Cellular and Molecular Immunology · doi:10.1038/s41423-024-01246-7 · Cited by 22 · see citing works
Sun, H., Li, Y., Zhang, Y., Zhao, X., Dong, X., Guo, Y., Mo, J., Che, N., Ban, X., Li, F., et al. (2023) · Frontiers in Immunology · doi:10.3389/fimmu.2022.1042835 · Cited by 19 · see citing works
Heidari‐Foroozan, M., Rezalotfi, A., & Rezaei, N. (2024) · International Reviews of Immunology · doi:10.1080/08830185.2024.2401352 · Cited by 18 · see citing works
Deng, C., Guo, H., Yan, D., Liang, T., Ye, X., & Li, Z. (2021) · BioMed Research International · doi:10.1155/2021/5546612 · Cited by 18 · see citing works
RetractedPerspectives and potential approaches for targeting neuropilin 1 in SARS-CoV-2 infection
Chapoval, S., & Keegan, A. (2021) · Molecular Medicine · doi:10.1186/s10020-021-00423-y · Cited by 19 · see citing works
Li, J., Tian, Y., Sun, J., Zeng, Z., Liu, Z., Ma, M., Zheng, Z., He, Y., & Kang, W. (2023) · Aging · doi:10.18632/aging.204646 · Cited by 18 · see citing works
Wang, Y., Chai, Y., Liu, Y., Liu, X., Zhang, Y., Yang, Z. F., Yin, S., Luo, J., Li, Z., Gu, Y., et al. (2025) · Immunity · doi:10.1016/j.immuni.2025.07.013 · Cited by 17 · see citing works
Yang, B., Chen, J., & Teng, Y. (2021) · Journal of Immunological Research · doi:10.1155/2021/9994004 · Cited by 15 · see citing works
Ruan, L., Chen, W., Zhao, X., Fang, N., & Li, T. (2022) · Journal of Oncology · doi:10.1155/2022/1084555 · Cited by 16 · see citing works
The interplay between gut bacteria and targeted therapies: implications for future cancer treatments
He, J., Chen, Y., Zhao, H., & Li, Y. (2025) · Molecular Medicine · doi:10.1186/s10020-025-01108-6 · Cited by 19 · see citing works
Wang, L., Wang, L., Wang, S., Zhou, Z., Liu, Z., Xu, P., Luo, X., Wu, T., Luo, F., & Yan, J. (2021) · Frontiers in Oncology · doi:10.3389/fonc.2021.657008 · Cited by 15 · see citing works
Myeloid cells meet CD8+ T cell exhaustion in cancer: What, why and how
Zhai, Y., Liang, X., & Deng, M. (2024) · Chinese Journal of Cancer Research · doi:10.21147/j.issn.1000-9604.2024.06.04 · Cited by 14 · see citing works
Li, X., Zhou, Y., Hu, J., Bai, Z., Meng, W., Zhang, L., Song, X., Wei, Y., Yan, J., & Zhou, Y. (2020) · Neoplasma · doi:10.4149/neo_2020_200914n982 · Cited by 14 · see citing works
Morianos, I., Tsitsopoulou, A., Potaris, Κ., Valakos, D., Fari, O., Vatsellas, G., Bostantzoglou, C., Photiades, A., Gaga, M., Xanthou, G., et al. (2021) · Journal of Experimental & Clinical Cancer Research · doi:10.1186/s13046-021-02092-5 · Cited by 14 · see citing works
El‐Hajjar, M., Gerhardt, L., Hong, M. M. Y., Krishnamoorthy, M., Figueredo, R., Zheng, X., Koropatnick, J. D., & Vareki, S. M. (2022) · Molecular Therapy · doi:10.1016/j.ymthe.2022.08.025 · Cited by 13 · see citing works
Kirchmair, A., Nemati, N., Lamberti, G., Trefny, M. P., Krogsdam, A., Siller, A., Hörtnagl, P., Schumacher, P., Sopper, S., Sandbichler, A. M., et al. (2023) · Frontiers in Immunology · doi:10.3389/fimmu.2023.1267816 · Cited by 13 · see citing works
Grebinoski, S., Pieklo, G. P., Zhang, Q., Visperas, A., Cui, J., Goulet, J., Xiao, H., Brunazzi, E. A., Cardello, C., Herrada, A. A., et al. (2024) · The Journal of Immunology · doi:10.4049/jimmunol.2300216 · Cited by 13 · see citing works
Self-citationChi, H., Deng, S., Xu, K., Zhang, Y., Song, T., Yu, J., Wang, Y., Liu, J., Zhang, Y., Shi, J., et al. (2024) · Cancer Research · doi:10.1158/0008-5472.can-24-2223 · Cited by 13 · see citing works
Thiol-Responsive Gold Nanodot Swarm with Glycol Chitosan for Photothermal Cancer Therapy
Jo, S., Sun, I., Yun, W. S., Kim, J., Lim, D., Ahn, C.-H., & Kim, K. (2021) · Molecules · doi:10.3390/molecules26195980 · Cited by 13 · see citing works
Liu, Y., Liu, Y., Gao, Y., Wang, L., Shi, H., & Xuan, C. (2021) · PLoS ONE · doi:10.1371/journal.pone.0260103 · Cited by 13 · see citing works
Wang, Z., Wang, K., Xue, Y., Chen, M., & Du, Y. (2022) · Journal of Cancer · doi:10.7150/jca.68673 · Cited by 13 · see citing works
Wang, L., Wang, L., Xu, P., Liu, C., Wang, S., Luo, X., Li, M., Liu, J., Zhao, Z., Lai, W., et al. (2022) · Molecular Pharmaceutics · doi:10.1021/acs.molpharmaceut.1c00912 · Cited by 12 · see citing works
Self-citationJiménez, D., & Arias, M. T. (2022) · Immunological Medicine · doi:10.1080/25785826.2022.2066251 · Cited by 12 · see citing works
Smith, G. T., Radin, D. P., & Tsirka, S. E. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.958620 · Cited by 12 · see citing works
PHD2 Constrains Antitumor CD8+ T-cell Activity
Donnet, C. B., Acolty, V., Azouz, A., Taquin, A., Henin, C., Cafarello, S. T., Denanglaire, S., Mazzone, M., Oldenhove, G., Léo, O., et al. (2023) · Cancer Immunology Research · doi:10.1158/2326-6066.cir-22-0099 · Cited by 12 · see citing works
Rossignol, J., Belaid, Z., Fouquet, G., Guillem, F., Rignault‐Bricard, R., Milpied, P. J., Renand, A., Coman, T., D’Aveni, M., Dussiot, M., et al. (2022) · iScience · doi:10.1016/j.isci.2022.104353 · Cited by 11 · see citing works
Fischer, A., Lersch, R., Krätzig, N. D. A., Strong, A. J., Friedrich, M., Weber, J., Engleitner, T., Öllinger, R., Yen, H.-Y., Kohlhofer, U., et al. (2023) · Cell Genomics · doi:10.1016/j.xgen.2023.100276 · Cited by 10 · see citing works
Yu, Y., Zeng, H., Jin, K.-F., You, R., Liu, Z.-X., Zhang, H., Liu, C., Su, X., Yan, S., Chang, Y.-Y., et al. (2022) · Cancer Immunology and Immunotherapy · doi:10.1007/s00262-022-03153-0 · Cited by 7 · see citing works
Self-citationEBV Vaccines in the Prevention and Treatment of Nasopharyngeal Carcinoma
Zhang, W., Wang, C., Meng, Y., He, L., & Dong, M. (2025) · Vaccines · doi:10.3390/vaccines13050478 · Cited by 10 · see citing works
Liu, D., Xiao, L. X., Wu, Y., Yue, C., Li, M., Sun, Y., & Yang, C. J. (2025) · Small Methods · doi:10.1002/smtd.202500770 · Cited by 9 · see citing works
The mitochondrial fission protein DRP1 influences memory CD8+ T cell formation and function
Stevens, M. G., Mason, F. M., & Bullock, T. N. J. (2023) · Journal of Leukocyte Biology · doi:10.1093/jleuko/qiad155 · Cited by 9 · see citing works
NRP1 cripples immunological memory
Acharya, N., & Anderson, A. C. (2020) · Nature Immunology · doi:10.1038/s41590-020-0759-5 · Cited by 9 · see citing works
Feng, D., Zhu, W., You, J., Shi, X., Han, P., Wei, W., Wei, Q., & Yang, L. (2022) · Molecules · doi:10.3390/molecules27186000 · Cited by 9 · see citing works
STAT6 Upregulates NRP1 Expression in Endothelial Cells and Promotes Angiogenesis
Gao, P., Ren, G., Liang, J., & Liu, J. (2022) · Frontiers in Oncology · doi:10.3389/fonc.2022.823377 · Cited by 8 · see citing works
Bai, Z., Yan, C., & Chang, D. (2023) · Discover Oncology · doi:10.1007/s12672-023-00821-0 · Cited by 8 · see citing works
Bioinformatics analysis and clinical significance of NRP-1 in triple-negative breast cancer
Ma, X., Liu, H., Shi, C., Zhao, Y., Wang, H., & Han, Z.-X. (2024) · Heliyon · doi:10.1016/j.heliyon.2024.e27368 · Cited by 7 · see citing works
Distinct roles of ADIPOR1 and ADIPOR2: A pan-cancer analysis
Chen, Z., Yang, H., Ren, Y.-F., Yang, Z., Huang, J.-Z., Li, C., Xiong, Y., & Yu, B. (2023) · Frontiers in Endocrinology · doi:10.3389/fendo.2023.1119534 · Cited by 9 · see citing works
Yang, X., Xu, T., Song, X., & Wu, Y. (2023) · International Journal of General Medicine · doi:10.2147/ijgm.s409336 · Cited by 7 · see citing works
Li, T., Ran, J., Miao, Z., Yang, M., Mou, D., Jiang, Y., Xu, X., Xie, Q., & Jin, K. (2023) · The Journal of Pathology · doi:10.1002/path.6221 · Cited by 7 · see citing works
Kang, P., Li, Y., Hu, Z., Lei, M., Cheng, J., Guo, X., Zhang, L., Lin, S., & Yuan, Q. (2022) · International Immunopharmacology · doi:10.1016/j.intimp.2022.108732 · Cited by 7 · see citing works
Dai, J., Pan, Y., Chen, Y., & Yao, S. (2022) · Frontiers in Genetics · doi:10.3389/fgene.2022.1024508 · Cited by 7 · see citing works
Membrane Proteins | The Plexin Family of Transmembrane Receptors
Buck, M. (2021) · Elsevier eBooks · doi:10.1016/b978-0-12-819460-7.00345-5 · Cited by 7 · see citing works
Immune Checkpoint Neuropilins as Novel Biomarkers and Therapeutic Targets for Pancreatic Cancer
He, L.-H., Zhang, X.-Z., Lao, M.-Y., Zhang, H.-J., Yang, H.-S., & Bai, X. (2023) · Cancers · doi:10.3390/cancers15082225 · Cited by 6 · see citing works
Neuropilin-1high monocytes protect against neonatal inflammation
Zheng, X.-Q., Lei, W., Zhang, Y.-M., Jin, H., Han, C., Wu, F., Jia, C., Zeng, R.-H., Chen, Z.-H., Zhang, Y.-X., et al. (2024) · Cellular & Molecular Immunology · doi:10.1038/s41423-024-01157-7 · Cited by 6 · see citing works
Abberger, H., Barthel, R., Bahr, J., Thiel, J., Luppus, S., Buer, J., Westendorf, A. M., & Hansen, W. (2021) · The Journal of Immunology · doi:10.4049/jimmunol.2100222 · Cited by 6 · see citing works
Zhou, W., Chen, J., & Wang, J. (2023) · Aging · doi:10.18632/aging.204869 · Cited by 6 · see citing works
Xiang, J.-Y., Ni, Y., Yu, J., Sun, H., Gu, Z., Li, Z., Yang, T., Feng, J., Su, L., Liu, L.-M., et al. (2025) · Nature Cancer · doi:10.1038/s43018-025-01059-1 · Cited by 5 · see citing works
Cabug, A. F., Crawford, J. C., McQuilten, H. A., Foo, I. J. H., Allen, L. F., Gebregzabher, D., Mettelman, R. C., Novak, T., Chou, J. S., Rowntree, L. C., et al. (2025) · Nature Communications · doi:10.1038/s41467-025-65262-5 · Cited by 5 · see citing works
Novel targets for immunotherapy associated with exhausted CD8 + T cells in cancer
Zhang, L., Zhang, B., Li, L., Ye, Y., Wu, Y., Yuan, Q., Xu, W., Wen, X., Guo, X., & Nian, S. (2022) · Journal of Cancer Research and Clinical Oncology · doi:10.1007/s00432-022-04326-1 · Cited by 5 · see citing works
Ullah, I., Mengersen, K. L., Pettitt, A. N., & Liquet, B. (2025) · Statistics in Medicine · doi:10.1002/sim.70110 · Cited by 4 · see citing works
Yang, M., Fang, Y., Li, X., Yang, B., Ma, Q., Cui, X., Jiang, L., & Ge, F. (2025) · International Immunopharmacology · doi:10.1016/j.intimp.2025.115385 · Cited by 4 · see citing works
Small molecule inhibitors of the co-receptor neuropilin-1
Liu, Y., Liang, K.-H., Zhang, W., Rao, G.-W., & Zheng, Q. (2025) · Drug Discovery Today · doi:10.1016/j.drudis.2025.104523 · Cited by 4 · see citing works
Wang, Y., Zhou, X., Liu, M., Huang, M., Chen, P., Li, X.-Y., Xue, F., Zhao, W., Liu, D., Li, L., et al. (2025) · Advancement of science · doi:10.1002/advs.202510545 · Cited by 5 · see citing works
Chen, S., Zhang, L.-M., Song, Y., Xie, K.-Y., Wang, Y., & Liang, Y. (2023) · Biochemical Genetics · doi:10.1007/s10528-023-10518-2 · Cited by 3 · see citing works
- Authors
- Liu, C., Somasundaram, A., Manne, S., Gocher, A. M., Szymczak-Workman, A. L., Vignali, K. M., Scott, E. N., Normolle, D. P., John Wherry, E., Lipson, E. J., Ferris, R. L., Bruno, T. C., Workman, C. J., & Vignali, D. A. A.
- Affiliations
- University of Pittsburgh (US)
- University of Pennsylvania (US)
- UPMC Hillman Cancer Center (US)
- Johns Hopkins University (US)
- Corresponding author
- Vignali, Dario A. A.
- ORCID
- Venue
- Nature Immunology
- Published
- 2020-07-13
- Volume
- 21
- Issue
- 9
- Pages
- 1010-1021
- ISSN
- 1529-2908 (ISSN-L)
- 1529-2916
- PMC
- PMC7442600
- OpenAlex
- W3040823189
- Cited by
- 151
- References
- 56
- Citations by year
- 2026: 13 · 2025: 36 · 2024: 18 · 2023: 27 · 2022: 31 · 2021: 20 · 2020: 6
- FWCI
- 7.59
- Type
- journal article
- Language
- en
- Open access
- green
- europepmc.org
- Licence
- Locations
- Nature Immunology (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- U.S. Department of Health & Human Services | National Institutes of Health (CA203689, AI108545, CA082084, CA247004-01, AI117950, AI082630, AI112521, AI115712, CA210944)
- U.S. Department of Health & Human Services | NIH | National Cancer Institute (CA047904, CA006973, CA097190)
- Topics
- Health Sciences › Medicine › Oncology › Cancer Immunotherapy and Biomarkers
- Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
- Life Sciences › Immunology and Microbiology › Immunology › Immunotherapy and Immune Responses
- Keywords
- neuropilin-1, T cell exhaustion, CD8+ T cell memory, immune checkpoint, antitumor immunity, anti-PD-1 therapy, tumor rechallenge, T cell self-renewal
- MeSH terms
- Immune Checkpoint Proteins, Animals, Humans, Immune Tolerance, Immunity, Immunologic Memory, Melanoma, Experimental, Signal Transduction, Mice, Knockout, CD8-Positive T-Lymphocytes, Neuropilin-1, Cell Line, Tumor, Mice, Precursor Cells, T-Lymphoid, Programmed Cell Death 1 Receptor
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