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Prognostic Impact of Memory CD8(+) T Cells on Immunotherapy in Human Cancers: A Systematic Review and Meta-Analysis

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Rejuvenating Effector/Exhausted CAR T Cells to Stem Cell Memory–Like CAR T Cells By Resting Them in the Presence of CXCL12 and the NOTCH Ligand

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Reprogramming dysfunctional CD8+ T cells to promote properties associated with natural HIV control

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GITR and TIGIT immunotherapy provokes divergent multicellular responses in the tumor microenvironment of gastrointestinal cancers

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Decoding lymphomyeloid divergence and immune hyporesponsiveness in G-CSF-primed human bone marrow by single-cell RNA-seq

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METI: deep profiling of tumor ecosystems by integrating cell morphology and spatial transcriptomics

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Single-cell analysis of multiple myelomas refines the molecular features of bortezomib treatment responsiveness

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Single-Cell TCR and Transcriptome Analysis: An Indispensable Tool for Studying T-Cell Biology and Cancer Immunotherapy

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OMIP ‐109: 45‐color full spectrum flow cytometry panel for deep immunophenotyping of the major lineages present in human peripheral blood mononuclear cells with emphasis on the T cell memory compartment

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Fc-Silent Anti-TIGIT Antibodies Potentiate Antitumor Immunity without Depleting Regulatory T Cells

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Dual modulation of cytotoxic and checkpoint receptors tunes the efficacy of adoptive Delta One T cell therapy against colorectal cancer

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Hiding in Plain Sight: Virtually Unrecognizable Memory Phenotype CD8+ T cells

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Merkel cell polyomavirus-specific and CD39+CLA+ CD8 T cells as blood-based predictive biomarkers for PD-1 blockade in Merkel cell carcinoma

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Single cell transcriptomics reveals recent CD8T cell receptor signaling in patients with coronary artery disease

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The effects of 5-aminolevulinic acid photodynamic therapy on the local immune response of women with cervical intraepithelial neoplasia grade 2

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IL-2-independent expansion, persistence, and antitumor activity in TIL expressing regulatable membrane-bound IL-15

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p38 inhibition enhances TCR-T cell function and antagonizes the immunosuppressive activity of TGF-β

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Spatial determinates of effector and memory CD8+ T cell fates*

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IFN-γ- and IL-17-producing CD8+ T (Tc17-1) cells in combination with poly-ICLC and peptide vaccine exhibit antiglioma activity

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Expression profiling of cerebrospinal fluid identifies dysregulated antiviral mechanisms in multiple sclerosis

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Two parallel worlds of memory T cells

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HSP-CAR30 with a high proportion of less-differentiated T cells promotes durable responses in refractory CD30+ lymphoma

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Human CD8 T‐stem cell memory subsets phenotypic and functional characterization are defined by expression of CD122 or CXCR3

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A minimal gene set characterizes TIL specific for diverse tumor antigens across different cancer types

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Analysis of the three-dimensional genome of exhausted CD8+ T cells reveals a critical role of IRF8 in their differentiation and functions in cancer

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BACH2 dosage establishes the hierarchy of stemness and fine-tunes antitumor immunity in CAR T cells

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Precise CRISPR-Cas9 gene repair in autologous memory T cells to treat familial hemophagocytic lymphohistiocytosis

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Cell Identity and Spatial Distribution of PD‐1/PD‐L1 Blockade Responders

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Distinct in vivo dynamics of donor-derived stem cell memory CAR T cells post-allogeneic HSCT relapse

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13C tracer analysis reveals the landscape of metabolic checkpoints in human CD8+ T cell differentiation and exhaustion

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Immunometabolic Adaptation of CD19-Targeted CAR T Cells in the Central Nervous System Microenvironment of Patients Promotes Memory Development

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Dysfunctional Sars-CoV-2-M protein-specific cytotoxic T lymphocytes in patients recovering from severe COVID-19

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Stem-like T cells and niches: Implications in human health and disease

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Renaissance of antiviral CD8+ T cell immunity in vaccination and disease

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Harnessing Biomaterials to Amplify Immunity in Aged Mice through T Memory Stem Cells

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Long-lived central memory γδ T cells confer protection against murine cytomegalovirus reinfection

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Anti-metabolite chemotherapy increases LAG-3 expressing tumor-infiltrating lymphocytes which can be targeted by combination immune checkpoint blockade

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Coupling of response biomarkers between tumor and peripheral blood in patients undergoing chemoimmunotherapy

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High-dimensional mapping of human CEACAM1 expression on immune cells and association with melanoma drug resistance

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Time to Move to the Single-Cell Level: Applications of Single-Cell Multi-Omics to Hematological Malignancies and Waldenström’s Macroglobulinemia—A Particularly Heterogeneous Lymphoma

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Small Gene Networks Delineate Immune Cell States and Characterize Immunotherapy Response in Melanoma

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Pre-treatment with systemic agents for advanced NSCLC elicits changes in the phenotype of autologous T cell therapy products

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Chemokine-mediated cell migration into the central nervous system in progressive multifocal leukoencephalopathy

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Novel Arf1 Inhibitors Drive Cancer Stem Cell Aging and Potentiate Anti‐Tumor Immunity

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Subunit protein CD40.SARS.CoV2 vaccine induces SARS-CoV-2-specific stem cell-like memory CD8+ T cells

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MIST: An interpretable and flexible deep learning framework for single–T cell transcriptome and receptor analysis

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Deciphering Immunosenescence From Child to Frailty: Transcriptional Changes, Inflammation Dynamics, and Adaptive Immune Alterations

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Origin and fine-tuning of effector CD8 T cell subpopulations in chronic infection

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CTSB+ macrophage repress memory immune hub in the liver metastasis site of colorectal cancer patient revealed by multi-omics analysis

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Normal Numbers of Stem Cell Memory T Cells Despite Strongly Reduced Naive T Cells Support Intact Memory T Cell Compartment in Ataxia Telangiectasia

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Target therapy of TIGIT; a novel approach of immunotherapy for the treatment of colorectal cancer

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SLAMF7 defines subsets of human effector CD8 T cells

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Restoring mitochondrial function promotes hematopoietic reconstitution from cord blood following cryopreservation-related functional decline

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Repertoire-based mapping and time-tracking of T helper cell subsets in scRNA-Seq

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Epigenetic landscapes drive CAR-T cell kinetics and fate decisions: Bridging persistence and resistance

Wang, K., Ou, K., Zeng, Y., Yue, C., Zhuo, Y., Wang, L., Chen, H., & Tu, S. (2025) · Critical Reviews in Oncology/Hematology · doi:10.1016/j.critrevonc.2025.104729 · Cited by 9

Impact of lymph node dissection on survival after neoadjuvant immunochemotherapy for esophageal squamous cell cancer: a double-center real-world retrospective study

Huang, Y. H., Lin, X., Fang, C., Li, Z., Chen, J., Xie, X., Wu, H., Yang, H., Luo, K., & Fu, J. (2025) · Cancer Immunology Immunotherapy · doi:10.1007/s00262-025-04168-z · Cited by 9

Abatacept restores dysregulated transcriptomic and proteomic profile in disorders of CTLA-4 insufficiency

Çatak, M. C., Sürücü, N., Catak, F. B., Kara, A., Cildir, S., Babayeva, R., Kayaoğlu, B., Bulutoğlu, A., Erman, B., Karakuş, İ. S., et al. (2025) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2025.08.027 · Cited by 9

Tumour-intrinsic features shape T cell differentiation through precursor to symptomatic multiple myeloma

Foster, K. A., Rees, E., Ainley, L., Laidler, A., Boyle, E. M., Lee, L. S. H., Ward, G., Galas‐Filipowicz, D., Fitzsimons, E., Mikolajczak, A., et al. (2026) · Nature Communications · doi:10.1038/s41467-026-68718-4 · Cited by 17

Inactivated tick-borne encephalitis vaccine elicits several overlapping waves of T cell response

Sycheva, A. L., Komech, E. A., Pogorelyy, M. V., Minervina, A. A., Urazbakhtin, S. Z., Salnikova, M. A., Vorovitch, M. F., Kopantzev, E. P., Zvyagin, I. V., Komkov, A. Y., et al. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.970285 · Cited by 11

Clinical Significance of BTLA and HVEM Expression on Circulating CD4 + T and CD8 + T Cells in Chronic Hepatitis B Virus Infection

Song, H., Chen, X., Tang, P., Xu, P., Huang, Z., & Wang, X.-F. (2022) · Viral Immunology · doi:10.1089/vim.2021.0134 · Cited by 9

Cytotoxic T cells are silenced to induce disease tolerance in human malariaPreprint

Sandoval, D. M., Bach, F. A., Ivens, A. C., Harding, A. C., Smith, N. L., Mazurczyk, M., Themistocleous, Y., Edwards, N. J., Silk, S. E., Barrett, J. R., et al. (2021) · medRxiv · doi:10.1101/2021.08.19.21262298 · Cited by 9

GFI1-driven transcriptional and epigenetic programs maintain CD8+ T cell stemness and persistence

Chaudhry, M. Z., Chen, E., Man, H. O., Jones, A., Denman, R., Yu, H., Huang, Q., Ilich, A., Schreuder, J., Navarro, S., et al. (2025) · Nature Immunology · doi:10.1038/s41590-025-02151-5 · Cited by 8

Orthogonal CRISPR screens to identify transcriptional and epigenetic regulators of human CD8 T cell functionPreprint

McCutcheon, S. R., Swartz, A. M., Brown, M. C., Barrera, A., Amador, C. M., Siklenka, K., Humayun, L. L., Isaacs, J. M., Reddy, T. E., Nair, S. K., et al. (2023) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2023.05.01.538906 · Cited by 8

A Phase II Open-Label, Randomized Clinical Trial of Atezolizumab with or without Human Recombinant IL-7 (CYT107) in Advanced Urothelial Cancer

Sweis, R. F., Chatta, G. S., Jain, R., Moon, H., Delacroix, S. E., Fang, A., D’Amico, L., Kask, A. S., Cheever, M. A., Fling, S. P., et al. (2024) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-24-1728 · Cited by 7

IL-4 induces CD22 expression to restrain the effector program of virtual memory T cells

Yang, B., Piedfort, O., Sanchez, G. S., Lavergne, A., Gong, M., Peng, G., Madrigal, A., Petrellis, G., Katsandegwaza, B., Rodriguez-Rodriguez, L., et al. (2025) · Science Immunology · doi:10.1126/sciimmunol.adk4841 · Cited by 7

A pH/MMP-9 smart dual-responsive liposome GBE@LP co-delivers and controls the release of GB1107/BMS1166/Enzalutamide for liver cancer immunotherapy

Lu, S., Zhang, C., Wu, H., Wang, J., Wang, J., Zhao, L., Ren, T., & Li, G. (2025) · Materials Today Bio · doi:10.1016/j.mtbio.2025.101801 · Cited by 8

A Potential Biomarker of Dynamic Change in Peripheral CD45RA−CD27+CD127+ Central Memory T Cells for Anti-PD-1 Therapy in Patients with Esophageal Squamous Cell Carcinoma

Sakuma, M., Mimura, K., Nakajima, S., Kaneta, A., Kikuchi, T., Nirei, A., Tada, T., Hanayama, H., Okayama, H., Sakamoto, W., et al. (2023) · Cancers · doi:10.3390/cancers15143641 · Cited by 7

Generation of Pure Highly Functional Human Anti-Tumor Specific Cytotoxic T Lymphocytes With Stem Cell-Like Memory Features for Melanoma Immunotherapy

Hamieh, M., Chatillon, J.-F., Dupel, E., Bayeux, F., Fauquembergue, É., Maby, P., Drouet, A., Duval-Modeste, A.-B., Adriouch, S., Boyer, O., et al. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.674276 · Cited by 8

Aberrant T-cell exhaustion in severe combined immunodeficiency survivors with poor T-cell reconstitution after transplantation

Labrosse, R., Boufaied, I., Bourdin, B., Gona, S., Randolph, H. E., Logan, B. R., Bourbonnais, S., Berthe, C., Chan, W., Buckley, R. H., et al. (2022) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2022.08.004 · Cited by 7

DISC1 as a prognostic biomarker correlated with immune infiltrates in gastric cancer

Zheng, S., Chen, Y., Yu, S., Weng, C., Lin, N., Luo, Z., Wang, Y., Xiong, P., Teng, Z., Wang, Y., et al. (2023) · Heliyon · doi:10.1016/j.heliyon.2023.e15058 · Cited by 7

Host T Cell Dedifferentiation Effects Drive HIV-1 Latency Stability

Dalecki, A. G., Greer, B. D., Duverger, A. E., Strange, E. L., Carlin, E., Wagner, F., Shi, B., Lowman, K. E., Perez, M. D., Tidwell, C., et al. (2022) · Journal of Virology · doi:10.1128/jvi.01974-21 · Cited by 7

c-Myb redefines the hierarchy of stem-like T cells

Heuser-Loy, C., & Gattinoni, L. (2022) · Nature Immunology · doi:10.1038/s41590-022-01319-7 · Cited by 7

Immune cell triads reprogram exhausted CD8+ T cells for effective tumor elimination

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Memory stem CD8+T cells in HIV/Mtb mono- and co-infection: characteristics, implications, and clinical significance

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Integrated multi-omics profiling reveals the role of the DNA methylation landscape in shaping biological heterogeneity and clinical behaviour of metastatic melanoma

Anichini, A., Caruso, F. P., Lagano, V., Noviello, T., Tufano, R., Nicolini, G., Molla, A., Bersani, I., Sgambelluri, F., Covre, A., et al. (2025) · Journal of Experimental & Clinical Cancer Research · doi:10.1186/s13046-025-03474-9 · Cited by 8

Longan polysaccharides promote Th1 and Treg cell differentiation via dendritic cells

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C‐X‐C chemokine receptor CXCR4 mediates diurnal changes in the aggregation and dispersion of CD8 + T cells within the tumor microenvironment

Tsuruta, A., Fujimoto, M., Hiraoka, Y., Taniguchi, A., Shiiba, Y., Inoki, T., Yamauchi, T., Yoshida, Y., Matsunaga, N., Ohdo, S., et al. (2025) · International Journal of Cancer · doi:10.1002/ijc.70252 · Cited by 7

Phenotypic and Immunometabolic Aspects on Stem Cell Memory and Resident Memory CD8+ T Cells

Manna, M. P. L., Azgomi, M. S., Tamburini, B., Badami, G. D., Mohammadnezhad, L., Dieli, F., & Caccamo, N. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.884148 · Cited by 6

Plasmodium falciparum infection induces T cell tolerance that is associated with decreased disease severity upon re-infection

Sandoval, D. M., Bach, F. A., Ivens, A. C., Harding, A. C., Smith, N. L., Mazurczyk, M., Themistocleous, Y., Edwards, N. J., Silk, S. E., Barrett, J. R., et al. (2025) · The Journal of Experimental Medicine · doi:10.1084/jem.20241667 · Cited by 17

Homeostatic cytokines tune naivety and stemness of cord blood-derived transgenic T cells

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Immune Control in Repeated Babesia microti Infection in a Patient With B-Cell Deficiency

Little, J. S., Oakley, M. S., Thorner, A. R., Johnston, D., Majam, V., Liakos, A. D., Novack, L. A., Zheng, H., Meredith, S., Chou, C., et al. (2023) · Open Forum Infectious Diseases · doi:10.1093/ofid/ofad568 · Cited by 6

CD4 + T cells are homeostatic regulators during Mtb reinfectionPreprint

Bromley, J. D., Ganchua, S. K. C., Nyquist, S. K., Maiello, P. A., Chao, M. C., Borish, H. J., Rodgers, M., Tomko, J. A., Kracinovsky, K. B., Mugahid, D., et al. (2023) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2023.12.20.572669 · Cited by 6

The Trm-Treg Axis as a tissue-encoded immune checkpoint in chronic inflammation and autoimmunity

Li, L., Xia, Y., & Liu, Y. (2025) · Autoimmunity Reviews · doi:10.1016/j.autrev.2025.103977 · Cited by 7

Stem-like CD8+ memory T cells with exhausted-like traits in humans: may they represent a pool of CD8 T cells that has undergone T cell receptor gene hypermutation?

Zamai, L. (2020) · doi:10.13140/rg.2.2.24857.95844

Transcriptional programming governs the transition from shared progenitors to divergent CD8 + T cell fates

Chaudhry, M. Z., & Belz, G. T. (2026) · Immunology and Cell Biology · doi:10.1111/imcb.70101 · Cited by 2

Progenitor effects and unique transcriptomic signatures linked to differentiation phenotype in clonally expanded antigen-specific CD8 T memory stem cells

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The Quest for CD8+ Memory Stem Cells

Neuenhahn, M., & Busch, D. H. (2009) · Immunity · doi:10.1016/j.immuni.2009.10.002 · Cited by 14

Delineation of a molecularly distinct terminally differentiated memory CD8 T cell population

Milner, J. J., Nguyen, H., Omilusik, K. D., Reina‐Campos, M., Tsai, M. S., Toma, C., Delpoux, A., Boland, B. S., Hedrick, S. Μ., Chang, J. T., et al. (2020) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2008571117 · Cited by 115