The DOI matches its Crossref record; 43 of the 43 references it cites were found in a registry or an index.
Neuromodulation of lumbosacral spinal networks enables independent stepping after complete paraplegia
Abstract
Spinal sensorimotor networks that are functionally disconnected from the brain because of spinal cord injury (SCI) can be facilitated via epidural electrical stimulation (EES) to restore robust, coordinated motor activity in humans with paralysis 1-3. Previously, we reported a clinical case of complete sensorimotor paralysis of the lower extremities in which EES restored the ability to stand and the ability to control step-like activity while side-lying or suspended vertically in a body-weight support system (BWS)4. Since then, dynamic task-specific training in the presence of EES, termed multimodal rehabilitation (MMR), was performed for 43 weeks and resulted in bilateral stepping on a treadmill, independent from trainer assistance or BWS. Additionally, MMR enabled independent stepping over ground while using a front-wheeled walker with trainer assistance at the hips to maintain balance. Furthermore, MMR engaged sensorimotor networks to achieve dynamic performance of standing and stepping. To our knowledge, this is the first report of independent stepping enabled by task-specific training in the presence of EES by a human with complete loss of lower extremity sensorimotor function due to SCI.
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“This recovery has been documented in various independent studies, including in participants with complete sensorimotor paralysis5,6,30–34.”
From Walking naturally after spinal cord injury using a brain–spine interface (2023) · cites this paper as [33]
In the citing paper
“The delivery of epidural electrical stimulation over the lumbar spinal cord has enabled many individuals with spinal cord injury to regain adaptive control over the activity of otherwise paralysed muscles.”
From Walking naturally after spinal cord injury using a brain–spine interface (2023) · cites this paper as [33]
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Items 201–300 of 570
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BackgroundVestibulospinal and Corticospinal Modulation of Lumbosacral Network Excitability in Human Subjects
Sayenko, D. G., Atkinson, D. A., Mink, A. M., Gurley, K. M., Edgerton, V. R., Harkema, S. J., & Gerasimenko, Y. (2018) · Frontiers in Physiology · doi:10.3389/fphys.2018.01746 · Cited by 19
Self-citationEpidural Electrical Stimulation for Functional Recovery in Incomplete Spinal Cord Injury
Ren, Y., Mo, L., Lu, J., Zhu, P., Yin, M., Jia, W., Liang, F., Han, X., & Zhao, J. (2025) · Cyborg and Bionic Systems · doi:10.34133/cbsystems.0314 · Cited by 18
“The pulse width is adjusted based on the patient’s spinal cord thickness, generally at 220 μ s [ 26 , 33 ].”
Smith, A. C., O’Dell, D. R., Albin, S. R., Berliner, J. C., Dungan, D., Robinson, E., Elliott, J. M., Carballido‐Gamio, J., Stevens‐Lapsley, J. E., & Weber, K. A., II (2021) · Archives of Physical Medicine and Rehabilitation · doi:10.1016/j.apmr.2021.07.792 · Cited by 18
Alashram, A. R., Padua, E., Raju, M., Romagnoli, C., & Annino, G. (2021) · Journal of Spinal Cord Medicine · doi:10.1080/10790268.2021.2000200 · Cited by 18
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“21,22,24,48 However, only two patients showed improvement in the score.”
Shackleton, C., Hodgkiss, D. D., Samejima, S., Miller, T., Pérez, M. A., Nightingale, T. E., Sachdeva, R., & Krassioukov, A. V. (2022) · Journal of Neurophysiology · doi:10.1152/jn.00367.2022 · Cited by 18
A Single Dermatome Clinical Prediction Rule for Independent Walking 1 Year After Spinal Cord Injury
Smith, A. C., Draganich, C., Thornton, W. A., Berliner, J. C., Lennarson, P. J., Rejc, E., Sevigny, M., Charlifue, S. W., Tefertiller, C., & Weber, K. A., II (2023) · Archives of Physical Medicine and Rehabilitation · doi:10.1016/j.apmr.2023.06.015 · Cited by 18
“For 25-29 Regarding an optimal time window of pinprick exam to optimize predictive performance, we found that the earlier time windows (within 0-3 days and 4-7 days of SCI) provided better PPV than the later time window (within 8-31 days of SCI).”
MethodSpinal maps of motoneuron activity during human locomotion: neuromechanical considerations
Avaltroni, P., Cappellini, G., Labini, F. S., Ivanenko, Y. P., & Lacquaniti, F. (2024) · Frontiers in Physiology · doi:10.3389/fphys.2024.1389436 · Cited by 18
2018 Yearbook of Neurorestoratology
Huang, H., Sharma, H. S., Chen, L., Saberi, H., & Mao, G. (2019) · Journal of Neurorestoratology · doi:10.26599/jnr.2019.9040003 · Cited by 18
“Vaquero et al. reported a phase 2 clinical trial in patients with chronic SCI that received three intrathecal administrations of MSCs.”
BackgroundInfluentialShkorbatova, P. Y., Lyakhovetskii, V. A., Pavlova, N., Popov, A., Bazhenova, E. Y., Kalinina, D. S., Gorskii, O., & Евгеньевич, М. П. (2020) · Frontiers in Systems Neuroscience · doi:10.3389/fnsys.2020.555593 · Cited by 18
Current insights into the management of spinal cord injury
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“Studies on the use of epidural spinal cord stimulation have shown to be effective in recovering various physiological functions, such as voluntary activation of upper [5] and lower limb muscles [6], independent stepping [7,8], postural stability [9,10], and assisted ambulation in humans post SCI [11,12].”
BackgroundSelf-citationOh, J., Scheffler, M. S., Mahan, E. E., King, S. T., Martin, C. A., Dinh, J., Steele, A. G., O’Malley, M. K., & Sayenko, D. G. (2023) · Topics in Spinal Cord Injury Rehabilitation · doi:10.46292/sci23-00040s · Cited by 17
“Grip testing occurred in weeks 1, 6, 9, and 14, where hand grip force was evaluated with and without TSS.”
MethodSelf-citationFadeev, F., Bashirov, F. V., Аршалуйсович, М. В., Izmailov, A., Povysheva, T. V., Sokolov, M. E., Kuznetsov, M. S., Александрович, Е. А., Salafutdinov, I. I., Rizvanov, A. A., et al. (2020) · Neural Regeneration Research · doi:10.4103/1673-5374.293150 · Cited by 17
“It is worth to mention that EES cannot be started in the period of spinal shock which may last several days after SCI (Gill et al., 2018) whereas the gene therapy could be applied in the acute phase of SCI (Izmailov et al., 2017a).”
BackgroundMethodInfluentialAl'Joboori, Y. D., Edgerton, V. R., & Ichiyama, R. M. (2020) · Brain Sciences · doi:10.3390/brainsci10110824 · Cited by 16
“These beneficial effects of ES following severe SCIs have additionally been shown to translate to humans with recovery of voluntary contraction of lower limb muscles, standing ability [6,7], and, most recently, walking [8,9].”
BackgroundInfluentialSelf-citationHistorical development and contemporary use of neuromodulation in human spinal cord injury
Harkema, S. J., Angeli, C., & Gerasimenko, Y. (2022) · Current Opinion in Neurology · doi:10.1097/wco.0000000000001080 · Cited by 18
Self-citationNanomedicine-enabled next-generation therapeutics for spinal cord injury
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“Recently, SCES has shown potential to improve multiple functions, including overground ambulation (Harkema et al., 2011; Angeli et al., 2014, 2018; Sayenko et al., 2014; Rejc et al., 2015; Gill et al., 2018; Wagner et al., 2018) and regulation of low blood pressure (Aslan et al.”
BackgroundMasaev, D., Suleimanova, A., Prudnikov, N. V., Serenko, M. V., Emelyanov, A. V., Demin, V. A., Lavrov, I. A., Talanov, M. O., & Erokhin, V. V. (2023) · Frontiers in Neuroscience · doi:10.3389/fnins.2023.1124950 · Cited by 17
“Recent studies indicated the use of the EES within a range of 15–30 Hz stimulation frequency for the recovery of motor functions in humans (Gill et al., 2018; Wagner et al., 2018).”
BackgroundSelf-citationSingh, R. E., Ahmadi, A., Parr, A. M., Samadani, U., Krassioukov, A. V., Netoff, T. I., & Darrow, D. (2023) · Journal of NeuroEngineering and Rehabilitation · doi:10.1186/s12984-023-01164-1 · Cited by 19
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“…of individuals, these studies have shown the ability of targeted spinal cord electrical stimulation to restore movement, standing, and walking in individuals with clinically complete paralysis (Harkema et al., 2011, Angeli et al., 2014, Angeli et al., 2018, Gill et al., 2018, Wagner et al., 2018).”
BackgroundManson, G. A., Atkinson, D. A., Shi, Z., Sheynin, J., Karmonik, C., Markley, R. L., & Sayenko, D. G. (2022) · Neuroimage Reports · doi:10.1016/j.ynirp.2022.100090 · Cited by 16
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Self-citationMuscle anatomy is reflected in the spatial organization of the spinal motoneuron pools
Taitano, R. I., Yakovenko, S., & Gritsenko, V. (2024) · Communications Biology · doi:10.1038/s42003-023-05742-w · Cited by 14
Prevalence of autonomic dysreflexia during spinal cord stimulation after spinal cord injury
Veith, D. D., Asp, A. J., Gill, M. L., Fernandez, K. A., Mills, C. J., Linde, M. B., Jahanian, O., Beck, L. A., Zhao, K. D., Grahn, P. J., et al. (2024) · Journal of Neurophysiology · doi:10.1152/jn.00343.2024 · Cited by 15
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Spinal cord fMRI with MB‐SWIFT for assessing epidural spinal cord stimulation in rats
Laakso, H., Lehto, L. J., Paasonen, J., Salo, R. A., Canna, A., Lavrov, I. A., Michaeli, S., Gröhn, O. H. J., & Mangia, S. (2021) · Magnetic Resonance in Medicine · doi:10.1002/mrm.28844 · Cited by 13
Self-citationSteele, A. G., Atkinson, D. A., Varghese, B., Oh, J., Markley, R. L., & Sayenko, D. G. (2021) · Journal of Clinical Medicine · doi:10.3390/jcm10245958 · Cited by 15
“Investigation of the relationship between the degree of remaining supraspinal connections with spinal networks and the ability to voluntarily control muscles of the lower limbs in individuals with SCI will be the next step to quantify the residual and regained function throughout the course of neurorehabilitation.”
BackgroundInfluentialSelf-citationEisdorfer, J. T., Sobotka-Briner, H., Schramfield, S., Moukarzel, G., Chen, J., Campion, T. J., III, Smit, R. D., Rauscher, B. C., Lemay, M. A., Smith, G. M., et al. (2022) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2022.872634 · Cited by 14
“In particular, epidural electrical stimulation (EES) applied to the lumbosacral spinal cord mediates functional improvements in patients with chronic SCI (Herman et al., 2002; Courtine et al., 2009; Harkema et al., 2011; Karimi et al., 2013; Angeli et al., 2014; Crosbie et al., 2014; Possover, 2014; Grahn et al., 2017…”
BackgroundEpidural Spinal Electrogram Provides Direct Spinal Recordings in Awake Human Participants
Burke, J. F., Kunwar, N., Yaroshinsky, M. S., Louie, K. H., Shirvalkar, P. R., Su, P., Henry, M., Pasvankas, G. W., Poree, L. R., Jacques, L. G., et al. (2021) · Frontiers in Human Neuroscience · doi:10.3389/fnhum.2021.721076 · Cited by 15
Neurorestoratology: New Advances in Clinical Therapy
Huang, H., Sharma, H. S., Chen, L., & Chen, D. (2022) · CNS & Neurological Disorders - Drug Targets · doi:10.2174/1871527321666220827093805 · Cited by 14
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“1 4 These processes can subsequently develop into irreversible atrophy of muscles in the paralyzed limbs.”
BackgroundA giant step for spinal cord injury research
Moritz, C. T. (2018) · Nature Neuroscience · doi:10.1038/s41593-018-0264-4 · Cited by 15
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Supraspinal control of motoneurons after paralysis enabled by spinal cord stimulationPreprint
Balaguer, J.-M., Prat-Ortega, G., Verma, N., Yadav, P., Sorensen, E., de Freitas, R., Ensel, S., Borda, L., Donadio, S., Liang, L., et al. (2023) · medRxiv · doi:10.1101/2023.11.29.23298779 · Cited by 13
“In the last two decades, a series of animal and clinical studies showed that epidural electrical spinal cord stimulation (SCS) can restore some degree of motor control of lower and upper limbs in people with spinal cord injury and stroke 1–7 .”
BackgroundSteele, A. G., Manson, G. A., Horner, P. J., Sayenko, D. G., & Contreras-Vidal, J. L. (2022) · Journal of Neural Engineering · doi:10.1088/1741-2552/ac7b4b · Cited by 15
“Published by IOP Publishing Ltd direct costs for a personwith SCIwho is 25 years old is between 2.1 and 5.4 million dollars [10].”
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Electrical Stimulation and Motor Function Rehabilitation in Spinal Cord Injury: A Systematic Review
Kanakis, A. K., Benetos, I. S., Evangelopoulos, D. S., Vlamis, J., Vasiliadis, E. S., Kotroni, A., & Pneumaticos, S. G. (2024) · Cureus · doi:10.7759/cureus.61436 · Cited by 13
“A follow-up conducted 43 weeks later by Gill et al. demonstrated further improvements, including bilateral stepping on a treadmill, independent body weight support, and independent overground stepping [18].”
MethodSalchow-Hömmen, C., Schauer, T., Müller, P., Kühn, A. A., Hofstoetter, U. S., & Wenger, N. (2021) · Journal of Clinical Medicine · doi:10.3390/jcm10225464 · Cited by 13
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Matson, K. J. E., Russ, D. E., Kathe, C., Maric, D., Hua, I., Krynitsky, J., Pursley, R. H., Sathyamurthy, A., Squair, J. W., Courtine, G., et al. (2021) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2021.04.28.441862 · Cited by 13
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“In addition to extensive task-specific (stepping and standing) training, the efficacy of ES was enhanced using an interleaved stimulation protocol [57] (independently controlled stimulation at 20 Hz applied”
MethodA Review of the Potential Use of Antioxidants in Spinal Cord Injuries
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Spinal cord stimulation for spinal cord injury – Where do we stand? A narrative review
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Targeting Central Nervous System Regeneration with Cell Type Specificity
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Innovations in Electrical Stimulation Harness Neural Plasticity to Restore Motor Function
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“Several groups have since shown amazing recovery of stepping[57] and over-ground walking[58,59] in patients with SCI, an unprecedented leap forward in treatment for these patients.”
BackgroundStimulus outputs induced by subdural electrodes on the cervical spinal cord in monkeys
Kato, K., Nishihara, Y., & Nishimura, Y. (2020) · Journal of Neural Engineering · doi:10.1088/1741-2552/ab63a3 · Cited by 12
“Repetitive epidural or intraspinal stimulation produces functionally coordinated movements in patients (Harkema et al 2011, Gill et al 2018) and animals (Mushahwar and Horch 2000, Mushahwar et al 2000, Saigal et al 2004, Moritz et al 2007, Zimmermann et al 2011; Sunshine et al 2013, Kasten et al…”
BackgroundKrucoff, M. O., Gramer, R., Lott, D., Kale, E. B., Yadav, A. P., Abd‐El‐Barr, M. M., Sinha, S. R., & Lad, S. P. (2020) · Spinal Cord Series and Cases · doi:10.1038/s41394-020-00345-7 · Cited by 13
Ji, Z., Yan, J., Li, C., Sun, Y., Wang, S., Tao, J., Liu, J., & Liu, Y. (2025) · Science Advances · doi:10.1126/sciadv.ads4938 · Cited by 13
Injectable Ventral Spinal Stimulator Evokes Programmable and Biomimetic Hindlimb Motion
Lin, D., Lee, J. M., Wang, C., Park, H., & Lieber, C. M. (2023) · Nano Letters · doi:10.1021/acs.nanolett.3c01806 · Cited by 11
Rybka, V., Šedivá, K., Špačková, L., Kolář, P., Bradáč, O., & Kříž, J. (2023) · International Journal of Neuroscience · doi:10.1080/00207454.2023.2273772 · Cited by 11
“Recovery of standing and walking ability in paraple-gics after esCs has been demonstrated by several research teams [17,22–24].”
Mukhametova, E., Militskova, A., Рамилевич, Б. А., Kharin, N. V., Семенова, Е. В., Александрович, С. О., Baltina, T., & Lavrov, I. A. (2023) · Mayo Clinic Proceedings Innovations Quality & Outcomes · doi:10.1016/j.mayocpiqo.2023.09.006 · Cited by 11
“9 Another possibility for improvement in motor control after SCI may come from the integration of sublesional and supralesional components of spinal network.”
BackgroundSelf-citationCombinatorial strategies for cell transplantation in traumatic spinal cord injury
Jagrit, V., Koffler, J. Y., & Dulin, J. N. (2024) · Frontiers in Neuroscience · doi:10.3389/fnins.2024.1349446 · Cited by 11
Taccola, G., Salazar, B., Apicella, R., Hogan, M., Horner, P. J., & Sayenko, D. G. (2020) · Frontiers in Systems Neuroscience · doi:10.3389/fnsys.2020.00044 · Cited by 11
Self-citationDiffusion Tensor Imaging: Tool for Tracking Injured Spinal Cord Fibres in Rat
Murgoci, A., Bačiak, L., Cubinkova, V., Smolek, T., Tvrdík, T., Juránek, I., Kafka, J., & Cizkova, D. (2019) · Neurochemical Research · doi:10.1007/s11064-019-02801-9 · Cited by 11
Spungen, A. M., Bauman, W. A., Biswas, K., Jones, K. M., Snodgrass, A. J., Goetz, L. L., Gorman, P. H., Kirshblum, S., Sabharwal, S., White, K. T., et al. (2020) · Contemporary Clinical Trials · doi:10.1016/j.cct.2020.106102 · Cited by 11
Shon, A., Brakel, K., Hook, M. A., & Park, H. (2021) · IEEE Transactions on Biomedical Engineering · doi:10.1109/tbme.2021.3054564 · Cited by 11
Audet, J., Harnie, J., Lecomte, C. G., Mari, S., Merlet, A. N., Prilutsky, B. I., Rybak, I. A., & Frigon, A. (2022) · Journal of Neurotrauma · doi:10.1089/neu.2022.0042 · Cited by 11
“Studies after spinal transection in kittens 51 and adult cats 52 reported an apparent loss of coordination between the forelimbs and hindlimbs, with the forelimbs taking more steps than the hindlimbs (2:1 fore-hind coordination).”
Restoration of complex movement in the paralyzed upper limb
Hasse, B. A., Sheets, D. E. G., Holly, N. L., Gothard, K. M., & Fuglevand, A. J. (2022) · Journal of Neural Engineering · doi:10.1088/1741-2552/ac7ad7 · Cited by 14
“Current attempts to restore limb function following spinal cord injury (SCI) rests on four main strategies: surgical reconstruction - often involving tendon transfers from non-paralyzed to paralyzed muscle, repair the injury using a variety of neuroprotective and neuroregenerative agents including cell transplantation…”
Wearable Jacket for Posture Correction Using Flexible Fabric Stretch Sensor for Working Age Groups
Santhosh Krishna, B., V, Godwin, J. J., Gratia, A. A., Keerthanaa, K., & Kiruthika, B. (2021) · Lecture notes in networks and systems · doi:10.1007/978-981-33-4687-1_30 · Cited by 10
Rehabilitation of motor and sensory function using spinal cord stimulation: Recent advances
Iversen, M. M., Harrison, A. T., Stanley, C. T., & Dalrymple, A. N. (2024) · Current Opinion in Biomedical Engineering · doi:10.1016/j.cobme.2024.100566 · Cited by 11
Blueprints for healing: central nervous system regeneration in zebrafish and neonatal mice
Cellini, B. R., Edachola, S. V., Faw, T. D., & Cigliola, V. (2025) · BMC Biology · doi:10.1186/s12915-025-02203-0 · Cited by 13
Benavides, F. D., Shine, M. G., Stefanovic, F., Chen, R. E., & Jo, H. J. (2025) · Frontiers in Neurology · doi:10.3389/fneur.2025.1587060 · Cited by 10
Samejima, S., Shackleton, C., Malik, R. N., Hosseinzadeh, A., Rempel, L., Phan, A.-D., Williams, A. M. M., Nightingale, T. E., Ghuman, A., Elliott, S., et al. (2025) · Bioelectronic Medicine · doi:10.1186/s42234-025-00183-8 · Cited by 13
“Recent evidence demonstrates that invasive epidural spinal cord stimulation can improve motor (Rowald et al. 2022; Gill et al. 2018; Angeli et al. 2018) and autonomic (Samejima et al. 2023; Harkema et al. 2018; Squair et al. 2021; Herrity et al. 2022; Shackleton et al. 2023) functions in…”
Fast inference of spinal neuromodulation for motor control using amortized neural networks
Govindarajan, L. N., Calvert, J. S., Parker, S. R., Jung, M., Darie, R., Miranda, P., Shaaya, E. A., Borton, D. A., & Serre, T. (2022) · Journal of Neural Engineering · doi:10.1088/1741-2552/ac9646 · Cited by 10
“The current strategy for determining patientspecific sensorimotor responses to EES, here defined as the EES evoked transynaptic activation of motor neurons via a subset of sensory fibers, is to construct a detailed associative map documenting the spatiotemporal patterns of electromyographic (EMG) activations [5, 7, 18…”
BackgroundMethodSelf-citationMesquita, R. M., Catavitello, G., Willems, P. A., & Dewolf, A. H. (2023) · European Journal of Applied Physiology · doi:10.1007/s00421-023-05169-5 · Cited by 10
Timing‐dependent synergies between motor cortex and posterior spinal stimulation in humans
McIntosh, J. R., Joiner, E. F., Goldberg, J. L., Greenwald, P. L., Dionne, A. C., Murray, L. M., Thuet, E. D., Modik, O., Shelkov, E., Lombardi, J. M., et al. (2024) · The Journal of Physiology · doi:10.1113/jp286183 · Cited by 10
“…activation fits with human studies where volitional control was regained with epidural SCS despite severe damage to the neural pathway (Angeli et al., 2018; Carhart et al., 2004; Gill et al., 2018; Inanici et al., 2018, 2021; Powell et al., 2023; Rowald et al., 2022; Wagner et al., 2018).”
BackgroundDalrymple, A. N., & Mushahwar, V. K. (2020) · Journal of Medical Robotics Research · doi:10.1142/s2424905x20410032 · Cited by 9
Yao, Q., Guan, J., Ma, L., Cheng, L., Duan, F., Xu, F., Zhao, W., Duan, W., Wu, H., Chen, Z., et al. (2020) · Neuromodulation Technology at the Neural Interface · doi:10.1111/ner.13344 · Cited by 10
“of WEES on ASIA grade A impairment are promising, they are still heterogeneous owing to the complete loss of supraspinal input (61,62).”
BackgroundKim, M., Moon, Y., Hunt, J., McKenzie, K. A., Horin, A. P., McGuire, M., Kim, K., Hargrove, L. J., & Jayaraman, A. (2021) · Frontiers in Human Neuroscience · doi:10.3389/fnhum.2021.660583 · Cited by 10
“Previous tSCS studies filtered the stimulation-induced artifact using reference sEMG electrodes placed over paraspinal muscles to record the artifacts from tSCS (Harkema et al., 2011; Angeli et al., 2018; Gill et al., 2018).”
BackgroundMethodInfluentialClinical Trial Designs for Neuromodulation in Chronic Spinal Cord Injury Using Epidural Stimulation
Boakye, M., Ugiliweneza, B., Madrigal, F. C., Mesbah, S., Ovechkin, A. V., Angeli, C., Bloom, O., Wecht, J. M., Ditterline, B. L., Harel, N. Y., et al. (2021) · Neuromodulation Technology at the Neural Interface · doi:10.1111/ner.13381 · Cited by 10
“The reported effects include the recovery of voluntary movement (6–11), walking/stepping (9,12,13), improved cardiovascular regulation (10,14–17), and improvement in other physiological consequences of SCI (18,19).”
BackgroundCheng, J., & Guan, N. N. (2023) · IBRO Neuroscience Reports · doi:10.1016/j.ibneur.2023.04.001 · Cited by 9
“With help of new medical interventions and rehabilitation strategies, SCI patients are starting to regain some of their lost motor functions (Harkema, 2011; Formento, 2018a; Darrow, 2019; Dimitrijevic et al., 1998; Danner, 2015; Gill, 2018; Angeli, 2018a; Herman, 2002; Wagner, 2018).”
BackgroundExoskeleton gait training with spinal cord neuromodulation
Ivanenko, Y. P., Shapkova, E. Y., Petrova, D., Kleeva, D. F., & Lebedev, M. (2023) · Frontiers in Human Neuroscience · doi:10.3389/fnhum.2023.1194702 · Cited by 9
“New control strategies such as brain-machine interfaces and spinal cord neuromodulation can improve the development and use of exoskeletons (Lebedev and Nicolelis, 2011; La Scaleia et al., 2014; Vouga et al., 2017; Gill et al., 2018; Benabid et al., 2019; Rowald et al., 2022).”
BackgroundYong, H., Song, H., Kim, D., Park, J., Heo, D., Cha, K., Song, M., Jung, S.-W., Choi, W. J., Hwang, P. T. J., et al. (2023) · ACS Energy Letters · doi:10.1021/acsenergylett.3c00708 · Cited by 10
Dzewaltowski, A. C., & Malcolm, P. (2024) · IEEE Transactions on Neural Systems and Rehabilitation Engineering · doi:10.1109/tnsre.2024.3419688 · Cited by 9
Scheffler, M. S., Martin, C. A., Dietz, V. A., Faraji, A. H., & Sayenko, D. G. (2024) · Clinical Neurophysiology · doi:10.1016/j.clinph.2024.06.015 · Cited by 9
Self-citationNoninvasive Electrical Modalities to Alleviate Respiratory Deficits Following Spinal Cord Injury
Tharu, N. S., Suthar, A., Gerasimenko, Y., Castillo, C., Ng, A., & Ovechkin, A. V. (2024) · Life · doi:10.3390/life14121657 · Cited by 9
“In studies investigating trunk and lower limb muscle activation during voluntary tasks in a patient with cervical motor-complete SCI (C7 AIS-B), we observed that respiratory muscles below the injury level could be activated when these tasks were assisted by scES applied below the lesion [54].”
Self-citationNon-invasive spinal neuromodulation enables stepping in children with complete spinal cord injury
Lucas, K. C. H., Singh, G., Alvarado, L. R., King, M., Stepp, N., Parikh, P., Ugiliweneza, B., Gerasimenko, Y., & Behrman, A. L. (2025) · Brain · doi:10.1093/brain/awaf115 · Cited by 9
Self-citationAdvances in Neuromodulation and Digital Brain–Spinal Cord Interfaces for Spinal Cord Injury
Jaszczuk, P., Bratelj, D., Capone, C., Rudnick, M., Pötzel, T., Verma, R. K., & Fiechter, M. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms26136021 · Cited by 11
“By bridging cortical signals to spinal circuits, useable walking function is generated [17,33].”
Atkinson, D. A., Steele, A. G., Manson, G. A., Sheynin, J., Oh, J., Gerasimenko, Y., & Sayenko, D. G. (2022) · Journal of Neurophysiology · doi:10.1152/jn.00456.2021 · Cited by 9
Self-citationNeuromodulation and quality of life for patient with spasticity after spinal cord injury
Рамилевич, Б. А., Bryukhovetskiy, I., Sharma, A., & Sharma, H. S. (2023) · International review of neurobiology · doi:10.1016/bs.irn.2023.03.003 · Cited by 9
Closed-Loop Neuromodulation: Listen to the Body
Oxley, T. J., & Opie, N. L. (2018) · World Neurosurgery · doi:10.1016/j.wneu.2018.11.132 · Cited by 9
Metadata
- Authors
- Gill, M. L., Grahn, P. J., Calvert, J. S., Linde, M. B., Lavrov, I. A., Strommen, J. A., Beck, L. A., Sayenko, D. G., Van Straaten, M. G., Drubach, D. I., Veith, D. D., Thoreson, A. R., Lopez, C., Gerasimenko, Y. P., Edgerton, V. R., Lee, K. H., & Zhao, K. D.
- Affiliations
- Mayo Clinic (US)
- Houston Methodist (US)
- Russian Academy of Sciences (RU)
- University of California, Los Angeles (US)
- Corresponding author
- Lee, Kendall H.
- Zhao, Kristin D.
- ORCID
- Venue
- Nature Medicine
- Published
- 2018-09-24
- Volume
- 24
- Issue
- 11
- Pages
- 1677-1682
- ISSN
- 1078-8956 (ISSN-L)
- 1546-170X
- OpenAlex
- W2892074957
- Cited by
- 574
- References
- 43
- Citations by year
- 2026: 51 · 2025: 63 · 2024: 58 · 2023: 81 · 2022: 87 · 2021: 94 · 2020: 72 · 2019: 50 · 2018: 16
- FWCI
- 44.13
- Type
- journal article
- Language
- en
- Update notices
- correction (2018-10-23)
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Nature Medicine (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Nature
- Topics
- Health Sciences › Medicine › Clinical Neurology › Spinal Cord Injury Research
- Health Sciences › Medicine › Rehabilitation › Stroke Rehabilitation and Recovery
- Physical Sciences › Engineering › Biomedical Engineering › Prosthetics and Rehabilitation Robotics
- Keywords
- spinal cord injury, complete paraplegia, epidural stimulation, multimodal rehabilitation, task-oriented training, body weight support, standing, paraplegia
- MeSH terms
- Adult, Electric Stimulation, Transcutaneous Electric Nerve Stimulation, Electromyography, Humans, Male, Motor Activity, Nerve Net, Paralysis, Paraplegia, Spinal Cord Injuries, Muscle, Skeletal
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