The epigenetic landscape of T cell exhaustion
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Epigenetic profiling suggests that exhausted T cells are a distinct cell linage.
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CD8+CD45RO+CCR7− effector memory T cells from older individuals show only few differences in chromatin accessibility compared to young effector memory T cells, and they lack epigenetic signatures of exhausted T cells.
“However, CD8+CD45RO+CCR7− effector memory T cells from older individuals show only few differences in terms of chromatin accessibility compared to young effector memory T cells, and they lack the epigenetic signatures of exhausted T cells”
From Successful and Maladaptive T Cell Aging (2017) · cites this paper as Sen et al., 2016
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“Chronic antigen stimulation induces T cell exhaustion, a differentiation state associated with a heritable epigenetic imprint that is distinct from that found in effector and memory T cells (Pauken et al., 2016; Philip et al., 2017; Schietinger et al., 2012; Schietinger et al., 2016; Sen et al., 2016; Wherry et al., 2…”
Background
- Authors
- Sen, D. R., Kaminski, J., Barnitz, R. A., Kurachi, M., Gerdemann, U., Yates, K. B., Tsao, H.-W., Godec, J., LaFleur, M. W., Brown, F. D., Tonnerre, P., Chung, R. T., Tully, D. C., Allen, T. M., Frahm, N., Lauer, G. M., Wherry, E. J., Yosef, N., & Haining, W. N.
- Affiliations
- Harvard University (US)
- University of California, Berkeley (US)
- Dana-Farber Cancer Institute (US)
- University of Pennsylvania (US)
- Ragon Institute of MGH, MIT and Harvard (US)
- Fred Hutch Cancer Center (US)
- Broad Institute (US)
- Corresponding author
- Sen, Debattama R.
- Kaminski, James
- Yosef, Nir
- Haining, W. Nicholas
- ORCID
- Venue
- Science
- Published
- 2016-12-02
- Volume
- 354
- Issue
- 6316
- Pages
- 1165-1169
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- PMC
- PMC5497589
- OpenAlex
- W2545009331
- Cited by
- 986
- References
- 26
- Citations by year
- 2026: 102 · 2025: 98 · 2024: 89 · 2023: 102 · 2022: 90 · 2021: 131 · 2020: 116 · 2019: 112 · 2018: 84 · 2017: 58 · 2016: 1 · 2014: 1
- FWCI
- 51.12
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Science (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- LSHTM Research Online (London School of Hygiene and Tropical Medicine) (acceptedVersion)
- eScholarship (California Digital Library) (submittedVersion)
- Funders
- NIH (AI115712, AI091493, AI082630, 1R21AI078809-01, UM1 AI068618)
- Topics
- Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
- Health Sciences › Medicine › Oncology › Cancer Immunotherapy and Biomarkers
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Epigenetics and DNA Methylation
- Keywords
- T cell exhaustion, epigenetic profiling, exhausted T cells, T cell lineage, chromatin regulation
- MeSH terms
- Gene Editing, T-bet Transcription Factor, Animals, Chromatin, Chronic Disease, Disease Models, Animal, Enhancer Elements, Genetic, Humans, Immunologic Memory, Immunotherapy, Lymphocytic Choriomeningitis, Mice, Inbred C57BL, Transcription, Genetic, HIV Infections, CD8-Positive T-Lymphocytes, Cell Lineage, Hepatitis C, Chronic, T-Box Domain Proteins, Epigenesis, Genetic, Mice, SOXB1 Transcription Factors, B7-H1 Antigen
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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